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P07659

- RPOL_BPT3

UniProt

P07659 - RPOL_BPT3

Protein

DNA-directed RNA polymerase

Gene

1

Organism
Enterobacteria phage T3 (Bacteriophage T3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Apr 1988)
      Previous versions | rss
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    Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei538 – 5381By similarity
    Active sitei632 – 6321By similarity
    Active sitei813 – 8131By similarity

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. DNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Transcription

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerase (EC:2.7.7.6)
    Gene namesi
    Name:1
    OrganismiEnterobacteria phage T3 (Bacteriophage T3)
    Taxonomic identifieri10759 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaeAutographivirinaeT7likevirus
    Virus hostiEscherichia coli [TaxID: 562]

    Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymerase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 884884DNA-directed RNA polymerasePRO_0000087748Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP07659.
    SMRiP07659. Positions 6-884.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.1320.10. 1 hit.
    1.10.287.260. 1 hit.
    InterProiIPR024075. DNA-dir_RNA_pol_helix_hairpin.
    IPR002092. DNA-dir_Rpol_phage-type.
    IPR029262. RPOL_N.
    [Graphical view]
    PANTHERiPTHR10102. PTHR10102. 1 hit.
    PfamiPF00940. RNA_pol. 1 hit.
    PF14700. RPOL_N. 1 hit.
    [Graphical view]
    PROSITEiPS00900. RNA_POL_PHAGE_1. 1 hit.
    PS00489. RNA_POL_PHAGE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P07659-1 [UniParc]FASTAAdd to Basket

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    MNIIENIEKN DFSEIELAAI PFNTLADHYG SALAKEQLAL EHESYELGER    50
    RFLKMLERQA KAGEIADNAA AKPLLATLLP KLTTRIVEWL EEYASKKGRK 100
    PSAYAPLQLL KPEASAFITL KVILASLTST NMTTIQAAAG MLGKAIEDEA 150
    RFGRIRDLEA KHFKKHVEEQ LNKRHGQVYK KAFMQVVEAD MIGRGLLGGE 200
    AWSSWDKETT MHVGIRLIEM LIESTGLVEL QRHNAGNAGS DHEALQLAQE 250
    YVDVLAKRAG ALAGISPMFQ PCVVPPKPWV AITGGGYWAN GRRPLALVRT 300
    HSKKGLMRYE DVYMPEVYKA VNLAQNTAWK INKKVLAVVN EIVNWKNCPV 350
    ADIPSLERQE LPPKPDDIDT NEAALKEWKK AAAGIYRLDK ARVSRRISLE 400
    FMLEQANKFA SKKAIWFPYN MDWRGRVYAV PMFNPQGNDM TKGLLTLAKG 450
    KPIGEEGFYW LKIHGANCAG VDKVPFPERI AFIEKHVDDI LACAKDPINN 500
    TWWAEQDSPF CFLAFCFEYA GVTHHGLSYN CSLPLAFDGS CSGIQHFSAM 550
    LRDEVGGRAV NLLPSETVQD IYGIVAQKVN EILKQDAING TPNEMITVTD 600
    KDTGEISEKL KLGTSTLAQQ WLAYGVTRSV TKRSVMTLAY GSKEFGFRQQ 650
    VLDDTIQPAI DSGKGLMFTQ PNQAAGYMAK LIWDAVSVTV VAAVEAMNWL 700
    KSAAKLLAAE VKDKKTKEIL RHRCAVHWTT PDGFPVWQEY RKPLQKRLDM 750
    IFLGQFRLQP TINTLKDSGI DAHKQESGIA PNFVHSQDGS HLRMTVVYAH 800
    EKYGIESFAL IHDSFGTIPA DAGKLFKAVR ETMVITYENN DVLADFYSQF 850
    ADQLHETQLD KMPPLPKKGN LNLQDILKSD FAFA 884
    Length:884
    Mass (Da):98,790
    Last modified:April 1, 1988 - v1
    Checksum:iD589E02D879ADA45
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X05031 Genomic DNA. Translation: CAA28696.1.
    X17255 Genomic DNA. Translation: CAA35121.1.
    X02981 Genomic DNA. Translation: CAA26719.1.
    PIRiA29060. RNBPT3.
    RefSeqiNP_523301.1. NC_003298.1.

    Genome annotation databases

    GeneIDi927437.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X05031 Genomic DNA. Translation: CAA28696.1 .
    X17255 Genomic DNA. Translation: CAA35121.1 .
    X02981 Genomic DNA. Translation: CAA26719.1 .
    PIRi A29060. RNBPT3.
    RefSeqi NP_523301.1. NC_003298.1.

    3D structure databases

    ProteinModelPortali P07659.
    SMRi P07659. Positions 6-884.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL4854.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 927437.

    Family and domain databases

    Gene3Di 1.10.1320.10. 1 hit.
    1.10.287.260. 1 hit.
    InterProi IPR024075. DNA-dir_RNA_pol_helix_hairpin.
    IPR002092. DNA-dir_Rpol_phage-type.
    IPR029262. RPOL_N.
    [Graphical view ]
    PANTHERi PTHR10102. PTHR10102. 1 hit.
    Pfami PF00940. RNA_pol. 1 hit.
    PF14700. RPOL_N. 1 hit.
    [Graphical view ]
    PROSITEi PS00900. RNA_POL_PHAGE_1. 1 hit.
    PS00489. RNA_POL_PHAGE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Hausmann.
    2. "Sequence of a conditionally essential region of bacteriophage T3, including the primary origin of DNA replication."
      Schmitt M.P., Beck P.J., Kearney C.A., Spence J.L., Digiovanni D., Condreay J.P., Molineux I.J.
      J. Mol. Biol. 193:479-495(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 855-884.
      Strain: Luria.

    Entry informationi

    Entry nameiRPOL_BPT3
    AccessioniPrimary (citable) accession number: P07659
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3