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Protein

DNA-directed RNA polymerase

Gene

1

Organism
Enterobacteria phage T3 (Bacteriophage T3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei538 – 5381By similarity
Active sitei632 – 6321By similarity
Active sitei813 – 8131By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase (EC:2.7.7.6)
Gene namesi
Name:1
OrganismiEnterobacteria phage T3 (Bacteriophage T3)
Taxonomic identifieri10759 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaeAutographivirinaeT7likevirus
Virus hostiEscherichia coli [TaxID: 562]

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 884884DNA-directed RNA polymerasePRO_0000087748Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP07659.
SMRiP07659. Positions 6-884.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK10908.

Family and domain databases

Gene3Di1.10.1320.10. 1 hit.
1.10.287.260. 1 hit.
InterProiIPR024075. DNA-dir_RNA_pol_helix_hairpin.
IPR002092. DNA-dir_Rpol_phage-type.
IPR029262. RPOL_N.
[Graphical view]
PANTHERiPTHR10102. PTHR10102. 1 hit.
PfamiPF00940. RNA_pol. 1 hit.
PF14700. RPOL_N. 1 hit.
[Graphical view]
PROSITEiPS00900. RNA_POL_PHAGE_1. 1 hit.
PS00489. RNA_POL_PHAGE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07659-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIIENIEKN DFSEIELAAI PFNTLADHYG SALAKEQLAL EHESYELGER
60 70 80 90 100
RFLKMLERQA KAGEIADNAA AKPLLATLLP KLTTRIVEWL EEYASKKGRK
110 120 130 140 150
PSAYAPLQLL KPEASAFITL KVILASLTST NMTTIQAAAG MLGKAIEDEA
160 170 180 190 200
RFGRIRDLEA KHFKKHVEEQ LNKRHGQVYK KAFMQVVEAD MIGRGLLGGE
210 220 230 240 250
AWSSWDKETT MHVGIRLIEM LIESTGLVEL QRHNAGNAGS DHEALQLAQE
260 270 280 290 300
YVDVLAKRAG ALAGISPMFQ PCVVPPKPWV AITGGGYWAN GRRPLALVRT
310 320 330 340 350
HSKKGLMRYE DVYMPEVYKA VNLAQNTAWK INKKVLAVVN EIVNWKNCPV
360 370 380 390 400
ADIPSLERQE LPPKPDDIDT NEAALKEWKK AAAGIYRLDK ARVSRRISLE
410 420 430 440 450
FMLEQANKFA SKKAIWFPYN MDWRGRVYAV PMFNPQGNDM TKGLLTLAKG
460 470 480 490 500
KPIGEEGFYW LKIHGANCAG VDKVPFPERI AFIEKHVDDI LACAKDPINN
510 520 530 540 550
TWWAEQDSPF CFLAFCFEYA GVTHHGLSYN CSLPLAFDGS CSGIQHFSAM
560 570 580 590 600
LRDEVGGRAV NLLPSETVQD IYGIVAQKVN EILKQDAING TPNEMITVTD
610 620 630 640 650
KDTGEISEKL KLGTSTLAQQ WLAYGVTRSV TKRSVMTLAY GSKEFGFRQQ
660 670 680 690 700
VLDDTIQPAI DSGKGLMFTQ PNQAAGYMAK LIWDAVSVTV VAAVEAMNWL
710 720 730 740 750
KSAAKLLAAE VKDKKTKEIL RHRCAVHWTT PDGFPVWQEY RKPLQKRLDM
760 770 780 790 800
IFLGQFRLQP TINTLKDSGI DAHKQESGIA PNFVHSQDGS HLRMTVVYAH
810 820 830 840 850
EKYGIESFAL IHDSFGTIPA DAGKLFKAVR ETMVITYENN DVLADFYSQF
860 870 880
ADQLHETQLD KMPPLPKKGN LNLQDILKSD FAFA
Length:884
Mass (Da):98,790
Last modified:April 1, 1988 - v1
Checksum:iD589E02D879ADA45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05031 Genomic DNA. Translation: CAA28696.1.
X17255 Genomic DNA. Translation: CAA35121.1.
X02981 Genomic DNA. Translation: CAA26719.1.
PIRiA29060. RNBPT3.
RefSeqiNP_523301.1. NC_003298.1.

Genome annotation databases

GeneIDi927437.
KEGGivg:927437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05031 Genomic DNA. Translation: CAA28696.1.
X17255 Genomic DNA. Translation: CAA35121.1.
X02981 Genomic DNA. Translation: CAA26719.1.
PIRiA29060. RNBPT3.
RefSeqiNP_523301.1. NC_003298.1.

3D structure databases

ProteinModelPortaliP07659.
SMRiP07659. Positions 6-884.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

ChEMBLiCHEMBL4854.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi927437.
KEGGivg:927437.

Phylogenomic databases

KOiK10908.

Miscellaneous databases

PROiP07659.

Family and domain databases

Gene3Di1.10.1320.10. 1 hit.
1.10.287.260. 1 hit.
InterProiIPR024075. DNA-dir_RNA_pol_helix_hairpin.
IPR002092. DNA-dir_Rpol_phage-type.
IPR029262. RPOL_N.
[Graphical view]
PANTHERiPTHR10102. PTHR10102. 1 hit.
PfamiPF00940. RNA_pol. 1 hit.
PF14700. RPOL_N. 1 hit.
[Graphical view]
PROSITEiPS00900. RNA_POL_PHAGE_1. 1 hit.
PS00489. RNA_POL_PHAGE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Hausmann.
  2. "Sequence of a conditionally essential region of bacteriophage T3, including the primary origin of DNA replication."
    Schmitt M.P., Beck P.J., Kearney C.A., Spence J.L., Digiovanni D., Condreay J.P., Molineux I.J.
    J. Mol. Biol. 193:479-495(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 855-884.
    Strain: Luria.

Entry informationi

Entry nameiRPOL_BPT3
AccessioniPrimary (citable) accession number: P07659
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: April 29, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.