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Protein

Cytochrome c oxidase subunit 1

Gene

cox1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi68Iron (heme A axial ligand)Curated1
Metal bindingi247Copper BCurated1
Metal bindingi251Copper BCurated1
Metal bindingi296Copper BCurated1
Metal bindingi297Copper BCurated1
Metal bindingi383Iron (heme A3 axial ligand)Curated1
Metal bindingi385Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:cox1
ORF Names:SPMIT.01
Encoded oniMitochondrion
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Mitochondrion

Organism-specific databases

PomBaseiSPMIT.01 cox1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834141 – 537Cytochrome c oxidase subunit 1Add BLAST537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki247 ↔ 2511'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

MaxQBiP07657
PaxDbiP07657
PRIDEiP07657

Interactioni

Protein-protein interaction databases

STRINGi4896.SPMIT.01.1

Structurei

3D structure databases

ProteinModelPortaliP07657
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000085274
InParanoidiP07657
KOiK02256
OMAiMSFWLLP
OrthoDBiEOG092C2KU4
PhylomeDBiP07657

Family and domain databases

CDDicd01663 Cyt_c_Oxidase_I, 1 hit
Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
IPR033944 Cyt_c_oxase_su1_dom
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit

Sequencei

Sequence statusi: Complete.

P07657-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSWWTYVNR WIFSTNAKDI AILYLLFGLV SGIIGSVFSF IIRMELSAPG
60 70 80 90 100
SQFLSGNGQL YNVAISAHGI LMIFFFIIPA LFGAFGNYLV PLMIGAPDVA
110 120 130 140 150
YPRVNNFTFW LLPPALMLLL ISALTEEGPG GGWTVYPPLS SITSHSGPAI
160 170 180 190 200
DLAILSLQLT GISSTLGSVN LIATMINMRA PGLSLYQMPL FAWAIMITSI
210 220 230 240 250
LLLLTLPVLA GGLFMLFSDR NLNTSFYAPE GGGDPVLYQH LFWFFGHPEV
260 270 280 290 300
YILIMPAFGV VSHIIPSLAH KPIFGKEGML WAMLSIALLG LMVWSHHLFT
310 320 330 340 350
VGLDVDTRAY FSAATMVIAI PTGIKIFSWL ATLTGGAIQW SRVPMLYAIG
360 370 380 390 400
FLILFTIGGL TGVILSNSVL DIAFHDTYFV VAHFHYVLSM GALFGLCGAY
410 420 430 440 450
YWSPKMFGLM YNETLASIQF WILFIGVNIV FGPQHFLGLN GMPRRIPDYP
460 470 480 490 500
EAFVGWNFVS SIGSVISILS LFLFMYVMYD QFTSNRVVKT NPYLIPSYFD
510 520 530
DNVIFVNEKL GVAQSIEWLL HSPVHEHAFN TLPTKSI
Length:537
Mass (Da):59,412
Last modified:December 15, 1998 - v4
Checksum:iFF4BFD284B27BBBA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti401Y → YY in AAB00165 (PubMed:3026914).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54421 Genomic DNA Translation: CAA38284.1
X00886 Genomic DNA Translation: CAA25421.1
M15671 Genomic DNA Translation: AAB00165.1
M15670, M15669 Genomic DNA Translation: AAB00164.1
PIRiS78195
RefSeqiNP_039499.1, NC_001326.1

Genome annotation databases

EnsemblFungiiSPMIT.01.1; SPMIT.01.1:pep; SPMIT.01
GeneIDi1669524
KEGGispo:ScpofMp01

Similar proteinsi

Entry informationi

Entry nameiCOX1_SCHPO
AccessioniPrimary (citable) accession number: P07657
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 15, 1998
Last modified: May 23, 2018
This is version 142 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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