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P07657

- COX1_SCHPO

UniProt

P07657 - COX1_SCHPO

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Protein

Cytochrome c oxidase subunit 1

Gene

cox1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi68 – 681Iron (heme A axial ligand)Curated
Metal bindingi247 – 2471Copper BCurated
Metal bindingi251 – 2511Copper BCurated
Metal bindingi296 – 2961Copper BCurated
Metal bindingi297 – 2971Copper BCurated
Metal bindingi383 – 3831Iron (heme A3 axial ligand)Curated
Metal bindingi385 – 3851Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: PomBase
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: PomBase
  2. hydrogen ion transmembrane transport Source: GOC
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:cox1
ORF Names:SPMIT.01
Encoded oniMitochondrion
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence AnalysisAdd
BLAST
Transmembranei70 – 9021HelicalSequence AnalysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence AnalysisAdd
BLAST
Transmembranei152 – 17221HelicalSequence AnalysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence AnalysisAdd
BLAST
Transmembranei241 – 26121HelicalSequence AnalysisAdd
BLAST
Transmembranei279 – 29921HelicalSequence AnalysisAdd
BLAST
Transmembranei318 – 33821HelicalSequence AnalysisAdd
BLAST
Transmembranei345 – 36521HelicalSequence AnalysisAdd
BLAST
Transmembranei379 – 39921HelicalSequence AnalysisAdd
BLAST
Transmembranei418 – 43821HelicalSequence AnalysisAdd
BLAST
Transmembranei458 – 47821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain complex IV Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 537537Cytochrome c oxidase subunit 1PRO_0000183414Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki247 ↔ 2511'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

MaxQBiP07657.

Interactioni

Protein-protein interaction databases

STRINGi4896.SPMIT.01-1.

Structurei

3D structure databases

ProteinModelPortaliP07657.
SMRiP07657. Positions 7-536.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085274.
InParanoidiP07657.
KOiK02256.
OrthoDBiEOG72C58S.
PhylomeDBiP07657.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07657-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSWWTYVNR WIFSTNAKDI AILYLLFGLV SGIIGSVFSF IIRMELSAPG
60 70 80 90 100
SQFLSGNGQL YNVAISAHGI LMIFFFIIPA LFGAFGNYLV PLMIGAPDVA
110 120 130 140 150
YPRVNNFTFW LLPPALMLLL ISALTEEGPG GGWTVYPPLS SITSHSGPAI
160 170 180 190 200
DLAILSLQLT GISSTLGSVN LIATMINMRA PGLSLYQMPL FAWAIMITSI
210 220 230 240 250
LLLLTLPVLA GGLFMLFSDR NLNTSFYAPE GGGDPVLYQH LFWFFGHPEV
260 270 280 290 300
YILIMPAFGV VSHIIPSLAH KPIFGKEGML WAMLSIALLG LMVWSHHLFT
310 320 330 340 350
VGLDVDTRAY FSAATMVIAI PTGIKIFSWL ATLTGGAIQW SRVPMLYAIG
360 370 380 390 400
FLILFTIGGL TGVILSNSVL DIAFHDTYFV VAHFHYVLSM GALFGLCGAY
410 420 430 440 450
YWSPKMFGLM YNETLASIQF WILFIGVNIV FGPQHFLGLN GMPRRIPDYP
460 470 480 490 500
EAFVGWNFVS SIGSVISILS LFLFMYVMYD QFTSNRVVKT NPYLIPSYFD
510 520 530
DNVIFVNEKL GVAQSIEWLL HSPVHEHAFN TLPTKSI
Length:537
Mass (Da):59,412
Last modified:December 15, 1998 - v4
Checksum:iFF4BFD284B27BBBA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti401 – 4011Y → YY in AAB00165. (PubMed:3026914)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54421 Genomic DNA. Translation: CAA38284.1.
X00886 Genomic DNA. Translation: CAA25421.1.
M15671 Genomic DNA. Translation: AAB00165.1.
M15670, M15669 Genomic DNA. Translation: AAB00164.1.
PIRiS78195.
RefSeqiNP_039499.1. NC_001326.1.

Genome annotation databases

EnsemblFungiiSPMIT.01.1; SPMIT.01.1:pep; SPMIT.01.
GeneIDi1669524.
KEGGispo:ScpofMp01.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54421 Genomic DNA. Translation: CAA38284.1 .
X00886 Genomic DNA. Translation: CAA25421.1 .
M15671 Genomic DNA. Translation: AAB00165.1 .
M15670 , M15669 Genomic DNA. Translation: AAB00164.1 .
PIRi S78195.
RefSeqi NP_039499.1. NC_001326.1.

3D structure databases

ProteinModelPortali P07657.
SMRi P07657. Positions 7-536.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4896.SPMIT.01-1.

Proteomic databases

MaxQBi P07657.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPMIT.01.1 ; SPMIT.01.1:pep ; SPMIT.01 .
GeneIDi 1669524.
KEGGi spo:ScpofMp01.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085274.
InParanoidi P07657.
KOi K02256.
OrthoDBi EOG72C58S.
PhylomeDBi P07657.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Miscellaneous databases

NextBioi 20797080.
PROi P07657.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mitochondrial genome of Schizosaccharomyces pombe."
    Lang B.F.
    (In) O'Brien S.J. (eds.); Genetic Maps (6th edition), pp.3118-3119, Cold Spring Harbor Laboratory Press, New York (1993)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AD7-50.
  2. "The mitochondrial genome of the fission yeast Schizosaccharomyces pombe: highly homologous introns are inserted at the same position of the otherwise less conserved cox1 genes in Schizosaccharomyces pombe and Aspergillus nidulans."
    Lang B.F.
    EMBO J. 3:2129-2136(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 201-537.
    Strain: AD7-50.
  3. "The mosaic cox1 gene in the mitochondrial genome of Schizosaccharomyces pombe: minimal structural requirements and evolution of group I introns."
    Trinkl H., Wolf K.
    Gene 45:289-297(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 136-409.
    Strain: EF1.

Entry informationi

Entry nameiCOX1_SCHPO
AccessioniPrimary (citable) accession number: P07657
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 15, 1998
Last modified: October 29, 2014
This is version 121 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3