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P07657

- COX1_SCHPO

UniProt

P07657 - COX1_SCHPO

Protein

Cytochrome c oxidase subunit 1

Gene

cox1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 4 (15 Dec 1998)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi68 – 681Iron (heme A axial ligand)Curated
    Metal bindingi247 – 2471Copper BCurated
    Metal bindingi251 – 2511Copper BCurated
    Metal bindingi296 – 2961Copper BCurated
    Metal bindingi297 – 2971Copper BCurated
    Metal bindingi383 – 3831Iron (heme A3 axial ligand)Curated
    Metal bindingi385 – 3851Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: PomBase
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: PomBase
    2. hydrogen ion transmembrane transport Source: GOC
    3. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:cox1
    ORF Names:SPMIT.01
    Encoded oniMitochondrion
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Mitochondrion

    Organism-specific databases

    PomBaseiSPMIT.01.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial respiratory chain complex IV Source: PomBase

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 537537Cytochrome c oxidase subunit 1PRO_0000183414Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki247 ↔ 2511'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Proteomic databases

    MaxQBiP07657.

    Interactioni

    Protein-protein interaction databases

    STRINGi4896.SPMIT.01-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP07657.
    SMRiP07657. Positions 7-536.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei70 – 9021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei152 – 17221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei190 – 21021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei279 – 29921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei318 – 33821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei345 – 36521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei379 – 39921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei418 – 43821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei458 – 47821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0843.
    HOGENOMiHOG000085274.
    KOiK02256.
    OrthoDBiEOG72C58S.
    PhylomeDBiP07657.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P07657-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSWWTYVNR WIFSTNAKDI AILYLLFGLV SGIIGSVFSF IIRMELSAPG    50
    SQFLSGNGQL YNVAISAHGI LMIFFFIIPA LFGAFGNYLV PLMIGAPDVA 100
    YPRVNNFTFW LLPPALMLLL ISALTEEGPG GGWTVYPPLS SITSHSGPAI 150
    DLAILSLQLT GISSTLGSVN LIATMINMRA PGLSLYQMPL FAWAIMITSI 200
    LLLLTLPVLA GGLFMLFSDR NLNTSFYAPE GGGDPVLYQH LFWFFGHPEV 250
    YILIMPAFGV VSHIIPSLAH KPIFGKEGML WAMLSIALLG LMVWSHHLFT 300
    VGLDVDTRAY FSAATMVIAI PTGIKIFSWL ATLTGGAIQW SRVPMLYAIG 350
    FLILFTIGGL TGVILSNSVL DIAFHDTYFV VAHFHYVLSM GALFGLCGAY 400
    YWSPKMFGLM YNETLASIQF WILFIGVNIV FGPQHFLGLN GMPRRIPDYP 450
    EAFVGWNFVS SIGSVISILS LFLFMYVMYD QFTSNRVVKT NPYLIPSYFD 500
    DNVIFVNEKL GVAQSIEWLL HSPVHEHAFN TLPTKSI 537
    Length:537
    Mass (Da):59,412
    Last modified:December 15, 1998 - v4
    Checksum:iFF4BFD284B27BBBA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti401 – 4011Y → YY in AAB00165. (PubMed:3026914)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54421 Genomic DNA. Translation: CAA38284.1.
    X00886 Genomic DNA. Translation: CAA25421.1.
    M15671 Genomic DNA. Translation: AAB00165.1.
    M15670, M15669 Genomic DNA. Translation: AAB00164.1.
    PIRiS78195.
    RefSeqiNP_039499.1. NC_001326.1.

    Genome annotation databases

    EnsemblFungiiSPMIT.01.1; SPMIT.01.1:pep; SPMIT.01.
    GeneIDi1669524.
    KEGGispo:ScpofMp01.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54421 Genomic DNA. Translation: CAA38284.1 .
    X00886 Genomic DNA. Translation: CAA25421.1 .
    M15671 Genomic DNA. Translation: AAB00165.1 .
    M15670 , M15669 Genomic DNA. Translation: AAB00164.1 .
    PIRi S78195.
    RefSeqi NP_039499.1. NC_001326.1.

    3D structure databases

    ProteinModelPortali P07657.
    SMRi P07657. Positions 7-536.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4896.SPMIT.01-1.

    Proteomic databases

    MaxQBi P07657.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPMIT.01.1 ; SPMIT.01.1:pep ; SPMIT.01 .
    GeneIDi 1669524.
    KEGGi spo:ScpofMp01.

    Organism-specific databases

    PomBasei SPMIT.01.

    Phylogenomic databases

    eggNOGi COG0843.
    HOGENOMi HOG000085274.
    KOi K02256.
    OrthoDBi EOG72C58S.
    PhylomeDBi P07657.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Miscellaneous databases

    NextBioi 20797080.
    PROi P07657.

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mitochondrial genome of Schizosaccharomyces pombe."
      Lang B.F.
      (In) O'Brien S.J. (eds.); Genetic Maps (6th edition), pp.3118-3119, Cold Spring Harbor Laboratory Press, New York (1993)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AD7-50.
    2. "The mitochondrial genome of the fission yeast Schizosaccharomyces pombe: highly homologous introns are inserted at the same position of the otherwise less conserved cox1 genes in Schizosaccharomyces pombe and Aspergillus nidulans."
      Lang B.F.
      EMBO J. 3:2129-2136(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 201-537.
      Strain: AD7-50.
    3. "The mosaic cox1 gene in the mitochondrial genome of Schizosaccharomyces pombe: minimal structural requirements and evolution of group I introns."
      Trinkl H., Wolf K.
      Gene 45:289-297(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 136-409.
      Strain: EF1.

    Entry informationi

    Entry nameiCOX1_SCHPO
    AccessioniPrimary (citable) accession number: P07657
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: December 15, 1998
    Last modified: October 1, 2014
    This is version 120 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3