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P07657 (COX1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:cox1
ORF Names:SPMIT.01
Encoded onMitochondrion
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length537 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 537537Cytochrome c oxidase subunit 1
PRO_0000183414

Regions

Transmembrane22 – 4221Helical; Potential
Transmembrane70 – 9021Helical; Potential
Transmembrane104 – 12421Helical; Potential
Transmembrane152 – 17221Helical; Potential
Transmembrane190 – 21021Helical; Potential
Transmembrane241 – 26121Helical; Potential
Transmembrane279 – 29921Helical; Potential
Transmembrane318 – 33821Helical; Potential
Transmembrane345 – 36521Helical; Potential
Transmembrane379 – 39921Helical; Potential
Transmembrane418 – 43821Helical; Potential
Transmembrane458 – 47821Helical; Potential

Sites

Metal binding681Iron (heme A axial ligand) Probable
Metal binding2471Copper B Probable
Metal binding2511Copper B Probable
Metal binding2961Copper B Probable
Metal binding2971Copper B Probable
Metal binding3831Iron (heme A3 axial ligand) Probable
Metal binding3851Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link247 ↔ 2511'-histidyl-3'-tyrosine (His-Tyr) By similarity

Experimental info

Sequence conflict4011Y → YY in AAB00165. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P07657 [UniParc].

Last modified December 15, 1998. Version 4.
Checksum: FF4BFD284B27BBBA

FASTA53759,412
        10         20         30         40         50         60 
MNSWWTYVNR WIFSTNAKDI AILYLLFGLV SGIIGSVFSF IIRMELSAPG SQFLSGNGQL 

        70         80         90        100        110        120 
YNVAISAHGI LMIFFFIIPA LFGAFGNYLV PLMIGAPDVA YPRVNNFTFW LLPPALMLLL 

       130        140        150        160        170        180 
ISALTEEGPG GGWTVYPPLS SITSHSGPAI DLAILSLQLT GISSTLGSVN LIATMINMRA 

       190        200        210        220        230        240 
PGLSLYQMPL FAWAIMITSI LLLLTLPVLA GGLFMLFSDR NLNTSFYAPE GGGDPVLYQH 

       250        260        270        280        290        300 
LFWFFGHPEV YILIMPAFGV VSHIIPSLAH KPIFGKEGML WAMLSIALLG LMVWSHHLFT 

       310        320        330        340        350        360 
VGLDVDTRAY FSAATMVIAI PTGIKIFSWL ATLTGGAIQW SRVPMLYAIG FLILFTIGGL 

       370        380        390        400        410        420 
TGVILSNSVL DIAFHDTYFV VAHFHYVLSM GALFGLCGAY YWSPKMFGLM YNETLASIQF 

       430        440        450        460        470        480 
WILFIGVNIV FGPQHFLGLN GMPRRIPDYP EAFVGWNFVS SIGSVISILS LFLFMYVMYD 

       490        500        510        520        530 
QFTSNRVVKT NPYLIPSYFD DNVIFVNEKL GVAQSIEWLL HSPVHEHAFN TLPTKSI 

« Hide

References

« Hide 'large scale' references
[1]"The mitochondrial genome of Schizosaccharomyces pombe."
Lang B.F.
(In) O'Brien S.J. (eds.); Genetic Maps (6th edition), pp.3118-3119, Cold Spring Harbor Laboratory Press, New York (1993)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AD7-50.
[2]"The mitochondrial genome of the fission yeast Schizosaccharomyces pombe: highly homologous introns are inserted at the same position of the otherwise less conserved cox1 genes in Schizosaccharomyces pombe and Aspergillus nidulans."
Lang B.F.
EMBO J. 3:2129-2136(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 201-537.
Strain: AD7-50.
[3]"The mosaic cox1 gene in the mitochondrial genome of Schizosaccharomyces pombe: minimal structural requirements and evolution of group I introns."
Trinkl H., Wolf K.
Gene 45:289-297(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 136-409.
Strain: EF1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X54421 Genomic DNA. Translation: CAA38284.1.
X00886 Genomic DNA. Translation: CAA25421.1.
M15671 Genomic DNA. Translation: AAB00165.1.
M15670, M15669 Genomic DNA. Translation: AAB00164.1.
PIRS78195.
RefSeqNP_039499.1. NC_001326.1.

3D structure databases

ProteinModelPortalP07657.
SMRP07657. Positions 7-536.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4896.SPMIT.01-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPMIT.01.1; SPMIT.01.1:pep; SPMIT.01.
GeneID1669524.
KEGGspo:ScpofMp01.

Organism-specific databases

PomBaseSPMIT.01.

Phylogenomic databases

eggNOGCOG0843.
HOGENOMHOG000085274.
KOK02256.
OrthoDBEOG72C58S.
PhylomeDBP07657.

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20797080.
PROP07657.

Entry information

Entry nameCOX1_SCHPO
AccessionPrimary (citable) accession number: P07657
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 15, 1998
Last modified: April 16, 2014
This is version 117 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways