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Protein

Cytochrome c oxidase subunit 1

Gene

cox1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi68Iron (heme A axial ligand)Curated1
Metal bindingi247Copper BCurated1
Metal bindingi251Copper BCurated1
Metal bindingi296Copper BCurated1
Metal bindingi297Copper BCurated1
Metal bindingi383Iron (heme A3 axial ligand)Curated1
Metal bindingi385Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:cox1
ORF Names:SPMIT.01
Encoded oniMitochondrion
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Mitochondrion

Organism-specific databases

PomBaseiSPMIT.01. cox1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834141 – 537Cytochrome c oxidase subunit 1Add BLAST537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki247 ↔ 2511'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

MaxQBiP07657.
PRIDEiP07657.

Structurei

3D structure databases

ProteinModelPortaliP07657.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000085274.
InParanoidiP07657.
KOiK02256.
OMAiPYHTFEE.
OrthoDBiEOG092C2KU4.
PhylomeDBiP07657.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07657-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSWWTYVNR WIFSTNAKDI AILYLLFGLV SGIIGSVFSF IIRMELSAPG
60 70 80 90 100
SQFLSGNGQL YNVAISAHGI LMIFFFIIPA LFGAFGNYLV PLMIGAPDVA
110 120 130 140 150
YPRVNNFTFW LLPPALMLLL ISALTEEGPG GGWTVYPPLS SITSHSGPAI
160 170 180 190 200
DLAILSLQLT GISSTLGSVN LIATMINMRA PGLSLYQMPL FAWAIMITSI
210 220 230 240 250
LLLLTLPVLA GGLFMLFSDR NLNTSFYAPE GGGDPVLYQH LFWFFGHPEV
260 270 280 290 300
YILIMPAFGV VSHIIPSLAH KPIFGKEGML WAMLSIALLG LMVWSHHLFT
310 320 330 340 350
VGLDVDTRAY FSAATMVIAI PTGIKIFSWL ATLTGGAIQW SRVPMLYAIG
360 370 380 390 400
FLILFTIGGL TGVILSNSVL DIAFHDTYFV VAHFHYVLSM GALFGLCGAY
410 420 430 440 450
YWSPKMFGLM YNETLASIQF WILFIGVNIV FGPQHFLGLN GMPRRIPDYP
460 470 480 490 500
EAFVGWNFVS SIGSVISILS LFLFMYVMYD QFTSNRVVKT NPYLIPSYFD
510 520 530
DNVIFVNEKL GVAQSIEWLL HSPVHEHAFN TLPTKSI
Length:537
Mass (Da):59,412
Last modified:December 15, 1998 - v4
Checksum:iFF4BFD284B27BBBA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti401Y → YY in AAB00165 (PubMed:3026914).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54421 Genomic DNA. Translation: CAA38284.1.
X00886 Genomic DNA. Translation: CAA25421.1.
M15671 Genomic DNA. Translation: AAB00165.1.
M15670, M15669 Genomic DNA. Translation: AAB00164.1.
PIRiS78195.
RefSeqiNP_039499.1. NC_001326.1.

Genome annotation databases

EnsemblFungiiSPMIT.01.1; SPMIT.01.1:pep; SPMIT.01.
GeneIDi1669524.
KEGGispo:ScpofMp01.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54421 Genomic DNA. Translation: CAA38284.1.
X00886 Genomic DNA. Translation: CAA25421.1.
M15671 Genomic DNA. Translation: AAB00165.1.
M15670, M15669 Genomic DNA. Translation: AAB00164.1.
PIRiS78195.
RefSeqiNP_039499.1. NC_001326.1.

3D structure databases

ProteinModelPortaliP07657.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiP07657.
PRIDEiP07657.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPMIT.01.1; SPMIT.01.1:pep; SPMIT.01.
GeneIDi1669524.
KEGGispo:ScpofMp01.

Organism-specific databases

PomBaseiSPMIT.01. cox1.

Phylogenomic databases

HOGENOMiHOG000085274.
InParanoidiP07657.
KOiK02256.
OMAiPYHTFEE.
OrthoDBiEOG092C2KU4.
PhylomeDBiP07657.

Enzyme and pathway databases

UniPathwayiUPA00705.

Miscellaneous databases

PROiP07657.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_SCHPO
AccessioniPrimary (citable) accession number: P07657
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 15, 1998
Last modified: November 30, 2016
This is version 134 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.