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P07648 (EX5C_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Exodeoxyribonuclease V gamma chain
EC=3.1.11.5
Alternative name(s):
Exodeoxyribonuclease V 125 kDa polypeptide
Gene names
Name:recC
Ordered Locus Names:b2822, JW2790
OrganismEscherichia coli (strain K12)
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length1122 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Exhibits a wide variety of catalytic activities including ATP-dependent exonuclease, ATP-stimulated endonuclease, ATP-dependent helicase and DNA-dependent ATPase activities.

Catalytic activity

Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.

Subunit structure

Consist of three subunits; recB, recC and recD.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11221122Exodeoxyribonuclease V gamma chain
PRO_0000087120

Secondary structure

1 ................................................................................................................................................................ 1122
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P07648 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: 48B90092DFC1BD21

FASTA1,122128,848
        10         20         30         40         50         60 
MLRVYHSNRL DVLEALMEFI VERERLDDPF EPEMILVQST GMAQWLQMTL SQKFGIAANI 

        70         80         90        100        110        120 
DFPLPASFIW DMFVRVLPEI PKESAFNKQS MSWKLMTLLP QLLEREDFTL LRHYLTDDSD 

       130        140        150        160        170        180 
KRKLFQLSSK AADLFDQYLV YRPDWLAQWE TGHLVEGLGE AQAWQAPLWK ALVEYTHQLG 

       190        200        210        220        230        240 
QPRWHRANLY QRFIETLESA TTCPPGLPSR VFICGISALP PVYLQALQAL GKHIEIHLLF 

       250        260        270        280        290        300 
TNPCRYYWGD IKDPAYLAKL LTRQRRHSFE DRELPLFRDS ENAGQLFNSD GEQDVGNPLL 

       310        320        330        340        350        360 
ASWGKLGRDY IYLLSDLESS QELDAFVDVT PDNLLHNIQS DILELENRAV AGVNIEEFSR 

       370        380        390        400        410        420 
SDNKRPLDPL DSSITFHVCH SPQREVEVLH DRLLAMLEED PTLTPRDIIV MVADIDSYSP 

       430        440        450        460        470        480 
FIQAVFGSAP ADRYLPYAIS DRRARQSHPV LEAFISLLSL PDSRFVSEDV LALLDVPVLA 

       490        500        510        520        530        540 
ARFDITEEGL RYLRQWVNES GIRWGIDDDN VRELELPATG QHTWRFGLTR MLLGYAMESA 

       550        560        570        580        590        600 
QGEWQSVLPY DESSGLIAEL VGHLASLLMQ LNIWRRGLAQ ERPLEEWLPV CRDMLNAFFL 

       610        620        630        640        650        660 
PDAETEAAMT LIEQQWQAII AEGLGAQYGD AVPLSLLRDE LAQRLDQERI SQRFLAGPVN 

       670        680        690        700        710        720 
ICTLMPMRSI PFKVVCLLGM NDGVYPRQLA PLGFDLMSQK PKRGDRSRRD DDRYLFLEAL 

       730        740        750        760        770        780 
ISAQQKLYIS YIGRSIQDNS ERFPSVLVQE LIDYIGQSHY LPGDEALNCD ESEARVKAHL 

       790        800        810        820        830        840 
TCLHTRMPFD PQNYQPGERQ SYAREWLPAA SQAGKAHSEF VQPLPFTLPE TVPLETLQRF 

       850        860        870        880        890        900 
WAHPVRAFFQ MRLQVNFRTE DSEIPDTEPF ILEGLSRYQI NQQLLNALVE QDDAERLFRR 

       910        920        930        940        950        960 
FRAAGDLPYG AFGEIFWETQ CQEMQQLADR VIACRQPGQS MEIDLACNGV QITGWLPQVQ 

       970        980        990       1000       1010       1020 
PDGLLRWRPS LLSVAQGMQL WLEHLVYCAS GGNGESRLFL RKDGEWRFPP LAAEQALHYL 

      1030       1040       1050       1060       1070       1080 
SQLIEGYREG MSAPLLVLPE SGGAWLKTCY DAQNDAMLDD DSTLQKARTK FLQAYEGNMM 

      1090       1100       1110       1120 
VRGEGDDIWY QRLWRQLTPE TMEAIVEQSQ RFLLPLFRFN QS

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of the Escherichia coli recC gene and of the thyA-recC intergenic region."
Finch P.W., Wilson R.E., Brown K., Hickson I.D., Tomkinson A.E., Emmerson P.T.
Nucleic Acids Res. 14:4437-4451(1986) [PubMed: 3520484] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"Complete nucleotide sequence of the Escherichia coli ptr gene encoding protease III."
Finch P.W., Wilson R.E., Brown K., Hickson I.D., Emmerson P.T.
Nucleic Acids Res. 14:7695-7703(1986) [PubMed: 3534791] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1114-1122.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X03966 Genomic DNA. Translation: CAA27604.1.
U29581 Genomic DNA. Translation: AAB40469.1.
U00096 Genomic DNA. Translation: AAC75861.1.
AP009048 Genomic DNA. Translation: BAE76891.1.
X06227 Genomic DNA. Translation: CAA29575.1.
PIRNCECXV. A24137.
RefSeqNP_417299.1. NC_000913.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1W36X-ray3.10C/F1-1122[»]
3K70X-ray3.59C/F1-1122[»]
ProteinModelPortalP07648.
SMRP07648. Positions 1-1121.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-10650N.
IntActP07648. 3 interactions.
MINTMINT-1318941.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000002378; EBESCP00000002378; EBESCG00000001940.
EBESCT00000002379; EBESCP00000002379; EBESCG00000001940.
EBESCT00000017650; EBESCP00000016941; EBESCG00000016706.
GeneID947294.
GenomeReviewsGene locus JW2790 in contig AP009048_GR.
Gene locus b2822 in contig U00096_GR.
KEGGecj:JW2790.
eco:b2822.
PATRIC32121062. VBIEscCol129921_2920.

Organism-specific databases

EchoBASEEB0818.
EcoGeneEG10825. recC.

Phylogenomic databases

eggNOGCOG1330.
GeneTreeEBGT00050000011012.
HOGENOMHBG576005.
OMANGIAQWL.
PhylomeDBP07648.
ProtClustDBPRK11069.

Enzyme and pathway databases

BioCycEcoCyc:EG10825-MONOMER.
MetaCyc:EG10825-MONOMER.

Gene expression databases

GenevestigatorP07648.

Family and domain databases

InterProIPR006697. ExoDNase_V_RecC_su.
IPR011335. Restrct_endonuc_II-like.
[Graphical view]
KOK03583.
SUPFAMSSF52980. Restrict_endonuc_II-like_core. 1 hit.
TIGRFAMsTIGR01450. RecC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameEX5C_ECOLI
AccessionPrimary (citable) accession number: P07648
Secondary accession number(s): Q2MA15
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: January 25, 2012
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

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