Reviewed,
UniProtKB/Swiss-Prot P07633 (PCCB_RAT)
Last modified
November 24, 2009.
Version 74.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Propionyl-CoA carboxylase beta chain, mitochondrial Short name=PCCase subunit beta EC=6.4.1.3 Alternative name(s): Propanoyl-CoA:carbon dioxide ligase subunit beta | ||
| Gene names |
| ||
| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 541 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA. |
| Pathway | |
| Subunit structure | Probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits. |
| Subcellular location | |
| Sequence similarities | Belongs to the accD/PCCB family. Contains 1 carboxyltransferase domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| PTM | Acetylation |
| Gene Ontology (GO) | |
| Biological process | cellular amino acid catabolic process Ref.1 Traceable author statement. Source: RGD fatty acid catabolic process Ref.1Traceable author statement. Source: RGD |
| Cellular component | mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW propionyl-CoA carboxylase activity Ref.1Traceable author statement. Source: RGD |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – ? | Mitochondrion | |||||||
| Chain | ? – 541 | Propionyl-CoA carboxylase beta chain, mitochondrial | PRO_0000000296 | ||||||
Regions | |||||||||
| Domain | 40 – 533 | 494 | Carboxyltransferase | ||||||
| Region | 327 – 360 | 34 | Acyl-CoA binding Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 62 | 1 | N6-acetyllysine By similarity | ||||||
Sequences
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References
| [1] | "Coding sequence of the precursor of the beta subunit of rat propionyl-CoA carboxylase." Kraus J.P., Firgaira F., Novotny J., Kalousek F., Williams K.R., Williamson C., Ohura T., Rosenberg L.E. Proc. Natl. Acad. Sci. U.S.A. 83:8049-8053(1986) [PubMed: 3464942] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M14634 mRNA. Translation: AAA41818.1. | |
| IPI | IPI00209480. |
| PIR | A25516. |
| UniGene | Rn.9732 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P07633. |
PTM databases | |
| PhosphoSite | P07633. |
Genome annotation databases | |
| Ensembl | ENSRNOT00000021657; ENSRNOP00000021657; ENSRNOG00000015869; Rattus norvegicus. [Genome view] |
Organism-specific databases | |
| RGD | 3265. Pccb. |
Phylogenomic databases | |
| HOVERGEN | P07633. |
Enzyme and pathway databases | |
| BioCyc | MetaCyc:MONOMER-8607. |
| BRENDA | 6.4.1.3. 248. |
Gene expression databases | |
| ArrayExpress | P07633. |
| Genevestigator | P07633. |
| GermOnline | ENSRNOG00000015869. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR000022. Carboxyl_trans. IPR011763. COA_CT_C. IPR011762. COA_CT_N. [Graphical view] |
| Pfam | PF01039. Carboxyl_trans. 1 hit. [Graphical view] |
| PROSITE | PS50989. COA_CT_CTER. 1 hit. PS50980. COA_CT_NTER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PCCB_RAT | ||||||||
| Accession | Primary (citable) accession number: P07633 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


