P07633 (PCCB_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Propionyl-CoA carboxylase beta chain, mitochondrial
Short name=PCCase subunit beta
EC=6.4.1.3

Alternative name(s):
Propanoyl-CoA:carbon dioxide ligase subunit beta

Gene names

Name:

Pccb

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	541 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.
Pathway	Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.
Subunit structure	Probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits.
Subcellular location	Mitochondrion matrix.
Sequence similarities	Belongs to the AccD/PCCB family. Contains 1 carboxyltransferase domain.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular amino acid catabolic process Traceable author statement Ref.1. Source: RGD fatty acid catabolic process Traceable author statement Ref.1. Source: RGD
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW propionyl-CoA carboxylase activity Traceable author statement Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 28	28	Mitochondrion By similarity
	Chain	29 – 541	513	Propionyl-CoA carboxylase beta chain, mitochondrial		PRO_0000000296
Regions
	Domain	40 – 533	494	Carboxyltransferase
	Region	327 – 360	34	Acyl-CoA binding Potential
Amino acid modifications
	Modified residue	62	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P07633 [UniParc]. Last modified April 1, 1988. Version 1. Checksum: 052E668E9EE23524	FASTA	541	58,626
	10 20 30 40 50 60 MAAVIRIRAM AAGTRLRVLN CGLGTTIRSL CSQPVSVNER IENKRHAALL GGGQRRIDAQ 70 80 90 100 110 120 HKRGKLTARE RISLLLDPGS FLESDMFVEH RCADFGMAAE KNKFPGDSVV TGRGRINGRL 130 140 150 160 170 180 VYVFSQDFTV FGGSLSGAHA QKICKIMDQA ITVGAPVIGL NDSGGARIQE GVESLAGYAD 190 200 210 220 230 240 IFLRNVTASG VIPQISLIMG PCAGGAVYSP ALTDFTFMVK DTSYLFITGP EFVKSVTNED 250 260 270 280 290 300 VTQEQLGGAK THTTVSGVAH RAFDNDVDAL CNLREFLNFL PLSNQDPASI RECHDPSDRL 310 320 330 340 350 360 VPELDTVVPL ESSKAYNMLD IIHAVIDERE FFEIMPNYAK NIVIGFARMN GRTVGIVGNQ 370 380 390 400 410 420 PNVASGCLDI NSSVKGARFV RFCDAFSIPL ITFVDVPGFL PGTAQEYGGI IRHGAKLLYA 430 440 450 460 470 480 FAEATVPKIT VITRKAYGGA YDVMSSKHLL GDTNYAWPTA EIAVMGAKGA VEIIFKGHED 490 500 510 520 530 540 VEAAQAEYVE KFANPFPAAV RGFVDDIIQP SSTRARICCD LEVLASKKVH RPWRKHANVP L

References

[1]	"Coding sequence of the precursor of the beta subunit of rat propionyl-CoA carboxylase." Kraus J.P., Firgaira F., Novotny J., Kalousek F., Williams K.R., Williamson C., Ohura T., Rosenberg L.E. Proc. Natl. Acad. Sci. U.S.A. 83:8049-8053(1986) [PubMed: 3464942] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M14634 mRNA. Translation: AAA41818.1.
IPI	IPI00209480.
PIR	A25516.
UniGene	Rn.9732.
3D structure databases
ProteinModelPortal	P07633.
SMR	P07633. Positions 39-541.
ModBase	Search...
Protein-protein interaction databases
IntAct	P07633. 1 interaction.
STRING	P07633.
PTM databases
PhosphoSite	P07633.
Proteomic databases
PRIDE	P07633.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
RGD	3265. Pccb.
Phylogenomic databases
eggNOG	roNOG06084.
HOVERGEN	HBG003970.
InParanoid	P07633.
OrthoDB	EOG44BB1Z.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-8607.
Gene expression databases
ArrayExpress	P07633.
Genevestigator	P07633.
GermOnline	ENSRNOG00000015869. Rattus norvegicus.
Family and domain databases
InterPro	IPR000022. Carboxyl_trans. IPR011763. COA_CT_C. IPR011762. COA_CT_N. [Graphical view]
Pfam	PF01039. Carboxyl_trans. 1 hit. [Graphical view]
PROSITE	PS50989. COA_CT_CTER. 1 hit. PS50980. COA_CT_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PCCB_RAT

Accession

Primary (citable) accession number: P07633

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	April 1, 1988
Last modified:	September 21, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program