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Protein

Superoxide dismutase [Cu-Zn]

Gene

Sod1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds 1 copper ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Copper; catalyticBy similarity1
Metal bindingi49Copper; catalyticBy similarity1
Metal bindingi64Copper; catalyticBy similarity1
Metal bindingi64Zinc; structuralBy similarity1
Metal bindingi72Zinc; structuralBy similarity1
Metal bindingi81Zinc; structuralBy similarity1
Metal bindingi84Zinc; structuralBy similarity1
Metal bindingi121Copper; catalyticBy similarity1

GO - Molecular functioni

  • chaperone binding Source: UniProtKB
  • copper ion binding Source: RGD
  • identical protein binding Source: Ensembl
  • protein phosphatase 2B binding Source: RGD
  • Rac GTPase binding Source: Ensembl
  • superoxide dismutase activity Source: RGD
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionAntioxidant, Oxidoreductase
LigandCopper, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-114608 Platelet degranulation
R-RNO-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
Gene namesi
Name:Sod1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi3731 Sod1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity2 Publications
ChainiPRO_00001640672 – 154Superoxide dismutase [Cu-Zn]Add BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei4N6-succinyllysineBy similarity1
Lipidationi7S-palmitoyl cysteineBy similarity1
Modified residuei10N6-succinyllysineBy similarity1
Disulfide bondi58 ↔ 147By similarity
Modified residuei92N6-succinyllysineBy similarity1
Modified residuei99PhosphoserineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei123N6-acetyllysine; alternateBy similarity1
Modified residuei123N6-succinyllysine; alternateBy similarity1
Modified residuei137N6-acetyllysine; alternateBy similarity1
Modified residuei137N6-succinyllysine; alternateBy similarity1

Post-translational modificationi

Palmitoylation helps nuclear targeting and decreases catalytic activity.By similarity
Succinylation, adjacent to copper catalytic site, probably inhibits activity. Desuccinylation by SIRT5 enhances activity.By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP07632
PRIDEiP07632

PTM databases

CarbonylDBiP07632
iPTMnetiP07632
PhosphoSitePlusiP07632

Expressioni

Gene expression databases

BgeeiENSRNOG00000002115
GenevisibleiP07632 RN

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi246910, 4 interactors
IntActiP07632, 1 interactor
MINTiP07632
STRINGi10116.ENSRNOP00000002885

Structurei

3D structure databases

ProteinModelPortaliP07632
SMRiP07632
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Curated

Phylogenomic databases

eggNOGiKOG0441 Eukaryota
COG2032 LUCA
GeneTreeiENSGT00530000063226
HOGENOMiHOG000263447
HOVERGENiHBG000062
InParanoidiP07632
KOiK04565
OMAiIHTFGDN
OrthoDBiEOG091G0OG2
PhylomeDBiP07632
TreeFamiTF105131

Family and domain databases

CDDicd00305 Cu-Zn_Superoxide_Dismutase, 1 hit
Gene3Di2.60.40.200, 1 hit
InterProiView protein in InterPro
IPR036423 SOD-like_Cu/Zn_dom_sf
IPR024134 SOD_Cu/Zn_/chaperone
IPR018152 SOD_Cu/Zn_BS
IPR001424 SOD_Cu_Zn_dom
PANTHERiPTHR10003 PTHR10003, 1 hit
PfamiView protein in Pfam
PF00080 Sod_Cu, 1 hit
PRINTSiPR00068 CUZNDISMTASE
SUPFAMiSSF49329 SSF49329, 1 hit
PROSITEiView protein in PROSITE
PS00087 SOD_CU_ZN_1, 1 hit
PS00332 SOD_CU_ZN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMKAVCVLK GDGPVQGVIH FEQKASGEPV VVSGQITGLT EGEHGFHVHQ
60 70 80 90 100
YGDNTQGCTT AGPHFNPHSK KHGGPADEER HVGDLGNVAA GKDGVANVSI
110 120 130 140 150
EDRVISLSGE HSIIGRTMVV HEKQDDLGKG GNEESTKTGN AGSRLACGVI

GIAQ
Length:154
Mass (Da):15,912
Last modified:January 23, 2007 - v2
Checksum:iB7D93A135E9279E9
GO

Sequence cautioni

The sequence AAA42160 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA79925 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00404 mRNA Translation: CAA68465.1
M25157 mRNA Translation: AAA42160.1 Different initiation.
X05634 mRNA Translation: CAA29121.1
Z21917
, Z21918, Z21919, Z21920 Genomic DNA Translation: CAA79925.1 Different initiation.
BC082800 mRNA Translation: AAH82800.1
PIRiJC1192
RefSeqiNP_058746.1, NM_017050.1
UniGeneiRn.6059

Genome annotation databases

EnsembliENSRNOT00000002885; ENSRNOP00000002885; ENSRNOG00000002115
GeneIDi24786
KEGGirno:24786
UCSCiRGD:3731 rat

Similar proteinsi

Entry informationi

Entry nameiSODC_RAT
AccessioniPrimary (citable) accession number: P07632
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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