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P07630 (CAH2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carbonic anhydrase 2

EC=4.2.1.1
Alternative name(s):
Carbonate dehydratase II
Carbonic anhydrase II
Short name=CA-II
Gene names
Name:CA2
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential for bone resorption and osteoclast differentiation By similarity. Reversible hydration of carbon dioxide.

Catalytic activity

H2CO3 = CO2 + H2O.

Cofactor

Zinc.

Enzyme regulation

Inhibited by acetazolamide By similarity.

Subcellular location

Cytoplasm. Cell membrane By similarity.

Sequence similarities

Belongs to the alpha-carbonic anhydrase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 260259Carbonic anhydrase 2
PRO_0000077423

Regions

Region198 – 1992Substrate binding By similarity

Sites

Active site641Proton acceptor By similarity
Active site671 By similarity
Active site1271 By similarity
Metal binding941Zinc; catalytic
Metal binding961Zinc; catalytic
Metal binding1191Zinc; catalytic

Experimental info

Sequence conflict51W → L in CAA28501. Ref.3
Sequence conflict81D → G in AAA48646. Ref.5
Sequence conflict871V → S in AAA48646. Ref.5
Sequence conflict2501L → V in CAA31175. Ref.2
Sequence conflict2501L → V in CAA29417. Ref.2

Secondary structure

.................................................. 260
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P07630 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 6723309BC77A4950

FASTA26029,008
        10         20         30         40         50         60 
MSHHWGYDSH NGPAHWHEHF PIANGERQSP IAISTKAARY DPALKPLSFS YDAGTAKAIV 

        70         80         90        100        110        120 
NNGHSFNVEF DDSSDKSVLQ GGALDGVYRL VQFHIHWGSC EGQGSEHTVD GVKYDAELHI 

       130        140        150        160        170        180 
VHWNVKYGKF AEALKHPDGL AVVGIFMKVG NAKPEIQKVV DALNSIQTKG KQASFTNFDP 

       190        200        210        220        230        240 
TGLLPPCRDY WTYPGSLTTP PLHECVIWHV LKEPITVSSE QMCKLRGLCF SAENEPVCRM 

       250        260 
VDNWRPCQPL KSREVRASFQ 

« Hide

References

[1]"A novel carbonic anhydrase II mRNA isolated from mature chicken testis displays a TATA box and other promoter sequences in a leader 5' untranslated region not present in somatic tissues."
Mezquita J., Pau M., Mezquita C.
Gene 147:231-235(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Hubbard White Mountain.
Tissue: Testis.
[2]"The chicken carbonic anhydrase II gene: evidence for a recent shift in intron position."
Yoshihara C.M., Lee J.-D., Dodgson J.B.
Nucleic Acids Res. 15:753-770(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: White leghorn.
[3]"Sequence of carbonic anhydrase II cDNA from chick retina."
Rogers J.H.
Eur. J. Biochem. 162:119-122(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-260.
Strain: White leghorn.
Tissue: Retina.
[4]"Utilization of the second polyadenylation signal at the 3' end of the chicken carbonic anhydrase II gene."
Godbout R., Andison R., Upton C., Day R.
Nucleic Acids Res. 18:1049-1049(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 222-260.
Tissue: Retina.
[5]"Isolation of the chicken carbonic anhydrase II gene."
Yoshihara C.M., Federspiel M., Dodgson J.B.
Ann. N. Y. Acad. Sci. 429:332-334(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-87.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z14957 mRNA. Translation: CAA78681.1.
X12639 mRNA. Translation: CAA31175.1.
X06000 expand/collapse EMBL AC list , X06001, X06002, X06003, X06004, X06005 Genomic DNA. Translation: CAA29417.1.
X04810 mRNA. Translation: CAA28501.1.
X17378 mRNA. Translation: CAA35250.1.
M25943 mRNA. Translation: AAA48646.1.
PIRJC2580.
RefSeqNP_990648.1. NM_205317.1.
UniGeneGga.3986.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q4Imodel-A1-260[»]
ProteinModelPortalP07630.
SMRP07630. Positions 2-260.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000025525.

Proteomic databases

PaxDbP07630.
PRIDEP07630.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000025572; ENSGALP00000025525; ENSGALG00000015862.
GeneID396257.
KEGGgga:396257.

Organism-specific databases

CTD760.

Phylogenomic databases

eggNOGCOG3338.
GeneTreeENSGT00750000117305.
HOGENOMHOG000112637.
HOVERGENHBG002837.
InParanoidP07630.
KOK18245.
OMANDENESH.
OrthoDBEOG7WMCK7.
PhylomeDBP07630.
TreeFamTF316425.

Family and domain databases

Gene3D3.10.200.10. 1 hit.
InterProIPR018443. CA2.
IPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
[Graphical view]
PANTHERPTHR18952. PTHR18952. 1 hit.
PTHR18952:SF90. PTHR18952:SF90. 1 hit.
PfamPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMSSF51069. SSF51069. 1 hit.
PROSITEPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816309.
PROP07630.

Entry information

Entry nameCAH2_CHICK
AccessionPrimary (citable) accession number: P07630
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references