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P07630

- CAH2_CHICK

UniProt

P07630 - CAH2_CHICK

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Protein

Carbonic anhydrase 2

Gene

CA2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide.By similarity

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Enzyme regulationi

Inhibited by acetazolamide.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641Proton acceptorBy similarity
Active sitei67 – 671By similarity
Metal bindingi94 – 941Zinc; catalytic
Metal bindingi96 – 961Zinc; catalytic
Metal bindingi119 – 1191Zinc; catalytic
Active sitei127 – 1271By similarity

GO - Molecular functioni

  1. carbonate dehydratase activity Source: UniProtKB-EC
  2. zinc ion binding Source: Ensembl

GO - Biological processi

  1. angiotensin-activated signaling pathway Source: Ensembl
  2. morphogenesis of an epithelium Source: Ensembl
  3. one-carbon metabolic process Source: InterPro
  4. positive regulation of cellular pH reduction Source: Ensembl
  5. positive regulation of dipeptide transmembrane transport Source: Ensembl
  6. positive regulation of synaptic transmission, GABAergic Source: Ensembl
  7. regulation of chloride transport Source: Ensembl
  8. regulation of intracellular pH Source: Ensembl
  9. secretion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_197145. Erythrocytes take up carbon dioxide and release oxygen.
REACT_197148. Reversible hydration of carbon dioxide.
REACT_197150. Erythrocytes take up oxygen and release carbon dioxide.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 2 (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase II
Carbonic anhydrase II
Short name:
CA-II
Gene namesi
Name:CA2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 2

Subcellular locationi

Cytoplasm. Cell membrane By similarity

GO - Cellular componenti

  1. apical part of cell Source: Ensembl
  2. cytoplasm Source: UniProtKB
  3. cytosol Source: Ensembl
  4. extracellular vesicular exosome Source: Ensembl
  5. myelin sheath Source: Ensembl
  6. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 260259Carbonic anhydrase 2PRO_0000077423Add
BLAST

Proteomic databases

PaxDbiP07630.
PRIDEiP07630.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025525.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q4Imodel-A1-260[»]
ProteinModelPortaliP07630.
SMRiP07630. Positions 2-260.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni198 – 1992Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Phylogenomic databases

eggNOGiCOG3338.
GeneTreeiENSGT00760000118915.
HOGENOMiHOG000112637.
HOVERGENiHBG002837.
InParanoidiP07630.
KOiK18245.
OMAiNDENESH.
OrthoDBiEOG7WMCK7.
PhylomeDBiP07630.
TreeFamiTF316425.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR018443. CA2.
IPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PTHR18952:SF90. PTHR18952:SF90. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07630-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHHWGYDSH NGPAHWHEHF PIANGERQSP IAISTKAARY DPALKPLSFS
60 70 80 90 100
YDAGTAKAIV NNGHSFNVEF DDSSDKSVLQ GGALDGVYRL VQFHIHWGSC
110 120 130 140 150
EGQGSEHTVD GVKYDAELHI VHWNVKYGKF AEALKHPDGL AVVGIFMKVG
160 170 180 190 200
NAKPEIQKVV DALNSIQTKG KQASFTNFDP TGLLPPCRDY WTYPGSLTTP
210 220 230 240 250
PLHECVIWHV LKEPITVSSE QMCKLRGLCF SAENEPVCRM VDNWRPCQPL
260
KSREVRASFQ
Length:260
Mass (Da):29,008
Last modified:January 23, 2007 - v3
Checksum:i6723309BC77A4950
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51W → L in CAA28501. (PubMed:3102231)Curated
Sequence conflicti8 – 81D → G in AAA48646. (PubMed:6331256)Curated
Sequence conflicti87 – 871V → S in AAA48646. (PubMed:6331256)Curated
Sequence conflicti250 – 2501L → V in CAA31175. (PubMed:3029691)Curated
Sequence conflicti250 – 2501L → V in CAA29417. (PubMed:3029691)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z14957 mRNA. Translation: CAA78681.1.
X12639 mRNA. Translation: CAA31175.1.
X06000
, X06001, X06002, X06003, X06004, X06005 Genomic DNA. Translation: CAA29417.1.
X04810 mRNA. Translation: CAA28501.1.
X17378 mRNA. Translation: CAA35250.1.
M25943 mRNA. Translation: AAA48646.1.
PIRiJC2580.
RefSeqiNP_990648.1. NM_205317.1.
UniGeneiGga.3986.

Genome annotation databases

EnsembliENSGALT00000025572; ENSGALP00000025525; ENSGALG00000015862.
GeneIDi396257.
KEGGigga:396257.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z14957 mRNA. Translation: CAA78681.1 .
X12639 mRNA. Translation: CAA31175.1 .
X06000
, X06001 , X06002 , X06003 , X06004 , X06005 Genomic DNA. Translation: CAA29417.1 .
X04810 mRNA. Translation: CAA28501.1 .
X17378 mRNA. Translation: CAA35250.1 .
M25943 mRNA. Translation: AAA48646.1 .
PIRi JC2580.
RefSeqi NP_990648.1. NM_205317.1.
UniGenei Gga.3986.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1Q4I model - A 1-260 [» ]
ProteinModelPortali P07630.
SMRi P07630. Positions 2-260.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000025525.

Proteomic databases

PaxDbi P07630.
PRIDEi P07630.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000025572 ; ENSGALP00000025525 ; ENSGALG00000015862 .
GeneIDi 396257.
KEGGi gga:396257.

Organism-specific databases

CTDi 760.

Phylogenomic databases

eggNOGi COG3338.
GeneTreei ENSGT00760000118915.
HOGENOMi HOG000112637.
HOVERGENi HBG002837.
InParanoidi P07630.
KOi K18245.
OMAi NDENESH.
OrthoDBi EOG7WMCK7.
PhylomeDBi P07630.
TreeFami TF316425.

Enzyme and pathway databases

Reactomei REACT_197145. Erythrocytes take up carbon dioxide and release oxygen.
REACT_197148. Reversible hydration of carbon dioxide.
REACT_197150. Erythrocytes take up oxygen and release carbon dioxide.

Miscellaneous databases

NextBioi 20816309.
PROi P07630.

Family and domain databases

Gene3Di 3.10.200.10. 1 hit.
InterProi IPR018443. CA2.
IPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
[Graphical view ]
PANTHERi PTHR18952. PTHR18952. 1 hit.
PTHR18952:SF90. PTHR18952:SF90. 1 hit.
Pfami PF00194. Carb_anhydrase. 1 hit.
[Graphical view ]
SMARTi SM01057. Carb_anhydrase. 1 hit.
[Graphical view ]
SUPFAMi SSF51069. SSF51069. 1 hit.
PROSITEi PS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel carbonic anhydrase II mRNA isolated from mature chicken testis displays a TATA box and other promoter sequences in a leader 5' untranslated region not present in somatic tissues."
    Mezquita J., Pau M., Mezquita C.
    Gene 147:231-235(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Hubbard White Mountain.
    Tissue: Testis.
  2. "The chicken carbonic anhydrase II gene: evidence for a recent shift in intron position."
    Yoshihara C.M., Lee J.-D., Dodgson J.B.
    Nucleic Acids Res. 15:753-770(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: White leghorn.
  3. "Sequence of carbonic anhydrase II cDNA from chick retina."
    Rogers J.H.
    Eur. J. Biochem. 162:119-122(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-260.
    Strain: White leghorn.
    Tissue: Retina.
  4. "Utilization of the second polyadenylation signal at the 3' end of the chicken carbonic anhydrase II gene."
    Godbout R., Andison R., Upton C., Day R.
    Nucleic Acids Res. 18:1049-1049(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 222-260.
    Tissue: Retina.
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-87.

Entry informationi

Entry nameiCAH2_CHICK
AccessioniPrimary (citable) accession number: P07630
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3