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Protein

Carbonic anhydrase 2

Gene

CA2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide.By similarity

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+By similarity

Enzyme regulationi

Inhibited by acetazolamide.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei64Proton acceptorBy similarity1
Active sitei67By similarity1
Metal bindingi94Zinc; catalyticBy similarity1
Metal bindingi96Zinc; catalyticBy similarity1
Metal bindingi119Zinc; catalyticBy similarity1
Active sitei127By similarity1

GO - Molecular functioni

  • carbonate dehydratase activity Source: AgBase
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cellular response to carbon dioxide Source: AgBase
  • one-carbon metabolic process Source: InterPro

Keywordsi

Molecular functionLyase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-GGA-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-GGA-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-GGA-1475029 Reversible hydration of carbon dioxide

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 2 (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase II
Carbonic anhydrase II
Short name:
CA-II
Gene namesi
Name:CA2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000774232 – 260Carbonic anhydrase 2Add BLAST259

Proteomic databases

PaxDbiP07630
PRIDEiP07630

Expressioni

Gene expression databases

BgeeiENSGALG00000015862

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025525

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q4Imodel-A1-260[»]
ProteinModelPortaliP07630
SMRiP07630
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 259Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST257

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni198 – 199Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
COG3338 LUCA
GeneTreeiENSGT00760000118915
HOGENOMiHOG000112637
HOVERGENiHBG002837
InParanoidiP07630
KOiK18245
OMAiHTVDKKK
OrthoDBiEOG091G0XFM
PhylomeDBiP07630
TreeFamiTF316425

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
IPR018338 Carbonic_anhydrase_a-class_CS
PANTHERiPTHR18952 PTHR18952, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS00162 ALPHA_CA_1, 1 hit
PS51144 ALPHA_CA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07630-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHHWGYDSH NGPAHWHEHF PIANGERQSP IAISTKAARY DPALKPLSFS
60 70 80 90 100
YDAGTAKAIV NNGHSFNVEF DDSSDKSVLQ GGALDGVYRL VQFHIHWGSC
110 120 130 140 150
EGQGSEHTVD GVKYDAELHI VHWNVKYGKF AEALKHPDGL AVVGIFMKVG
160 170 180 190 200
NAKPEIQKVV DALNSIQTKG KQASFTNFDP TGLLPPCRDY WTYPGSLTTP
210 220 230 240 250
PLHECVIWHV LKEPITVSSE QMCKLRGLCF SAENEPVCRM VDNWRPCQPL
260
KSREVRASFQ
Length:260
Mass (Da):29,008
Last modified:January 23, 2007 - v3
Checksum:i6723309BC77A4950
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5W → L in CAA28501 (PubMed:3102231).Curated1
Sequence conflicti8D → G in AAA48646 (PubMed:6331256).Curated1
Sequence conflicti87V → S in AAA48646 (PubMed:6331256).Curated1
Sequence conflicti250L → V in CAA31175 (PubMed:3029691).Curated1
Sequence conflicti250L → V in CAA29417 (PubMed:3029691).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z14957 mRNA Translation: CAA78681.1
X12639 mRNA Translation: CAA31175.1
X06000
, X06001, X06002, X06003, X06004, X06005 Genomic DNA Translation: CAA29417.1
X04810 mRNA Translation: CAA28501.1
X17378 mRNA Translation: CAA35250.1
M25943 mRNA Translation: AAA48646.1
PIRiJC2580
RefSeqiNP_990648.1, NM_205317.1
UniGeneiGga.3986

Genome annotation databases

EnsembliENSGALT00000052439; ENSGALP00000056391; ENSGALG00000030781
GeneIDi396257
KEGGigga:396257

Similar proteinsi

Entry informationi

Entry nameiCAH2_CHICK
AccessioniPrimary (citable) accession number: P07630
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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