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P07628

- K1KB8_MOUSE

UniProt

P07628 - K1KB8_MOUSE

Protein

Kallikrein 1-related peptidase b8

Gene

Klk1b8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Apr 1988)
      Previous versions | rss
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    Functioni

    Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

    Catalytic activityi

    Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Charge relay system
    Active sitei120 – 1201Charge relay system
    Active sitei213 – 2131Charge relay system

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BRENDAi3.4.21.118. 3474.
    ReactomeiREACT_199000. Activation of Matrix Metalloproteinases.

    Protein family/group databases

    MEROPSiS01.067.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kallikrein 1-related peptidase b8 (EC:3.4.21.35)
    Alternative name(s):
    Glandular kallikrein K8
    Short name:
    mGK-8
    Tissue kallikrein-8
    Gene namesi
    Name:Klk1b8
    Synonyms:Klk-8, Klk8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:892018. Klk1b8.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818CuratedAdd
    BLAST
    Propeptidei19 – 246Activation peptideCuratedPRO_0000027977
    Chaini25 – 261237Kallikrein 1-related peptidase b8PRO_0000027978Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 173PROSITE-ProRule annotation
    Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
    Glycosylationi102 – 1021N-linked (GlcNAc...)Curated
    Disulfide bondi152 ↔ 219PROSITE-ProRule annotation
    Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
    Disulfide bondi209 ↔ 234PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    MaxQBiP07628.
    PaxDbiP07628.
    PRIDEiP07628.

    Expressioni

    Gene expression databases

    BgeeiP07628.
    CleanExiMM_KLK1B8.
    MM_KLK8.
    GenevestigatoriP07628.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000072063.

    Structurei

    3D structure databases

    ProteinModelPortaliP07628.
    SMRiP07628. Positions 25-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 258234Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00750000117405.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP07628.
    KOiK01325.
    OMAiCKSEDHA.
    OrthoDBiEOG75B84T.
    PhylomeDBiP07628.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07628-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRFLILFLAL SLGGIDAAPP LQSRVVGGFN CEKNSQPWQV AVYDNKEHIC    50
    GGVLLERNWV LTAAHCYVDQ YEVWLGKNKL FQEEPSAQHR LVSKSFPHPG 100
    FNMSLLTLKE IPPGADFSND LMLLRLSKPA DITDAVKPIT LPTKESKLGS 150
    TCLASGWGSI TPTKWQKPDD LQCVFLKLLP IKNCIENHNV KVTDVMLCAG 200
    EMSGGKNICK GDSGGPLICD SVLQGITSTG PIPCGKPGVP AMYTNLIKFN 250
    SWIKDTMTKN S 261
    Length:261
    Mass (Da):28,531
    Last modified:April 1, 1988 - v1
    Checksum:iD0174F7093137322
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03994 mRNA. Translation: CAA27630.1.
    M18587 Genomic DNA. Translation: AAA39347.1.
    M18607 Genomic DNA. Translation: AAA39348.1.
    CCDSiCCDS21189.1.
    PIRiA24378.
    RefSeqiNP_032483.1. NM_008457.2.
    UniGeneiMm.435488.

    Genome annotation databases

    EnsembliENSMUST00000072204; ENSMUSP00000072063; ENSMUSG00000063089.
    GeneIDi16624.
    KEGGimmu:16624.
    UCSCiuc009gob.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03994 mRNA. Translation: CAA27630.1 .
    M18587 Genomic DNA. Translation: AAA39347.1 .
    M18607 Genomic DNA. Translation: AAA39348.1 .
    CCDSi CCDS21189.1.
    PIRi A24378.
    RefSeqi NP_032483.1. NM_008457.2.
    UniGenei Mm.435488.

    3D structure databases

    ProteinModelPortali P07628.
    SMRi P07628. Positions 25-261.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000072063.

    Protein family/group databases

    MEROPSi S01.067.

    Proteomic databases

    MaxQBi P07628.
    PaxDbi P07628.
    PRIDEi P07628.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000072204 ; ENSMUSP00000072063 ; ENSMUSG00000063089 .
    GeneIDi 16624.
    KEGGi mmu:16624.
    UCSCi uc009gob.1. mouse.

    Organism-specific databases

    CTDi 16624.
    MGIi MGI:892018. Klk1b8.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00750000117405.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P07628.
    KOi K01325.
    OMAi CKSEDHA.
    OrthoDBi EOG75B84T.
    PhylomeDBi P07628.
    TreeFami TF331065.

    Enzyme and pathway databases

    BRENDAi 3.4.21.118. 3474.
    Reactomei REACT_199000. Activation of Matrix Metalloproteinases.

    Miscellaneous databases

    NextBioi 290239.
    PROi P07628.
    SOURCEi Search...

    Gene expression databases

    Bgeei P07628.
    CleanExi MM_KLK1B8.
    MM_KLK8.
    Genevestigatori P07628.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of a cDNA clone coding for a novel kallikrein from mouse submaxillary gland."
      Fahnestock M., Brundage S., Shooter E.M.
      Nucleic Acids Res. 14:4823-4835(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus."
      Evans B.A., Drinkwater C.C., Richards R.I.
      J. Biol. Chem. 262:8027-8034(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 16-54 AND 70-122.

    Entry informationi

    Entry nameiK1KB8_MOUSE
    AccessioniPrimary (citable) accession number: P07628
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3