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P07628

- K1KB8_MOUSE

UniProt

P07628 - K1KB8_MOUSE

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Protein
Kallikrein 1-related peptidase b8
Gene
Klk1b8, Klk-8, Klk8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651Charge relay system
Active sitei120 – 1201Charge relay system
Active sitei213 – 2131Charge relay system

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.118. 3474.
ReactomeiREACT_199000. Activation of Matrix Metalloproteinases.

Protein family/group databases

MEROPSiS01.067.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein 1-related peptidase b8 (EC:3.4.21.35)
Alternative name(s):
Glandular kallikrein K8
Short name:
mGK-8
Tissue kallikrein-8
Gene namesi
Name:Klk1b8
Synonyms:Klk-8, Klk8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:892018. Klk1b8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Inferred
Add
BLAST
Propeptidei19 – 246Activation peptide Inferred
PRO_0000027977
Chaini25 – 261237Kallikrein 1-related peptidase b8
PRO_0000027978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 173 By similarity
Disulfide bondi50 ↔ 66 By similarity
Glycosylationi102 – 1021N-linked (GlcNAc...) Inferred
Disulfide bondi152 ↔ 219 By similarity
Disulfide bondi184 ↔ 198 By similarity
Disulfide bondi209 ↔ 234 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP07628.
PaxDbiP07628.
PRIDEiP07628.

Expressioni

Gene expression databases

BgeeiP07628.
CleanExiMM_KLK1B8.
MM_KLK8.
GenevestigatoriP07628.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072063.

Structurei

3D structure databases

ProteinModelPortaliP07628.
SMRiP07628. Positions 25-261.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 258234Peptidase S1
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00750000117405.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP07628.
KOiK01325.
OMAiCKSEDHA.
OrthoDBiEOG75B84T.
PhylomeDBiP07628.
TreeFamiTF331065.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07628-1 [UniParc]FASTAAdd to Basket

« Hide

MRFLILFLAL SLGGIDAAPP LQSRVVGGFN CEKNSQPWQV AVYDNKEHIC    50
GGVLLERNWV LTAAHCYVDQ YEVWLGKNKL FQEEPSAQHR LVSKSFPHPG 100
FNMSLLTLKE IPPGADFSND LMLLRLSKPA DITDAVKPIT LPTKESKLGS 150
TCLASGWGSI TPTKWQKPDD LQCVFLKLLP IKNCIENHNV KVTDVMLCAG 200
EMSGGKNICK GDSGGPLICD SVLQGITSTG PIPCGKPGVP AMYTNLIKFN 250
SWIKDTMTKN S 261
Length:261
Mass (Da):28,531
Last modified:April 1, 1988 - v1
Checksum:iD0174F7093137322
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X03994 mRNA. Translation: CAA27630.1.
M18587 Genomic DNA. Translation: AAA39347.1.
M18607 Genomic DNA. Translation: AAA39348.1.
CCDSiCCDS21189.1.
PIRiA24378.
RefSeqiNP_032483.1. NM_008457.2.
UniGeneiMm.435488.

Genome annotation databases

EnsembliENSMUST00000072204; ENSMUSP00000072063; ENSMUSG00000063089.
GeneIDi16624.
KEGGimmu:16624.
UCSCiuc009gob.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X03994 mRNA. Translation: CAA27630.1 .
M18587 Genomic DNA. Translation: AAA39347.1 .
M18607 Genomic DNA. Translation: AAA39348.1 .
CCDSi CCDS21189.1.
PIRi A24378.
RefSeqi NP_032483.1. NM_008457.2.
UniGenei Mm.435488.

3D structure databases

ProteinModelPortali P07628.
SMRi P07628. Positions 25-261.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000072063.

Protein family/group databases

MEROPSi S01.067.

Proteomic databases

MaxQBi P07628.
PaxDbi P07628.
PRIDEi P07628.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072204 ; ENSMUSP00000072063 ; ENSMUSG00000063089 .
GeneIDi 16624.
KEGGi mmu:16624.
UCSCi uc009gob.1. mouse.

Organism-specific databases

CTDi 16624.
MGIi MGI:892018. Klk1b8.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00750000117405.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P07628.
KOi K01325.
OMAi CKSEDHA.
OrthoDBi EOG75B84T.
PhylomeDBi P07628.
TreeFami TF331065.

Enzyme and pathway databases

BRENDAi 3.4.21.118. 3474.
Reactomei REACT_199000. Activation of Matrix Metalloproteinases.

Miscellaneous databases

NextBioi 290239.
PROi P07628.
SOURCEi Search...

Gene expression databases

Bgeei P07628.
CleanExi MM_KLK1B8.
MM_KLK8.
Genevestigatori P07628.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence of a cDNA clone coding for a novel kallikrein from mouse submaxillary gland."
    Fahnestock M., Brundage S., Shooter E.M.
    Nucleic Acids Res. 14:4823-4835(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus."
    Evans B.A., Drinkwater C.C., Richards R.I.
    J. Biol. Chem. 262:8027-8034(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 16-54 AND 70-122.

Entry informationi

Entry nameiK1KB8_MOUSE
AccessioniPrimary (citable) accession number: P07628
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: September 3, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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