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Protein

Protein J5

Gene

VACWR097

Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Envelope protein part of the entry-fusion complex responsible for the virus membrane fusion with host cell membrane during virus entry. Also plays a role in cell-cell fusion (syncytium formation).

GO - Biological processi

Keywordsi

Biological processFusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Protein J5
Alternative name(s):
Protein F11
Gene namesi
Ordered Locus Names:VACWR097
ORF Names:J5L
OrganismiVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Taxonomic identifieri10254 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000000344 Componenti: Genome

Subcellular locationi

  • Virion membrane Curated; Single-pass membrane protein Curated

  • Note: Component of the mature virion (MV) membrane. The mature virion is located in the cytoplasm of infected cells and is probably released by cell lysis.

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 111Virion surfaceCuratedAdd BLAST111
Transmembranei112 – 132Helical; Signal-anchorSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000995951 – 133Protein J5Add BLAST133

Proteomic databases

PRIDEiP07618.

Interactioni

Subunit structurei

Part of a stable entry-fusion complex (EFC) which is at least composed of proteins A16, A21, A28, G3, G9, H2, J5, and L5. Formation of the viral membrane is necessary for the assembly of the complex.1 Publication

Protein-protein interaction databases

IntActiP07618. 1 interactor.
MINTiMINT-6740551.

Family & Domainsi

Sequence similaritiesi

Belongs to the poxviridae A16/G9/J5 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG0900012O.

Family and domain databases

InterProiView protein in InterPro
IPR004251. Pox_virus_G9/A16.
PfamiView protein in Pfam
PF03003. Pox_G9-A16. 1 hit.

Sequencei

Sequence statusi: Complete.

P07618-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDEQIYAFC DANKDDIRCK CIYPDKSIVR IGIDTRLPYY CWYEPCKRSD
60 70 80 90 100
ALLPASLKKN ITKCNVSDCT ISLGNVSITD SKLDVNNVCD SKRVATENIA
110 120 130
VRYLNQEIRY PIIDIKWLPI GLLALAILIL AFF
Length:133
Mass (Da):15,158
Last modified:December 7, 2004 - v2
Checksum:iFE7D976F31B87309
GO

Sequence cautioni

The sequence CAA26019 differs from that shown. Reason: Frameshift at position 124.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01978 Genomic DNA. Translation: CAA26019.1. Frameshift.
M13209 Genomic DNA. Translation: AAB59834.1.
AY243312 Genomic DNA. Translation: AAO89376.1.
PIRiB26216. QQVZEL.
RefSeqiYP_232979.1. NC_006998.1.

Genome annotation databases

GeneIDi3707553.
KEGGivg:3707553.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiJ5_VACCW
AccessioniPrimary (citable) accession number: P07618
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 7, 2004
Last modified: March 15, 2017
This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families