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P07605

- KITH_RFVKA

UniProt

P07605 - KITH_RFVKA

Protein

Thymidine kinase

Gene

TK

Organism
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 2 (14 Dec 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei85 – 851Proton acceptorSequence Analysis
    Binding sitei115 – 1151Substrate; via amide nitrogenBy similarity
    Metal bindingi140 – 1401ZincBy similarity
    Metal bindingi143 – 1431ZincBy similarity
    Metal bindingi172 – 1721ZincBy similarity
    Metal bindingi175 – 1751ZincBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 208ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:TK
    ORF Names:s061R
    OrganismiRabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza))
    Taxonomic identifieri10272 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeLeporipoxvirus
    Virus hostiOryctolagus cuniculus (Rabbit) [TaxID: 9986]
    ProteomesiUP000000868: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 178178Thymidine kinasePRO_0000174935Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP07605.
    SMRiP07605. Positions 6-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni159 – 1635Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the thymidine kinase family.Curated

    Family and domain databases

    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P07605-1 [UniParc]FASTAAdd to Basket

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    MTMYGGHIHL IIGPMFAGKS TELIRLVRRY QIAKHKCLVV KYEKDIRYGN    50
    GVCTHDNMSI TAVCTPSLDK IDSVAENAEV IGIDEGQFFP NIATFCERMA 100
    NAGKVLIVAA LDGTFQRKPF SNISELIPLA ENVTKLNAVC MYCYKNGSFS 150
    KRLGDKMEIE VIGGSDKYKS VCRKCYFF 178
    Length:178
    Mass (Da):19,896
    Last modified:December 14, 2011 - v2
    Checksum:i51A7775471A99D53
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 32Missing in AAA47227. (PubMed:3023681)Curated
    Sequence conflicti102 – 1021A → R in AAA47227. (PubMed:3023681)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M14493 Genomic DNA. Translation: AAA47227.1.
    AF170722 Genomic DNA. Translation: AAF17943.1.
    PIRiA26102. KIVZSF.
    RefSeqiNP_051950.1. NC_001266.1.

    Genome annotation databases

    GeneIDi1486904.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M14493 Genomic DNA. Translation: AAA47227.1 .
    AF170722 Genomic DNA. Translation: AAF17943.1 .
    PIRi A26102. KIVZSF.
    RefSeqi NP_051950.1. NC_001266.1.

    3D structure databases

    ProteinModelPortali P07605.
    SMRi P07605. Positions 6-177.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1486904.

    Family and domain databases

    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and nucleotide sequence of the thymidine kinase gene of Shope fibroma virus."
      Upton C., McFadden G.
      J. Virol. 60:920-927(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Tumorigenic poxviruses: analysis of viral DNA sequences implicated in the tumorigenicity of Shope fibroma virus and malignant rabbit virus."
      Upton C., McFadden G.
      Virology 152:308-321(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Sequence and analysis of a portion of the genomes of Shope fibroma virus and malignant rabbit fibroma virus that is important for viral replication in lymphocytes."
      Strayer D.S., Jerng H.H., O'Connor K.
      Virology 185:585-595(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The complete genome sequence of shope (Rabbit) fibroma virus."
      Willer D.O., McFadden G., Evans D.H.
      Virology 264:319-343(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiKITH_RFVKA
    AccessioniPrimary (citable) accession number: P07605
    Secondary accession number(s): Q9Q910
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: December 14, 2011
    Last modified: October 1, 2014
    This is version 59 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3