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P07605 (KITH_RFVKA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidine kinase
EC=2.7.1.21
Gene names
Name:TK
ORF Names:s061R
OrganismRabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) [Reference proteome]
Taxonomic identifier10272 [NCBI]
Taxonomic lineageViruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Leporipoxvirus ›
Virus hostOryctolagus cuniculus (Rabbit) [TaxID: 9986]

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 178178Thymidine kinase
PRO_0000174935

Regions

Nucleotide binding13 – 208ATP By similarity
Region159 – 1635Substrate binding By similarity

Sites

Active site851Proton acceptor Potential
Metal binding1401Zinc By similarity
Metal binding1431Zinc By similarity
Metal binding1721Zinc By similarity
Metal binding1751Zinc By similarity
Binding site1151Substrate; via amide nitrogen By similarity

Experimental info

Sequence conflict2 – 32Missing in AAA47227. Ref.1
Sequence conflict1021A → R in AAA47227. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P07605 [UniParc].

Last modified December 14, 2011. Version 2.
Checksum: 51A7775471A99D53

FASTA17819,896
        10         20         30         40         50         60 
MTMYGGHIHL IIGPMFAGKS TELIRLVRRY QIAKHKCLVV KYEKDIRYGN GVCTHDNMSI 

        70         80         90        100        110        120 
TAVCTPSLDK IDSVAENAEV IGIDEGQFFP NIATFCERMA NAGKVLIVAA LDGTFQRKPF 

       130        140        150        160        170 
SNISELIPLA ENVTKLNAVC MYCYKNGSFS KRLGDKMEIE VIGGSDKYKS VCRKCYFF

« Hide

References

« Hide 'large scale' references
[1]"Identification and nucleotide sequence of the thymidine kinase gene of Shope fibroma virus."
Upton C., McFadden G.
J. Virol. 60:920-927(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Tumorigenic poxviruses: analysis of viral DNA sequences implicated in the tumorigenicity of Shope fibroma virus and malignant rabbit virus."
Upton C., McFadden G.
Virology 152:308-321(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Sequence and analysis of a portion of the genomes of Shope fibroma virus and malignant rabbit fibroma virus that is important for viral replication in lymphocytes."
Strayer D.S., Jerng H.H., O'Connor K.
Virology 185:585-595(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The complete genome sequence of shope (Rabbit) fibroma virus."
Willer D.O., McFadden G., Evans D.H.
Virology 264:319-343(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M14493 Genomic DNA. Translation: AAA47227.1.
AF170722 Genomic DNA. Translation: AAF17943.1.
PIRKIVZSF. A26102.
RefSeqNP_051950.1. NC_001266.1.

3D structure databases

ProteinModelPortalP07605.
SMRP07605. Positions 6-177.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1486904.

Phylogenomic databases

ProtClustDBCLSP2509781.

Family and domain databases

InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_RFVKA
AccessionPrimary (citable) accession number: P07605
Secondary accession number(s): Q9Q910
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 14, 2011
Last modified: May 29, 2013
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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