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Protein

Thymidine kinase

Gene

TK

Organism
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85Proton acceptorSequence analysis1
Binding sitei115Substrate; via amide nitrogenBy similarity1
Metal bindingi140ZincBy similarity1
Metal bindingi143ZincBy similarity1
Metal bindingi172ZincBy similarity1
Metal bindingi175ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
ORF Names:s061R
OrganismiRabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza))
Taxonomic identifieri10272 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeLeporipoxvirus
Virus hostiOryctolagus cuniculus (Rabbit) [TaxID: 9986]
Proteomesi
  • UP000000868 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001749351 – 178Thymidine kinaseAdd BLAST178

Structurei

3D structure databases

ProteinModelPortaliP07605.
SMRiP07605.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni159 – 163Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the thymidine kinase family.Curated

Phylogenomic databases

KOiK00857.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07605-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMYGGHIHL IIGPMFAGKS TELIRLVRRY QIAKHKCLVV KYEKDIRYGN
60 70 80 90 100
GVCTHDNMSI TAVCTPSLDK IDSVAENAEV IGIDEGQFFP NIATFCERMA
110 120 130 140 150
NAGKVLIVAA LDGTFQRKPF SNISELIPLA ENVTKLNAVC MYCYKNGSFS
160 170
KRLGDKMEIE VIGGSDKYKS VCRKCYFF
Length:178
Mass (Da):19,896
Last modified:December 14, 2011 - v2
Checksum:i51A7775471A99D53
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 3Missing in AAA47227 (PubMed:3023681).Curated2
Sequence conflicti102A → R in AAA47227 (PubMed:3023681).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14493 Genomic DNA. Translation: AAA47227.1.
AF170722 Genomic DNA. Translation: AAF17943.1.
PIRiA26102. KIVZSF.
RefSeqiNP_051950.1. NC_001266.1.

Genome annotation databases

GeneIDi1486904.
KEGGivg:1486904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14493 Genomic DNA. Translation: AAA47227.1.
AF170722 Genomic DNA. Translation: AAF17943.1.
PIRiA26102. KIVZSF.
RefSeqiNP_051950.1. NC_001266.1.

3D structure databases

ProteinModelPortaliP07605.
SMRiP07605.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1486904.
KEGGivg:1486904.

Phylogenomic databases

KOiK00857.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKITH_RFVKA
AccessioniPrimary (citable) accession number: P07605
Secondary accession number(s): Q9Q910
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 14, 2011
Last modified: November 2, 2016
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.