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P07603 (PHFS_DESVH) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Periplasmic [Fe] hydrogenase small subunit

EC=1.12.7.2
Alternative name(s):
Fe hydrogenlyase small chain
Gene names
Name:hydB
Ordered Locus Names:DVU_1770
OrganismDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303) [Reference proteome] [HAMAP]
Taxonomic identifier882 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Protein attributes

Sequence length123 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in hydrogen uptake for the reduction of sulfate to hydrogen sulfide in an electron transport chain. Cytochrome c3 is likely to be the physiological electron carrier for the enzyme.

Catalytic activity

H2 + 2 oxidized ferredoxin = 2 reduced ferredoxin + 2 H+.

Subunit structure

Heterodimer of a large and a small subunit.

Subcellular location

Periplasm.

Post-translational modification

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434Tat-type signal Ref.3
Chain35 – 12389Periplasmic [Fe] hydrogenase small subunit
PRO_0000013413

Secondary structure

............. 123
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P07603 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: 2F4F7A4304ECD47B

FASTA12313,624
        10         20         30         40         50         60 
MQIASITRRG FLKVACVTTG AALIGIRMTG KAVAAVKQIK DYMLDRINGV YGADAKFPVR 

        70         80         90        100        110        120 
ASQDNTQVKA LYKSYLEKPL GHKSHDLLHT HWFDKSKGVK ELTTAGKLPN PRASEFEGPY 


PYE 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of the gene encoding the hydrogenase from Desulfovibrio vulgaris (Hildenborough)."
Voordouw G., Brenner S.
Eur. J. Biochem. 148:515-520(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough."
Heidelberg J.F., Seshadri R., Haveman S.A., Hemme C.L., Paulsen I.T., Kolonay J.F., Eisen J.A., Ward N.L., Methe B.A., Brinkac L.M., Daugherty S.C., DeBoy R.T., Dodson R.J., Durkin A.S., Madupu R., Nelson W.C., Sullivan S.A., Fouts D.E. expand/collapse author list , Haft D.H., Selengut J., Peterson J.D., Davidsen T.M., Zafar N., Zhou L., Radune D., Dimitrov G., Hance M., Tran K., Khouri H.M., Gill J., Utterback T.R., Feldblyum T.V., Wall J.D., Voordouw G., Fraser C.M.
Nat. Biotechnol. 22:554-559(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hildenborough / ATCC 29579 / NCIMB 8303.
[3]"Identification of three classes of hydrogenase in the genus, Desulfovibrio."
Prickril B.C., He S.H., Li C., Menon N.K., Choi E.S., Przybyla A.E., Dervartanian D.V., Peck H.D. Jr., Fauque G., le Gall J., Teixeira M., Moura I., Moura J.J.G., Patil D., Huynh B.H.
Biochem. Biophys. Res. Commun. 149:369-377(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 35-69.
[4]"Putative signal peptide on the small subunit of the periplasmic hydrogenase from Desulfovibrio vulgaris."
Prickril B.C., Czechowski M.H., Przybyla A.E., Peck H.D. Jr., le Gall J.
J. Bacteriol. 167:722-725(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: SIGNAL SEQUENCE CLEAVAGE SITE.
[5]"Desulfovibrio desulfuricans iron hydrogenase: the structure shows unusual coordination to an active site Fe binuclear center."
Nicolet Y., Piras C., Legrand P., Hatchikian E.C., Fontecilla-Camps J.-C.
Structure 7:13-23(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X02416 Genomic DNA. Translation: CAA26267.1.
AE017285 Genomic DNA. Translation: AAS96247.1.
PIRHQDVFS. B24551.
RefSeqYP_010988.1. NC_002937.3.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1E08NMR-D36-123[»]
1GX7NMR-D36-123[»]
1HFEX-ray1.60S/T1-123[»]
ProteinModelPortalP07603.
SMRP07603. Positions 36-123.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-6187N.
STRING882.DVU1770.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS96247; AAS96247; DVU_1770.
GeneID2795817.
KEGGdvu:DVU1770.
PATRIC32063306. VBIDesVul119526_1626.

Phylogenomic databases

eggNOGNOG282997.
KOK00534.
OMARVSHANP.
OrthoDBEOG6GTZMV.
ProtClustDBCLSK907410.

Enzyme and pathway databases

BioCycDVUL882:GJIL-1811-MONOMER.

Family and domain databases

Gene3D4.10.260.20. 1 hit.
InterProIPR008953. Fe_hydrogenase_ssu.
IPR003149. Fe_hydrogenase_ssu-like.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view]
PfamPF02256. Fe_hyd_SSU. 1 hit.
[Graphical view]
SMARTSM00902. Fe_hyd_SSU. 1 hit.
[Graphical view]
SUPFAMSSF48674. SSF48674. 1 hit.
TIGRFAMsTIGR01409. TAT_signal_seq. 1 hit.
PROSITEPS51318. TAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP07603.

Entry information

Entry namePHFS_DESVH
AccessionPrimary (citable) accession number: P07603
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 13, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references