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Protein

Non-specific lipid-transfer protein 1

Gene

LTP1

Organism
Hordeum vulgare (Barley)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.

Caution

Was originally thought to be an inhibitor of alpha-amylase or of a protease and was known as PAPI: probable alpha-amylase/protease inhibitor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific lipid-transfer protein 1
Short name:
LTP 1
Alternative name(s):
Probable amylase/protease inhibitor
Gene namesi
Name:LTP1
Synonyms:PAPI
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeHordeinaeHordeum

Pathology & Biotechi

Biotechnological usei

During brewing process, structural and chemical modifications of the protein occur. Both unfolding of the structure and glycation should increased the amphiphilicity of the protein, leading to foam-promoting forms that concentrate in beer foams.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000001838127 – 117Non-specific lipid-transfer protein 1Add BLAST91

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 76Combined sources3 Publications
Lipidationi33Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester1 Publication1
Disulfide bondi39 ↔ 53Combined sources3 Publications
Disulfide bondi54 ↔ 99Combined sources3 Publications
Disulfide bondi74 ↔ 113Combined sources3 Publications

Keywords - PTMi

Disulfide bond, Lipoprotein

Expressioni

Tissue specificityi

Aleurone layer of developing and germinating seeds.1 Publication

Gene expression databases

ExpressionAtlasiP07597 baseline and differential

Structurei

Secondary structure

1117
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 36Combined sources8
Helixi37 – 39Combined sources3
Helixi40 – 43Combined sources4
Helixi51 – 63Combined sources13
Helixi67 – 82Combined sources16
Beta strandi84 – 86Combined sources3
Helixi89 – 98Combined sources10
Beta strandi107 – 110Combined sources4
Helixi113 – 115Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BE2NMR-A27-117[»]
1JTBNMR-A27-117[»]
1LIPNMR-A27-117[»]
1MIDX-ray1.71A27-117[»]
3GSHX-ray1.80A/B27-117[»]
ProteinModelPortaliP07597
SMRiP07597
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07597

Family & Domainsi

Sequence similaritiesi

Belongs to the plant LTP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J475 Eukaryota
ENOG410YWBC LUCA

Family and domain databases

InterProiView protein in InterPro
IPR036312 Bifun_inhib/LTP/seed_sf
IPR016140 Bifunc_inhib/LTP/seed_store
IPR000528 Plant_LTP
PfamiView protein in Pfam
PF00234 Tryp_alpha_amyl, 1 hit
PRINTSiPR00382 LIPIDTRNSFER
SMARTiView protein in SMART
SM00499 AAI, 1 hit
SUPFAMiSSF47699 SSF47699, 1 hit
PROSITEiView protein in PROSITE
PS00597 PLANT_LTP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07597-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARAQVLLMA AALVLMLTAA PRAAVALNCG QVDSKMKPCL TYVQGGPGPS
60 70 80 90 100
GECCNGVRDL HNQAQSSGDR QTVCNCLKGI ARGIHNLNLN NAASIPSKCN
110
VNVPYTISPD IDCSRIY
Length:117
Mass (Da):12,301
Last modified:April 1, 1988 - v1
Checksum:i31209513AF00E444
GO

Sequence cautioni

The sequence CAA42832 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15207 mRNA Translation: AAA32970.1
X05168 mRNA Translation: CAA28805.1
X59253 Genomic DNA Translation: CAA41946.1
X60292 Genomic DNA Translation: CAA42832.1 Sequence problems.
PIRiS20507
T05947
UniGeneiHv.23091

Similar proteinsi

Entry informationi

Entry nameiNLTP1_HORVU
AccessioniPrimary (citable) accession number: P07597
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing
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Main funding by: National Institutes of Health