UniProtKB - P07585 (PGS2_HUMAN)
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Protein
Decorin
Gene
DCN
Organism
Homo sapiens (Human)
Status
Functioni
May affect the rate of fibrils formation.
GO - Molecular functioni
- collagen binding Source: Ensembl
- extracellular matrix binding Source: Ensembl
- glycosaminoglycan binding Source: Ensembl
- protein kinase inhibitor activity Source: GO_Central
- protein N-terminus binding Source: Ensembl
- RNA binding Source: UniProtKB
GO - Biological processi
- aging Source: Ensembl
- animal organ morphogenesis Source: ProtInc
- chondroitin sulfate biosynthetic process Source: Reactome
- chondroitin sulfate catabolic process Source: Reactome
- cytokine-mediated signaling pathway Source: GO_Central
- dermatan sulfate biosynthetic process Source: Reactome
- extracellular matrix disassembly Source: Reactome
- extracellular matrix organization Source: Reactome
- glycosaminoglycan metabolic process Source: Reactome
- kidney development Source: Ensembl
- negative regulation of angiogenesis Source: MGI
- negative regulation of endothelial cell migration Source: MGI
- negative regulation of JAK-STAT cascade Source: GO_Central
- negative regulation of protein kinase activity Source: GO_Central
- negative regulation of vascular endothelial growth factor signaling pathway Source: MGI
- peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: Ensembl
- placenta development Source: Ensembl
- positive regulation of autophagy Source: CACAO
- positive regulation of macroautophagy Source: MGI
- positive regulation of mitochondrial depolarization Source: MGI
- positive regulation of mitochondrial fission Source: MGI
- positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- response to lipopolysaccharide Source: Ensembl
- response to mechanical stimulus Source: Ensembl
- skeletal muscle tissue development Source: Ensembl
- wound healing Source: Ensembl
Enzyme and pathway databases
Reactomei | R-HSA-1474228. Degradation of the extracellular matrix. R-HSA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis. R-HSA-2022870. Chondroitin sulfate biosynthesis. R-HSA-2022923. Dermatan sulfate biosynthesis. R-HSA-2024101. CS/DS degradation. R-HSA-3000178. ECM proteoglycans. R-HSA-3560783. Defective B4GALT7 causes EDS, progeroid type. R-HSA-3560801. Defective B3GAT3 causes JDSSDHD. R-HSA-3595172. Defective CHST3 causes SEDCJD. R-HSA-3595174. Defective CHST14 causes EDS, musculocontractural type. R-HSA-3595177. Defective CHSY1 causes TPBS. R-HSA-4420332. Defective B3GALT6 causes EDSP2 and SEMDJL1. |
SIGNORi | P07585. |
Names & Taxonomyi
Protein namesi | Recommended name: DecorinAlternative name(s): Bone proteoglycan II PG-S2 PG40 |
Gene namesi | Name:DCN Synonyms:SLRR1B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000011465.16. |
HGNCi | HGNC:2705. DCN. |
MIMi | 125255. gene. |
neXtProti | NX_P07585. |
Pathology & Biotechi
Involvement in diseasei
Corneal dystrophy, congenital stromal (CSCD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent.
See also OMIM:610048Keywords - Diseasei
Corneal dystrophyOrganism-specific databases
DisGeNETi | 1634. |
GeneReviewsi | DCN. |
MalaCardsi | DCN. |
MIMi | 610048. phenotype. |
OpenTargetsi | ENSG00000011465. |
Orphaneti | 101068. Congenital stromal corneal dystrophy. |
PharmGKBi | PA27177. |
Chemistry databases
DrugBanki | DB03754. Tris. |
Polymorphism and mutation databases
BioMutai | DCN. |
DMDMi | 129951. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | By similarityAdd BLAST | 16 | |
PropeptideiPRO_0000032709 | 17 – 30 | 2 PublicationsAdd BLAST | 14 | |
ChainiPRO_0000032710 | 31 – 359 | DecorinAdd BLAST | 329 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 34 | O-linked (Xyl...) (glycosaminoglycan) serine1 Publication | 1 | |
Disulfide bondi | 54 ↔ 60 | By similarity | ||
Disulfide bondi | 58 ↔ 67 | By similarity | ||
Glycosylationi | 211 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 262 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 303 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 313 ↔ 346 | By similarity |
Post-translational modificationi
The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.
Keywords - PTMi
Disulfide bond, Glycoprotein, ProteoglycanProteomic databases
EPDi | P07585. |
PaxDbi | P07585. |
PeptideAtlasi | P07585. |
PRIDEi | P07585. |
PTM databases
iPTMneti | P07585. |
PhosphoSitePlusi | P07585. |
Miscellaneous databases
PMAP-CutDBi | P07585. |
Expressioni
Gene expression databases
Bgeei | ENSG00000011465. |
CleanExi | HS_DCN. |
ExpressionAtlasi | P07585. baseline and differential. |
Genevisiblei | P07585. HS. |
Organism-specific databases
HPAi | CAB017118. CAB068930. HPA003315. HPA064736. |
Interactioni
Subunit structurei
Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).By similarity
Binary interactionsi
GO - Molecular functioni
- collagen binding Source: Ensembl
- protein N-terminus binding Source: Ensembl
Protein-protein interaction databases
BioGridi | 108002. 20 interactors. |
IntActi | P07585. 14 interactors. |
STRINGi | 9606.ENSP00000052754. |
Structurei
3D structure databases
ProteinModelPortali | P07585. |
SMRi | P07585. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 73 – 93 | LRR 1Add BLAST | 21 | |
Repeati | 94 – 117 | LRR 2Add BLAST | 24 | |
Repeati | 118 – 141 | LRR 3Add BLAST | 24 | |
Repeati | 142 – 162 | LRR 4Add BLAST | 21 | |
Repeati | 163 – 186 | LRR 5Add BLAST | 24 | |
Repeati | 187 – 212 | LRR 6Add BLAST | 26 | |
Repeati | 213 – 233 | LRR 7Add BLAST | 21 | |
Repeati | 234 – 257 | LRR 8Add BLAST | 24 | |
Repeati | 258 – 281 | LRR 9Add BLAST | 24 | |
Repeati | 282 – 304 | LRR 10Add BLAST | 23 | |
Repeati | 305 – 334 | LRR 11Add BLAST | 30 | |
Repeati | 335 – 359 | LRR 12Add BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 54 – 67 | Cys-richAdd BLAST | 14 |
Sequence similaritiesi
Keywords - Domaini
Leucine-rich repeat, Repeat, SignalPhylogenomic databases
eggNOGi | KOG0619. Eukaryota. COG4886. LUCA. |
GeneTreei | ENSGT00760000118969. |
HOGENOMi | HOG000261690. |
HOVERGENi | HBG016052. |
InParanoidi | P07585. |
KOi | K04660. |
OMAi | PLGPVCP. |
OrthoDBi | EOG091G044B. |
PhylomeDBi | P07585. |
TreeFami | TF334562. |
Family and domain databases
Gene3Di | 3.80.10.10. 1 hit. |
InterProi | View protein in InterPro IPR028549. Decorin. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR032675. LRR_dom_sf. IPR000372. LRRNT. IPR016352. SLRP_I_decor/aspor/byglycan. |
PANTHERi | PTHR44053:SF2. PTHR44053:SF2. 1 hit. |
Pfami | View protein in Pfam PF13855. LRR_8. 3 hits. PF01462. LRRNT. 1 hit. |
PIRSFi | PIRSF002490. SLRP_I. 1 hit. |
SMARTi | View protein in SMART SM00369. LRR_TYP. 6 hits. SM00013. LRRNT. 1 hit. |
PROSITEi | View protein in PROSITE PS51450. LRR. 8 hits. |
s (5)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basket
Isoform A (identifier: P07585-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MKATIILLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPEV PDDRDFEPSL
60 70 80 90 100
GPVCPFRCQC HLRVVQCSDL GLDKVPKDLP PDTTLLDLQN NKITEIKDGD
110 120 130 140 150
FKNLKNLHAL ILVNNKISKV SPGAFTPLVK LERLYLSKNQ LKELPEKMPK
160 170 180 190 200
TLQELRAHEN EITKVRKVTF NGLNQMIVIE LGTNPLKSSG IENGAFQGMK
210 220 230 240 250
KLSYIRIADT NITSIPQGLP PSLTELHLDG NKISRVDAAS LKGLNNLAKL
260 270 280 290 300
GLSFNSISAV DNGSLANTPH LRELHLDNNK LTRVPGGLAE HKYIQVVYLH
310 320 330 340 350
NNNISVVGSS DFCPPGHNTK KASYSGVSLF SNPVQYWEIQ PSTFRCVYVR
SAIQLGNYK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | G → A AA sequence (PubMed:3597437).Curated | 1 | |
Sequence conflicti | 45 | D → P AA sequence (PubMed:3597437).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014351 | 268 | T → M1 PublicationCorresponds to variant dbSNP:rs3138268Ensembl. | 1 | |
Natural variantiVAR_011975 | 273 | E → Q. Corresponds to variant dbSNP:rs1803344Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006172 | 71 – 179 | Missing in isoform B. 1 PublicationAdd BLAST | 109 | |
Alternative sequenceiVSP_006175 | 72 – 75 | LDKV → CLPS in isoform E. 1 Publication | 4 | |
Alternative sequenceiVSP_006173 | 73 – 219 | Missing in isoform C. 1 PublicationAdd BLAST | 147 | |
Alternative sequenceiVSP_006176 | 76 – 359 | Missing in isoform E. 1 PublicationAdd BLAST | 284 | |
Alternative sequenceiVSP_006174 | 109 – 295 | Missing in isoform D. 1 PublicationAdd BLAST | 187 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | PGS2_HUMAN | |
Accessioni | P07585Primary (citable) accession number: P07585 Secondary accession number(s): Q9P0Z0 Q9Y5N9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | April 1, 1988 | |
Last modified: | March 28, 2018 | |
This is version 202 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |