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Protein

Decorin

Gene

DCN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May affect the rate of fibrils formation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000011465-MONOMER.
ReactomeiR-HSA-1474228. Degradation of the extracellular matrix.
R-HSA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-HSA-2022870. Chondroitin sulfate biosynthesis.
R-HSA-2022923. Dermatan sulfate biosynthesis.
R-HSA-2024101. CS/DS degradation.
R-HSA-3000178. ECM proteoglycans.
R-HSA-3560783. Defective B4GALT7 causes EDS, progeroid type.
R-HSA-3560801. Defective B3GAT3 causes JDSSDHD.
R-HSA-3595172. Defective CHST3 causes SEDCJD.
R-HSA-3595174. Defective CHST14 causes EDS, musculocontractural type.
R-HSA-3595177. Defective CHSY1 causes TPBS.
R-HSA-4420332. Defective B3GALT6 causes EDSP2 and SEMDJL1.

Names & Taxonomyi

Protein namesi
Recommended name:
Decorin
Alternative name(s):
Bone proteoglycan II
PG-S2
PG40
Gene namesi
Name:DCN
Synonyms:SLRR1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:2705. DCN.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Corneal dystrophy, congenital stromal (CSCD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent.
See also OMIM:610048

Keywords - Diseasei

Corneal dystrophy

Organism-specific databases

DisGeNETi1634.
MalaCardsiDCN.
MIMi610048. phenotype.
OpenTargetsiENSG00000011465.
Orphaneti101068. Congenital stromal corneal dystrophy.
PharmGKBiPA27177.

Chemistry databases

DrugBankiDB03754. Tris.

Polymorphism and mutation databases

BioMutaiDCN.
DMDMi129951.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16By similarityAdd BLAST16
PropeptideiPRO_000003270917 – 302 PublicationsAdd BLAST14
ChainiPRO_000003271031 – 359DecorinAdd BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34O-linked (Xyl...) (glycosaminoglycan)1 Publication1
Disulfide bondi54 ↔ 60By similarity
Disulfide bondi58 ↔ 67By similarity
Glycosylationi211N-linked (GlcNAc...)1 Publication1
Glycosylationi262N-linked (GlcNAc...)1 Publication1
Glycosylationi303N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi313 ↔ 346By similarity

Post-translational modificationi

The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiP07585.
PeptideAtlasiP07585.
PRIDEiP07585.

PTM databases

iPTMnetiP07585.
PhosphoSitePlusiP07585.

Miscellaneous databases

PMAP-CutDBP07585.

Expressioni

Gene expression databases

BgeeiENSG00000011465.
CleanExiHS_DCN.
ExpressionAtlasiP07585. baseline and differential.
GenevisibleiP07585. HS.

Organism-specific databases

HPAiCAB017118.
HPA003315.

Interactioni

Subunit structurei

Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
BMP1P13497-22EBI-9663608,EBI-12509497
FN1P027519EBI-9663608,EBI-1220319

Protein-protein interaction databases

BioGridi108002. 19 interactors.
IntActiP07585. 12 interactors.
STRINGi9606.ENSP00000052754.

Structurei

3D structure databases

ProteinModelPortaliP07585.
SMRiP07585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati73 – 93LRR 1Add BLAST21
Repeati94 – 117LRR 2Add BLAST24
Repeati118 – 141LRR 3Add BLAST24
Repeati142 – 162LRR 4Add BLAST21
Repeati163 – 186LRR 5Add BLAST24
Repeati187 – 212LRR 6Add BLAST26
Repeati213 – 233LRR 7Add BLAST21
Repeati234 – 257LRR 8Add BLAST24
Repeati258 – 281LRR 9Add BLAST24
Repeati282 – 304LRR 10Add BLAST23
Repeati305 – 334LRR 11Add BLAST30
Repeati335 – 359LRR 12Add BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi54 – 67Cys-richAdd BLAST14

Sequence similaritiesi

Contains 12 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000261690.
HOVERGENiHBG016052.
InParanoidiP07585.
KOiK04660.
OMAiPLGPVCP.
OrthoDBiEOG091G044B.
PhylomeDBiP07585.
TreeFamiTF334562.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR028549. Decorin.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view]
PANTHERiPTHR24369:SF5. PTHR24369:SF5. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PIRSFiPIRSF002490. SLRP_I. 1 hit.
SMARTiSM00369. LRR_TYP. 6 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P07585-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKATIILLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPEV PDDRDFEPSL
60 70 80 90 100
GPVCPFRCQC HLRVVQCSDL GLDKVPKDLP PDTTLLDLQN NKITEIKDGD
110 120 130 140 150
FKNLKNLHAL ILVNNKISKV SPGAFTPLVK LERLYLSKNQ LKELPEKMPK
160 170 180 190 200
TLQELRAHEN EITKVRKVTF NGLNQMIVIE LGTNPLKSSG IENGAFQGMK
210 220 230 240 250
KLSYIRIADT NITSIPQGLP PSLTELHLDG NKISRVDAAS LKGLNNLAKL
260 270 280 290 300
GLSFNSISAV DNGSLANTPH LRELHLDNNK LTRVPGGLAE HKYIQVVYLH
310 320 330 340 350
NNNISVVGSS DFCPPGHNTK KASYSGVSLF SNPVQYWEIQ PSTFRCVYVR

SAIQLGNYK
Length:359
Mass (Da):39,747
Last modified:April 1, 1988 - v1
Checksum:iFF511E871A1A52DD
GO
Isoform B (identifier: P07585-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-179: Missing.

Show »
Length:250
Mass (Da):27,353
Checksum:i5AA599BE479F68D9
GO
Isoform C (identifier: P07585-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-219: Missing.

Show »
Length:212
Mass (Da):23,278
Checksum:i0BCF8BC8CBA92CA9
GO
Isoform D (identifier: P07585-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-295: Missing.

Show »
Length:172
Mass (Da):19,243
Checksum:i7EA011E351163971
GO
Isoform E (identifier: P07585-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-75: LDKV → CLPS
     76-359: Missing.

Show »
Length:75
Mass (Da):8,266
Checksum:i781856DC9E377479
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37G → A AA sequence (PubMed:3597437).Curated1
Sequence conflicti45D → P AA sequence (PubMed:3597437).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014351268T → M.1 PublicationCorresponds to variant rs3138268dbSNPEnsembl.1
Natural variantiVAR_011975273E → Q.Corresponds to variant rs1803344dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00617271 – 179Missing in isoform B. 1 PublicationAdd BLAST109
Alternative sequenceiVSP_00617572 – 75LDKV → CLPS in isoform E. 1 Publication4
Alternative sequenceiVSP_00617373 – 219Missing in isoform C. 1 PublicationAdd BLAST147
Alternative sequenceiVSP_00617676 – 359Missing in isoform E. 1 PublicationAdd BLAST284
Alternative sequenceiVSP_006174109 – 295Missing in isoform D. 1 PublicationAdd BLAST187

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14219 mRNA. Translation: AAB00774.1.
L01131
, L01125, L01126, L01127, L01129, L01130 Genomic DNA. Translation: AAA52301.1. Sequence problems.
AH005442 Genomic DNA. Translation: AAB60901.1.
AF138300 mRNA. Translation: AAD44713.1.
AF138301 mRNA. Translation: AAF61437.1.
AF138302 mRNA. Translation: AAD44714.1.
AF138303 mRNA. Translation: AAF61438.1.
AF138304 mRNA. Translation: AAD44715.1.
BT019800 mRNA. Translation: AAV38603.1.
AF491944 Genomic DNA. Translation: AAL92176.1.
BC005322 mRNA. Translation: AAH05322.1.
CCDSiCCDS44951.1. [P07585-5]
CCDS9039.1. [P07585-1]
CCDS9040.1. [P07585-2]
CCDS9041.1. [P07585-3]
CCDS9042.1. [P07585-4]
PIRiA45016. NBHUC8.
B28457.
RefSeqiNP_001911.1. NM_001920.4. [P07585-1]
NP_598010.1. NM_133503.3. [P07585-1]
NP_598011.1. NM_133504.3. [P07585-2]
NP_598012.1. NM_133505.3. [P07585-3]
NP_598013.1. NM_133506.3. [P07585-4]
NP_598014.1. NM_133507.3. [P07585-5]
XP_005268750.1. XM_005268693.1. [P07585-1]
XP_006719333.1. XM_006719270.1. [P07585-1]
XP_016874406.1. XM_017018917.1. [P07585-1]
UniGeneiHs.156316.
Hs.530910.

Genome annotation databases

EnsembliENST00000052754; ENSP00000052754; ENSG00000011465. [P07585-1]
ENST00000393155; ENSP00000376862; ENSG00000011465. [P07585-1]
ENST00000420120; ENSP00000413723; ENSG00000011465. [P07585-2]
ENST00000425043; ENSP00000401021; ENSG00000011465. [P07585-3]
ENST00000441303; ENSP00000399815; ENSG00000011465. [P07585-4]
ENST00000456569; ENSP00000398514; ENSG00000011465. [P07585-5]
ENST00000547568; ENSP00000447674; ENSG00000011465. [P07585-3]
ENST00000552962; ENSP00000447654; ENSG00000011465. [P07585-1]
GeneIDi1634.
KEGGihsa:1634.
UCSCiuc001tbo.4. human. [P07585-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14219 mRNA. Translation: AAB00774.1.
L01131
, L01125, L01126, L01127, L01129, L01130 Genomic DNA. Translation: AAA52301.1. Sequence problems.
AH005442 Genomic DNA. Translation: AAB60901.1.
AF138300 mRNA. Translation: AAD44713.1.
AF138301 mRNA. Translation: AAF61437.1.
AF138302 mRNA. Translation: AAD44714.1.
AF138303 mRNA. Translation: AAF61438.1.
AF138304 mRNA. Translation: AAD44715.1.
BT019800 mRNA. Translation: AAV38603.1.
AF491944 Genomic DNA. Translation: AAL92176.1.
BC005322 mRNA. Translation: AAH05322.1.
CCDSiCCDS44951.1. [P07585-5]
CCDS9039.1. [P07585-1]
CCDS9040.1. [P07585-2]
CCDS9041.1. [P07585-3]
CCDS9042.1. [P07585-4]
PIRiA45016. NBHUC8.
B28457.
RefSeqiNP_001911.1. NM_001920.4. [P07585-1]
NP_598010.1. NM_133503.3. [P07585-1]
NP_598011.1. NM_133504.3. [P07585-2]
NP_598012.1. NM_133505.3. [P07585-3]
NP_598013.1. NM_133506.3. [P07585-4]
NP_598014.1. NM_133507.3. [P07585-5]
XP_005268750.1. XM_005268693.1. [P07585-1]
XP_006719333.1. XM_006719270.1. [P07585-1]
XP_016874406.1. XM_017018917.1. [P07585-1]
UniGeneiHs.156316.
Hs.530910.

3D structure databases

ProteinModelPortaliP07585.
SMRiP07585.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108002. 19 interactors.
IntActiP07585. 12 interactors.
STRINGi9606.ENSP00000052754.

Chemistry databases

DrugBankiDB03754. Tris.

PTM databases

iPTMnetiP07585.
PhosphoSitePlusiP07585.

Polymorphism and mutation databases

BioMutaiDCN.
DMDMi129951.

Proteomic databases

PaxDbiP07585.
PeptideAtlasiP07585.
PRIDEiP07585.

Protocols and materials databases

DNASUi1634.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000052754; ENSP00000052754; ENSG00000011465. [P07585-1]
ENST00000393155; ENSP00000376862; ENSG00000011465. [P07585-1]
ENST00000420120; ENSP00000413723; ENSG00000011465. [P07585-2]
ENST00000425043; ENSP00000401021; ENSG00000011465. [P07585-3]
ENST00000441303; ENSP00000399815; ENSG00000011465. [P07585-4]
ENST00000456569; ENSP00000398514; ENSG00000011465. [P07585-5]
ENST00000547568; ENSP00000447674; ENSG00000011465. [P07585-3]
ENST00000552962; ENSP00000447654; ENSG00000011465. [P07585-1]
GeneIDi1634.
KEGGihsa:1634.
UCSCiuc001tbo.4. human. [P07585-1]

Organism-specific databases

CTDi1634.
DisGeNETi1634.
GeneCardsiDCN.
GeneReviewsiDCN.
HGNCiHGNC:2705. DCN.
HPAiCAB017118.
HPA003315.
MalaCardsiDCN.
MIMi125255. gene.
610048. phenotype.
neXtProtiNX_P07585.
OpenTargetsiENSG00000011465.
Orphaneti101068. Congenital stromal corneal dystrophy.
PharmGKBiPA27177.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000261690.
HOVERGENiHBG016052.
InParanoidiP07585.
KOiK04660.
OMAiPLGPVCP.
OrthoDBiEOG091G044B.
PhylomeDBiP07585.
TreeFamiTF334562.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000011465-MONOMER.
ReactomeiR-HSA-1474228. Degradation of the extracellular matrix.
R-HSA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-HSA-2022870. Chondroitin sulfate biosynthesis.
R-HSA-2022923. Dermatan sulfate biosynthesis.
R-HSA-2024101. CS/DS degradation.
R-HSA-3000178. ECM proteoglycans.
R-HSA-3560783. Defective B4GALT7 causes EDS, progeroid type.
R-HSA-3560801. Defective B3GAT3 causes JDSSDHD.
R-HSA-3595172. Defective CHST3 causes SEDCJD.
R-HSA-3595174. Defective CHST14 causes EDS, musculocontractural type.
R-HSA-3595177. Defective CHSY1 causes TPBS.
R-HSA-4420332. Defective B3GALT6 causes EDSP2 and SEMDJL1.

Miscellaneous databases

ChiTaRSiDCN. human.
GeneWikiiDecorin.
GenomeRNAii1634.
PMAP-CutDBP07585.
PROiP07585.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000011465.
CleanExiHS_DCN.
ExpressionAtlasiP07585. baseline and differential.
GenevisibleiP07585. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR028549. Decorin.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view]
PANTHERiPTHR24369:SF5. PTHR24369:SF5. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PIRSFiPIRSF002490. SLRP_I. 1 hit.
SMARTiSM00369. LRR_TYP. 6 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGS2_HUMAN
AccessioniPrimary (citable) accession number: P07585
Secondary accession number(s): Q9P0Z0
, Q9P0Z1, Q9Y5N8, Q9Y5N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 30, 2016
This is version 191 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.