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Protein

Beta-galactoside-binding lectin

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein binds beta-galactoside. Its physiological function is not yet known. It may be involved in the regulation of differentiation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54Beta-galactosideBy similarity1
Binding sitei63Beta-galactosideBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandLectin

Enzyme and pathway databases

ReactomeiR-GGA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-GGA-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactoside-binding lectin
Alternative name(s):
14 kDa lectin
C-14
Galectin CG-1B
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi8C → V: No redox-dependent shape changes. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL2189155

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000769512 – 135Beta-galactoside-binding lectinAdd BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Disulfide bondi3 ↔ 8Redox-active1 Publication
Disulfide bondi8Interchain; in linked form1 Publication

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiP07583
PRIDEiP07583

PTM databases

iPTMnetiP07583

Expressioni

Tissue specificityi

Mainly in the intestine (adult), mainly in the skin (embryo).

Gene expression databases

BgeeiENSGALG00000012420

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020275

Chemistry databases

BindingDBiP07583

Structurei

Secondary structure

1135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 9Combined sources3
Beta strandi18 – 25Combined sources8
Beta strandi31 – 39Combined sources9
Beta strandi42 – 53Combined sources12
Beta strandi56 – 68Combined sources13
Beta strandi74 – 76Combined sources3
Beta strandi86 – 93Combined sources8
Beta strandi95 – 102Combined sources8
Beta strandi105 – 110Combined sources6
Beta strandi120 – 135Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DUIX-ray2.10A/B1-135[»]
ProteinModelPortaliP07583
SMRiP07583
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07583

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 135GalectinPROSITE-ProRule annotationAdd BLAST131

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni46 – 50Beta-galactoside bindingBy similarity5
Regioni70 – 76Beta-galactoside bindingSequence analysis7
Regioni70 – 73Beta-galactoside bindingBy similarity4

Phylogenomic databases

eggNOGiKOG3587 Eukaryota
ENOG4111EA0 LUCA
GeneTreeiENSGT00440000034263
HOGENOMiHOG000059539
HOVERGENiHBG006255
InParanoidiP07583
OMAiPVCTNLG
OrthoDBiEOG091G0S7H
PhylomeDBiP07583
TreeFamiTF315551

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001079 Galectin_CRD
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07583-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCQGPVCTN LGLKPGQRLT VKGIIAPNAK SFVMNLGKDS THLGLHFNPR
60 70 80 90 100
FDAHGDVNLI VCNSKKMEEW GTEQRETVFP FQKGAPIEIT FSINPSDLTV
110 120 130
HLPGHQFSFP NRLGLSVFDY FDTHGDFTLR SVSWE
Length:135
Mass (Da):15,063
Last modified:January 23, 2007 - v2
Checksum:i5059E30CC51F899A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11674 mRNA Translation: AAA48779.1
D00311 Genomic DNA Translation: BAA00214.1
PIRiJX0042 LNCH14
RefSeqiNP_990826.1, NM_205495.1
UniGeneiGga.854

Genome annotation databases

EnsembliENSGALT00000020302; ENSGALP00000020275; ENSGALG00000012420
GeneIDi396491
KEGGigga:396491

Similar proteinsi

Entry informationi

Entry nameiLEG4_CHICK
AccessioniPrimary (citable) accession number: P07583
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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