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Protein

Beta-galactoside-binding lectin

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein binds beta-galactoside. Its physiological function is not yet known. It may be involved in the regulation of differentiation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541Beta-galactosideBy similarity
Binding sitei63 – 631Beta-galactosideBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactoside-binding lectin
Alternative name(s):
14 kDa lectin
C-14
Galectin CG-1B
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi8 – 81C → V: No redox-dependent shape changes. 1 Publication

Chemistry

ChEMBLiCHEMBL2189155.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 135134Beta-galactoside-binding lectinPRO_0000076951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Disulfide bondi3 ↔ 8Redox-active1 Publication
Disulfide bondi8 – 8Interchain; in linked form1 Publication

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiP07583.
PRIDEiP07583.

Expressioni

Tissue specificityi

Mainly in the intestine (adult), mainly in the skin (embryo).

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020275.

Chemistry

BindingDBiP07583.

Structurei

Secondary structure

1
135
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 93Combined sources
Beta strandi18 – 258Combined sources
Beta strandi31 – 399Combined sources
Beta strandi42 – 5312Combined sources
Beta strandi56 – 6813Combined sources
Beta strandi74 – 763Combined sources
Beta strandi86 – 938Combined sources
Beta strandi95 – 1028Combined sources
Beta strandi105 – 1106Combined sources
Beta strandi120 – 13516Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DUIX-ray2.10A/B1-135[»]
ProteinModelPortaliP07583.
SMRiP07583. Positions 5-135.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07583.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 135131GalectinPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni46 – 505Beta-galactoside bindingBy similarity
Regioni70 – 767Beta-galactoside bindingSequence analysis
Regioni70 – 734Beta-galactoside bindingBy similarity

Sequence similaritiesi

Contains 1 galectin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00440000034263.
HOGENOMiHOG000059539.
HOVERGENiHBG006255.
InParanoidiP07583.
OMAiNAHGDEN.
OrthoDBiEOG7NKKN0.
PhylomeDBiP07583.
TreeFamiTF315551.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07583-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCQGPVCTN LGLKPGQRLT VKGIIAPNAK SFVMNLGKDS THLGLHFNPR
60 70 80 90 100
FDAHGDVNLI VCNSKKMEEW GTEQRETVFP FQKGAPIEIT FSINPSDLTV
110 120 130
HLPGHQFSFP NRLGLSVFDY FDTHGDFTLR SVSWE
Length:135
Mass (Da):15,063
Last modified:January 23, 2007 - v2
Checksum:i5059E30CC51F899A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11674 mRNA. Translation: AAA48779.1.
D00311 Genomic DNA. Translation: BAA00214.1.
PIRiJX0042. LNCH14.
RefSeqiNP_990826.1. NM_205495.1.
UniGeneiGga.854.

Genome annotation databases

EnsembliENSGALT00000020302; ENSGALP00000020275; ENSGALG00000012420.
GeneIDi396491.
KEGGigga:396491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11674 mRNA. Translation: AAA48779.1.
D00311 Genomic DNA. Translation: BAA00214.1.
PIRiJX0042. LNCH14.
RefSeqiNP_990826.1. NM_205495.1.
UniGeneiGga.854.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DUIX-ray2.10A/B1-135[»]
ProteinModelPortaliP07583.
SMRiP07583. Positions 5-135.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020275.

Chemistry

BindingDBiP07583.
ChEMBLiCHEMBL2189155.

Proteomic databases

PaxDbiP07583.
PRIDEiP07583.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000020302; ENSGALP00000020275; ENSGALG00000012420.
GeneIDi396491.
KEGGigga:396491.

Organism-specific databases

CTDi3956.

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00440000034263.
HOGENOMiHOG000059539.
HOVERGENiHBG006255.
InParanoidiP07583.
OMAiNAHGDEN.
OrthoDBiEOG7NKKN0.
PhylomeDBiP07583.
TreeFamiTF315551.

Miscellaneous databases

EvolutionaryTraceiP07583.
NextBioi20816530.
PROiP07583.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of chick 14K beta-galactoside-binding lectin mRNA."
    Ohyama Y., Hirabayashi J., Oda Y., Ohno S., Kawasaki H., Suzuki K., Kasai K.
    Biochem. Biophys. Res. Commun. 134:51-56(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and characterization of the chick 14K beta-galactoside-binding lectin gene."
    Ohyama Y., Kasai K.
    J. Biochem. 104:173-177(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete amino acid sequence of 14 kDa beta-galactoside-binding lectin of chick embryo."
    Hirabayashi J., Kawasaki H., Suzuki K., Kasai K.
    J. Biochem. 101:775-787(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-135.
    Tissue: Embryo.
  4. "Homodimeric chicken galectin CG-1B (C-14): Crystal structure and detection of unique redox-dependent shape changes involving inter- and intrasubunit disulfide bridges by gel filtration, ultracentrifugation, site-directed mutagenesis, and peptide mass fingerprinting."
    Lopez-Lucendo M.F., Solis D., Saiz J.L., Kaltner H., Russwurm R., Andre S., Gabius H.J., Romero A.
    J. Mol. Biol. 386:366-378(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS), SUBUNIT, MUTAGENESIS OF CYS-8, DISULFIDE BOND.
    Strain: Bantam.

Entry informationi

Entry nameiLEG4_CHICK
AccessioniPrimary (citable) accession number: P07583
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: December 9, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.