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Protein

Protease

Gene

pro

Organism
Mason-Pfizer monkey virus (MPMV) (Simian Mason-Pfizer virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei188 – 1881PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BRENDAi3.4.23.B6. 3195.

Protein family/group databases

MEROPSiA02.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Protease (EC:3.4.23.-)
Gene namesi
Name:pro
OrganismiMason-Pfizer monkey virus (MPMV) (Simian Mason-Pfizer virus)
Taxonomic identifieri11855 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeBetaretrovirus
Virus hostiMacaca mulatta (Rhesus macaque) [TaxID: 9544]
Proteomesi
  • UP000008870 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314ProteasePRO_0000199550Add
BLAST

Structurei

Secondary structure

1
314
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi38 – 403Combined sources
Beta strandi49 – 546Combined sources
Beta strandi59 – 613Combined sources
Helixi63 – 653Combined sources
Beta strandi68 – 758Combined sources
Beta strandi82 – 876Combined sources
Helixi90 – 945Combined sources
Beta strandi97 – 993Combined sources
Beta strandi102 – 1043Combined sources
Beta strandi110 – 1189Combined sources
Beta strandi123 – 1253Combined sources
Beta strandi130 – 1389Combined sources
Beta strandi169 – 1724Combined sources
Beta strandi173 – 1786Combined sources
Beta strandi181 – 1877Combined sources
Beta strandi195 – 1973Combined sources
Helixi198 – 2003Combined sources
Beta strandi207 – 2093Combined sources
Beta strandi211 – 2144Combined sources
Helixi219 – 2213Combined sources
Beta strandi224 – 2285Combined sources
Beta strandi230 – 2334Combined sources
Turni235 – 2373Combined sources
Beta strandi239 – 2424Combined sources
Beta strandi245 – 2473Combined sources
Helixi257 – 2604Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NSONMR-A163-267[»]
2D4LX-ray1.70A11-162[»]
2D4MX-ray1.85A11-162[»]
2D4NX-ray1.53A11-162[»]
3SQFX-ray1.63A/B163-276[»]
3TP1X-ray1.60A11-162[»]
3TPWX-ray1.65A11-162[»]
ProteinModelPortaliP07570.
SMRiP07570. Positions 35-147, 163-269.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07570.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini183 – 25977Peptidase A2PROSITE-ProRule annotationAdd
BLAST
Domaini270 – 31445G-patchPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 G-patch domain.PROSITE-ProRule annotation
Contains 1 peptidase A2 domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
2.70.40.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR000467. G_patch_dom.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
PF01585. G-patch. 1 hit.
PF00077. RVP. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF51283. SSF51283. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50174. G_PATCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07570-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SRKPNTTPSG KRVEGPAPGP ETSLWGSQLC SSQQKQPISK LTRATPGSAG
60 70 80 90 100
LDLCSTSHTV LTPEMGPQAL STGIYGPLPP NTFGLILGRS SITMKGLQVY
110 120 130 140 150
PGVIDNDYTG EIKIMAKAVN NIVTVSQGNR IAQLILLPLI ETDNKVQQPY
160 170 180 190 200
RGQGSFGSSD IYWVQPITCQ KPSLTLWLDD KMFTGLIDTG ADVTIIKLED
210 220 230 240 250
WPPNWPITDT LTNLRGIGQS NNPKQSSKYL TWRDKENNSG LIKPFVIPNL
260 270 280 290 300
PVNLWGRDLL SQMKIMMCSP NDIVTAQMLA QGYSPGKGLG KKENGILHPI
310
PNQGQSNKKG FGNF
Length:314
Mass (Da):34,128
Last modified:August 1, 1988 - v1
Checksum:i405B311B423F9391
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12349 Genomic RNA. No translation available.
PIRiB25839. PRLJMP.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12349 Genomic RNA. No translation available.
PIRiB25839. PRLJMP.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NSONMR-A163-267[»]
2D4LX-ray1.70A11-162[»]
2D4MX-ray1.85A11-162[»]
2D4NX-ray1.53A11-162[»]
3SQFX-ray1.63A/B163-276[»]
3TP1X-ray1.60A11-162[»]
3TPWX-ray1.65A11-162[»]
ProteinModelPortaliP07570.
SMRiP07570. Positions 35-147, 163-269.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiA02.009.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi3.4.23.B6. 3195.

Miscellaneous databases

EvolutionaryTraceiP07570.

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
2.70.40.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR000467. G_patch_dom.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
PF01585. G-patch. 1 hit.
PF00077. RVP. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF51283. SSF51283. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50174. G_PATCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of Mason-Pfizer monkey virus: an immunosuppressive D-type retrovirus."
    Sonigo P., Barker C., Hunter E., Wain-Hobson S.
    Cell 45:375-385(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] (CLONE 6A).

Entry informationi

Entry nameiVPRT_MPMV
AccessioniPrimary (citable) accession number: P07570
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: January 20, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.