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Protein

Protease

Gene

pro

Organism
Mason-Pfizer monkey virus (MPMV) (Simian Mason-Pfizer virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei188PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BRENDAi3.4.23.B6. 3195.

Protein family/group databases

MEROPSiA02.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Protease (EC:3.4.23.-)
Gene namesi
Name:pro
OrganismiMason-Pfizer monkey virus (MPMV) (Simian Mason-Pfizer virus)
Taxonomic identifieri11855 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeBetaretrovirus
Virus hostiMacaca mulatta (Rhesus macaque) [TaxID: 9544]
Proteomesi
  • UP000008870 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001995501 – 314ProteaseAdd BLAST314

Structurei

Secondary structure

1314
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi38 – 40Combined sources3
Beta strandi49 – 54Combined sources6
Beta strandi59 – 61Combined sources3
Helixi63 – 65Combined sources3
Beta strandi68 – 75Combined sources8
Beta strandi82 – 87Combined sources6
Helixi90 – 94Combined sources5
Beta strandi97 – 99Combined sources3
Beta strandi102 – 104Combined sources3
Beta strandi110 – 118Combined sources9
Beta strandi123 – 125Combined sources3
Beta strandi130 – 138Combined sources9
Beta strandi169 – 172Combined sources4
Beta strandi173 – 178Combined sources6
Beta strandi181 – 187Combined sources7
Beta strandi195 – 197Combined sources3
Helixi198 – 200Combined sources3
Beta strandi207 – 209Combined sources3
Beta strandi211 – 214Combined sources4
Helixi219 – 221Combined sources3
Beta strandi224 – 228Combined sources5
Beta strandi230 – 233Combined sources4
Turni235 – 237Combined sources3
Beta strandi239 – 242Combined sources4
Beta strandi245 – 247Combined sources3
Helixi257 – 260Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NSONMR-A163-267[»]
2D4LX-ray1.70A11-162[»]
2D4MX-ray1.85A11-162[»]
2D4NX-ray1.53A11-162[»]
3SQFX-ray1.63A/B163-276[»]
3TP1X-ray1.60A11-162[»]
3TPWX-ray1.65A11-162[»]
ProteinModelPortaliP07570.
SMRiP07570.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07570.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini183 – 259Peptidase A2PROSITE-ProRule annotationAdd BLAST77
Domaini270 – 314G-patchPROSITE-ProRule annotationAdd BLAST45

Sequence similaritiesi

Contains 1 G-patch domain.PROSITE-ProRule annotation
Contains 1 peptidase A2 domain.PROSITE-ProRule annotation

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
Gene3Di2.40.70.10. 1 hit.
2.70.40.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR033704. dUTPase_trimeric.
IPR000467. G_patch_dom.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
PF01585. G-patch. 1 hit.
PF00077. RVP. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF51283. SSF51283. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50174. G_PATCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07570-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SRKPNTTPSG KRVEGPAPGP ETSLWGSQLC SSQQKQPISK LTRATPGSAG
60 70 80 90 100
LDLCSTSHTV LTPEMGPQAL STGIYGPLPP NTFGLILGRS SITMKGLQVY
110 120 130 140 150
PGVIDNDYTG EIKIMAKAVN NIVTVSQGNR IAQLILLPLI ETDNKVQQPY
160 170 180 190 200
RGQGSFGSSD IYWVQPITCQ KPSLTLWLDD KMFTGLIDTG ADVTIIKLED
210 220 230 240 250
WPPNWPITDT LTNLRGIGQS NNPKQSSKYL TWRDKENNSG LIKPFVIPNL
260 270 280 290 300
PVNLWGRDLL SQMKIMMCSP NDIVTAQMLA QGYSPGKGLG KKENGILHPI
310
PNQGQSNKKG FGNF
Length:314
Mass (Da):34,128
Last modified:August 1, 1988 - v1
Checksum:i405B311B423F9391
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12349 Genomic RNA. No translation available.
PIRiB25839. PRLJMP.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12349 Genomic RNA. No translation available.
PIRiB25839. PRLJMP.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NSONMR-A163-267[»]
2D4LX-ray1.70A11-162[»]
2D4MX-ray1.85A11-162[»]
2D4NX-ray1.53A11-162[»]
3SQFX-ray1.63A/B163-276[»]
3TP1X-ray1.60A11-162[»]
3TPWX-ray1.65A11-162[»]
ProteinModelPortaliP07570.
SMRiP07570.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiA02.009.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi3.4.23.B6. 3195.

Miscellaneous databases

EvolutionaryTraceiP07570.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
Gene3Di2.40.70.10. 1 hit.
2.70.40.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR033704. dUTPase_trimeric.
IPR000467. G_patch_dom.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
PF01585. G-patch. 1 hit.
PF00077. RVP. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF51283. SSF51283. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50174. G_PATCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVPRT_MPMV
AccessioniPrimary (citable) accession number: P07570
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.