Cytochrome b-c1 complex subunit 10

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P07552 (QCR10_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 106. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome b-c1 complex subunit 10

Alternative name(s):
Complex III subunit 10
Complex III subunit XI
Ubiquinol-cytochrome c reductase complex 6.4 kDa protein

Gene names

Name:	UQCR11
Synonyms:	UQCR

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	56 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor.
Subunit structure	The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the UQCR11/QCR10 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro ubiquinol-cytochrome-c reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 56

Cytochrome b-c1 complex subunit 10

PRO_0000193559

Regions

Transmembrane

16 – 36

Helical; Potential

Experimental info

Sequence conflict

S → Q AA sequence Ref.1

Sequence conflict

W → S AA sequence Ref.1

Sequence conflict

W → S AA sequence Ref.1

Secondary structure

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P07552 [UniParc].

Last modified December 15, 1998. Version 2.
Checksum: A412EA7EB58F45FE
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FASTA

6,520

        10         20         30         40         50 
MLTRFLGPRY RQLARNWVPT ASLWGAVGAV GLVWATDWRL ILDWVPYING KFKKDD

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and amino acid sequence of the smallest subunit of beef heart bc1 complex." Schaegger H., Borchart U., Aquila H., Link T.A., von Jagow G. FEBS Lett. 190:89-94(1985) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Heart.
[2]	"Primary structure of the smallest (6.4-kDa) subunit of human and bovine ubiquinol-cytochrome c reductase deduced from cDNA sequences." Islam M.M., Suzuki H., Yoneda M., Tanaka M. Biochem. Mol. Biol. Int. 41:1109-1116(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart muscle.
[3]	NIH - Mammalian Gene Collection (MGC) project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus and Hereford. Tissue: Fetal pons and Ileum.
[4]	"Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria." Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J. Science 277:60-66(1997) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
[5]	Erratum Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J. Science 278:2037-2037(1997)
[6]	"Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex." Iwata S., Lee J.W., Okada K., Lee J.K., Iwata M., Rasmussen B., Link T.A., Ramaswamy S., Jap B.K. Science 281:64-71(1998) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
[7]	"The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition." Gao X., Wen X., Yu C., Esser L., Tsao S., Quinn B., Zhang L., Yu L., Xia D. Biochemistry 41:11692-11702(2002) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
[8]	"Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex." Esser L., Quinn B., Li Y.F., Zhang M., Elberry M., Yu L., Yu C.A., Xia D. J. Mol. Biol. 341:281-302(2004) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS).
[9]	"Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex." Esser L., Gong X., Yang S., Yu L., Yu C.A., Xia D. Proc. Natl. Acad. Sci. U.S.A. 103:13045-13050(2006) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D55637 mRNA. Translation: BAA21747.1.
BC102080 mRNA. Translation: AAI02081.1.
BC126774 mRNA. Translation: AAI26775.1.

IPI

IPI00716677.

PIR

CBBOC6. A24096.

RefSeq

NP_776640.1. NM_174215.2.

UniGene

Bt.5040.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1BE3	X-ray	3.00	K	1-56	[»]
1BGY	X-ray	3.00	K/W	1-56	[»]
1L0L	X-ray	2.35	K	1-56	[»]
1L0N	X-ray	2.60	K	1-56	[»]
1NTK	X-ray	2.60	K	1-56	[»]
1NTM	X-ray	2.40	K	1-56	[»]
1NTZ	X-ray	2.60	K	1-56	[»]
1NU1	X-ray	3.20	K	1-56	[»]
1QCR	X-ray	2.70	K	1-45	[»]
1SQB	X-ray	2.69	K	1-56	[»]
1SQP	X-ray	2.70	K	1-56	[»]
1SQQ	X-ray	3.00	K	1-56	[»]
1SQV	X-ray	2.85	K	1-56	[»]
1SQX	X-ray	2.60	K	1-56	[»]
2FYU	X-ray	2.26	K	1-56	[»]
2YBB	electron microscopy	19.00	K/k	1-56	[»]

ProteinModelPortal

P07552.

SMR

P07552. Positions 1-54.

ModBase

Search...

Protein-protein interaction databases

STRING

9913.ENSBTAP00000011458.

Proteomic databases

PRIDE

P07552.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSBTAT00000011458; ENSBTAP00000011458; ENSBTAG00000008692.

GeneID

281570.

KEGG

bta:281570.

Organism-specific databases

CTD

10975.

Phylogenomic databases

eggNOG

NOG70565.

GeneTree

ENSGT00390000018299.

HOGENOM

HOG000030914.

HOVERGEN

HBG105467.

InParanoid

P07552.

K00420.

OMA

GMWGAVG.

OrthoDB

EOG4J119V.

Enzyme and pathway databases

BioCyc

CATTLE:281570-MONOMER.

Family and domain databases

InterPro

IPR015089. Ubiquinol_cytC_Rdtase_cplx_6.4.
[Graphical view]

PANTHER

PTHR15420. PTHR15420. 1 hit.

Pfam

PF08997. UCR_6-4kD. 1 hit.
[Graphical view]

SUPFAM

SSF81518. Ub-CytCRdtase_cplx_6.4kD. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P07552.

NextBio

20805520.

Entry information

Entry name

QCR10_BOVIN

Accession

Primary (citable) accession number: P07552
Secondary accession number(s): A1A4P1, O18996, Q3T176

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	December 15, 1998
Last modified:	May 29, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Other

Entry information

Relevant documents