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P07552

- QCR10_BOVIN

UniProt

P07552 - QCR10_BOVIN

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Protein

Cytochrome b-c1 complex subunit 10

Gene

UQCR11

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain.
This protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor.

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. ubiquinol-cytochrome-c reductase activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiREACT_223064. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 10
Alternative name(s):
Complex III subunit 10
Complex III subunit XI
Ubiquinol-cytochrome c reductase complex 6.4 kDa protein
Gene namesi
Name:UQCR11
Synonyms:UQCR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5656Cytochrome b-c1 complex subunit 10PRO_0000193559Add
BLAST

Proteomic databases

PRIDEiP07552.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011458.

Structurei

Secondary structure

1
56
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 54Combined sources
Helixi8 – 3629Combined sources
Helixi39 – 424Combined sources
Beta strandi44 – 474Combined sources
Helixi48 – 514Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BE3X-ray3.00K1-56[»]
1BGYX-ray3.00K/W1-56[»]
1L0LX-ray2.35K1-56[»]
1L0NX-ray2.60K1-56[»]
1NTKX-ray2.60K1-56[»]
1NTMX-ray2.40K1-56[»]
1NTZX-ray2.60K1-56[»]
1NU1X-ray3.20K1-56[»]
1QCRX-ray2.70K1-45[»]
1SQBX-ray2.69K1-56[»]
1SQPX-ray2.70K1-56[»]
1SQQX-ray3.00K1-56[»]
1SQVX-ray2.85K1-56[»]
1SQXX-ray2.60K1-56[»]
2FYUX-ray2.26K1-56[»]
2YBBelectron microscopy19.00K/k1-56[»]
ProteinModelPortaliP07552.
SMRiP07552. Positions 1-54.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07552.

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCR11/QCR10 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG70565.
GeneTreeiENSGT00390000018299.
HOGENOMiHOG000030914.
HOVERGENiHBG105467.
InParanoidiP07552.
KOiK00420.
OMAiLAKNWMP.
OrthoDBiEOG7DFXG3.
TreeFamiTF105034.

Family and domain databases

Gene3Di1.20.5.220. 1 hit.
InterProiIPR029027. Single_a-helix.
IPR015089. UQCR.
[Graphical view]
PANTHERiPTHR15420. PTHR15420. 1 hit.
PfamiPF08997. UCR_6-4kD. 1 hit.
[Graphical view]
SUPFAMiSSF81518. SSF81518. 1 hit.

Sequencei

Sequence statusi: Complete.

P07552-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTRFLGPRY RQLARNWVPT ASLWGAVGAV GLVWATDWRL ILDWVPYING

KFKKDD
Length:56
Mass (Da):6,520
Last modified:December 15, 1998 - v2
Checksum:iA412EA7EB58F45FE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221S → Q AA sequence (PubMed:2995132)Curated
Sequence conflicti34 – 341W → S AA sequence (PubMed:2995132)Curated
Sequence conflicti38 – 381W → S AA sequence (PubMed:2995132)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D55637 mRNA. Translation: BAA21747.1.
BC102080 mRNA. Translation: AAI02081.1.
BC126774 mRNA. Translation: AAI26775.1.
PIRiA24096. CBBOC6.
RefSeqiNP_776640.1. NM_174215.2.
UniGeneiBt.5040.

Genome annotation databases

EnsembliENSBTAT00000011458; ENSBTAP00000011458; ENSBTAG00000008692.
GeneIDi281570.
KEGGibta:281570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D55637 mRNA. Translation: BAA21747.1 .
BC102080 mRNA. Translation: AAI02081.1 .
BC126774 mRNA. Translation: AAI26775.1 .
PIRi A24096. CBBOC6.
RefSeqi NP_776640.1. NM_174215.2.
UniGenei Bt.5040.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BE3 X-ray 3.00 K 1-56 [» ]
1BGY X-ray 3.00 K/W 1-56 [» ]
1L0L X-ray 2.35 K 1-56 [» ]
1L0N X-ray 2.60 K 1-56 [» ]
1NTK X-ray 2.60 K 1-56 [» ]
1NTM X-ray 2.40 K 1-56 [» ]
1NTZ X-ray 2.60 K 1-56 [» ]
1NU1 X-ray 3.20 K 1-56 [» ]
1QCR X-ray 2.70 K 1-45 [» ]
1SQB X-ray 2.69 K 1-56 [» ]
1SQP X-ray 2.70 K 1-56 [» ]
1SQQ X-ray 3.00 K 1-56 [» ]
1SQV X-ray 2.85 K 1-56 [» ]
1SQX X-ray 2.60 K 1-56 [» ]
2FYU X-ray 2.26 K 1-56 [» ]
2YBB electron microscopy 19.00 K/k 1-56 [» ]
ProteinModelPortali P07552.
SMRi P07552. Positions 1-54.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000011458.

Proteomic databases

PRIDEi P07552.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000011458 ; ENSBTAP00000011458 ; ENSBTAG00000008692 .
GeneIDi 281570.
KEGGi bta:281570.

Organism-specific databases

CTDi 10975.

Phylogenomic databases

eggNOGi NOG70565.
GeneTreei ENSGT00390000018299.
HOGENOMi HOG000030914.
HOVERGENi HBG105467.
InParanoidi P07552.
KOi K00420.
OMAi LAKNWMP.
OrthoDBi EOG7DFXG3.
TreeFami TF105034.

Enzyme and pathway databases

Reactomei REACT_223064. Respiratory electron transport.

Miscellaneous databases

EvolutionaryTracei P07552.
NextBioi 20805520.

Family and domain databases

Gene3Di 1.20.5.220. 1 hit.
InterProi IPR029027. Single_a-helix.
IPR015089. UQCR.
[Graphical view ]
PANTHERi PTHR15420. PTHR15420. 1 hit.
Pfami PF08997. UCR_6-4kD. 1 hit.
[Graphical view ]
SUPFAMi SSF81518. SSF81518. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and amino acid sequence of the smallest subunit of beef heart bc1 complex."
    Schaegger H., Borchart U., Aquila H., Link T.A., von Jagow G.
    FEBS Lett. 190:89-94(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Heart.
  2. "Primary structure of the smallest (6.4-kDa) subunit of human and bovine ubiquinol-cytochrome c reductase deduced from cDNA sequences."
    Islam M.M., Suzuki H., Yoneda M., Tanaka M.
    Biochem. Mol. Biol. Int. 41:1109-1116(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart muscle.
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus and Hereford.
    Tissue: Fetal pons and Ileum.
  4. "Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria."
    Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
    Science 277:60-66(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
  5. Erratum
    Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
    Science 278:2037-2037(1997)
  6. "Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex."
    Iwata S., Lee J.W., Okada K., Lee J.K., Iwata M., Rasmussen B., Link T.A., Ramaswamy S., Jap B.K.
    Science 281:64-71(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
  7. "The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition."
    Gao X., Wen X., Yu C., Esser L., Tsao S., Quinn B., Zhang L., Yu L., Xia D.
    Biochemistry 41:11692-11702(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
  8. "Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex."
    Esser L., Quinn B., Li Y.F., Zhang M., Elberry M., Yu L., Yu C.A., Xia D.
    J. Mol. Biol. 341:281-302(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS).
  9. "Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex."
    Esser L., Gong X., Yang S., Yu L., Yu C.A., Xia D.
    Proc. Natl. Acad. Sci. U.S.A. 103:13045-13050(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS).

Entry informationi

Entry nameiQCR10_BOVIN
AccessioniPrimary (citable) accession number: P07552
Secondary accession number(s): A1A4P1, O18996, Q3T176
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 15, 1998
Last modified: November 26, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3