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P07552 (QCR10_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome b-c1 complex subunit 10
Alternative name(s):
Complex III subunit 10
Complex III subunit XI
Ubiquinol-cytochrome c reductase complex 6.4 kDa protein
Gene names
Name:UQCR11
Synonyms:UQCR
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length56 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain.

This protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor.

Subunit structure

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the UQCR11/QCR10 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5656Cytochrome b-c1 complex subunit 10
PRO_0000193559

Regions

Transmembrane16 – 3621Helical; Potential

Experimental info

Sequence conflict221S → Q AA sequence Ref.1
Sequence conflict341W → S AA sequence Ref.1
Sequence conflict381W → S AA sequence Ref.1

Secondary structure

.......... 56
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P07552 [UniParc].

Last modified December 15, 1998. Version 2.
Checksum: A412EA7EB58F45FE

FASTA566,520
        10         20         30         40         50 
MLTRFLGPRY RQLARNWVPT ASLWGAVGAV GLVWATDWRL ILDWVPYING KFKKDD 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and amino acid sequence of the smallest subunit of beef heart bc1 complex."
Schaegger H., Borchart U., Aquila H., Link T.A., von Jagow G.
FEBS Lett. 190:89-94(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Heart.
[2]"Primary structure of the smallest (6.4-kDa) subunit of human and bovine ubiquinol-cytochrome c reductase deduced from cDNA sequences."
Islam M.M., Suzuki H., Yoneda M., Tanaka M.
Biochem. Mol. Biol. Int. 41:1109-1116(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart muscle.
[3]NIH - Mammalian Gene Collection (MGC) project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus and Hereford.
Tissue: Fetal pons and Ileum.
[4]"Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria."
Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
Science 277:60-66(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
[5]Erratum
Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
Science 278:2037-2037(1997)
[6]"Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex."
Iwata S., Lee J.W., Okada K., Lee J.K., Iwata M., Rasmussen B., Link T.A., Ramaswamy S., Jap B.K.
Science 281:64-71(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
[7]"The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition."
Gao X., Wen X., Yu C., Esser L., Tsao S., Quinn B., Zhang L., Yu L., Xia D.
Biochemistry 41:11692-11702(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
[8]"Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex."
Esser L., Quinn B., Li Y.F., Zhang M., Elberry M., Yu L., Yu C.A., Xia D.
J. Mol. Biol. 341:281-302(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS).
[9]"Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex."
Esser L., Gong X., Yang S., Yu L., Yu C.A., Xia D.
Proc. Natl. Acad. Sci. U.S.A. 103:13045-13050(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D55637 mRNA. Translation: BAA21747.1.
BC102080 mRNA. Translation: AAI02081.1.
BC126774 mRNA. Translation: AAI26775.1.
PIRCBBOC6. A24096.
RefSeqNP_776640.1. NM_174215.2.
UniGeneBt.5040.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1BE3X-ray3.00K1-56[»]
1BGYX-ray3.00K/W1-56[»]
1L0LX-ray2.35K1-56[»]
1L0NX-ray2.60K1-56[»]
1NTKX-ray2.60K1-56[»]
1NTMX-ray2.40K1-56[»]
1NTZX-ray2.60K1-56[»]
1NU1X-ray3.20K1-56[»]
1QCRX-ray2.70K1-45[»]
1SQBX-ray2.69K1-56[»]
1SQPX-ray2.70K1-56[»]
1SQQX-ray3.00K1-56[»]
1SQVX-ray2.85K1-56[»]
1SQXX-ray2.60K1-56[»]
2FYUX-ray2.26K1-56[»]
2YBBelectron microscopy19.00K/k1-56[»]
ProteinModelPortalP07552.
SMRP07552. Positions 1-54.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000011458.

Proteomic databases

PRIDEP07552.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000011458; ENSBTAP00000011458; ENSBTAG00000008692.
GeneID281570.
KEGGbta:281570.

Organism-specific databases

CTD10975.

Phylogenomic databases

eggNOGNOG70565.
GeneTreeENSGT00390000018299.
HOGENOMHOG000030914.
HOVERGENHBG105467.
InParanoidP07552.
KOK00420.
OMAGMWGAVG.
OrthoDBEOG7DFXG3.
TreeFamTF105034.

Family and domain databases

InterProIPR015089. UQCR.
[Graphical view]
PANTHERPTHR15420. PTHR15420. 1 hit.
PfamPF08997. UCR_6-4kD. 1 hit.
[Graphical view]
SUPFAMSSF81518. SSF81518. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP07552.
NextBio20805520.

Entry information

Entry nameQCR10_BOVIN
AccessionPrimary (citable) accession number: P07552
Secondary accession number(s): A1A4P1, O18996, Q3T176
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 15, 1998
Last modified: April 16, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references