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P07552

- QCR10_BOVIN

UniProt

P07552 - QCR10_BOVIN

Protein

Cytochrome b-c1 complex subunit 10

Gene

UQCR11

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain.
    This protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor.

    GO - Molecular functioni

    1. electron carrier activity Source: InterPro
    2. ubiquinol-cytochrome-c reductase activity Source: InterPro

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome b-c1 complex subunit 10
    Alternative name(s):
    Complex III subunit 10
    Complex III subunit XI
    Ubiquinol-cytochrome c reductase complex 6.4 kDa protein
    Gene namesi
    Name:UQCR11
    Synonyms:UQCR
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 7

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5656Cytochrome b-c1 complex subunit 10PRO_0000193559Add
    BLAST

    Proteomic databases

    PRIDEiP07552.

    Interactioni

    Subunit structurei

    The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000011458.

    Structurei

    Secondary structure

    1
    56
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2 – 54
    Helixi8 – 3629
    Helixi39 – 424
    Beta strandi44 – 474
    Helixi48 – 514

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BE3X-ray3.00K1-56[»]
    1BGYX-ray3.00K/W1-56[»]
    1L0LX-ray2.35K1-56[»]
    1L0NX-ray2.60K1-56[»]
    1NTKX-ray2.60K1-56[»]
    1NTMX-ray2.40K1-56[»]
    1NTZX-ray2.60K1-56[»]
    1NU1X-ray3.20K1-56[»]
    1QCRX-ray2.70K1-45[»]
    1SQBX-ray2.69K1-56[»]
    1SQPX-ray2.70K1-56[»]
    1SQQX-ray3.00K1-56[»]
    1SQVX-ray2.85K1-56[»]
    1SQXX-ray2.60K1-56[»]
    2FYUX-ray2.26K1-56[»]
    2YBBelectron microscopy19.00K/k1-56[»]
    ProteinModelPortaliP07552.
    SMRiP07552. Positions 1-54.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP07552.

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UQCR11/QCR10 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG70565.
    GeneTreeiENSGT00390000018299.
    HOGENOMiHOG000030914.
    HOVERGENiHBG105467.
    InParanoidiP07552.
    KOiK00420.
    OMAiLAKNWMP.
    OrthoDBiEOG7DFXG3.
    TreeFamiTF105034.

    Family and domain databases

    Gene3Di1.20.5.220. 1 hit.
    InterProiIPR029027. Single_a-helix.
    IPR015089. UQCR.
    [Graphical view]
    PANTHERiPTHR15420. PTHR15420. 1 hit.
    PfamiPF08997. UCR_6-4kD. 1 hit.
    [Graphical view]
    SUPFAMiSSF81518. SSF81518. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P07552-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTRFLGPRY RQLARNWVPT ASLWGAVGAV GLVWATDWRL ILDWVPYING   50
    KFKKDD 56
    Length:56
    Mass (Da):6,520
    Last modified:December 15, 1998 - v2
    Checksum:iA412EA7EB58F45FE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 221S → Q AA sequence (PubMed:2995132)Curated
    Sequence conflicti34 – 341W → S AA sequence (PubMed:2995132)Curated
    Sequence conflicti38 – 381W → S AA sequence (PubMed:2995132)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D55637 mRNA. Translation: BAA21747.1.
    BC102080 mRNA. Translation: AAI02081.1.
    BC126774 mRNA. Translation: AAI26775.1.
    PIRiA24096. CBBOC6.
    RefSeqiNP_776640.1. NM_174215.2.
    UniGeneiBt.5040.

    Genome annotation databases

    EnsembliENSBTAT00000011458; ENSBTAP00000011458; ENSBTAG00000008692.
    GeneIDi281570.
    KEGGibta:281570.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D55637 mRNA. Translation: BAA21747.1 .
    BC102080 mRNA. Translation: AAI02081.1 .
    BC126774 mRNA. Translation: AAI26775.1 .
    PIRi A24096. CBBOC6.
    RefSeqi NP_776640.1. NM_174215.2.
    UniGenei Bt.5040.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BE3 X-ray 3.00 K 1-56 [» ]
    1BGY X-ray 3.00 K/W 1-56 [» ]
    1L0L X-ray 2.35 K 1-56 [» ]
    1L0N X-ray 2.60 K 1-56 [» ]
    1NTK X-ray 2.60 K 1-56 [» ]
    1NTM X-ray 2.40 K 1-56 [» ]
    1NTZ X-ray 2.60 K 1-56 [» ]
    1NU1 X-ray 3.20 K 1-56 [» ]
    1QCR X-ray 2.70 K 1-45 [» ]
    1SQB X-ray 2.69 K 1-56 [» ]
    1SQP X-ray 2.70 K 1-56 [» ]
    1SQQ X-ray 3.00 K 1-56 [» ]
    1SQV X-ray 2.85 K 1-56 [» ]
    1SQX X-ray 2.60 K 1-56 [» ]
    2FYU X-ray 2.26 K 1-56 [» ]
    2YBB electron microscopy 19.00 K/k 1-56 [» ]
    ProteinModelPortali P07552.
    SMRi P07552. Positions 1-54.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000011458.

    Proteomic databases

    PRIDEi P07552.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000011458 ; ENSBTAP00000011458 ; ENSBTAG00000008692 .
    GeneIDi 281570.
    KEGGi bta:281570.

    Organism-specific databases

    CTDi 10975.

    Phylogenomic databases

    eggNOGi NOG70565.
    GeneTreei ENSGT00390000018299.
    HOGENOMi HOG000030914.
    HOVERGENi HBG105467.
    InParanoidi P07552.
    KOi K00420.
    OMAi LAKNWMP.
    OrthoDBi EOG7DFXG3.
    TreeFami TF105034.

    Miscellaneous databases

    EvolutionaryTracei P07552.
    NextBioi 20805520.

    Family and domain databases

    Gene3Di 1.20.5.220. 1 hit.
    InterProi IPR029027. Single_a-helix.
    IPR015089. UQCR.
    [Graphical view ]
    PANTHERi PTHR15420. PTHR15420. 1 hit.
    Pfami PF08997. UCR_6-4kD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81518. SSF81518. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and amino acid sequence of the smallest subunit of beef heart bc1 complex."
      Schaegger H., Borchart U., Aquila H., Link T.A., von Jagow G.
      FEBS Lett. 190:89-94(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Heart.
    2. "Primary structure of the smallest (6.4-kDa) subunit of human and bovine ubiquinol-cytochrome c reductase deduced from cDNA sequences."
      Islam M.M., Suzuki H., Yoneda M., Tanaka M.
      Biochem. Mol. Biol. Int. 41:1109-1116(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart muscle.
    3. NIH - Mammalian Gene Collection (MGC) project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus and Hereford.
      Tissue: Fetal pons and Ileum.
    4. "Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria."
      Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
      Science 277:60-66(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
    5. Erratum
      Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
      Science 278:2037-2037(1997)
    6. "Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex."
      Iwata S., Lee J.W., Okada K., Lee J.K., Iwata M., Rasmussen B., Link T.A., Ramaswamy S., Jap B.K.
      Science 281:64-71(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
    7. "The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition."
      Gao X., Wen X., Yu C., Esser L., Tsao S., Quinn B., Zhang L., Yu L., Xia D.
      Biochemistry 41:11692-11702(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
    8. "Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex."
      Esser L., Quinn B., Li Y.F., Zhang M., Elberry M., Yu L., Yu C.A., Xia D.
      J. Mol. Biol. 341:281-302(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS).
    9. "Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex."
      Esser L., Gong X., Yang S., Yu L., Yu C.A., Xia D.
      Proc. Natl. Acad. Sci. U.S.A. 103:13045-13050(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS).

    Entry informationi

    Entry nameiQCR10_BOVIN
    AccessioniPrimary (citable) accession number: P07552
    Secondary accession number(s): A1A4P1, O18996, Q3T176
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: December 15, 1998
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3