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Protein

Homeotic protein deformed

Gene

Dfd

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Homeotic protein controlling Drosophila head development. Transcriptional activator of the apoptotic activator protein rpr in cells at the maxillary/mandibular boundary.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi366 – 425HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • activating transcription factor binding Source: FlyBase
  • enhancer sequence-specific DNA binding Source: FlyBase
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: FlyBase
  • sequence-specific DNA binding Source: FlyBase
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: FlyBase
  • transcription factor activity, sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • embryonic brain development Source: FlyBase
  • head development Source: FlyBase
  • head morphogenesis Source: FlyBase
  • negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • positive regulation of apoptotic process involved in morphogenesis Source: FlyBase
  • positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • posterior head segmentation Source: FlyBase
  • regulation of gene expression Source: FlyBase
  • specification of segmental identity, head Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeotic protein deformed
Gene namesi
Name:Dfd
ORF Names:CG2189
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0000439. Dfd.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002611 – 586Homeotic protein deformedAdd BLAST586

Proteomic databases

PaxDbiP07548.
PRIDEiP07548.

Expressioni

Tissue specificityi

Expressed in the mandibular and maxillary segments of the head, with some expression in the posterior intercalary segment which become part of the CNS. In the imaginal tissues, expressed in part of the eye antennal disk which give rise to portions of the head capsule and to a small patch of expression in the basal-most portion of the labial disk.1 Publication

Gene expression databases

BgeeiFBgn0000439.
ExpressionAtlasiP07548. differential.
GenevisibleiP07548. DM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
exdP404272EBI-458925,EBI-101537

GO - Molecular functioni

  • activating transcription factor binding Source: FlyBase

Protein-protein interaction databases

BioGridi66030. 39 interactors.
DIPiDIP-18055N.
IntActiP07548. 23 interactors.
MINTiMINT-858733.
STRINGi7227.FBpp0081138.

Structurei

3D structure databases

ProteinModelPortaliP07548.
SMRiP07548.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi343 – 348Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi50 – 75Gly-richAdd BLAST26
Compositional biasi76 – 158His-richAdd BLAST83
Compositional biasi188 – 226Gly-richAdd BLAST39
Compositional biasi290 – 331Asp-richAdd BLAST42
Compositional biasi460 – 476Gln-richAdd BLAST17
Compositional biasi524 – 551Asn-richAdd BLAST28

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
HOGENOMiHOG000290519.
InParanoidiP07548.
KOiK09304.
OMAiGMTGHPH.
OrthoDBiEOG091G09XD.
PhylomeDBiP07548.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P07548-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSFLMGYPH APHHVQSPMS MGNGLDPKFP PLADDYHHYN GHYSMTASTG
60 70 80 90 100
HMSGAVGGGA GVGSVGGGGA GGMTGHPHSM HPADMVSDYM AHHHNPHSHS
110 120 130 140 150
HSHTHSLPHH HSNSAISGHH QASAGGYSSN YANATPPSHP HSHPHAHPHQ
160 170 180 190 200
SLGYYVHHAP EFISAGAVHS DPTNGYGPAA NVPNTSNGGG GGGSGAVLGG
210 220 230 240 250
GAVGGSANGY YGGYGGGYGT ANGSVGSTHS QGHSPHSQMM DLPLQCSSTE
260 270 280 290 300
PPTNTALGLQ ELGLKLEKRI EEAVPAGQQL QELGMRLRCD DMGSENDDMS
310 320 330 340 350
EEDRLMLDRS PDELGSNDND DDLGDSDSDE DLMAETTDGE RIIYPWMKKI
360 370 380 390 400
HVAGVANGSY QPGMEPKRQR TAYTRHQILE LEKEFHYNRY LTRRRRIEIA
410 420 430 440 450
HTLVLSERQI KIWFQNRRMK WKKDNKLPNT KNVRKKTVDA NGNPTPVAKK
460 470 480 490 500
PTKRAASKKQ QQAQQQQQSQ QQQTQQTPVM NECIRSDSLE SIGDVSSSLG
510 520 530 540 550
NPPYIPAAPE TTSSYPGSQQ HLSNNNNNGS GNNNNNNNNN NSNLNNNNNN
560 570 580
NQMGHTNLHG HLQQQQSDLM TNLQLHIKQD YDLTAL
Length:586
Mass (Da):63,380
Last modified:June 21, 2005 - v2
Checksum:i9A7C79C744FAFF18
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32L → V in CAA28782 (PubMed:16453752).Curated1
Sequence conflicti227S → I in AAA28375 (PubMed:3938363).Curated1
Sequence conflicti442G → A (PubMed:2416463).Curated1
Sequence conflicti443N → K in AAA28375 (PubMed:3938363).Curated1
Sequence conflicti456Missing (PubMed:2416463).Curated1
Sequence conflicti477T → TQQT (PubMed:16453752).Curated1
Sequence conflicti477T → TQQT (PubMed:3938363).Curated1
Sequence conflicti541N → NN in CAA28782 (PubMed:16453752).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05136 Genomic DNA. Translation: CAA28782.1.
AE001572 Genomic DNA. Translation: AAD19796.1.
AE014297 Genomic DNA. Translation: AAF54083.2.
M13373 mRNA. Translation: AAA28375.1.
PIRiA26638.
RefSeqiNP_477201.1. NM_057853.3.

Genome annotation databases

EnsemblMetazoaiFBtr0081621; FBpp0081138; FBgn0000439.
GeneIDi40832.
KEGGidme:Dmel_CG2189.
UCSCiCG2189-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiDFD_DROME
AccessioniPrimary (citable) accession number: P07548
Secondary accession number(s): Q9UAL9, Q9VI48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: June 21, 2005
Last modified: September 27, 2017
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families