Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeotic protein deformed

Gene

Dfd

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Homeotic protein controlling Drosophila head development. Transcriptional activator of the apoptotic activator protein rpr in cells at the maxillary/mandibular boundary.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi366 – 42560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • activating transcription factor binding Source: FlyBase
  • enhancer sequence-specific DNA binding Source: FlyBase
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: FlyBase
  • sequence-specific DNA binding Source: FlyBase
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: FlyBase
  • transcription factor activity, sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • embryonic brain development Source: FlyBase
  • head development Source: FlyBase
  • head morphogenesis Source: FlyBase
  • negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • positive regulation of apoptotic process involved in morphogenesis Source: FlyBase
  • positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • posterior head segmentation Source: FlyBase
  • regulation of gene expression Source: FlyBase
  • specification of segmental identity, head Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeotic protein deformed
Gene namesi
Name:Dfd
ORF Names:CG2189
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0000439. Dfd.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 586586Homeotic protein deformedPRO_0000200261Add
BLAST

Proteomic databases

PaxDbiP07548.

Expressioni

Tissue specificityi

Expressed in the mandibular and maxillary segments of the head, with some expression in the posterior intercalary segment which become part of the CNS. In the imaginal tissues, expressed in part of the eye antennal disk which give rise to portions of the head capsule and to a small patch of expression in the basal-most portion of the labial disk.1 Publication

Gene expression databases

BgeeiP07548.
GenevisibleiP07548. DM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
exdP404272EBI-458925,EBI-101537

GO - Molecular functioni

  • activating transcription factor binding Source: FlyBase

Protein-protein interaction databases

BioGridi66030. 47 interactions.
DIPiDIP-18055N.
IntActiP07548. 20 interactions.
MINTiMINT-858733.
STRINGi7227.FBpp0081138.

Structurei

3D structure databases

ProteinModelPortaliP07548.
SMRiP07548. Positions 373-426.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi343 – 3486Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi50 – 7526Gly-richAdd
BLAST
Compositional biasi76 – 15883His-richAdd
BLAST
Compositional biasi188 – 22639Gly-richAdd
BLAST
Compositional biasi290 – 33142Asp-richAdd
BLAST
Compositional biasi460 – 47617Gln-richAdd
BLAST
Compositional biasi524 – 55128Asn-richAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000290519.
InParanoidiP07548.
KOiK09304.
OMAiHHSNSAI.
OrthoDBiEOG780RP4.
PhylomeDBiP07548.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07548-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSFLMGYPH APHHVQSPMS MGNGLDPKFP PLADDYHHYN GHYSMTASTG
60 70 80 90 100
HMSGAVGGGA GVGSVGGGGA GGMTGHPHSM HPADMVSDYM AHHHNPHSHS
110 120 130 140 150
HSHTHSLPHH HSNSAISGHH QASAGGYSSN YANATPPSHP HSHPHAHPHQ
160 170 180 190 200
SLGYYVHHAP EFISAGAVHS DPTNGYGPAA NVPNTSNGGG GGGSGAVLGG
210 220 230 240 250
GAVGGSANGY YGGYGGGYGT ANGSVGSTHS QGHSPHSQMM DLPLQCSSTE
260 270 280 290 300
PPTNTALGLQ ELGLKLEKRI EEAVPAGQQL QELGMRLRCD DMGSENDDMS
310 320 330 340 350
EEDRLMLDRS PDELGSNDND DDLGDSDSDE DLMAETTDGE RIIYPWMKKI
360 370 380 390 400
HVAGVANGSY QPGMEPKRQR TAYTRHQILE LEKEFHYNRY LTRRRRIEIA
410 420 430 440 450
HTLVLSERQI KIWFQNRRMK WKKDNKLPNT KNVRKKTVDA NGNPTPVAKK
460 470 480 490 500
PTKRAASKKQ QQAQQQQQSQ QQQTQQTPVM NECIRSDSLE SIGDVSSSLG
510 520 530 540 550
NPPYIPAAPE TTSSYPGSQQ HLSNNNNNGS GNNNNNNNNN NSNLNNNNNN
560 570 580
NQMGHTNLHG HLQQQQSDLM TNLQLHIKQD YDLTAL
Length:586
Mass (Da):63,380
Last modified:June 21, 2005 - v2
Checksum:i9A7C79C744FAFF18
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321L → V in CAA28782 (PubMed:16453752).Curated
Sequence conflicti227 – 2271S → I in AAA28375 (PubMed:3938363).Curated
Sequence conflicti442 – 4421G → A (PubMed:2416463).Curated
Sequence conflicti443 – 4431N → K in AAA28375 (PubMed:3938363).Curated
Sequence conflicti456 – 4561Missing (PubMed:2416463).Curated
Sequence conflicti477 – 4771T → TQQT (PubMed:16453752).Curated
Sequence conflicti477 – 4771T → TQQT (PubMed:3938363).Curated
Sequence conflicti541 – 5411N → NN in CAA28782 (PubMed:16453752).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05136 Genomic DNA. Translation: CAA28782.1.
AE001572 Genomic DNA. Translation: AAD19796.1.
AE014297 Genomic DNA. Translation: AAF54083.2.
M13373 mRNA. Translation: AAA28375.1.
PIRiA26638.
RefSeqiNP_477201.1. NM_057853.3.

Genome annotation databases

EnsemblMetazoaiFBtr0081621; FBpp0081138; FBgn0000439.
GeneIDi40832.
KEGGidme:Dmel_CG2189.
UCSCiCG2189-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05136 Genomic DNA. Translation: CAA28782.1.
AE001572 Genomic DNA. Translation: AAD19796.1.
AE014297 Genomic DNA. Translation: AAF54083.2.
M13373 mRNA. Translation: AAA28375.1.
PIRiA26638.
RefSeqiNP_477201.1. NM_057853.3.

3D structure databases

ProteinModelPortaliP07548.
SMRiP07548. Positions 373-426.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi66030. 47 interactions.
DIPiDIP-18055N.
IntActiP07548. 20 interactions.
MINTiMINT-858733.
STRINGi7227.FBpp0081138.

Proteomic databases

PaxDbiP07548.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0081621; FBpp0081138; FBgn0000439.
GeneIDi40832.
KEGGidme:Dmel_CG2189.
UCSCiCG2189-RA. d. melanogaster.

Organism-specific databases

CTDi40832.
FlyBaseiFBgn0000439. Dfd.

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000290519.
InParanoidiP07548.
KOiK09304.
OMAiHHSNSAI.
OrthoDBiEOG780RP4.
PhylomeDBiP07548.

Miscellaneous databases

GenomeRNAii40832.
NextBioi820832.
PROiP07548.

Gene expression databases

BgeeiP07548.
GenevisibleiP07548. DM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Developmental and molecular analysis of Deformed: a homeotic gene controlling Drosophila head development."
    Regulski M., McGinnis N., Chadwick R., McGinnis W.
    EMBO J. 6:767-777(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. "Complete sequence of the Antennapedia complex of Drosophila."
    Celniker S.E., Pfeiffer B.D., Knafels J., Martin C.H., Mayeda C.A., Palazzolo M.J.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Berkeley.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. "Common properties of proteins encoded by the Antennapedia complex genes of Drosophila melanogaster."
    Laughon A., Carroll S.B., Storfer F.A., Riley P.D., Scott M.P.
    Cold Spring Harb. Symp. Quant. Biol. 50:253-262(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 163-586.
  6. "Homeo box genes of the Antennapedia and bithorax complexes of Drosophila."
    Regulski M., Harding K., Kostriken R., Karch F., Levine M., McGinnis W.
    Cell 43:71-80(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 366-482.
  7. "The Drosophila Hox gene deformed sculpts head morphology via direct regulation of the apoptosis activator reaper."
    Lohmann I., McGinnis N., Bodmer M., McGinnis W.
    Cell 110:457-466(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Hox genes and the evolution of the arthropod body plan."
    Hughes C.L., Kaufman T.C.
    Evol. Dev. 4:459-499(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiDFD_DROME
AccessioniPrimary (citable) accession number: P07548
Secondary accession number(s): Q9UAL9, Q9VI48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: June 21, 2005
Last modified: May 11, 2016
This is version 158 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.