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P07540

- LYS_BPPZA

UniProt

P07540 - LYS_BPPZA

Protein

Lysozyme

Gene

15

Organism
Bacillus phage PZA (Bacteriophage PZA)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Apr 1988)
      Previous versions | rss
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    • Comment

    Functioni

    Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei15 – 151Proton donorBy similarity

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro
    2. cytolysis Source: UniProtKB-KW
    3. defense response to bacterium Source: UniProtKB-KW
    4. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiCBM50. Carbohydrate-Binding Module Family 50.
    GH24. Glycoside Hydrolase Family 24.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme (EC:3.2.1.17)
    Alternative name(s):
    Endolysin
    Late protein gp15
    Lysis protein
    Muramidase
    Gene namesi
    Name:15
    OrganismiBacillus phage PZA (Bacteriophage PZA)
    Taxonomic identifieri10757 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaePicovirinaePhi29likevirus
    Virus hostiBacillus subtilis [TaxID: 1423]
    ProteomesiUP000000855: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 258258LysozymePRO_0000218106Add
    BLAST

    Expressioni

    Keywords - Developmental stagei

    Late protein

    Structurei

    3D structure databases

    ProteinModelPortaliP07540.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati163 – 20745LysM 1Add
    BLAST
    Repeati214 – 25845LysM 2Add
    BLAST

    Domaini

    LysM repeats are thought to be involved in peptidoglycan binding.

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 24 family.Curated
    Contains 2 LysM repeats.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    Gene3Di1.10.530.40. 1 hit.
    3.10.350.10. 2 hits.
    InterProiIPR002196. Glyco_hydro_24.
    IPR018392. LysM_dom.
    IPR023346. Lysozyme-like_dom.
    IPR023347. Lysozyme_dom.
    [Graphical view]
    PfamiPF01476. LysM. 2 hits.
    PF00959. Phage_lysozyme. 1 hit.
    [Graphical view]
    SMARTiSM00257. LysM. 2 hits.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.
    SSF54106. SSF54106. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    P07540-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQISQAGINL IKSFEGLQLK AYKAVPTEKH YTIGYGHYGS DVSPRQVITA    50
    KQAEDMLRDD VQAFVDGVNK ALKVSVTQNQ FDALVSFAYN VGLGAFRSSS 100
    LLEYLNEGRT ALAAAEFPRW NKSGGKVYQG LVNRRAQEQA LFNSGTPKNV 150
    SRGTSSSKVT PKYKVKSGDN LTKIAKKHNT TVATLLKLNP SIKDPNMIRV 200
    GQTINVTGSG GKTHKVKSGD TLSKIAVDNK TTVSRLMSLN PEITNPNHIK 250
    VGQTIRLS 258
    Length:258
    Mass (Da):28,052
    Last modified:April 1, 1988 - v1
    Checksum:i1A57FC5334637169
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11813 Genomic DNA. Translation: AAA88492.1.
    PIRiA26215. WMBP15.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11813 Genomic DNA. Translation: AAA88492.1 .
    PIRi A26215. WMBP15.

    3D structure databases

    ProteinModelPortali P07540.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi CBM50. Carbohydrate-Binding Module Family 50.
    GH24. Glycoside Hydrolase Family 24.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.530.40. 1 hit.
    3.10.350.10. 2 hits.
    InterProi IPR002196. Glyco_hydro_24.
    IPR018392. LysM_dom.
    IPR023346. Lysozyme-like_dom.
    IPR023347. Lysozyme_dom.
    [Graphical view ]
    Pfami PF01476. LysM. 2 hits.
    PF00959. Phage_lysozyme. 1 hit.
    [Graphical view ]
    SMARTi SM00257. LysM. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    SSF54106. SSF54106. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the late region of Bacillus subtilis phage PZA, a close relative of phi 29."
      Paces V., Vlcek C., Urbanek P.
      Gene 44:107-114(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiLYS_BPPZA
    AccessioniPrimary (citable) accession number: P07540
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3