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P07540

- LYS_BPPZA

UniProt

P07540 - LYS_BPPZA

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Protein

Lysozyme

Gene

15

Organism
Bacillus phage PZA (Bacteriophage PZA)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei15 – 151Proton donorBy similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiCBM50. Carbohydrate-Binding Module Family 50.
GH24. Glycoside Hydrolase Family 24.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme (EC:3.2.1.17)
Alternative name(s):
Endolysin
Late protein gp15
Lysis protein
Muramidase
Gene namesi
Name:15
OrganismiBacillus phage PZA (Bacteriophage PZA)
Taxonomic identifieri10757 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaePicovirinaePhi29likevirus
Virus hostiBacillus subtilis [TaxID: 1423]
ProteomesiUP000000855: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258LysozymePRO_0000218106Add
BLAST

Expressioni

Keywords - Developmental stagei

Late protein

Structurei

3D structure databases

ProteinModelPortaliP07540.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati163 – 20745LysM 1Add
BLAST
Repeati214 – 25845LysM 2Add
BLAST

Domaini

LysM repeats are thought to be involved in peptidoglycan binding.

Sequence similaritiesi

Belongs to the glycosyl hydrolase 24 family.Curated
Contains 2 LysM repeats.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.530.40. 1 hit.
3.10.350.10. 2 hits.
InterProiIPR002196. Glyco_hydro_24.
IPR018392. LysM_dom.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamiPF01476. LysM. 2 hits.
PF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SMARTiSM00257. LysM. 2 hits.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
SSF54106. SSF54106. 2 hits.

Sequencei

Sequence statusi: Complete.

P07540-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQISQAGINL IKSFEGLQLK AYKAVPTEKH YTIGYGHYGS DVSPRQVITA
60 70 80 90 100
KQAEDMLRDD VQAFVDGVNK ALKVSVTQNQ FDALVSFAYN VGLGAFRSSS
110 120 130 140 150
LLEYLNEGRT ALAAAEFPRW NKSGGKVYQG LVNRRAQEQA LFNSGTPKNV
160 170 180 190 200
SRGTSSSKVT PKYKVKSGDN LTKIAKKHNT TVATLLKLNP SIKDPNMIRV
210 220 230 240 250
GQTINVTGSG GKTHKVKSGD TLSKIAVDNK TTVSRLMSLN PEITNPNHIK

VGQTIRLS
Length:258
Mass (Da):28,052
Last modified:April 1, 1988 - v1
Checksum:i1A57FC5334637169
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11813 Genomic DNA. Translation: AAA88492.1.
PIRiA26215. WMBP15.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11813 Genomic DNA. Translation: AAA88492.1 .
PIRi A26215. WMBP15.

3D structure databases

ProteinModelPortali P07540.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi CBM50. Carbohydrate-Binding Module Family 50.
GH24. Glycoside Hydrolase Family 24.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.530.40. 1 hit.
3.10.350.10. 2 hits.
InterProi IPR002196. Glyco_hydro_24.
IPR018392. LysM_dom.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view ]
Pfami PF01476. LysM. 2 hits.
PF00959. Phage_lysozyme. 1 hit.
[Graphical view ]
SMARTi SM00257. LysM. 2 hits.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
SSF54106. SSF54106. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the late region of Bacillus subtilis phage PZA, a close relative of phi 29."
    Paces V., Vlcek C., Urbanek P.
    Gene 44:107-114(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiLYS_BPPZA
AccessioniPrimary (citable) accession number: P07540
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: October 1, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3