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Protein

Endo-1,4-beta-xylanase A

Gene

xynA

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

pH dependencei

Active over a very broad pH range.

Pathwayi: xylan degradation

This protein is involved in the pathway xylan degradation, which is part of Glycan degradation.
View all proteins of this organism that are known to be involved in the pathway xylan degradation and in Glycan degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei195Proton donorBy similarity1
Active sitei301NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Enzyme and pathway databases

BRENDAi3.2.1.8. 661.
UniPathwayiUPA00114.

Protein family/group databases

CAZyiGH10. Glycoside Hydrolase Family 10.

Names & Taxonomyi

Protein namesi
Recommended name:
Endo-1,4-beta-xylanase A (EC:3.2.1.8)
Short name:
Xylanase A
Alternative name(s):
1,4-beta-D-xylan xylanohydrolase A
Gene namesi
Name:xynA
Ordered Locus Names:BH2120
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 281 PublicationAdd BLAST28
ChainiPRO_000000796729 – 396Endo-1,4-beta-xylanase AAdd BLAST368

Interactioni

Protein-protein interaction databases

STRINGi272558.BH2120.

Structurei

Secondary structure

1396
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi51 – 53Combined sources3
Helixi57 – 60Combined sources4
Turni61 – 64Combined sources4
Beta strandi66 – 71Combined sources6
Helixi73 – 75Combined sources3
Helixi78 – 87Combined sources10
Beta strandi89 – 95Combined sources7
Helixi99 – 102Combined sources4
Helixi112 – 124Combined sources13
Beta strandi127 – 130Combined sources4
Beta strandi133 – 138Combined sources6
Helixi141 – 144Combined sources4
Helixi152 – 154Combined sources3
Helixi158 – 183Combined sources26
Turni184 – 186Combined sources3
Beta strandi188 – 195Combined sources8
Beta strandi201 – 203Combined sources3
Helixi207 – 212Combined sources6
Helixi215 – 228Combined sources14
Beta strandi234 – 239Combined sources6
Helixi244 – 259Combined sources16
Beta strandi266 – 269Combined sources4
Beta strandi272 – 276Combined sources5
Helixi280 – 291Combined sources12
Turni292 – 294Combined sources3
Beta strandi296 – 307Combined sources12
Helixi318 – 320Combined sources3
Helixi323 – 342Combined sources20
Helixi344 – 346Combined sources3
Beta strandi347 – 356Combined sources10
Helixi361 – 369Combined sources9
Turni370 – 372Combined sources3
Beta strandi379 – 381Combined sources3
Beta strandi385 – 387Combined sources3
Helixi389 – 395Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2UWFX-ray2.10A48-396[»]
ProteinModelPortaliP07528.
SMRiP07528.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07528.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 396GH10PROSITE-ProRule annotationAdd BLAST346

Sequence similaritiesi

Contains 1 GH10 (glycosyl hydrolase family 10) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105D9F. Bacteria.
COG3693. LUCA.
HOGENOMiHOG000019847.
KOiK01181.
OMAiDANSWIP.
OrthoDBiPOG091H0Y2G.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001000. GH10.
IPR031158. GH10_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00331. Glyco_hydro_10. 1 hit.
[Graphical view]
PRINTSiPR00134. GLHYDRLASE10.
SMARTiSM00633. Glyco_10. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00591. GH10_1. 1 hit.
PS51760. GH10_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07528-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITLFRKPFV AGLAISLLVG GGIGNVAAAQ GGPPKSGVFG ENEKRNDQPF
60 70 80 90 100
AWQVASLSER YQEQFDIGAA VEPYQLEGRQ AQILKHHYNS LVAENAMKPE
110 120 130 140 150
SLQPREGEWN WEGADKIVEF ARKHNMELRF HTLVWHSQVP EWFFIDEDGN
160 170 180 190 200
RMVDETDPDK REANKQLLLE RMENHIKTVV ERYKDDVTSW DVVNEVIDDG
210 220 230 240 250
GGLRESEWYQ ITGTDYIKVA FETARKYGGE EAKLYINDYN TEVPSKRDDL
260 270 280 290 300
YNLVKDLLEQ GVPIDGVGHQ SHIQIGWPSI EDTRASFEKF TSLGLDNQVT
310 320 330 340 350
ELDMSLYGWP PTGAYTSYDD IPAELLQAQA DRYDQLFELY EELAADISSV
360 370 380 390
TFWGIADNHT WLDGRAREYN NGVGIDAPFV FDHNYRVKPA YWRIID
Length:396
Mass (Da):45,294
Last modified:April 1, 1988 - v1
Checksum:i29C1F46BE00E180C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00087 Genomic DNA. Translation: BAA00055.1.
BA000004 Genomic DNA. Translation: BAB05839.1.
PIRiH83914.
JD0003.
RefSeqiWP_010898277.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB05839; BAB05839; BAB05839.
KEGGibha:BH2120.
PATRICi18941396. VBIBacHal18977_2211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00087 Genomic DNA. Translation: BAA00055.1.
BA000004 Genomic DNA. Translation: BAB05839.1.
PIRiH83914.
JD0003.
RefSeqiWP_010898277.1. NC_002570.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2UWFX-ray2.10A48-396[»]
ProteinModelPortaliP07528.
SMRiP07528.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272558.BH2120.

Protein family/group databases

CAZyiGH10. Glycoside Hydrolase Family 10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB05839; BAB05839; BAB05839.
KEGGibha:BH2120.
PATRICi18941396. VBIBacHal18977_2211.

Phylogenomic databases

eggNOGiENOG4105D9F. Bacteria.
COG3693. LUCA.
HOGENOMiHOG000019847.
KOiK01181.
OMAiDANSWIP.
OrthoDBiPOG091H0Y2G.

Enzyme and pathway databases

UniPathwayiUPA00114.
BRENDAi3.2.1.8. 661.

Miscellaneous databases

EvolutionaryTraceiP07528.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001000. GH10.
IPR031158. GH10_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00331. Glyco_hydro_10. 1 hit.
[Graphical view]
PRINTSiPR00134. GLHYDRLASE10.
SMARTiSM00633. Glyco_10. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00591. GH10_1. 1 hit.
PS51760. GH10_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXYNA_BACHD
AccessioniPrimary (citable) accession number: P07528
Secondary accession number(s): Q9JPV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.