ID   TYRO_STRAT              Reviewed;         273 AA.
AC   P07524;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   20-JAN-2009, entry version 51.
DE   RecName: Full=Tyrosinase;
DE            EC=1.14.18.1;
DE   AltName: Full=Monophenol monooxygenase;
GN   Name=melC2; Synonyms=mel;
OS   Streptomyces antibioticus.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1890;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=86031341; PubMed=3932128; DOI=10.1016/0378-1119(85)90262-8;
RA   Bernan V., Filpula D., Herber W., Bibb M.J., Katz E.;
RT   "The nucleotide sequence of the tyrosinase gene from Streptomyces
RT   antibioticus and characterization of the gene product.";
RL   Gene 37:101-110(1985).
CC   -!- FUNCTION: This is a copper-containing oxidase that functions in
CC       the formation of pigments such as melanins and other polyphenolic
CC       compounds.
CC   -!- CATALYTIC ACTIVITY: L-tyrosine + L-dopa + O(2) = L-dopa +
CC       dopaquinone + H(2)O.
CC   -!- COFACTOR: Binds 2 copper ions per subunit (By similarity).
CC   -!- SIMILARITY: Belongs to the tyrosinase family.
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DR   EMBL; M11582; AAA88571.1; -; Genomic_DNA.
DR   PIR; B23971; B23971.
DR   HSSP; O61363; 1JS8.
DR   SMR; P07524; 2-272.
DR   BRENDA; 1.14.18.1; 96840.
DR   GO; GO:0005507; F:copper ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004503; F:monophenol monooxygenase activity; IEA:EC.
DR   GO; GO:0006583; P:melanin biosynthetic process from tyrosine; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR008922; Di-copper_centre.
DR   InterPro; IPR002227; Tyrosinase.
DR   Gene3D; G3DSA:1.10.1280.10; Di-copper_centre; 1.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   PRINTS; PR00092; TYROSINASE.
DR   PROSITE; PS00497; TYROSINASE_1; 1.
DR   PROSITE; PS00498; TYROSINASE_2; 1.
PE   3: Inferred from homology;
KW   Copper; Melanin biosynthesis; Metal-binding; Monooxygenase;
KW   Oxidoreductase.
FT   INIT_MET      1      1       Removed.
FT   CHAIN         2    273       Tyrosinase.
FT                                /FTId=PRO_0000186737.
FT   METAL        38     38       Copper A (By similarity).
FT   METAL        54     54       Copper A (By similarity).
FT   METAL        63     63       Copper A (By similarity).
FT   METAL       190    190       Copper B (By similarity).
FT   METAL       194    194       Copper B (By similarity).
FT   METAL       216    216       Copper B (By similarity).
SQ   SEQUENCE   273 AA;  30739 MW;  FF22A3701AF975BA CRC64;
     MTVRKNQASL TAEEKRRFVA ALLELKRTGR YDAFVTTHNA FILGDTDNGE RTGHRSPSFL
     PWHRRFLLEF ERALQSVDAS VALPYWDWSA DRSTRSSLWA PDFLGGTGRS RDGQVMDGPF
     AASAGNWPIN VRVDGRTFLR RALGAGVSEL PTRAEVDSVL AMATYDMAPW NSGSDGFRNH
     LEGWRGVNLH NRVHVWVGGQ MATGVSPNDP VFWLHHAYID KLWAEWQRRH PSSPYLPGGG
     TPNVVDLNET MKPWNDTTPA ALLDHTRHYT FDV
//