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P07524 (TYRO_STRAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosinase

EC=1.14.18.1
Alternative name(s):
Monophenol monooxygenase
Gene names
Name:melC2
Synonyms:mel
OrganismStreptomyces antibioticus
Taxonomic identifier1890 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.

Catalytic activity

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.

L-tyrosine + O2 = dopaquinone + H2O.

Cofactor

Binds 2 copper ions per subunit By similarity.

Sequence similarities

Belongs to the tyrosinase family.

Ontologies

Keywords
   Biological processMelanin biosynthesis
   LigandCopper
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Biological_processmelanin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

monophenol monooxygenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 273272Tyrosinase
PRO_0000186737

Sites

Metal binding381Copper A By similarity
Metal binding541Copper A By similarity
Metal binding631Copper A By similarity
Metal binding1901Copper B By similarity
Metal binding1941Copper B By similarity
Metal binding2161Copper B By similarity

Sequences

Sequence LengthMass (Da)Tools
P07524 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: FF22A3701AF975BA

FASTA27330,739
        10         20         30         40         50         60 
MTVRKNQASL TAEEKRRFVA ALLELKRTGR YDAFVTTHNA FILGDTDNGE RTGHRSPSFL 

        70         80         90        100        110        120 
PWHRRFLLEF ERALQSVDAS VALPYWDWSA DRSTRSSLWA PDFLGGTGRS RDGQVMDGPF 

       130        140        150        160        170        180 
AASAGNWPIN VRVDGRTFLR RALGAGVSEL PTRAEVDSVL AMATYDMAPW NSGSDGFRNH 

       190        200        210        220        230        240 
LEGWRGVNLH NRVHVWVGGQ MATGVSPNDP VFWLHHAYID KLWAEWQRRH PSSPYLPGGG 

       250        260        270 
TPNVVDLNET MKPWNDTTPA ALLDHTRHYT FDV 

« Hide

References

[1]"The nucleotide sequence of the tyrosinase gene from Streptomyces antibioticus and characterization of the gene product."
Bernan V., Filpula D., Herber W., Bibb M.J., Katz E.
Gene 37:101-110(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M11582 Genomic DNA. Translation: AAA88571.1.
PIRB23971.

3D structure databases

ProteinModelPortalP07524.
SMRP07524. Positions 2-272.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.1280.10. 1 hit.
InterProIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSPR00092. TYROSINASE.
SUPFAMSSF48056. SSF48056. 1 hit.
PROSITEPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYRO_STRAT
AccessionPrimary (citable) accession number: P07524
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families