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P07524

- TYRO_STRAT

UniProt

P07524 - TYRO_STRAT

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Protein

Tyrosinase

Gene
melC2, mel
Organism
Streptomyces antibioticus
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.

Catalytic activityi

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.
L-tyrosine + O2 = dopaquinone + H2O.

Cofactori

Binds 2 copper ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381Copper A By similarity
Metal bindingi54 – 541Copper A By similarity
Metal bindingi63 – 631Copper A By similarity
Metal bindingi190 – 1901Copper B By similarity
Metal bindingi194 – 1941Copper B By similarity
Metal bindingi216 – 2161Copper B By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. monophenol monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. melanin biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosinase (EC:1.14.18.1)
Alternative name(s):
Monophenol monooxygenase
Gene namesi
Name:melC2
Synonyms:mel
OrganismiStreptomyces antibioticus
Taxonomic identifieri1890 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 273272TyrosinasePRO_0000186737Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP07524.
SMRiP07524. Positions 2-272.

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07524-1 [UniParc]FASTAAdd to Basket

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MTVRKNQASL TAEEKRRFVA ALLELKRTGR YDAFVTTHNA FILGDTDNGE    50
RTGHRSPSFL PWHRRFLLEF ERALQSVDAS VALPYWDWSA DRSTRSSLWA 100
PDFLGGTGRS RDGQVMDGPF AASAGNWPIN VRVDGRTFLR RALGAGVSEL 150
PTRAEVDSVL AMATYDMAPW NSGSDGFRNH LEGWRGVNLH NRVHVWVGGQ 200
MATGVSPNDP VFWLHHAYID KLWAEWQRRH PSSPYLPGGG TPNVVDLNET 250
MKPWNDTTPA ALLDHTRHYT FDV 273
Length:273
Mass (Da):30,739
Last modified:January 23, 2007 - v2
Checksum:iFF22A3701AF975BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11582 Genomic DNA. Translation: AAA88571.1.
PIRiB23971.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11582 Genomic DNA. Translation: AAA88571.1 .
PIRi B23971.

3D structure databases

ProteinModelPortali P07524.
SMRi P07524. Positions 2-272.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1280.10. 1 hit.
InterProi IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view ]
Pfami PF00264. Tyrosinase. 1 hit.
[Graphical view ]
PRINTSi PR00092. TYROSINASE.
SUPFAMi SSF48056. SSF48056. 1 hit.
PROSITEi PS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The nucleotide sequence of the tyrosinase gene from Streptomyces antibioticus and characterization of the gene product."
    Bernan V., Filpula D., Herber W., Bibb M.J., Katz E.
    Gene 37:101-110(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiTYRO_STRAT
AccessioniPrimary (citable) accession number: P07524
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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