Reviewed, UniProtKB/Swiss-Prot P07524 (TYRO_STRAT)

Names and origin

Protein names

Recommended name:
    Tyrosinase
    EC=1.14.18.1
Alternative name(s):
    Monophenol monooxygenase

Gene names

Name:	melC2
Synonyms:	mel

Organism

Streptomyces antibioticus

Taxonomic identifier

1890 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.
Catalytic activity	L-tyrosine + L-dopa + O2 = L-dopa + dopaquinone + H2O.
Cofactor	Binds 2 copper ions per subunit By similarity.
Sequence similarities	Belongs to the tyrosinase family.

Ontologies

Keywords
Biological process	Melanin biosynthesis
Ligand	Copper Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	melanin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW monophenol monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 273	272	Tyrosinase		PRO_0000186737
Sites
	Metal binding	38	1	Copper A By similarity
	Metal binding	54	1	Copper A By similarity
	Metal binding	63	1	Copper A By similarity
	Metal binding	190	1	Copper B By similarity
	Metal binding	194	1	Copper B By similarity
	Metal binding	216	1	Copper B By similarity

Sequences

	Sequence		Length	Mass (Da)
	P07524-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: FF22A3701AF975BA	FASTA	273	30,739
	10 20 30 40 50 60 MTVRKNQASL TAEEKRRFVA ALLELKRTGR YDAFVTTHNA FILGDTDNGE RTGHRSPSFL 70 80 90 100 110 120 PWHRRFLLEF ERALQSVDAS VALPYWDWSA DRSTRSSLWA PDFLGGTGRS RDGQVMDGPF 130 140 150 160 170 180 AASAGNWPIN VRVDGRTFLR RALGAGVSEL PTRAEVDSVL AMATYDMAPW NSGSDGFRNH 190 200 210 220 230 240 LEGWRGVNLH NRVHVWVGGQ MATGVSPNDP VFWLHHAYID KLWAEWQRRH PSSPYLPGGG 250 260 270 TPNVVDLNET MKPWNDTTPA ALLDHTRHYT FDV

References

[1]	"The nucleotide sequence of the tyrosinase gene from Streptomyces antibioticus and characterization of the gene product." Bernan V., Filpula D., Herber W., Bibb M.J., Katz E. Gene 37:101-110(1985) [PubMed: 3932128] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M11582 Genomic DNA. Translation: AAA88571.1.
PIR	B23971.
3D structure databases
SMR	P07524. Positions 2-272.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.14.18.1. 96840.
Family and domain databases
InterPro	IPR008922. Di-copper_centre. IPR002227. Tyrosinase. [Graphical view]
Gene3D	G3DSA:1.10.1280.10. Di-copper_centre. 1 hit.
Pfam	PF00264. Tyrosinase. 1 hit. [Graphical view]
PRINTS	PR00092. TYROSINASE.
PROSITE	PS00497. TYROSINASE_1. 1 hit. PS00498. TYROSINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYRO_STRAT

Accession

Primary (citable) accession number: P07524

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	January 23, 2007
Last modified:	November 24, 2009
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)