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P07524

- TYRO_STRAT

UniProt

P07524 - TYRO_STRAT

Protein

Tyrosinase

Gene

melC2

Organism
Streptomyces antibioticus
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.

    Catalytic activityi

    2 L-dopa + O2 = 2 dopaquinone + 2 H2O.
    L-tyrosine + O2 = dopaquinone + H2O.

    Cofactori

    Binds 2 copper ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi38 – 381Copper ABy similarity
    Metal bindingi54 – 541Copper ABy similarity
    Metal bindingi63 – 631Copper ABy similarity
    Metal bindingi190 – 1901Copper BBy similarity
    Metal bindingi194 – 1941Copper BBy similarity
    Metal bindingi216 – 2161Copper BBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. monophenol monooxygenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. melanin biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Melanin biosynthesis

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosinase (EC:1.14.18.1)
    Alternative name(s):
    Monophenol monooxygenase
    Gene namesi
    Name:melC2
    Synonyms:mel
    OrganismiStreptomyces antibioticus
    Taxonomic identifieri1890 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 273272TyrosinasePRO_0000186737Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP07524.
    SMRiP07524. Positions 2-272.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tyrosinase family.Curated

    Family and domain databases

    Gene3Di1.10.1280.10. 1 hit.
    InterProiIPR002227. Tyrosinase_Cu-bd.
    IPR008922. Unchr_di-copper_centre.
    [Graphical view]
    PfamiPF00264. Tyrosinase. 1 hit.
    [Graphical view]
    PRINTSiPR00092. TYROSINASE.
    SUPFAMiSSF48056. SSF48056. 1 hit.
    PROSITEiPS00497. TYROSINASE_1. 1 hit.
    PS00498. TYROSINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07524-1 [UniParc]FASTAAdd to Basket

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    MTVRKNQASL TAEEKRRFVA ALLELKRTGR YDAFVTTHNA FILGDTDNGE    50
    RTGHRSPSFL PWHRRFLLEF ERALQSVDAS VALPYWDWSA DRSTRSSLWA 100
    PDFLGGTGRS RDGQVMDGPF AASAGNWPIN VRVDGRTFLR RALGAGVSEL 150
    PTRAEVDSVL AMATYDMAPW NSGSDGFRNH LEGWRGVNLH NRVHVWVGGQ 200
    MATGVSPNDP VFWLHHAYID KLWAEWQRRH PSSPYLPGGG TPNVVDLNET 250
    MKPWNDTTPA ALLDHTRHYT FDV 273
    Length:273
    Mass (Da):30,739
    Last modified:January 23, 2007 - v2
    Checksum:iFF22A3701AF975BA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11582 Genomic DNA. Translation: AAA88571.1.
    PIRiB23971.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11582 Genomic DNA. Translation: AAA88571.1 .
    PIRi B23971.

    3D structure databases

    ProteinModelPortali P07524.
    SMRi P07524. Positions 2-272.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.1280.10. 1 hit.
    InterProi IPR002227. Tyrosinase_Cu-bd.
    IPR008922. Unchr_di-copper_centre.
    [Graphical view ]
    Pfami PF00264. Tyrosinase. 1 hit.
    [Graphical view ]
    PRINTSi PR00092. TYROSINASE.
    SUPFAMi SSF48056. SSF48056. 1 hit.
    PROSITEi PS00497. TYROSINASE_1. 1 hit.
    PS00498. TYROSINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of the tyrosinase gene from Streptomyces antibioticus and characterization of the gene product."
      Bernan V., Filpula D., Herber W., Bibb M.J., Katz E.
      Gene 37:101-110(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiTYRO_STRAT
    AccessioniPrimary (citable) accession number: P07524
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3