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Protein

Protein phosphatase 1 regulatory subunit 1B

Gene

PPP1R1B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of protein-phosphatase 1.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Enzyme and pathway databases

ReactomeiR-BTA-180024. DARPP-32 events.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 1B
Alternative name(s):
DARPP-32
Dopamine- and cAMP-regulated neuronal phosphoprotein
Gene namesi
Name:PPP1R1B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202Protein phosphatase 1 regulatory subunit 1BPRO_0000071472Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei34 – 341Phosphothreonine; by PKA1 Publication
Modified residuei45 – 451PhosphoserineBy similarity
Modified residuei46 – 461PhosphoserineBy similarity
Modified residuei75 – 751Phosphothreonine; by CDK5By similarity
Modified residuei102 – 1021PhosphoserineBy similarity
Modified residuei135 – 1351PhosphoserineBy similarity

Post-translational modificationi

Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.
Phosphorylation of Thr-34 is required for activity.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP07516.
PRIDEiP07516.

PTM databases

iPTMnetiP07516.

Interactioni

Protein-protein interaction databases

DIPiDIP-20N.
STRINGi9913.ENSBTAP00000007930.

Structurei

3D structure databases

DisProtiDP00421.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi119 – 13416Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J1BH. Eukaryota.
ENOG4111TN1. LUCA.
GeneTreeiENSGT00730000111283.
HOGENOMiHOG000290193.
HOVERGENiHBG099182.
InParanoidiP07516.
KOiK15494.
OMAiPAMLFRV.
OrthoDBiEOG7PCJJG.
TreeFamiTF332576.

Family and domain databases

InterProiIPR015670. DARPP-32.
IPR008466. PPP1R1A/B/C.
[Graphical view]
PANTHERiPTHR15417. PTHR15417. 1 hit.
PTHR15417:SF2. PTHR15417:SF2. 1 hit.
PfamiPF05395. DARPP-32. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07516-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPKDRKKIQ FSVPAPPSQL DPRQVEMIRR RRPTPAMLFR LSEHSSPEEE
60 70 80 90 100
ASPHQRASGE GHHLKSKRSN PCAYTPPSLK AVQRIAESHL QSISNLGENQ
110 120 130 140 150
ASEEEDELGE LRELGYPREE EEEEEEEDEE EEEDSQAEVL KGSRGSAGQK
160 170 180 190 200
TTYGQGLEGP WERPPPLDGP QRDGSSEDQV EDPALNEPGE EPQRPAHPEP

GT
Length:202
Mass (Da):22,614
Last modified:April 1, 1988 - v1
Checksum:i11192D2BED766763
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27444 mRNA. Translation: AAA57248.1.
BC118264 mRNA. Translation: AAI18265.1.
PIRiA45668. A26301.
RefSeqiNP_777072.1. NM_174647.2.
UniGeneiBt.4706.

Genome annotation databases

EnsembliENSBTAT00000007930; ENSBTAP00000007930; ENSBTAG00000006035.
GeneIDi282459.
KEGGibta:282459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27444 mRNA. Translation: AAA57248.1.
BC118264 mRNA. Translation: AAI18265.1.
PIRiA45668. A26301.
RefSeqiNP_777072.1. NM_174647.2.
UniGeneiBt.4706.

3D structure databases

DisProtiDP00421.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-20N.
STRINGi9913.ENSBTAP00000007930.

PTM databases

iPTMnetiP07516.

Proteomic databases

PaxDbiP07516.
PRIDEiP07516.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000007930; ENSBTAP00000007930; ENSBTAG00000006035.
GeneIDi282459.
KEGGibta:282459.

Organism-specific databases

CTDi84152.

Phylogenomic databases

eggNOGiENOG410J1BH. Eukaryota.
ENOG4111TN1. LUCA.
GeneTreeiENSGT00730000111283.
HOGENOMiHOG000290193.
HOVERGENiHBG099182.
InParanoidiP07516.
KOiK15494.
OMAiPAMLFRV.
OrthoDBiEOG7PCJJG.
TreeFamiTF332576.

Enzyme and pathway databases

ReactomeiR-BTA-180024. DARPP-32 events.

Family and domain databases

InterProiIPR015670. DARPP-32.
IPR008466. PPP1R1A/B/C.
[Graphical view]
PANTHERiPTHR15417. PTHR15417. 1 hit.
PTHR15417:SF2. PTHR15417:SF2. 1 hit.
PfamiPF05395. DARPP-32. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DARPP-32, a dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Primary structure and homology with protein phosphatase inhibitor-1."
    Williams K.R., Hemmings H.C. Jr., Lopresti M.B., Konigsberg W.H., Greengard P.
    J. Biol. Chem. 261:1890-1903(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, ACETYLATION AT MET-1, PHOSPHORYLATION AT THR-34.
  2. "Cloning of cDNA for DARPP-32, a dopamine- and cyclic AMP-regulated neuronal phosphoprotein."
    Kurihara T., Lewis R.M., Eisler J., Greengard P.
    J. Neurosci. 8:508-517(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Basal ganglia.

Entry informationi

Entry nameiPPR1B_BOVIN
AccessioniPrimary (citable) accession number: P07516
Secondary accession number(s): Q17QN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.