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Protein

Natriuretic peptides A

Gene

NPPA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone, Vasoactive

Enzyme and pathway databases

ReactomeiR-BTA-5578768 Physiological factors

Names & Taxonomyi

Protein namesi
Recommended name:
Natriuretic peptides A
Alternative name(s):
Prepronatriodilatin
Cleaved into the following chain:
Alternative name(s):
Atrial natriuretic peptide
Short name:
ANP
Gene namesi
Name:NPPA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Organism-specific databases

VGNCiVGNC:32210 NPPA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
PropeptideiPRO_000000148225 – 122CuratedAdd BLAST98
PeptideiPRO_0000001483123 – 150Atrial natriuretic factor1 PublicationAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi129 ↔ 145By similarity

Post-translational modificationi

Cleaved by CORIN upon secretion to produce the functional hormone.By similarity
Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei122 – 123Cleavage; by CORIN1 Publication2
Sitei129 – 130Cleavage; by MMEBy similarity2

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP07501

Expressioni

Gene expression databases

BgeeiENSBTAG00000006709

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008819

Structurei

3D structure databases

SMRiP07501
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW5F Eukaryota
ENOG410ZUY6 LUCA
GeneTreeiENSGT00510000048659
HOGENOMiHOG000033937
HOVERGENiHBG004227
InParanoidiP07501
KOiK12334
OMAiCNSFRYR
OrthoDBiEOG091G0SV3
TreeFamiTF106304

Family and domain databases

InterProiView protein in InterPro
IPR000663 Natr_peptide
IPR030480 Natr_peptide_CS
IPR002407 Natriuretic_peptide_atrial
PfamiView protein in Pfam
PF00212 ANP, 1 hit
PRINTSiPR00711 ANATPEPTIDE
PR00710 NATPEPTIDES
SMARTiView protein in SMART
SM00183 NAT_PEP, 1 hit
PROSITEiView protein in PROSITE
PS00263 NATRIURETIC_PEPTIDE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSAITVSF LLFLAFQLPG QTGANPVYGS VSNADLMDFK NLLDRLEDKM
60 70 80 90 100
PLEDEAVPSQ VLSEQNEEAG APLSPLSEMP PWMGEVNPAQ REGGVLGRGP
110 120 130 140 150
WESSDRSALL KSKLRALLTA PRSLRRSSCF GGRMDRIGAQ SGLGCNSFRY

RR
Length:152
Mass (Da):16,518
Last modified:July 1, 1989 - v2
Checksum:i48D040FAE01DFD15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13145 Genomic DNA Translation: AAA30375.1
BC149029 mRNA Translation: AAI49030.1
PIRiA90124 AWBO
RefSeqiNP_776549.1, NM_174124.1
UniGeneiBt.29967

Genome annotation databases

EnsembliENSBTAT00000008819; ENSBTAP00000008819; ENSBTAG00000006709
GeneIDi281355
KEGGibta:281355

Similar proteinsi

Entry informationi

Entry nameiANF_BOVIN
AccessioniPrimary (citable) accession number: P07501
Secondary accession number(s): A6QNW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: July 1, 1989
Last modified: April 25, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health