P07501 (ANF_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Natriuretic peptides A

Alternative name(s):
Prepronatriodilatin

Cleaved into the following chain:

1. Atrial natriuretic factor
   Short name=ANF
   Alternative name(s):
   Atrial natriuretic peptide
   Short name=ANP

Gene names

Name:

NPPA

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	152 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilatation. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 By similarity.
Subcellular location	Secreted.
Post-translational modification	Cleaved by CORIN upon secretion to produce the functional hormone By similarity.
Sequence similarities	Belongs to the natriuretic peptide family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone Vasoactive
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	cGMP biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB receptor guanylyl cyclase signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB regulation of blood vessel size Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hormone activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Propeptide	25 – 122	98			PRO_0000001482
	Peptide	123 – 150	28	Atrial natriuretic factor Ref.3		PRO_0000001483
Sites
	Site	122 – 123	2	Cleavage; by CORIN By similarity
Amino acid modifications
	Disulfide bond	129 ↔ 145

Sequences

	Sequence		Length	Mass (Da)
	P07501 [UniParc]. Last modified July 1, 1989. Version 2. Checksum: 48D040FAE01DFD15	FASTA	152	16,518
	10 20 30 40 50 60 MGSSAITVSF LLFLAFQLPG QTGANPVYGS VSNADLMDFK NLLDRLEDKM PLEDEAVPSQ 70 80 90 100 110 120 VLSEQNEEAG APLSPLSEMP PWMGEVNPAQ REGGVLGRGP WESSDRSALL KSKLRALLTA 130 140 150 PRSLRRSSCF GGRMDRIGAQ SGLGCNSFRY RR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and analysis of the bovine atrial natriuretic peptide precursor gene." Vlasuk G.P., Miller J., Bencen G.H., Lewicki J.A. Biochem. Biophys. Res. Commun. 136:396-403(1986) [PubMed: 2939830] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Heart ventricle.
[3]	"Purification and sequence determination of bovine atrial natriuretic factor." Ong H., McNicoll N., Lazure C., Seidah N., Chretien M., Cantin M., de Lean A. Life Sci. 38:1309-1315(1986) [PubMed: 3007908] [Abstract] Cited for: PROTEIN SEQUENCE OF 123-150.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M13145 Genomic DNA. Translation: AAA30375.1. BC149029 mRNA. Translation: AAI49030.1.
IPI	IPI00715265.
PIR	AWBO. A90124.
RefSeq	NP_776549.1. NM_174124.1.
UniGene	Bt.29967.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P07501.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000008819; ENSBTAP00000008819; ENSBTAG00000006709.
GeneID	281355.
KEGG	bta:281355.
Organism-specific databases
CTD	4878.
Phylogenomic databases
eggNOG	maNOG20137.
GeneTree	ENSGT00510000048659.
HOVERGEN	HBG004227.
InParanoid	P07501.
OMA	EVPPWTG.
OrthoDB	EOG40K81J.
Family and domain databases
InterPro	IPR000663. Natr_peptide. IPR002407. Natriuretic_peptide_atrial. [Graphical view]
KO	K12334.
Pfam	PF00212. ANP. 1 hit. [Graphical view]
PRINTS	PR00711. ANATPEPTIDE. PR00710. NATPEPTIDES.
SMART	SM00183. NAT_PEP. 1 hit. [Graphical view]
PROSITE	PS00263. NATRIURETIC_PEPTIDE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ANF_BOVIN

Accession

Primary (citable) accession number: P07501
Secondary accession number(s): A6QNW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	July 1, 1989
Last modified:	November 16, 2011
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program