P07500 (ANF_RABIT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Natriuretic peptides A

Alternative name(s):
Prepronatriodilatin

Cleaved into the following chain:

1. Atrial natriuretic factor
   Short name=ANF
   Alternative name(s):
   Atrial natriuretic peptide
   Short name=ANP

Gene names

Name:

NPPA

Organism

Oryctolagus cuniculus (Rabbit) [Complete proteome]

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	153 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilatation. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 By similarity.
Subcellular location	Secreted.
Post-translational modification	Cleaved by CORIN upon secretion to produce the functional hormone By similarity.
Sequence similarities	Belongs to the natriuretic peptide family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone Vasoactive
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cGMP biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB receptor guanylyl cyclase signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB regulation of blood vessel size Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hormone activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Propeptide	26 – 123	98			PRO_0000001503
	Peptide	124 – 151	28	Atrial natriuretic factor		PRO_0000001504
Sites
	Site	123 – 124	2	Cleavage; by CORIN By similarity
Amino acid modifications
	Disulfide bond	130 ↔ 146		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P07500 [UniParc]. Last modified April 1, 1988. Version 1. Checksum: 8214A58D073D3236	FASTA	153	16,843
	10 20 30 40 50 60 MGPFSTITVS FLFCLAFWHP DQIGANPVYN AMSNADLMDF KNLLDHLEDR MPFEDEAVPP 70 80 90 100 110 120 QALSEQSDEA GAALSPLPEV PPWTGEVSPA QRDGEALGRS TWEASERSAL LKSKLRALLT 130 140 150 APRSLRRSSC FGGRIDRIGA QSGLGCNSFR YRR

References

[1]

"Structure of dog and rabbit precursors of atrial natriuretic polypeptides deduced from nucleotide sequence of cloned cDNA." Oikawa S., Imai M., Inuzuka C., Tawaragi Y., Nakazato H., Matsuo H. Biochem. Biophys. Res. Commun. 132:892-899(1985) [PubMed: 2934062] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M12046 mRNA. Translation: AAA31162.1.
PIR	AWRB. B25302.
RefSeq	NP_001075731.1. NM_001082262.1.
UniGene	Ocu.1827.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P07500.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100009087.
Organism-specific databases
CTD	4878.
Phylogenomic databases
eggNOG	maNOG20137.
GeneTree	ENSGT00510000048659.
HOVERGEN	HBG004227.
OrthoDB	EOG40K81J.
Family and domain databases
InterPro	IPR000663. Natr_peptide. IPR002407. Natriuretic_peptide_atrial. [Graphical view]
Pfam	PF00212. ANP. 1 hit. [Graphical view]
PRINTS	PR00711. ANATPEPTIDE. PR00710. NATPEPTIDES.
SMART	SM00183. NAT_PEP. 1 hit. [Graphical view]
PROSITE	PS00263. NATRIURETIC_PEPTIDE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ANF_RABIT

Accession

Primary (citable) accession number: P07500

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	April 1, 1988
Last modified:	November 16, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program