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Protein

Natriuretic peptides A

Gene

NPPA

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone, Vasoactive

Enzyme and pathway databases

ReactomeiR-CFA-5578768. Physiological factors.

Names & Taxonomyi

Protein namesi
Recommended name:
Natriuretic peptides A
Alternative name(s):
Prepronatriodilatin
Cleaved into the following chain:
Alternative name(s):
Atrial natriuretic peptide
Short name:
ANP
Gene namesi
Name:NPPA
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Propeptidei24 – 12198CuratedPRO_0000001484Add
BLAST
Peptidei122 – 14928Atrial natriuretic factorBy similarityPRO_0000001485Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi128 ↔ 144By similarity

Post-translational modificationi

Cleaved by CORIN upon secretion to produce the functional hormone.By similarity
Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei121 – 1222Cleavage; by CORINBy similarity
Sitei128 – 1292Cleavage; by MMEBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP07499.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000024318.

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW5F. Eukaryota.
ENOG410ZUY6. LUCA.
GeneTreeiENSGT00510000048659.
HOGENOMiHOG000033937.
HOVERGENiHBG004227.
InParanoidiP07499.
KOiK12334.
OMAiGCNSFRY.
OrthoDBiEOG091G0SV3.
TreeFamiTF106304.

Family and domain databases

InterProiIPR000663. Natr_peptide.
IPR030480. Natr_peptide_CS.
IPR002407. Natriuretic_peptide_atrial.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
PRINTSiPR00711. ANATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSPIAASFL LFLAVQLLGQ TGANPVYGSV SNADLLDFKN LLDRLEDKMP
60 70 80 90 100
LEDEAESPQA LSEQNAEAGA ALSPLPEVPP WTGEVSPAQR DGGALGRSPW
110 120 130 140
DSSDRSALLK SKLRALLAAP RSLRRSSCFG GRMDRIGAQS GLGCNSFRY
Length:149
Mass (Da):15,819
Last modified:April 1, 1988 - v1
Checksum:i9BA3A11C0B7557DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12045 mRNA. Translation: AAA30828.1.
PIRiA25302. AWDG.
RefSeqiNP_001300780.1. NM_001313851.1.

Genome annotation databases

EnsembliENSCAFT00000026190; ENSCAFP00000024318; ENSCAFG00000016539.
GeneIDi608289.
KEGGicfa:608289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12045 mRNA. Translation: AAA30828.1.
PIRiA25302. AWDG.
RefSeqiNP_001300780.1. NM_001313851.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000024318.

Proteomic databases

PaxDbiP07499.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000026190; ENSCAFP00000024318; ENSCAFG00000016539.
GeneIDi608289.
KEGGicfa:608289.

Organism-specific databases

CTDi4878.

Phylogenomic databases

eggNOGiENOG410IW5F. Eukaryota.
ENOG410ZUY6. LUCA.
GeneTreeiENSGT00510000048659.
HOGENOMiHOG000033937.
HOVERGENiHBG004227.
InParanoidiP07499.
KOiK12334.
OMAiGCNSFRY.
OrthoDBiEOG091G0SV3.
TreeFamiTF106304.

Enzyme and pathway databases

ReactomeiR-CFA-5578768. Physiological factors.

Family and domain databases

InterProiIPR000663. Natr_peptide.
IPR030480. Natr_peptide_CS.
IPR002407. Natriuretic_peptide_atrial.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
PRINTSiPR00711. ANATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANF_CANLF
AccessioniPrimary (citable) accession number: P07499
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.