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P07498 (CASK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 145. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kappa-casein
Gene names
Name:CSN3
Synonyms:CASK, CSN10, CSNK
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length182 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.

Subunit structure

Heteromultimers composed of alpha-s1 casein and kappa casein linked by disulfide bonds.

Subcellular location

Secreted.

Tissue specificity

Mammary gland specific. Secreted in milk.

Post-translational modification

The N-terminus is blocked.

Sequence similarities

Belongs to the kappa-casein family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionMilk protein
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processlactation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020
Chain21 – 182162Kappa-casein
PRO_0000004498

Sites

Site117 – 1182Cleavage; by chymosin/rennin

Amino acid modifications

Glycosylation1331O-linked (GalNAc...) Ref.6
Glycosylation1431O-linked (GalNAc...) Ref.6
Glycosylation1481O-linked (GalNAc...) Ref.6
Glycosylation1511O-linked (GalNAc...) Ref.6
Glycosylation1571O-linked (GalNAc...) Ref.6
Glycosylation1671O-linked (GalNAc...) Ref.6
Glycosylation1691O-linked (GalNAc...) Ref.6

Natural variations

Natural variant751Y → C. Ref.4
Corresponds to variant rs17850702 [ dbSNP | Ensembl ].
VAR_026338
Natural variant1101R → L. Ref.3
Corresponds to variant rs1048152 [ dbSNP | Ensembl ].
VAR_026339
Natural variant1451A → T. Ref.1
Corresponds to variant rs3775739 [ dbSNP | Ensembl ].
VAR_026340

Experimental info

Sequence conflict25 – 273QKQ → EQK AA sequence Ref.5
Sequence conflict1531D → N AA sequence Ref.5
Sequence conflict1611F → T AA sequence Ref.6
Sequence conflict1621S → T AA sequence Ref.5
Sequence conflict1621S → T AA sequence Ref.6
Sequence conflict1731T → P AA sequence Ref.5
Sequence conflict1731T → P AA sequence Ref.6
Sequence conflict178 – 1814TPPT → PTTS AA sequence Ref.5
Sequence conflict178 – 1814TPPT → PTTS AA sequence Ref.6

Sequences

Sequence LengthMass (Da)Tools
P07498 [UniParc].

Last modified October 1, 1996. Version 3.
Checksum: 8A1609D2D5C94895

FASTA18220,305
        10         20         30         40         50         60 
MKSFLLVVNA LALTLPFLAV EVQNQKQPAC HENDERPFYQ KTAPYVPMYY VPNSYPYYGT 

        70         80         90        100        110        120 
NLYQRRPAIA INNPYVPRTY YANPAVVRPH AQIPQRQYLP NSHPPTVVRR PNLHPSFIAI 

       130        140        150        160        170        180 
PPKKIQDKII IPTINTIATV EPTPAPATEP TVDSVVTPEA FSESIITSTP ETTTVAVTPP 


TA 

« Hide

References

« Hide 'large scale' references
[1]Menon R.S., Jeffers K.F., Chang Y.F., Ham R.G.
Submitted (JUL-1991) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-145.
[2]"Cloning and sequencing of human kappa-casein cDNA."
Bergstroem S., Hansson L., Hernell O., Loennerdal B., Nilsson A.K., Stroemqvist M.
DNA Seq. 3:245-246(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Mammary gland.
[3]"Structure of the human kappa-casein gene."
Edlund A., Johansson T., Leidvik B., Hansson L.
Gene 174:65-69(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT LEU-110.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT CYS-75.
Tissue: Brain.
[5]"Preparation and amino acid sequence of human kappa-casein."
Brignon G., Chtourou A., Ribadeau-Dumas B.
FEBS Lett. 188:48-54(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 25-182.
[6]"Localisation and importance of the sugar part of human casein."
Fiat A.-M., Jolles J., Aubert J.-P., Loucheux-Lefebvre M.H., Jolles P.
Eur. J. Biochem. 111:333-339(1980) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 118-182, GLYCOSYLATION AT THR-133; THR-143; THR-148; THR-151; THR-157; THR-167 AND THR-169.
[7]"Structural features of a peptide corresponding to human kappa-casein residues 84-101 by 1H-nuclear magnetic resonance spectroscopy."
Plowman J.E., Creamer L.K., Liddell M.J., Cross J.J.
J. Dairy Res. 66:53-63(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 108-125.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Of buttons, digestion and glue - Issue 16 of November 2001

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M73628 mRNA. Translation: AAA59456.1.
X66417 mRNA. Translation: CAA47048.1.
U51899 Genomic DNA. Translation: AAC50772.1.
BC010935 mRNA. Translation: AAH10935.1.
PIRKKHU. JC4957.
RefSeqNP_005203.2. NM_005212.2.
UniGeneHs.54415.

3D structure databases

ProteinModelPortalP07498.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107835. 5 interactions.
IntActP07498. 2 interactions.
MINTMINT-7034630.
STRING9606.ENSP00000304822.

Protein family/group databases

Allergome1064. Hom s 8.

PTM databases

PhosphoSiteP07498.
UniCarbKBP07498.

Proteomic databases

PRIDEP07498.

Protocols and materials databases

DNASU1448.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304954; ENSP00000304822; ENSG00000171209.
GeneID1448.
KEGGhsa:1448.
UCSCuc003hfe.4. human.

Organism-specific databases

CTD1448.
GeneCardsGC04P071156.
HGNCHGNC:2446. CSN3.
HPAHPA035953.
MIM601695. gene.
neXtProtNX_P07498.
PharmGKBPA26949.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40632.
HOGENOMHOG000111309.
HOVERGENHBG005246.
InParanoidP07498.
KOK17282.
OMAIPPKKIQ.
OrthoDBEOG7MWH09.
PhylomeDBP07498.
TreeFamTF338369.

Gene expression databases

BgeeP07498.
CleanExHS_CASK.
HS_CSN3.
GenevestigatorP07498.

Family and domain databases

InterProIPR000117. Casein_kappa.
[Graphical view]
PANTHERPTHR11470. PTHR11470. 1 hit.
PfamPF00997. Casein_kappa. 1 hit.
[Graphical view]
PIRSFPIRSF002374. Casein_kappa. 1 hit.
ProtoNetSearch...

Other

GeneWikiCSN3_(gene).
GenomeRNAi1448.
NextBio5951.
PMAP-CutDBP07498.
PROP07498.
SOURCESearch...

Entry information

Entry nameCASK_HUMAN
AccessionPrimary (citable) accession number: P07498
Secondary accession number(s): Q13575
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 145 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM