Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P07498

- CASK_HUMAN

UniProt

P07498 - CASK_HUMAN

Protein

Kappa-casein

Gene

CSN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei117 – 1182Cleavage; by chymosin/rennin

    GO - Biological processi

    1. lactation Source: UniProt
    2. protein stabilization Source: UniProt

    Keywords - Molecular functioni

    Milk protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kappa-casein
    Gene namesi
    Name:CSN3
    Synonyms:CASK, CSN10, CSNK
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:2446. CSN3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26949.

    Protein family/group databases

    Allergomei1064. Hom s 8.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Add
    BLAST
    Chaini21 – 182162Kappa-caseinPRO_0000004498Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi133 – 1331O-linked (GalNAc...)1 Publication
    Glycosylationi143 – 1431O-linked (GalNAc...)1 Publication
    Glycosylationi148 – 1481O-linked (GalNAc...)1 Publication
    Glycosylationi151 – 1511O-linked (GalNAc...)1 Publication
    Glycosylationi157 – 1571O-linked (GalNAc...)1 Publication
    Glycosylationi167 – 1671O-linked (GalNAc...)1 Publication
    Glycosylationi169 – 1691O-linked (GalNAc...)1 Publication

    Post-translational modificationi

    The N-terminus is blocked.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP07498.

    PTM databases

    PhosphoSiteiP07498.
    UniCarbKBiP07498.

    Miscellaneous databases

    PMAP-CutDBP07498.

    Expressioni

    Tissue specificityi

    Mammary gland specific. Secreted in milk.

    Gene expression databases

    BgeeiP07498.
    CleanExiHS_CASK.
    HS_CSN3.
    GenevestigatoriP07498.

    Organism-specific databases

    HPAiHPA035953.

    Interactioni

    Subunit structurei

    Heteromultimers composed of alpha-s1 casein and kappa casein linked by disulfide bonds.

    Protein-protein interaction databases

    BioGridi107835. 5 interactions.
    IntActiP07498. 2 interactions.
    MINTiMINT-7034630.
    STRINGi9606.ENSP00000304822.

    Structurei

    3D structure databases

    ProteinModelPortaliP07498.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the kappa-casein family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40632.
    HOGENOMiHOG000111309.
    HOVERGENiHBG005246.
    InParanoidiP07498.
    KOiK17282.
    OMAiIPPKKIQ.
    OrthoDBiEOG7MWH09.
    PhylomeDBiP07498.
    TreeFamiTF338369.

    Family and domain databases

    InterProiIPR000117. Casein_kappa.
    [Graphical view]
    PANTHERiPTHR11470. PTHR11470. 1 hit.
    PfamiPF00997. Casein_kappa. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002374. Casein_kappa. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07498-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSFLLVVNA LALTLPFLAV EVQNQKQPAC HENDERPFYQ KTAPYVPMYY    50
    VPNSYPYYGT NLYQRRPAIA INNPYVPRTY YANPAVVRPH AQIPQRQYLP 100
    NSHPPTVVRR PNLHPSFIAI PPKKIQDKII IPTINTIATV EPTPAPATEP 150
    TVDSVVTPEA FSESIITSTP ETTTVAVTPP TA 182
    Length:182
    Mass (Da):20,305
    Last modified:October 1, 1996 - v3
    Checksum:i8A1609D2D5C94895
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 273QKQ → EQK AA sequence (PubMed:4018271)Curated
    Sequence conflicti153 – 1531D → N AA sequence (PubMed:4018271)Curated
    Sequence conflicti161 – 1611F → T AA sequence (PubMed:7460900)Curated
    Sequence conflicti162 – 1621S → T AA sequence (PubMed:4018271)Curated
    Sequence conflicti162 – 1621S → T AA sequence (PubMed:7460900)Curated
    Sequence conflicti173 – 1731T → P AA sequence (PubMed:4018271)Curated
    Sequence conflicti173 – 1731T → P AA sequence (PubMed:7460900)Curated
    Sequence conflicti178 – 1814TPPT → PTTS AA sequence (PubMed:4018271)Curated
    Sequence conflicti178 – 1814TPPT → PTTS AA sequence (PubMed:7460900)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti75 – 751Y → C.1 Publication
    Corresponds to variant rs17850702 [ dbSNP | Ensembl ].
    VAR_026338
    Natural varianti110 – 1101R → L.1 Publication
    Corresponds to variant rs1048152 [ dbSNP | Ensembl ].
    VAR_026339
    Natural varianti145 – 1451A → T.1 Publication
    Corresponds to variant rs3775739 [ dbSNP | Ensembl ].
    VAR_026340

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73628 mRNA. Translation: AAA59456.1.
    X66417 mRNA. Translation: CAA47048.1.
    U51899 Genomic DNA. Translation: AAC50772.1.
    BC010935 mRNA. Translation: AAH10935.1.
    CCDSiCCDS3538.1.
    PIRiJC4957. KKHU.
    RefSeqiNP_005203.2. NM_005212.2.
    UniGeneiHs.54415.

    Genome annotation databases

    EnsembliENST00000304954; ENSP00000304822; ENSG00000171209.
    GeneIDi1448.
    KEGGihsa:1448.
    UCSCiuc003hfe.4. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Of buttons, digestion and glue - Issue 16 of November 2001

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73628 mRNA. Translation: AAA59456.1 .
    X66417 mRNA. Translation: CAA47048.1 .
    U51899 Genomic DNA. Translation: AAC50772.1 .
    BC010935 mRNA. Translation: AAH10935.1 .
    CCDSi CCDS3538.1.
    PIRi JC4957. KKHU.
    RefSeqi NP_005203.2. NM_005212.2.
    UniGenei Hs.54415.

    3D structure databases

    ProteinModelPortali P07498.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107835. 5 interactions.
    IntActi P07498. 2 interactions.
    MINTi MINT-7034630.
    STRINGi 9606.ENSP00000304822.

    Protein family/group databases

    Allergomei 1064. Hom s 8.

    PTM databases

    PhosphoSitei P07498.
    UniCarbKBi P07498.

    Proteomic databases

    PRIDEi P07498.

    Protocols and materials databases

    DNASUi 1448.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304954 ; ENSP00000304822 ; ENSG00000171209 .
    GeneIDi 1448.
    KEGGi hsa:1448.
    UCSCi uc003hfe.4. human.

    Organism-specific databases

    CTDi 1448.
    GeneCardsi GC04P071156.
    HGNCi HGNC:2446. CSN3.
    HPAi HPA035953.
    MIMi 601695. gene.
    neXtProti NX_P07498.
    PharmGKBi PA26949.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40632.
    HOGENOMi HOG000111309.
    HOVERGENi HBG005246.
    InParanoidi P07498.
    KOi K17282.
    OMAi IPPKKIQ.
    OrthoDBi EOG7MWH09.
    PhylomeDBi P07498.
    TreeFami TF338369.

    Miscellaneous databases

    GeneWikii CSN3_(gene).
    GenomeRNAii 1448.
    NextBioi 5951.
    PMAP-CutDB P07498.
    PROi P07498.
    SOURCEi Search...

    Gene expression databases

    Bgeei P07498.
    CleanExi HS_CASK.
    HS_CSN3.
    Genevestigatori P07498.

    Family and domain databases

    InterProi IPR000117. Casein_kappa.
    [Graphical view ]
    PANTHERi PTHR11470. PTHR11470. 1 hit.
    Pfami PF00997. Casein_kappa. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002374. Casein_kappa. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Menon R.S., Jeffers K.F., Chang Y.F., Ham R.G.
      Submitted (JUL-1991) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-145.
    2. "Cloning and sequencing of human kappa-casein cDNA."
      Bergstroem S., Hansson L., Hernell O., Loennerdal B., Nilsson A.K., Stroemqvist M.
      DNA Seq. 3:245-246(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Mammary gland.
    3. "Structure of the human kappa-casein gene."
      Edlund A., Johansson T., Leidvik B., Hansson L.
      Gene 174:65-69(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT LEU-110.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT CYS-75.
      Tissue: Brain.
    5. "Preparation and amino acid sequence of human kappa-casein."
      Brignon G., Chtourou A., Ribadeau-Dumas B.
      FEBS Lett. 188:48-54(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-182.
    6. "Localisation and importance of the sugar part of human casein."
      Fiat A.-M., Jolles J., Aubert J.-P., Loucheux-Lefebvre M.H., Jolles P.
      Eur. J. Biochem. 111:333-339(1980) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 118-182, GLYCOSYLATION AT THR-133; THR-143; THR-148; THR-151; THR-157; THR-167 AND THR-169.
    7. "Structural features of a peptide corresponding to human kappa-casein residues 84-101 by 1H-nuclear magnetic resonance spectroscopy."
      Plowman J.E., Creamer L.K., Liddell M.J., Cross J.J.
      J. Dairy Res. 66:53-63(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 108-125.

    Entry informationi

    Entry nameiCASK_HUMAN
    AccessioniPrimary (citable) accession number: P07498
    Secondary accession number(s): Q13575
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 148 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3