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Protein

Kappa-casein

Gene

CSN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.

GO - Biological processi

  • lactation Source: UniProtKB
  • protein stabilization Source: UniProtKB
  • transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Milk protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171209-MONOMER.
ReactomeiR-HSA-5223345. Miscellaneous transport and binding events.

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-casein
Gene namesi
Name:CSN3
Synonyms:CASK, CSN10, CSNK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:2446. CSN3.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1448.
OpenTargetsiENSG00000171209.
PharmGKBiPA26949.

Protein family/group databases

Allergomei1064. Hom s 8.

Chemistry databases

ChEMBLiCHEMBL3621024.

Polymorphism and mutation databases

BioMutaiCSN3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000000449821 – 182Kappa-caseinAdd BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi133O-linked (GalNAc...)1 Publication1
Glycosylationi143O-linked (GalNAc...)1 Publication1
Glycosylationi148O-linked (GalNAc...)1 Publication1
Glycosylationi151O-linked (GalNAc...)1 Publication1
Modified residuei157Phosphothreonine; alternateBy similarity1
Glycosylationi157O-linked (GalNAc...); alternate1 Publication1
Glycosylationi167O-linked (GalNAc...)1 Publication1
Glycosylationi169O-linked (GalNAc...)1 Publication1
Glycosylationi178O-linked (GalNAc...)By similarity1

Post-translational modificationi

The N-terminus is blocked.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei117 – 118Cleavage; by chymosin/rennin2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP07498.
PeptideAtlasiP07498.
PRIDEiP07498.
TopDownProteomicsiP07498.

PTM databases

PhosphoSitePlusiP07498.
SwissPalmiP07498.
UniCarbKBiP07498.

Miscellaneous databases

PMAP-CutDBP07498.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

BgeeiENSG00000171209.
CleanExiHS_CASK.
HS_CSN3.
GenevisibleiP07498. HS.

Organism-specific databases

HPAiHPA035953.

Interactioni

Subunit structurei

Heteromultimers composed of alpha-s1 casein and kappa casein linked by disulfide bonds.

Binary interactionsi

WithEntry#Exp.IntActNotes
RBPMSQ930623EBI-2602175,EBI-740322

Protein-protein interaction databases

BioGridi107835. 7 interactors.
IntActiP07498. 5 interactors.
MINTiMINT-7034630.
STRINGi9606.ENSP00000304822.

Structurei

3D structure databases

ProteinModelPortaliP07498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the kappa-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCVG. Eukaryota.
ENOG4111E7Q. LUCA.
GeneTreeiENSGT00390000009184.
HOGENOMiHOG000111309.
HOVERGENiHBG005246.
InParanoidiP07498.
KOiK17282.
OMAiIPPKKIQ.
OrthoDBiEOG091G105X.
PhylomeDBiP07498.
TreeFamiTF338369.

Family and domain databases

InterProiIPR000117. Casein_kappa.
[Graphical view]
PANTHERiPTHR11470. PTHR11470. 1 hit.
PfamiPF00997. Casein_kappa. 1 hit.
[Graphical view]
PIRSFiPIRSF002374. Casein_kappa. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07498-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSFLLVVNA LALTLPFLAV EVQNQKQPAC HENDERPFYQ KTAPYVPMYY
60 70 80 90 100
VPNSYPYYGT NLYQRRPAIA INNPYVPRTY YANPAVVRPH AQIPQRQYLP
110 120 130 140 150
NSHPPTVVRR PNLHPSFIAI PPKKIQDKII IPTINTIATV EPTPAPATEP
160 170 180
TVDSVVTPEA FSESIITSTP ETTTVAVTPP TA
Length:182
Mass (Da):20,305
Last modified:October 1, 1996 - v3
Checksum:i8A1609D2D5C94895
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25 – 27QKQ → EQK AA sequence (PubMed:4018271).Curated3
Sequence conflicti153D → N AA sequence (PubMed:4018271).Curated1
Sequence conflicti161F → T AA sequence (PubMed:7460900).Curated1
Sequence conflicti162S → T AA sequence (PubMed:4018271).Curated1
Sequence conflicti162S → T AA sequence (PubMed:7460900).Curated1
Sequence conflicti173T → P AA sequence (PubMed:4018271).Curated1
Sequence conflicti173T → P AA sequence (PubMed:7460900).Curated1
Sequence conflicti178 – 181TPPT → PTTS AA sequence (PubMed:4018271).Curated4
Sequence conflicti178 – 181TPPT → PTTS AA sequence (PubMed:7460900).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02633875Y → C.1 PublicationCorresponds to variant rs17850702dbSNPEnsembl.1
Natural variantiVAR_026339110R → L.1 PublicationCorresponds to variant rs1048152dbSNPEnsembl.1
Natural variantiVAR_026340145A → T.1 PublicationCorresponds to variant rs3775739dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73628 mRNA. Translation: AAA59456.1.
X66417 mRNA. Translation: CAA47048.1.
U51899 Genomic DNA. Translation: AAC50772.1.
BC010935 mRNA. Translation: AAH10935.1.
CCDSiCCDS3538.1.
PIRiJC4957. KKHU.
RefSeqiNP_005203.2. NM_005212.2.
XP_011529922.1. XM_011531620.2.
XP_016863250.1. XM_017007761.1.
UniGeneiHs.54415.

Genome annotation databases

EnsembliENST00000304954; ENSP00000304822; ENSG00000171209.
GeneIDi1448.
KEGGihsa:1448.
UCSCiuc003hfe.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

Of buttons, digestion and glue - Issue 16 of November 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73628 mRNA. Translation: AAA59456.1.
X66417 mRNA. Translation: CAA47048.1.
U51899 Genomic DNA. Translation: AAC50772.1.
BC010935 mRNA. Translation: AAH10935.1.
CCDSiCCDS3538.1.
PIRiJC4957. KKHU.
RefSeqiNP_005203.2. NM_005212.2.
XP_011529922.1. XM_011531620.2.
XP_016863250.1. XM_017007761.1.
UniGeneiHs.54415.

3D structure databases

ProteinModelPortaliP07498.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107835. 7 interactors.
IntActiP07498. 5 interactors.
MINTiMINT-7034630.
STRINGi9606.ENSP00000304822.

Chemistry databases

ChEMBLiCHEMBL3621024.

Protein family/group databases

Allergomei1064. Hom s 8.

PTM databases

PhosphoSitePlusiP07498.
SwissPalmiP07498.
UniCarbKBiP07498.

Polymorphism and mutation databases

BioMutaiCSN3.

Proteomic databases

PaxDbiP07498.
PeptideAtlasiP07498.
PRIDEiP07498.
TopDownProteomicsiP07498.

Protocols and materials databases

DNASUi1448.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304954; ENSP00000304822; ENSG00000171209.
GeneIDi1448.
KEGGihsa:1448.
UCSCiuc003hfe.5. human.

Organism-specific databases

CTDi1448.
DisGeNETi1448.
GeneCardsiCSN3.
HGNCiHGNC:2446. CSN3.
HPAiHPA035953.
MIMi601695. gene.
neXtProtiNX_P07498.
OpenTargetsiENSG00000171209.
PharmGKBiPA26949.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCVG. Eukaryota.
ENOG4111E7Q. LUCA.
GeneTreeiENSGT00390000009184.
HOGENOMiHOG000111309.
HOVERGENiHBG005246.
InParanoidiP07498.
KOiK17282.
OMAiIPPKKIQ.
OrthoDBiEOG091G105X.
PhylomeDBiP07498.
TreeFamiTF338369.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171209-MONOMER.
ReactomeiR-HSA-5223345. Miscellaneous transport and binding events.

Miscellaneous databases

GeneWikiiCSN3_(gene).
GenomeRNAii1448.
PMAP-CutDBP07498.
PROiP07498.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171209.
CleanExiHS_CASK.
HS_CSN3.
GenevisibleiP07498. HS.

Family and domain databases

InterProiIPR000117. Casein_kappa.
[Graphical view]
PANTHERiPTHR11470. PTHR11470. 1 hit.
PfamiPF00997. Casein_kappa. 1 hit.
[Graphical view]
PIRSFiPIRSF002374. Casein_kappa. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCASK_HUMAN
AccessioniPrimary (citable) accession number: P07498
Secondary accession number(s): Q13575
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 166 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.