ID GRP_HUMAN Reviewed; 148 AA. AC P07492; P07491; P81553; Q14454; Q53YA0; Q9BSY7; DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot. DT 05-OCT-2010, sequence version 2. DT 25-JAN-2012, entry version 112. DE RecName: Full=Gastrin-releasing peptide; DE Short=GRP; DE Contains: DE RecName: Full=Neuromedin-C; DE AltName: Full=GRP-10; DE Flags: Precursor; GN Name=GRP; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF RP 70-148 (ISOFORM 2), AND VARIANT SER-4. RX MEDLINE=86094341; PubMed=3001723; DOI=10.1073/pnas.83.1.19; RA Spindel E.R., Zilberberg M.D., Habener J.F., Chin W.W.; RT "Two prohormones for gastrin-releasing peptide are encoded by two RT mRNAs differing by 19 nucleotides."; RL Proc. Natl. Acad. Sci. U.S.A. 83:19-23(1986). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND AMIDATION AT MET-50. RX MEDLINE=89096899; PubMed=3211139; RA Lebacq-Verheyden A.-M., Kasprzyk P.G., Raum M.G., RA van Wyke Coelingh K., Lebacq J.A., Battey J.F.; RT "Posttranslational processing of endogenous and of baculovirus- RT expressed human gastrin-releasing peptide precursor."; RL Mol. Cell. Biol. 8:3129-3135(1988). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING. RX MEDLINE=86111953; PubMed=3003116; RA Sausville E.A., Lebacq-Verheyden A.-M., Spindel E.R., Cuttitta F., RA Gazdar A.F., Battey J.F.; RT "Expression of the gastrin-releasing peptide gene in human small cell RT lung cancer. Evidence for alternative processing resulting in three RT distinct mRNAs."; RL J. Biol. Chem. 261:2451-2457(1986). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) system donor RT vector."; RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16177791; DOI=10.1038/nature03983; RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., RA Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., RA FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., RA Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R., RA Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., RA Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., RA Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., RA O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.; RT "DNA sequence and analysis of human chromosome 18."; RL Nature 437:551-555(2005). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Lung; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: GRP stimulates gastrin release as well as other CC gastrointestinal hormones. Operates as a negative feedback CC regulating fear and established a causal relationship between GRP- CC receptor gene expression, long-term potentiation, and amygdala- CC dependent memory for fear (By similarity). CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=P07492-1; Sequence=Displayed; CC Name=2; CC IsoId=P07492-2; Sequence=VSP_000549; CC Name=3; CC IsoId=P07492-3; Sequence=VSP_000550; CC -!- SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin CC family. CC -!- SEQUENCE CAUTION: CC Sequence=AAA52612.1; Type=Erroneous gene model prediction; CC -!- WEB RESOURCE: Name=Wikipedia; Note=Gastrin-releasing peptide CC entry; CC URL="http://en.wikipedia.org/wiki/Gastrin_releasing_peptide"; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; K02054; AAA52613.1; -; mRNA. DR EMBL; M12550; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; M12512; AAA52612.1; ALT_SEQ; Genomic_DNA. DR EMBL; M12511; AAA52612.1; JOINED; Genomic_DNA. DR EMBL; M12512; AAA52611.1; -; Genomic_DNA. DR EMBL; M12511; AAA52611.1; JOINED; Genomic_DNA. DR EMBL; BT006803; AAP35449.1; -; mRNA. DR EMBL; AC067859; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471096; EAW63091.1; -; Genomic_DNA. DR EMBL; BC004488; AAH04488.1; -; mRNA. DR IPI; IPI00011722; -. DR IPI; IPI00218671; -. DR IPI; IPI00218672; -. DR PIR; A26182; A26182. DR PIR; B26182; B26182. DR RefSeq; NP_001012530.1; NM_001012512.1. DR RefSeq; NP_001012531.1; NM_001012513.1. DR RefSeq; NP_002082.2; NM_002091.3. DR UniGene; Hs.153444; -. DR ProteinModelPortal; P07492; -. DR STRING; P07492; -. DR DMDM; 308153451; -. DR PRIDE; P07492; -. DR Ensembl; ENST00000256857; ENSP00000256857; ENSG00000134443. DR GeneID; 2922; -. DR KEGG; hsa:2922; -. DR UCSC; uc002lhu.1; human. DR UCSC; uc002lhw.1; human. DR CTD; 2922; -. DR GeneCards; GC18P056861; -. DR HGNC; HGNC:4605; GRP. DR HPA; HPA007314; -. DR MIM; 137260; gene. DR neXtProt; NX_P07492; -. DR PharmGKB; PA28999; -. DR eggNOG; prNOG20784; -. DR GeneTree; ENSGT00390000017865; -. DR HOGENOM; HBG125737; -. DR HOVERGEN; HBG005912; -. DR InParanoid; P07492; -. DR OMA; LTKMYPR; -. DR OrthoDB; EOG4F4SCM; -. DR PhylomeDB; P07492; -. DR Reactome; REACT_111102; Signal Transduction. DR NextBio; 11585; -. DR ArrayExpress; P07492; -. DR Bgee; P07492; -. DR CleanEx; HS_GRP; -. DR Genevestigator; P07492; -. DR GermOnline; ENSG00000134443; Homo sapiens. DR GO; GO:0005615; C:extracellular space; IDA:MGI. DR GO; GO:0005184; F:neuropeptide hormone activity; IDA:MGI. DR GO; GO:0007218; P:neuropeptide signaling pathway; IDA:MGI. DR InterPro; IPR000874; Bombesin. DR InterPro; IPR015674; Gastrin-RP. DR KO; K05224; -. DR PANTHER; PTHR16866; Gastrin-RP; 1. DR Pfam; PF02044; Bombesin; 1. DR PROSITE; PS00257; BOMBESIN; 1. PE 1: Evidence at protein level; KW Alternative splicing; Amidation; Cleavage on pair of basic residues; KW Complete proteome; Polymorphism; Reference proteome; Secreted; Signal. FT SIGNAL 1 23 FT PEPTIDE 24 50 Gastrin-releasing peptide. FT /FTId=PRO_0000003035. FT PEPTIDE 41 50 Neuromedin-C. FT /FTId=PRO_0000003036. FT PROPEP 54 148 FT /FTId=PRO_0000003037. FT MOD_RES 50 50 Methionine amide. FT VAR_SEQ 122 148 VGSKGKVGRLSAPGSQREGRNPQLNQQ -> LVDSLLQVLN FT VKEGTPS (in isoform 2). FT /FTId=VSP_000549. FT VAR_SEQ 128 134 Missing (in isoform 3). FT /FTId=VSP_000550. FT VARIANT 4 4 R -> S (in dbSNP:rs1062557). FT /FTId=VAR_027834. SQ SEQUENCE 148 AA; 16213 MW; 6A9ED9E2748255BD CRC64; MRGRELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM GKKSTGESSS VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ PKALGNQQPS WDSEDSSNFK DVGSKGKVGR LSAPGSQREG RNPQLNQQ //