Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P07492 (GRP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gastrin-releasing peptide

Short name=GRP

Cleaved into the following chain:

  1. Neuromedin-C
    Alternative name(s):
    GRP-10
Gene names
Name:GRP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length148 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the bombesin/neuromedin-B/ranatensin family.

Sequence caution

The sequence AAA52612.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P07492-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P07492-2)

The sequence of this isoform differs from the canonical sequence as follows:
     122-148: VGSKGKVGRLSAPGSQREGRNPQLNQQ → LVDSLLQVLNVKEGTPS
Isoform 3 (identifier: P07492-3)

The sequence of this isoform differs from the canonical sequence as follows:
     128-134: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323
Peptide24 – 5027Gastrin-releasing peptide
PRO_0000003035
Peptide41 – 5010Neuromedin-C
PRO_0000003036
Propeptide54 – 14895
PRO_0000003037

Amino acid modifications

Modified residue501Methionine amide Ref.2

Natural variations

Alternative sequence122 – 14827VGSKG…QLNQQ → LVDSLLQVLNVKEGTPS in isoform 2.
VSP_000549
Alternative sequence128 – 1347Missing in isoform 3.
VSP_000550
Natural variant41R → S. Ref.1
Corresponds to variant rs1062557 [ dbSNP | Ensembl ].
VAR_027834

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 5, 2010. Version 2.
Checksum: 6A9ED9E2748255BD

FASTA14816,213
        10         20         30         40         50         60 
MRGRELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM GKKSTGESSS 

        70         80         90        100        110        120 
VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ PKALGNQQPS WDSEDSSNFK 

       130        140 
DVGSKGKVGR LSAPGSQREG RNPQLNQQ 

« Hide

Isoform 2 [UniParc].

Checksum: EDBB3BCB301A2FDD
Show »

FASTA13815,176
Isoform 3 [UniParc].

Checksum: E2564E75ADAFCFCD
Show »

FASTA14115,533

References

« Hide 'large scale' references
[1]"Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides."
Spindel E.R., Zilberberg M.D., Habener J.F., Chin W.W.
Proc. Natl. Acad. Sci. U.S.A. 83:19-23(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 70-148 (ISOFORM 2), VARIANT SER-4.
[2]"Posttranslational processing of endogenous and of baculovirus-expressed human gastrin-releasing peptide precursor."
Lebacq-Verheyden A.-M., Kasprzyk P.G., Raum M.G., van Wyke Coelingh K., Lebacq J.A., Battey J.F.
Mol. Cell. Biol. 8:3129-3135(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], AMIDATION AT MET-50.
[3]"Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs."
Sausville E.A., Lebacq-Verheyden A.-M., Spindel E.R., Cuttitta F., Gazdar A.F., Battey J.F.
J. Biol. Chem. 261:2451-2457(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"DNA sequence and analysis of human chromosome 18."
Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. expand/collapse author list , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lung.
+Additional computationally mapped references.

Web resources

Wikipedia

Gastrin-releasing peptide entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K02054 mRNA. Translation: AAA52613.1.
M12550 mRNA. No translation available.
M12512, M12511 Genomic DNA. Translation: AAA52612.1. Sequence problems.
M12512, M12511 Genomic DNA. Translation: AAA52611.1.
BT006803 mRNA. Translation: AAP35449.1.
AC067859 Genomic DNA. No translation available.
CH471096 Genomic DNA. Translation: EAW63091.1.
BC004488 mRNA. Translation: AAH04488.1.
PIRA26182.
B26182.
RefSeqNP_001012530.1. NM_001012512.1.
NP_001012531.1. NM_001012513.1.
NP_002082.2. NM_002091.3.
UniGeneHs.153444.

3D structure databases

ProteinModelPortalP07492.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000256857.

Chemistry

BindingDBP07492.

Polymorphism databases

DMDM308153451.

Proteomic databases

PaxDbP07492.
PRIDEP07492.

Protocols and materials databases

DNASU2922.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000256857; ENSP00000256857; ENSG00000134443. [P07492-1]
ENST00000420468; ENSP00000389696; ENSG00000134443. [P07492-3]
ENST00000529320; ENSP00000434101; ENSG00000134443. [P07492-2]
GeneID2922.
KEGGhsa:2922.
UCSCuc002lhu.3. human. [P07492-2]
uc002lhv.3. human. [P07492-1]
uc002lhw.3. human. [P07492-3]

Organism-specific databases

CTD2922.
GeneCardsGC18P056861.
HGNCHGNC:4605. GRP.
HPAHPA007314.
MIM137260. gene.
neXtProtNX_P07492.
PharmGKBPA28999.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45311.
HOGENOMHOG000112821.
HOVERGENHBG005912.
InParanoidP07492.
KOK05224.
OMACQAPRGP.
OrthoDBEOG71G9XW.
PhylomeDBP07492.
TreeFamTF336391.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP07492.
CleanExHS_GRP.
GenevestigatorP07492.

Family and domain databases

InterProIPR000874. Bombesin.
IPR015674. Gastrin-RP.
[Graphical view]
PANTHERPTHR16866. PTHR16866. 1 hit.
PfamPF02044. Bombesin. 1 hit.
[Graphical view]
PROSITEPS00257. BOMBESIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGastrin-releasing_peptide.
GenomeRNAi2922.
NextBio11585.
PMAP-CutDBQ53YA0.
PROP07492.
SOURCESearch...

Entry information

Entry nameGRP_HUMAN
AccessionPrimary (citable) accession number: P07492
Secondary accession number(s): P07491 expand/collapse secondary AC list , P81553, Q14454, Q53YA0, Q9BSY7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM