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P07492

- GRP_HUMAN

UniProt

P07492 - GRP_HUMAN

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Protein

Gastrin-releasing peptide

Gene

GRP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear (By similarity).By similarity

GO - Molecular functioni

  1. neuropeptide hormone activity Source: MGI
  2. receptor binding Source: ProtInc

GO - Biological processi

  1. neuropeptide signaling pathway Source: MGI
  2. signal transduction Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_24019. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin-releasing peptide
Short name:
GRP
Cleaved into the following chain:
Alternative name(s):
GRP-10
Gene namesi
Name:GRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:4605. GRP.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28999.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Peptidei24 – 5027Gastrin-releasing peptidePRO_0000003035Add
BLAST
Peptidei41 – 5010Neuromedin-CPRO_0000003036
Propeptidei54 – 14895PRO_0000003037Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei50 – 501Methionine amide1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP07492.
PRIDEiP07492.

Miscellaneous databases

PMAP-CutDBQ53YA0.

Expressioni

Gene expression databases

BgeeiP07492.
CleanExiHS_GRP.
GenevestigatoriP07492.

Organism-specific databases

HPAiHPA007314.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000256857.

Structurei

3D structure databases

ProteinModelPortaliP07492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45311.
GeneTreeiENSGT00390000017865.
HOGENOMiHOG000112821.
HOVERGENiHBG005912.
InParanoidiP07492.
KOiK05224.
OMAiCKYVNID.
OrthoDBiEOG71G9XW.
PhylomeDBiP07492.
TreeFamiTF336391.

Family and domain databases

InterProiIPR000874. Bombesin.
IPR015674. Gastrin-RP.
[Graphical view]
PANTHERiPTHR16866:SF1. PTHR16866:SF1. 1 hit.
PfamiPF02044. Bombesin. 1 hit.
[Graphical view]
PROSITEiPS00257. BOMBESIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P07492-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGRELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM
60 70 80 90 100
GKKSTGESSS VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ
110 120 130 140
PKALGNQQPS WDSEDSSNFK DVGSKGKVGR LSAPGSQREG RNPQLNQQ
Length:148
Mass (Da):16,213
Last modified:October 5, 2010 - v2
Checksum:i6A9ED9E2748255BD
GO
Isoform 2 (identifier: P07492-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-148: VGSKGKVGRLSAPGSQREGRNPQLNQQ → LVDSLLQVLNVKEGTPS

Show »
Length:138
Mass (Da):15,176
Checksum:iEDBB3BCB301A2FDD
GO
Isoform 3 (identifier: P07492-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-134: Missing.

Show »
Length:141
Mass (Da):15,533
Checksum:iE2564E75ADAFCFCD
GO

Sequence cautioni

The sequence AAA52612.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41R → S.1 Publication
Corresponds to variant rs1062557 [ dbSNP | Ensembl ].
VAR_027834

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei122 – 14827VGSKG…QLNQQ → LVDSLLQVLNVKEGTPS in isoform 2. 1 PublicationVSP_000549Add
BLAST
Alternative sequencei128 – 1347Missing in isoform 3. CuratedVSP_000550

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02054 mRNA. Translation: AAA52613.1.
M12550 mRNA. No translation available.
M12512, M12511 Genomic DNA. Translation: AAA52612.1. Sequence problems.
M12512, M12511 Genomic DNA. Translation: AAA52611.1.
BT006803 mRNA. Translation: AAP35449.1.
AC067859 Genomic DNA. No translation available.
CH471096 Genomic DNA. Translation: EAW63091.1.
BC004488 mRNA. Translation: AAH04488.1.
CCDSiCCDS11971.1. [P07492-1]
CCDS45877.1. [P07492-3]
CCDS45878.1. [P07492-2]
PIRiA26182.
B26182.
RefSeqiNP_001012530.1. NM_001012512.1. [P07492-3]
NP_001012531.1. NM_001012513.1. [P07492-2]
NP_002082.2. NM_002091.3. [P07492-1]
UniGeneiHs.153444.

Genome annotation databases

EnsembliENST00000256857; ENSP00000256857; ENSG00000134443. [P07492-1]
ENST00000420468; ENSP00000389696; ENSG00000134443. [P07492-3]
ENST00000529320; ENSP00000434101; ENSG00000134443. [P07492-2]
GeneIDi2922.
KEGGihsa:2922.
UCSCiuc002lhu.3. human. [P07492-2]
uc002lhv.3. human. [P07492-1]
uc002lhw.3. human. [P07492-3]

Polymorphism databases

DMDMi308153451.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Gastrin-releasing peptide entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02054 mRNA. Translation: AAA52613.1 .
M12550 mRNA. No translation available.
M12512 , M12511 Genomic DNA. Translation: AAA52612.1 . Sequence problems.
M12512 , M12511 Genomic DNA. Translation: AAA52611.1 .
BT006803 mRNA. Translation: AAP35449.1 .
AC067859 Genomic DNA. No translation available.
CH471096 Genomic DNA. Translation: EAW63091.1 .
BC004488 mRNA. Translation: AAH04488.1 .
CCDSi CCDS11971.1. [P07492-1 ]
CCDS45877.1. [P07492-3 ]
CCDS45878.1. [P07492-2 ]
PIRi A26182.
B26182.
RefSeqi NP_001012530.1. NM_001012512.1. [P07492-3 ]
NP_001012531.1. NM_001012513.1. [P07492-2 ]
NP_002082.2. NM_002091.3. [P07492-1 ]
UniGenei Hs.153444.

3D structure databases

ProteinModelPortali P07492.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000256857.

Polymorphism databases

DMDMi 308153451.

Proteomic databases

PaxDbi P07492.
PRIDEi P07492.

Protocols and materials databases

DNASUi 2922.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000256857 ; ENSP00000256857 ; ENSG00000134443 . [P07492-1 ]
ENST00000420468 ; ENSP00000389696 ; ENSG00000134443 . [P07492-3 ]
ENST00000529320 ; ENSP00000434101 ; ENSG00000134443 . [P07492-2 ]
GeneIDi 2922.
KEGGi hsa:2922.
UCSCi uc002lhu.3. human. [P07492-2 ]
uc002lhv.3. human. [P07492-1 ]
uc002lhw.3. human. [P07492-3 ]

Organism-specific databases

CTDi 2922.
GeneCardsi GC18P056861.
HGNCi HGNC:4605. GRP.
HPAi HPA007314.
MIMi 137260. gene.
neXtProti NX_P07492.
PharmGKBi PA28999.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45311.
GeneTreei ENSGT00390000017865.
HOGENOMi HOG000112821.
HOVERGENi HBG005912.
InParanoidi P07492.
KOi K05224.
OMAi CKYVNID.
OrthoDBi EOG71G9XW.
PhylomeDBi P07492.
TreeFami TF336391.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_24019. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

Miscellaneous databases

GeneWikii Gastrin-releasing_peptide.
GenomeRNAii 2922.
NextBioi 11585.
PMAP-CutDB Q53YA0.
PROi P07492.
SOURCEi Search...

Gene expression databases

Bgeei P07492.
CleanExi HS_GRP.
Genevestigatori P07492.

Family and domain databases

InterProi IPR000874. Bombesin.
IPR015674. Gastrin-RP.
[Graphical view ]
PANTHERi PTHR16866:SF1. PTHR16866:SF1. 1 hit.
Pfami PF02044. Bombesin. 1 hit.
[Graphical view ]
PROSITEi PS00257. BOMBESIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides."
    Spindel E.R., Zilberberg M.D., Habener J.F., Chin W.W.
    Proc. Natl. Acad. Sci. U.S.A. 83:19-23(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 70-148 (ISOFORM 2), VARIANT SER-4.
  2. "Posttranslational processing of endogenous and of baculovirus-expressed human gastrin-releasing peptide precursor."
    Lebacq-Verheyden A.-M., Kasprzyk P.G., Raum M.G., van Wyke Coelingh K., Lebacq J.A., Battey J.F.
    Mol. Cell. Biol. 8:3129-3135(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], AMIDATION AT MET-50.
  3. "Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs."
    Sausville E.A., Lebacq-Verheyden A.-M., Spindel E.R., Cuttitta F., Gazdar A.F., Battey J.F.
    J. Biol. Chem. 261:2451-2457(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.

Entry informationi

Entry nameiGRP_HUMAN
AccessioniPrimary (citable) accession number: P07492
Secondary accession number(s): P07491
, P81553, Q14454, Q53YA0, Q9BSY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: October 5, 2010
Last modified: November 26, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3