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P07492

- GRP_HUMAN

UniProt

P07492 - GRP_HUMAN

Protein

Gastrin-releasing peptide

Gene

GRP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear By similarity.By similarity

    GO - Molecular functioni

    1. neuropeptide hormone activity Source: MGI
    2. receptor binding Source: ProtInc

    GO - Biological processi

    1. neuropeptide signaling pathway Source: MGI
    2. signal transduction Source: ProtInc

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_24019. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gastrin-releasing peptide
    Short name:
    GRP
    Cleaved into the following chain:
    Alternative name(s):
    GRP-10
    Gene namesi
    Name:GRP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:4605. GRP.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28999.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Add
    BLAST
    Peptidei24 – 5027Gastrin-releasing peptidePRO_0000003035Add
    BLAST
    Peptidei41 – 5010Neuromedin-CPRO_0000003036
    Propeptidei54 – 14895PRO_0000003037Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei50 – 501Methionine amide1 Publication

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues

    Proteomic databases

    PaxDbiP07492.
    PRIDEiP07492.

    Miscellaneous databases

    PMAP-CutDBQ53YA0.

    Expressioni

    Gene expression databases

    BgeeiP07492.
    CleanExiHS_GRP.
    GenevestigatoriP07492.

    Organism-specific databases

    HPAiHPA007314.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000256857.

    Structurei

    3D structure databases

    ProteinModelPortaliP07492.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45311.
    HOGENOMiHOG000112821.
    HOVERGENiHBG005912.
    InParanoidiP07492.
    KOiK05224.
    OMAiCKYVNID.
    OrthoDBiEOG71G9XW.
    PhylomeDBiP07492.
    TreeFamiTF336391.

    Family and domain databases

    InterProiIPR000874. Bombesin.
    IPR015674. Gastrin-RP.
    [Graphical view]
    PANTHERiPTHR16866:SF1. PTHR16866:SF1. 1 hit.
    PfamiPF02044. Bombesin. 1 hit.
    [Graphical view]
    PROSITEiPS00257. BOMBESIN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P07492-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRGRELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM    50
    GKKSTGESSS VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ 100
    PKALGNQQPS WDSEDSSNFK DVGSKGKVGR LSAPGSQREG RNPQLNQQ 148
    Length:148
    Mass (Da):16,213
    Last modified:October 5, 2010 - v2
    Checksum:i6A9ED9E2748255BD
    GO
    Isoform 2 (identifier: P07492-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         122-148: VGSKGKVGRLSAPGSQREGRNPQLNQQ → LVDSLLQVLNVKEGTPS

    Show »
    Length:138
    Mass (Da):15,176
    Checksum:iEDBB3BCB301A2FDD
    GO
    Isoform 3 (identifier: P07492-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         128-134: Missing.

    Show »
    Length:141
    Mass (Da):15,533
    Checksum:iE2564E75ADAFCFCD
    GO

    Sequence cautioni

    The sequence AAA52612.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41R → S.1 Publication
    Corresponds to variant rs1062557 [ dbSNP | Ensembl ].
    VAR_027834

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei122 – 14827VGSKG…QLNQQ → LVDSLLQVLNVKEGTPS in isoform 2. 1 PublicationVSP_000549Add
    BLAST
    Alternative sequencei128 – 1347Missing in isoform 3. CuratedVSP_000550

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02054 mRNA. Translation: AAA52613.1.
    M12550 mRNA. No translation available.
    M12512, M12511 Genomic DNA. Translation: AAA52612.1. Sequence problems.
    M12512, M12511 Genomic DNA. Translation: AAA52611.1.
    BT006803 mRNA. Translation: AAP35449.1.
    AC067859 Genomic DNA. No translation available.
    CH471096 Genomic DNA. Translation: EAW63091.1.
    BC004488 mRNA. Translation: AAH04488.1.
    CCDSiCCDS11971.1. [P07492-1]
    CCDS45877.1. [P07492-3]
    CCDS45878.1. [P07492-2]
    PIRiA26182.
    B26182.
    RefSeqiNP_001012530.1. NM_001012512.1. [P07492-3]
    NP_001012531.1. NM_001012513.1. [P07492-2]
    NP_002082.2. NM_002091.3. [P07492-1]
    UniGeneiHs.153444.

    Genome annotation databases

    EnsembliENST00000256857; ENSP00000256857; ENSG00000134443. [P07492-1]
    ENST00000420468; ENSP00000389696; ENSG00000134443. [P07492-3]
    ENST00000529320; ENSP00000434101; ENSG00000134443. [P07492-2]
    GeneIDi2922.
    KEGGihsa:2922.
    UCSCiuc002lhu.3. human. [P07492-2]
    uc002lhv.3. human. [P07492-1]
    uc002lhw.3. human. [P07492-3]

    Polymorphism databases

    DMDMi308153451.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Gastrin-releasing peptide entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02054 mRNA. Translation: AAA52613.1 .
    M12550 mRNA. No translation available.
    M12512 , M12511 Genomic DNA. Translation: AAA52612.1 . Sequence problems.
    M12512 , M12511 Genomic DNA. Translation: AAA52611.1 .
    BT006803 mRNA. Translation: AAP35449.1 .
    AC067859 Genomic DNA. No translation available.
    CH471096 Genomic DNA. Translation: EAW63091.1 .
    BC004488 mRNA. Translation: AAH04488.1 .
    CCDSi CCDS11971.1. [P07492-1 ]
    CCDS45877.1. [P07492-3 ]
    CCDS45878.1. [P07492-2 ]
    PIRi A26182.
    B26182.
    RefSeqi NP_001012530.1. NM_001012512.1. [P07492-3 ]
    NP_001012531.1. NM_001012513.1. [P07492-2 ]
    NP_002082.2. NM_002091.3. [P07492-1 ]
    UniGenei Hs.153444.

    3D structure databases

    ProteinModelPortali P07492.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000256857.

    Chemistry

    BindingDBi P07492.

    Polymorphism databases

    DMDMi 308153451.

    Proteomic databases

    PaxDbi P07492.
    PRIDEi P07492.

    Protocols and materials databases

    DNASUi 2922.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000256857 ; ENSP00000256857 ; ENSG00000134443 . [P07492-1 ]
    ENST00000420468 ; ENSP00000389696 ; ENSG00000134443 . [P07492-3 ]
    ENST00000529320 ; ENSP00000434101 ; ENSG00000134443 . [P07492-2 ]
    GeneIDi 2922.
    KEGGi hsa:2922.
    UCSCi uc002lhu.3. human. [P07492-2 ]
    uc002lhv.3. human. [P07492-1 ]
    uc002lhw.3. human. [P07492-3 ]

    Organism-specific databases

    CTDi 2922.
    GeneCardsi GC18P056861.
    HGNCi HGNC:4605. GRP.
    HPAi HPA007314.
    MIMi 137260. gene.
    neXtProti NX_P07492.
    PharmGKBi PA28999.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45311.
    HOGENOMi HOG000112821.
    HOVERGENi HBG005912.
    InParanoidi P07492.
    KOi K05224.
    OMAi CKYVNID.
    OrthoDBi EOG71G9XW.
    PhylomeDBi P07492.
    TreeFami TF336391.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_24019. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

    Miscellaneous databases

    GeneWikii Gastrin-releasing_peptide.
    GenomeRNAii 2922.
    NextBioi 11585.
    PMAP-CutDB Q53YA0.
    PROi P07492.
    SOURCEi Search...

    Gene expression databases

    Bgeei P07492.
    CleanExi HS_GRP.
    Genevestigatori P07492.

    Family and domain databases

    InterProi IPR000874. Bombesin.
    IPR015674. Gastrin-RP.
    [Graphical view ]
    PANTHERi PTHR16866:SF1. PTHR16866:SF1. 1 hit.
    Pfami PF02044. Bombesin. 1 hit.
    [Graphical view ]
    PROSITEi PS00257. BOMBESIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides."
      Spindel E.R., Zilberberg M.D., Habener J.F., Chin W.W.
      Proc. Natl. Acad. Sci. U.S.A. 83:19-23(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 70-148 (ISOFORM 2), VARIANT SER-4.
    2. "Posttranslational processing of endogenous and of baculovirus-expressed human gastrin-releasing peptide precursor."
      Lebacq-Verheyden A.-M., Kasprzyk P.G., Raum M.G., van Wyke Coelingh K., Lebacq J.A., Battey J.F.
      Mol. Cell. Biol. 8:3129-3135(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], AMIDATION AT MET-50.
    3. "Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs."
      Sausville E.A., Lebacq-Verheyden A.-M., Spindel E.R., Cuttitta F., Gazdar A.F., Battey J.F.
      J. Biol. Chem. 261:2451-2457(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.

    Entry informationi

    Entry nameiGRP_HUMAN
    AccessioniPrimary (citable) accession number: P07492
    Secondary accession number(s): P07491
    , P81553, Q14454, Q53YA0, Q9BSY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 137 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3