P07492 (GRP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gastrin-releasing peptide
Short name=GRP

Cleaved into the following chain:

1. Neuromedin-C
   Alternative name(s):
   GRP-10

Gene names

Name:

GRP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the bombesin/neuromedin-B/ranatensin family.
Sequence caution	The sequence AAA52612.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
PTM	Amidation Cleavage on pair of basic residues
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Inferred from direct assay PubMed 8756537. Source: MGI
Cellular_component	extracellular space Inferred from direct assay PubMed 8756537. Source: MGI
Molecular_function	neuropeptide hormone activity Inferred from direct assay PubMed 8756537. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P07492-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P07492-2)

The sequence of this isoform differs from the canonical sequence as follows:
     122-148: VGSKGKVGRLSAPGSQREGRNPQLNQQ → LVDSLLQVLNVKEGTPS

Isoform 3 (identifier: P07492-3)

The sequence of this isoform differs from the canonical sequence as follows:
     128-134: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23
	Peptide	24 – 50	27	Gastrin-releasing peptide		PRO_0000003035
	Peptide	41 – 50	10	Neuromedin-C		PRO_0000003036
	Propeptide	54 – 148	95			PRO_0000003037
Amino acid modifications
	Modified residue	50	1	Methionine amide Ref.2
Natural variations
	Alternative sequence	122 – 148	27	VGSKG…QLNQQ → LVDSLLQVLNVKEGTPS in isoform 2.		VSP_000549
	Alternative sequence	128 – 134	7	Missing in isoform 3.		VSP_000550
	Natural variant	4	1	R → S. Ref.1 Corresponds to variant rs1062557 [ dbSNP | Ensembl ].		VAR_027834

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 5, 2010. Version 2. Checksum: 6A9ED9E2748255BD	FASTA	148	16,213
	10 20 30 40 50 60 MRGRELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM GKKSTGESSS 70 80 90 100 110 120 VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ PKALGNQQPS WDSEDSSNFK 130 140 DVGSKGKVGR LSAPGSQREG RNPQLNQQ
	Isoform 2 [UniParc]. Checksum: EDBB3BCB301A2FDD	FASTA	138	15,176
	10 20 30 40 50 60 MRGRELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM GKKSTGESSS 70 80 90 100 110 120 VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ PKALGNQQPS WDSEDSSNFK 130 DLVDSLLQVL NVKEGTPS
	Isoform 3 [UniParc]. Checksum: E2564E75ADAFCFCD	FASTA	141	15,533
	10 20 30 40 50 60 MRGRELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM GKKSTGESSS 70 80 90 100 110 120 VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ PKALGNQQPS WDSEDSSNFK 130 140 DVGSKGKGSQ REGRNPQLNQ Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides." Spindel E.R., Zilberberg M.D., Habener J.F., Chin W.W. Proc. Natl. Acad. Sci. U.S.A. 83:19-23(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 70-148 (ISOFORM 2), VARIANT SER-4.
[2]	"Posttranslational processing of endogenous and of baculovirus-expressed human gastrin-releasing peptide precursor." Lebacq-Verheyden A.-M., Kasprzyk P.G., Raum M.G., van Wyke Coelingh K., Lebacq J.A., Battey J.F. Mol. Cell. Biol. 8:3129-3135(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], AMIDATION AT MET-50.
[3]	"Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs." Sausville E.A., Lebacq-Verheyden A.-M., Spindel E.R., Cuttitta F., Gazdar A.F., Battey J.F. J. Biol. Chem. 261:2451-2457(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung.
+	Additional computationally mapped references.

Web resources

Wikipedia

Gastrin-releasing peptide entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	K02054 mRNA. Translation: AAA52613.1. M12550 mRNA. No translation available. M12512, M12511 Genomic DNA. Translation: AAA52612.1. Sequence problems. M12512, M12511 Genomic DNA. Translation: AAA52611.1. BT006803 mRNA. Translation: AAP35449.1. AC067859 Genomic DNA. No translation available. CH471096 Genomic DNA. Translation: EAW63091.1. BC004488 mRNA. Translation: AAH04488.1.
IPI	IPI00011722. IPI00218671. IPI00218672.
PIR	A26182. B26182.
RefSeq	NP_001012530.1. NM_001012512.1. NP_001012531.1. NM_001012513.1. NP_002082.2. NM_002091.3.
UniGene	Hs.153444.
3D structure databases
ProteinModelPortal	P07492.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000256857.
Polymorphism databases
DMDM	308153451.
Proteomic databases
PaxDb	P07492.
PRIDE	P07492.
Protocols and materials databases
DNASU	2922.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000256857; ENSP00000256857; ENSG00000134443. ENST00000420468; ENSP00000389696; ENSG00000134443. ENST00000529320; ENSP00000434101; ENSG00000134443.
GeneID	2922.
KEGG	hsa:2922.
UCSC	uc002lhu.3. human. uc002lhv.3. human. uc002lhw.3. human.
Organism-specific databases
CTD	2922.
GeneCards	GC18P056861.
HGNC	HGNC:4605. GRP.
HPA	HPA007314.
MIM	137260. gene.
neXtProt	NX_P07492.
PharmGKB	PA28999.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45311.
HOGENOM	HOG000112821.
HOVERGEN	HBG005912.
InParanoid	P07492.
KO	K05224.
OMA	LTKMYPR.
OrthoDB	EOG4F4SCM.
PhylomeDB	P07492.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	P07492.
CleanEx	HS_GRP.
Genevestigator	P07492.
GermOnline	ENSG00000134443. Homo sapiens.
Family and domain databases
InterPro	IPR000874. Bombesin. IPR015674. Gastrin-RP. [Graphical view]
PANTHER	PTHR16866. PTHR16866. 1 hit.
Pfam	PF02044. Bombesin. 1 hit. [Graphical view]
PROSITE	PS00257. BOMBESIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P07492.
GenomeRNAi	2922.
NextBio	11585.
PMAP-CutDB	Q53YA0.
SOURCE	Search...

Entry information

Entry name

GRP_HUMAN

Accession

Primary (citable) accession number: P07492
Secondary accession number(s): P07491 , P81553, Q14454, Q53YA0, Q9BSY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	October 5, 2010
Last modified:	April 3, 2013
This is version 124 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.