Reviewed, UniProtKB/Swiss-Prot P07492 (GRP_HUMAN)

Names and origin

Protein names

Recommended name:
    Gastrin-releasing peptide
      Short name=GRP
Cleaved into the following 1 chains:
    1- Recommended name:
            Neuromedin-C
        Alternative name(s):
            GRP-10

Gene names

Name:

GRP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the bombesin/neuromedin-B/ranatensin family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
PTM	Amidation Cleavage on pair of basic residues
Gene Ontology (GO)
Biological process	signal transduction Non-traceable author statement. Source: ProtInc
Molecular function	receptor binding Non-traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P07492-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P07492-2)

The sequence of this isoform differs from the canonical sequence as follows:
     122-148: VGSKGKVGRLSAPGSQREGRNPQLNQQ → LVDSLLQVLNVKEGTPS

Isoform 3 (identifier: P07492-3)

The sequence of this isoform differs from the canonical sequence as follows:
     128-134: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 23	23
	Peptide	24 – 50	27	Gastrin-releasing peptide
	Peptide	41 – 50	10	Neuromedin-C
	Propeptide	54 – 148	95
Amino acid modifications
	Modified residue	50	1	Methionine amide
Natural variations
	Alternative sequence	122 – 148	27	VGSKG…QLNQQ → LVDSLLQVLNVKEGTPS in isoform 2.
	Alternative sequence	128 – 134	7	Missing in isoform 3.
	Natural variant	4	1	S → R: dbSNP rs1062557.

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 1, 1988. Version 1. Checksum: 2B55B93904825466	FASTA	148	16,144
	10 20 30 40 50 60 MRGSELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM GKKSTGESSS 70 80 90 100 110 120 VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ PKALGNQQPS WDSEDSSNFK 130 140 DVGSKGKVGR LSAPGSQREG RNPQLNQQ
	Isoform 2 [UniParc]. Checksum: ECFE3BCB315F2F28		138	15,107
	10 20 30 40 50 60 MRGSELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM GKKSTGESSS 70 80 90 100 110 120 VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ PKALGNQQPS WDSEDSSNFK 130 DLVDSLLQVL NVKEGTPS
	Isoform 3 [UniParc]. Checksum: 8926D004E8AFCFCC		141	15,464
	10 20 30 40 50 60 MRGSELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM GKKSTGESSS 70 80 90 100 110 120 VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ PKALGNQQPS WDSEDSSNFK 130 140 DVGSKGKGSQ REGRNPQLNQ Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides." Spindel E.R., Zilberberg M.D., Habener J.F., Chin W.W. Proc. Natl. Acad. Sci. U.S.A. 83:19-23(1986) [PubMed: 3001723] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
[2]	"Posttranslational processing of endogenous and of baculovirus-expressed human gastrin-releasing peptide precursor." Lebacq-Verheyden A.-M., Kasprzyk P.G., Raum M.G., van Wyke Coelingh K., Lebacq J.A., Battey J.F. Mol. Cell. Biol. 8:3129-3135(1988) [PubMed: 3211139] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], AMIDATION AT MET-50.
[3]	"Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs." Sausville E.A., Lebacq-Verheyden A.M., Spindel E.R., Cuttitta F., Gazdar A.F., Battey J.F. J. Biol. Chem. 261:2451-2457(1986) [PubMed: 3003116] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-4. Tissue: Lung.
+	Additional computationally mapped references.

Web resources

Wikipedia

Gastrin-releasing peptide entry

Cross-references

Sequence databases
EMBLGenBankDDBJ	K02054 mRNA. Translation: AAA52613.1. M12550 mRNA. No translation available. M12512, M12511 Genomic DNA. Translation: AAA52612.1. Sequence problems. M12512, M12511 Genomic DNA. Translation: AAA52611.1. BC004488 mRNA. Translation: AAH04488.1.
PIR	A26182. B26182.
RefSeq	NP_001012530.1. NP_001012531.1. NP_002082.2.
UniGene	Hs.153444
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000134443. Homo sapiens. [Contig view]
GeneID	2922.
KEGG	hsa:2922.
Organism-specific databases
HGNC	HGNC:4605. GRP.
HPA	HPA007314.
MIM	137260. gene.
PharmGKB	PA24627.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P07492.
HOVERGEN	P07492.
Gene expression databases
ArrayExpress	P07492.
CleanEx	HS_GRP.
GermOnline	ENSG00000134443. Homo sapiens.
Family and domain databases
InterPro	IPR000874. Bombesin. IPR015674. Gastrin-RP. [Graphical view]
PANTHER	PTHR16866. Gastrin-RP. 1 hit.
Pfam	PF02044. Bombesin. 1 hit. [Graphical view]
PROSITE	PS00257. BOMBESIN. 1 hit. [Graphical view]
ProDom	P07492. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

GRP_HUMAN

Accession

Primary (citable) accession number: P07492
Secondary accession number(s): P07491 , P81553, Q14454, Q9BSY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	April 1, 1988
Last modified:	September 2, 2008
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)