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Protein

Gastrin-releasing peptide

Gene

GRP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear (By similarity).By similarity

GO - Molecular functioni

  • neuropeptide hormone activity Source: MGI
  • receptor binding Source: ProtInc

GO - Biological processi

  • neuropeptide signaling pathway Source: MGI
  • signal transduction Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-381771. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
R-HSA-416476. G alpha (q) signalling events.
SIGNORiP07492.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin-releasing peptide
Short name:
GRP
Cleaved into the following chain:
Alternative name(s):
GRP-10
Gene namesi
Name:GRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:4605. GRP.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: Reactome
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28999.

Polymorphism and mutation databases

BioMutaiGRP.
DMDMi308153451.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Peptidei24 – 5027Gastrin-releasing peptidePRO_0000003035Add
BLAST
Peptidei41 – 5010Neuromedin-CPRO_0000003036
Propeptidei54 – 14895PRO_0000003037Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei50 – 501Methionine amide1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP07492.
PeptideAtlasiP07492.
PRIDEiP07492.

PTM databases

iPTMnetiP07492.
PhosphoSiteiP07492.

Miscellaneous databases

PMAP-CutDBQ53YA0.

Expressioni

Gene expression databases

BgeeiENSG00000134443.
CleanExiHS_GRP.
ExpressionAtlasiP07492. baseline and differential.
GenevisibleiP07492. HS.

Organism-specific databases

HPAiHPA007314.

Interactioni

GO - Molecular functioni

  • neuropeptide hormone activity Source: MGI
  • receptor binding Source: ProtInc

Protein-protein interaction databases

STRINGi9606.ENSP00000256857.

Structurei

Secondary structure

1
148
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi45 – 484Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2N0BNMR-A41-50[»]
2N0CNMR-A41-50[»]
2N0DNMR-A41-50[»]
2N0ENMR-A41-50[»]
2N0FNMR-A41-50[»]
2N0GNMR-A41-50[»]
2N0HNMR-A41-50[»]
ProteinModelPortaliP07492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ53. Eukaryota.
ENOG4111D8H. LUCA.
GeneTreeiENSGT00390000017865.
HOGENOMiHOG000112821.
HOVERGENiHBG005912.
InParanoidiP07492.
KOiK05224.
OMAiLTKMYPR.
OrthoDBiEOG091G0VOZ.
PhylomeDBiP07492.
TreeFamiTF336391.

Family and domain databases

InterProiIPR000874. Bombesin.
IPR015674. Gastrin-RP.
[Graphical view]
PANTHERiPTHR16866:SF2. PTHR16866:SF2. 1 hit.
PfamiPF02044. Bombesin. 1 hit.
[Graphical view]
PROSITEiPS00257. BOMBESIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P07492-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGRELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM
60 70 80 90 100
GKKSTGESSS VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ
110 120 130 140
PKALGNQQPS WDSEDSSNFK DVGSKGKVGR LSAPGSQREG RNPQLNQQ
Length:148
Mass (Da):16,213
Last modified:October 5, 2010 - v2
Checksum:i6A9ED9E2748255BD
GO
Isoform 2 (identifier: P07492-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-148: VGSKGKVGRLSAPGSQREGRNPQLNQQ → LVDSLLQVLNVKEGTPS

Show »
Length:138
Mass (Da):15,176
Checksum:iEDBB3BCB301A2FDD
GO
Isoform 3 (identifier: P07492-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-134: Missing.

Show »
Length:141
Mass (Da):15,533
Checksum:iE2564E75ADAFCFCD
GO

Sequence cautioni

The sequence AAA52612 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41R → S.1 Publication
Corresponds to variant rs1062557 [ dbSNP | Ensembl ].
VAR_027834

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei122 – 14827VGSKG…QLNQQ → LVDSLLQVLNVKEGTPS in isoform 2. 1 PublicationVSP_000549Add
BLAST
Alternative sequencei128 – 1347Missing in isoform 3. CuratedVSP_000550

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02054 mRNA. Translation: AAA52613.1.
M12550 mRNA. No translation available.
M12512, M12511 Genomic DNA. Translation: AAA52612.1. Sequence problems.
M12512, M12511 Genomic DNA. Translation: AAA52611.1.
BT006803 mRNA. Translation: AAP35449.1.
AC067859 Genomic DNA. No translation available.
CH471096 Genomic DNA. Translation: EAW63091.1.
BC004488 mRNA. Translation: AAH04488.1.
CCDSiCCDS11971.1. [P07492-1]
CCDS45877.1. [P07492-3]
CCDS45878.1. [P07492-2]
PIRiA26182.
B26182.
RefSeqiNP_001012530.1. NM_001012512.2. [P07492-3]
NP_001012531.1. NM_001012513.2. [P07492-2]
NP_002082.2. NM_002091.4. [P07492-1]
UniGeneiHs.153444.

Genome annotation databases

EnsembliENST00000256857; ENSP00000256857; ENSG00000134443. [P07492-1]
ENST00000420468; ENSP00000389696; ENSG00000134443. [P07492-3]
ENST00000529320; ENSP00000434101; ENSG00000134443. [P07492-2]
GeneIDi2922.
KEGGihsa:2922.
UCSCiuc002lhu.4. human. [P07492-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Gastrin-releasing peptide entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02054 mRNA. Translation: AAA52613.1.
M12550 mRNA. No translation available.
M12512, M12511 Genomic DNA. Translation: AAA52612.1. Sequence problems.
M12512, M12511 Genomic DNA. Translation: AAA52611.1.
BT006803 mRNA. Translation: AAP35449.1.
AC067859 Genomic DNA. No translation available.
CH471096 Genomic DNA. Translation: EAW63091.1.
BC004488 mRNA. Translation: AAH04488.1.
CCDSiCCDS11971.1. [P07492-1]
CCDS45877.1. [P07492-3]
CCDS45878.1. [P07492-2]
PIRiA26182.
B26182.
RefSeqiNP_001012530.1. NM_001012512.2. [P07492-3]
NP_001012531.1. NM_001012513.2. [P07492-2]
NP_002082.2. NM_002091.4. [P07492-1]
UniGeneiHs.153444.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2N0BNMR-A41-50[»]
2N0CNMR-A41-50[»]
2N0DNMR-A41-50[»]
2N0ENMR-A41-50[»]
2N0FNMR-A41-50[»]
2N0GNMR-A41-50[»]
2N0HNMR-A41-50[»]
ProteinModelPortaliP07492.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000256857.

PTM databases

iPTMnetiP07492.
PhosphoSiteiP07492.

Polymorphism and mutation databases

BioMutaiGRP.
DMDMi308153451.

Proteomic databases

PaxDbiP07492.
PeptideAtlasiP07492.
PRIDEiP07492.

Protocols and materials databases

DNASUi2922.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256857; ENSP00000256857; ENSG00000134443. [P07492-1]
ENST00000420468; ENSP00000389696; ENSG00000134443. [P07492-3]
ENST00000529320; ENSP00000434101; ENSG00000134443. [P07492-2]
GeneIDi2922.
KEGGihsa:2922.
UCSCiuc002lhu.4. human. [P07492-1]

Organism-specific databases

CTDi2922.
GeneCardsiGRP.
HGNCiHGNC:4605. GRP.
HPAiHPA007314.
MIMi137260. gene.
neXtProtiNX_P07492.
PharmGKBiPA28999.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ53. Eukaryota.
ENOG4111D8H. LUCA.
GeneTreeiENSGT00390000017865.
HOGENOMiHOG000112821.
HOVERGENiHBG005912.
InParanoidiP07492.
KOiK05224.
OMAiLTKMYPR.
OrthoDBiEOG091G0VOZ.
PhylomeDBiP07492.
TreeFamiTF336391.

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-381771. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
R-HSA-416476. G alpha (q) signalling events.
SIGNORiP07492.

Miscellaneous databases

GeneWikiiGastrin-releasing_peptide.
GenomeRNAii2922.
PMAP-CutDBQ53YA0.
PROiP07492.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134443.
CleanExiHS_GRP.
ExpressionAtlasiP07492. baseline and differential.
GenevisibleiP07492. HS.

Family and domain databases

InterProiIPR000874. Bombesin.
IPR015674. Gastrin-RP.
[Graphical view]
PANTHERiPTHR16866:SF2. PTHR16866:SF2. 1 hit.
PfamiPF02044. Bombesin. 1 hit.
[Graphical view]
PROSITEiPS00257. BOMBESIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRP_HUMAN
AccessioniPrimary (citable) accession number: P07492
Secondary accession number(s): P07491
, P81553, Q14454, Q53YA0, Q9BSY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: October 5, 2010
Last modified: September 7, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.