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Reviewed, UniProtKB/Swiss-Prot P07492 (GRP_HUMAN)

Last modified September 2, 2008. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Gastrin-releasing peptide
      Short name=GRP
Cleaved into the following 1 chains:
    1- Recommended name:
            Neuromedin-C
        Alternative name(s):
            GRP-10
Gene names
Name: GRP
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length148 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the bombesin/neuromedin-B/ranatensin family.

Ontologies

Keywords

   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   PTMAmidation
Cleavage on pair of basic residues

Gene Ontology (GO)

   Biological processsignal transduction

Non-traceable author statement. Source: ProtInc

   Molecular functionreceptor binding

Non-traceable author statement. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P07492-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P07492-2)

The sequence of this isoform differs from the canonical sequence as follows:
     122-148: VGSKGKVGRLSAPGSQREGRNPQLNQQ → LVDSLLQVLNVKEGTPS
Isoform 3 (identifier: P07492-3)

The sequence of this isoform differs from the canonical sequence as follows:
     128-134: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Signal peptide1 – 2323
Peptide24 – 5027Gastrin-releasing peptide
Peptide41 – 5010Neuromedin-C
Propeptide54 – 14895

Amino acid modifications

Modified residue501Methionine amide

Natural variations

Alternative sequence122 – 14827VGSKG…QLNQQ → LVDSLLQVLNVKEGTPS in isoform 2.
Alternative sequence128 – 1347Missing in isoform 3.
Natural variant41S → R: dbSNP rs1062557.

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: 2B55B93904825466

FASTA14816,144
        10         20         30         40         50         60 
MRGSELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM GKKSTGESSS 

        70         80         90        100        110        120 
VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ PKALGNQQPS WDSEDSSNFK 

       130        140 
DVGSKGKVGR LSAPGSQREG RNPQLNQQ 

« Hide

Isoform 2 [UniParc].

Checksum: ECFE3BCB315F2F28
Show »

13815,107
Isoform 3 [UniParc].

Checksum: 8926D004E8AFCFCC
Show »

14115,464

References

« Hide 'large scale' references
[1]"Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides."
Spindel E.R., Zilberberg M.D., Habener J.F., Chin W.W.
Proc. Natl. Acad. Sci. U.S.A. 83:19-23(1986) [PubMed: 3001723] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
[2]"Posttranslational processing of endogenous and of baculovirus-expressed human gastrin-releasing peptide precursor."
Lebacq-Verheyden A.-M., Kasprzyk P.G., Raum M.G., van Wyke Coelingh K., Lebacq J.A., Battey J.F.
Mol. Cell. Biol. 8:3129-3135(1988) [PubMed: 3211139] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], AMIDATION AT MET-50.
[3]"Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs."
Sausville E.A., Lebacq-Verheyden A.M., Spindel E.R., Cuttitta F., Gazdar A.F., Battey J.F.
J. Biol. Chem. 261:2451-2457(1986) [PubMed: 3003116] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-4.
Tissue: Lung.
+Additional computationally mapped references.

Web resources

Wikipedia

Gastrin-releasing peptide entry

Cross-references

Sequence databases

K02054 mRNA. Translation: AAA52613.1.
M12550 mRNA. No translation available.
M12512, M12511 Genomic DNA. Translation: AAA52612.1. Sequence problems.
M12512, M12511 Genomic DNA. Translation: AAA52611.1.
BC004488 mRNA. Translation: AAH04488.1.
PIRA26182.
B26182.
RefSeqNP_001012530.1.
NP_001012531.1.
NP_002082.2.
UniGeneHs.153444

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSG00000134443. Homo sapiens. [Contig view]
GeneID2922.
KEGGhsa:2922.

Organism-specific databases

HGNCHGNC:4605. GRP.
HPAHPA007314.
MIM137260. gene.
PharmGKBPA24627.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMP07492.
HOVERGENP07492.

Gene expression databases

ArrayExpressP07492.
CleanExHS_GRP.
GermOnlineENSG00000134443. Homo sapiens.

Family and domain databases

InterProIPR000874. Bombesin.
IPR015674. Gastrin-RP.
[Graphical view]
PANTHERPTHR16866. Gastrin-RP. 1 hit.
PfamPF02044. Bombesin. 1 hit.
[Graphical view]
PROSITEPS00257. BOMBESIN. 1 hit.
[Graphical view]
ProDomP07492.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

SOURCESearch...
ProtoNetSearch...

Entry information

Entry nameGRP_HUMAN
AccessionPrimary (citable) accession number: P07492
Secondary accession number(s): P07491 expand/collapse secondary AC list , P81553, Q14454, Q9BSY7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: September 2, 2008
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents