Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gastrin-releasing peptide

Gene

GRP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity).By similarity

GO - Molecular functioni

  • neuropeptide hormone activity Source: MGI
  • receptor binding Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-381771. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
R-HSA-416476. G alpha (q) signalling events.
SIGNORiP07492.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin-releasing peptide
Short name:
GRP
Cleaved into the following chain:
Alternative name(s):
GRP-10
Gene namesi
Name:GRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000134443.9.
HGNCiHGNC:4605. GRP.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2922.
OpenTargetsiENSG00000134443.
PharmGKBiPA28999.

Polymorphism and mutation databases

BioMutaiGRP.
DMDMi308153451.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
PeptideiPRO_000000303524 – 50Gastrin-releasing peptideAdd BLAST27
PeptideiPRO_000000303641 – 50Neuromedin-C10
PropeptideiPRO_000000303754 – 148Add BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50Methionine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP07492.
PeptideAtlasiP07492.
PRIDEiP07492.

PTM databases

iPTMnetiP07492.
PhosphoSitePlusiP07492.

Miscellaneous databases

PMAP-CutDBiQ53YA0.

Expressioni

Gene expression databases

BgeeiENSG00000134443.
CleanExiHS_GRP.
ExpressionAtlasiP07492. baseline and differential.
GenevisibleiP07492. HS.

Interactioni

GO - Molecular functioni

  • neuropeptide hormone activity Source: MGI
  • receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi109179. 12 interactors.
IntActiP07492. 1 interactor.
STRINGi9606.ENSP00000256857.

Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi45 – 48Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N0BNMR-A41-50[»]
2N0CNMR-A41-50[»]
2N0DNMR-A41-50[»]
2N0ENMR-A41-50[»]
2N0FNMR-A41-50[»]
2N0GNMR-A41-50[»]
2N0HNMR-A41-50[»]
ProteinModelPortaliP07492.
SMRiP07492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ53. Eukaryota.
ENOG4111D8H. LUCA.
GeneTreeiENSGT00390000017865.
HOGENOMiHOG000112821.
HOVERGENiHBG005912.
InParanoidiP07492.
KOiK05224.
OMAiYIRWEEA.
OrthoDBiEOG091G0VOZ.
PhylomeDBiP07492.
TreeFamiTF336391.

Family and domain databases

InterProiView protein in InterPro
IPR000874. Bombesin.
IPR015674. Gastrin-RP.
PANTHERiPTHR16866:SF4. PTHR16866:SF4. 1 hit.
PfamiView protein in Pfam
PF02044. Bombesin. 1 hit.
PROSITEiView protein in PROSITE
PS00257. BOMBESIN. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P07492-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGRELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM
60 70 80 90 100
GKKSTGESSS VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ
110 120 130 140
PKALGNQQPS WDSEDSSNFK DVGSKGKVGR LSAPGSQREG RNPQLNQQ
Length:148
Mass (Da):16,213
Last modified:October 5, 2010 - v2
Checksum:i6A9ED9E2748255BD
GO
Isoform 2 (identifier: P07492-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-148: VGSKGKVGRLSAPGSQREGRNPQLNQQ → LVDSLLQVLNVKEGTPS

Show »
Length:138
Mass (Da):15,176
Checksum:iEDBB3BCB301A2FDD
GO
Isoform 3 (identifier: P07492-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-134: Missing.

Show »
Length:141
Mass (Da):15,533
Checksum:iE2564E75ADAFCFCD
GO

Sequence cautioni

The sequence AAA52612 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0278344R → S1 PublicationCorresponds to variant dbSNP:rs1062557Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000549122 – 148VGSKG…QLNQQ → LVDSLLQVLNVKEGTPS in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_000550128 – 134Missing in isoform 3. Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02054 mRNA. Translation: AAA52613.1.
M12550 mRNA. No translation available.
M12512, M12511 Genomic DNA. Translation: AAA52612.1. Sequence problems.
M12512, M12511 Genomic DNA. Translation: AAA52611.1.
BT006803 mRNA. Translation: AAP35449.1.
AC067859 Genomic DNA. No translation available.
CH471096 Genomic DNA. Translation: EAW63091.1.
BC004488 mRNA. Translation: AAH04488.1.
CCDSiCCDS11971.1. [P07492-1]
CCDS45877.1. [P07492-3]
CCDS45878.1. [P07492-2]
PIRiA26182.
B26182.
RefSeqiNP_001012530.1. NM_001012512.2. [P07492-3]
NP_001012531.1. NM_001012513.2. [P07492-2]
NP_002082.2. NM_002091.4. [P07492-1]
UniGeneiHs.153444.

Genome annotation databases

EnsembliENST00000256857; ENSP00000256857; ENSG00000134443. [P07492-1]
ENST00000420468; ENSP00000389696; ENSG00000134443. [P07492-3]
ENST00000529320; ENSP00000434101; ENSG00000134443. [P07492-2]
GeneIDi2922.
KEGGihsa:2922.
UCSCiuc002lhu.4. human. [P07492-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGRP_HUMAN
AccessioniPrimary (citable) accession number: P07492
Secondary accession number(s): P07491
, P81553, Q14454, Q53YA0, Q9BSY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: October 5, 2010
Last modified: September 27, 2017
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families