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Protein

Progonadoliberin-1

Gene

Gnrh1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei26 – 261Appears to be essential for biological activity

GO - Molecular functioni

  • gonadotropin hormone-releasing hormone activity Source: RGD

GO - Biological processi

  • aging Source: RGD
  • estrous cycle Source: RGD
  • female pregnancy Source: RGD
  • male sex determination Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of immature T cell proliferation Source: RGD
  • negative regulation of neuron migration Source: Ensembl
  • ovulation Source: RGD
  • ovulation cycle Source: RGD
  • regulation of gene expression Source: Ensembl
  • regulation of ovarian follicle development Source: Ensembl
  • response to corticosteroid Source: RGD
  • response to ethanol Source: Ensembl
  • response to lipopolysaccharide Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to peptide hormone Source: RGD
  • response to potassium ion Source: RGD
  • response to prolactin Source: RGD
  • response to prostaglandin E Source: RGD
  • response to testosterone Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-375281. Hormone ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Progonadoliberin-1
Alternative name(s):
Progonadoliberin I
Cleaved into the following 2 chains:
Alternative name(s):
Gonadoliberin I
Gonadotropin-releasing hormone I
Short name:
GnRH-I
Luliberin I
Luteinizing hormone-releasing hormone I
Short name:
LH-RH I
Alternative name(s):
Prolactin release-inhibiting factor I
Gene namesi
Name:Gnrh1
Synonyms:Gnrh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi2720. Gnrh1.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: RGD
  • cytoplasmic side of rough endoplasmic reticulum membrane Source: RGD
  • dendrite Source: RGD
  • extracellular space Source: RGD
  • Golgi-associated vesicle Source: RGD
  • mitochondrion Source: RGD
  • neuron projection Source: RGD
  • neurosecretory vesicle Source: RGD
  • perikaryon Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 9269Progonadoliberin-1PRO_0000012410Add
BLAST
Peptidei24 – 3310Gonadoliberin-1PRO_0000012411
Peptidei37 – 9256Prolactin release-inhibiting factor 1PRO_0000012412Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
Modified residuei33 – 331Glycine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP07490.

Expressioni

Tissue specificityi

Central nervous system.

Gene expression databases

GenevisibleiP07490. RN.

Interactioni

GO - Molecular functioni

  • gonadotropin hormone-releasing hormone activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018006.

Chemistry

BindingDBiP07490.

Family & Domainsi

Sequence similaritiesi

Belongs to the GnRH family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J18B. Eukaryota.
ENOG410ZDKS. LUCA.
GeneTreeiENSGT00390000008225.
HOGENOMiHOG000033698.
HOVERGENiHBG014746.
InParanoidiP07490.
KOiK05252.
OMAiSGQHWSY.
OrthoDBiEOG7JX36N.
PhylomeDBiP07490.
TreeFamiTF330934.

Family and domain databases

InterProiIPR002012. GnRH.
IPR019792. Gonadoliberin_I.
IPR004079. Gonadoliberin_I_precursor.
[Graphical view]
PANTHERiPTHR10522. PTHR10522. 1 hit.
PfamiPF00446. GnRH. 1 hit.
[Graphical view]
PRINTSiPR01541. GONADOLIBRNI.
PROSITEiPS00473. GNRH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07490-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METIPKLMAA VVLLTVCLEG CSSQHWSYGL RPGGKRNTEH LVDSFQEMGK
60 70 80 90
EEDQMAEPQN FECTVHWPRS PLRDLRGALE RLIEEEAGQK KM
Length:92
Mass (Da):10,500
Last modified:April 1, 1988 - v1
Checksum:i494B5C64DA8A3EB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S50870 mRNA. Translation: AAB24572.1.
M12579 mRNA. Translation: AAA41263.1.
M31670 Genomic DNA. Translation: AAA41264.1.
M15527 mRNA. Translation: AAA42141.1. Sequence problems.
M15529 mRNA. Translation: AAA42139.1.
M15528 mRNA. No translation available.
PIRiA40147. RHRTG.
RefSeqiNP_036899.1. NM_012767.2.
UniGeneiRn.159986.
Rn.59459.

Genome annotation databases

EnsembliENSRNOT00000018006; ENSRNOP00000018006; ENSRNOG00000013441.
GeneIDi25194.
KEGGirno:25194.
UCSCiRGD:2720. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S50870 mRNA. Translation: AAB24572.1.
M12579 mRNA. Translation: AAA41263.1.
M31670 Genomic DNA. Translation: AAA41264.1.
M15527 mRNA. Translation: AAA42141.1. Sequence problems.
M15529 mRNA. Translation: AAA42139.1.
M15528 mRNA. No translation available.
PIRiA40147. RHRTG.
RefSeqiNP_036899.1. NM_012767.2.
UniGeneiRn.159986.
Rn.59459.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018006.

Chemistry

BindingDBiP07490.

Proteomic databases

PaxDbiP07490.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018006; ENSRNOP00000018006; ENSRNOG00000013441.
GeneIDi25194.
KEGGirno:25194.
UCSCiRGD:2720. rat.

Organism-specific databases

CTDi2796.
RGDi2720. Gnrh1.

Phylogenomic databases

eggNOGiENOG410J18B. Eukaryota.
ENOG410ZDKS. LUCA.
GeneTreeiENSGT00390000008225.
HOGENOMiHOG000033698.
HOVERGENiHBG014746.
InParanoidiP07490.
KOiK05252.
OMAiSGQHWSY.
OrthoDBiEOG7JX36N.
PhylomeDBiP07490.
TreeFamiTF330934.

Enzyme and pathway databases

ReactomeiR-RNO-375281. Hormone ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP07490.

Gene expression databases

GenevisibleiP07490. RN.

Family and domain databases

InterProiIPR002012. GnRH.
IPR019792. Gonadoliberin_I.
IPR004079. Gonadoliberin_I_precursor.
[Graphical view]
PANTHERiPTHR10522. PTHR10522. 1 hit.
PfamiPF00446. GnRH. 1 hit.
[Graphical view]
PRINTSiPR01541. GONADOLIBRNI.
PROSITEiPS00473. GNRH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and rat."
    Adelman J.P., Mason A.J., Hayflick J.S., Seeburg P.H.
    Proc. Natl. Acad. Sci. U.S.A. 83:179-183(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The rat gonadotropin-releasing hormone: SH locus: structure and hypothalamic expression."
    Bond C.T., Hayflick J.S., Seeburg P.H., Adelman J.P.
    Mol. Endocrinol. 3:1257-1262(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Thymocytes express a mRNA that is identical to hypothalamic luteinizing hormone-releasing hormone mRNA."
    Maier C.C., Marchetti B., Leboeuf R.D., Blalock J.E.
    Cell. Mol. Neurobiol. 12:447-454(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Thymus.
  4. "Two mammalian genes transcribed from opposite strands of the same DNA locus."
    Adelman J.P., Bond C.T., Douglass J., Herbert E.
    Science 235:1514-1517(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-47.
    Tissue: Heart.

Entry informationi

Entry nameiGON1_RAT
AccessioniPrimary (citable) accession number: P07490
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.