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Protein

Progonadoliberin-1

Gene

Gnrh1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei26Appears to be essential for biological activity1

GO - Molecular functioni

  • gonadotropin hormone-releasing hormone activity Source: RGD

GO - Biological processi

  • aging Source: RGD
  • estrous cycle Source: RGD
  • female pregnancy Source: RGD
  • male sex determination Source: RGD
  • multicellular organism development Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of immature T cell proliferation Source: RGD
  • negative regulation of neuron migration Source: RGD
  • ovulation Source: RGD
  • ovulation cycle Source: RGD
  • regulation of gene expression Source: RGD
  • regulation of ovarian follicle development Source: RGD
  • response to corticosteroid Source: RGD
  • response to ethanol Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to peptide hormone Source: RGD
  • response to potassium ion Source: RGD
  • response to prolactin Source: RGD
  • response to prostaglandin E Source: RGD
  • response to steroid hormone Source: RGD
  • response to testosterone Source: RGD

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-RNO-375281. Hormone ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Progonadoliberin-1
Alternative name(s):
Progonadoliberin I
Cleaved into the following 2 chains:
Alternative name(s):
Gonadoliberin I
Gonadotropin-releasing hormone I
Short name:
GnRH-I
Luliberin I
Luteinizing hormone-releasing hormone I
Short name:
LH-RH I
Alternative name(s):
Prolactin release-inhibiting factor I
Gene namesi
Name:Gnrh1
Synonyms:Gnrh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi2720. Gnrh1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
ChainiPRO_000001241024 – 92Progonadoliberin-1Add BLAST69
PeptideiPRO_000001241124 – 33Gonadoliberin-110
PeptideiPRO_000001241237 – 92Prolactin release-inhibiting factor 1Add BLAST56

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acidBy similarity1
Modified residuei33Glycine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP07490.

Expressioni

Tissue specificityi

Central nervous system.

Gene expression databases

BgeeiENSRNOG00000013441.
GenevisibleiP07490. RN.

Interactioni

GO - Molecular functioni

  • gonadotropin hormone-releasing hormone activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018006.

Chemistry databases

BindingDBiP07490.

Structurei

3D structure databases

SMRiP07490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GnRH family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J18B. Eukaryota.
ENOG410ZDKS. LUCA.
GeneTreeiENSGT00390000008225.
HOGENOMiHOG000033698.
HOVERGENiHBG014746.
InParanoidiP07490.
KOiK05252.
OMAiEPQRFEC.
OrthoDBiEOG091G147V.
PhylomeDBiP07490.
TreeFamiTF330934.

Family and domain databases

InterProiView protein in InterPro
IPR002012. GnRH.
IPR019792. Gonadoliberin_I.
IPR004079. Gonadoliberin_I_precursor.
PANTHERiPTHR10522. PTHR10522. 1 hit.
PTHR10522:SF0. PTHR10522:SF0. 1 hit.
PfamiView protein in Pfam
PF00446. GnRH. 1 hit.
PRINTSiPR01541. GONADOLIBRNI.
PROSITEiView protein in PROSITE
PS00473. GNRH. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07490-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METIPKLMAA VVLLTVCLEG CSSQHWSYGL RPGGKRNTEH LVDSFQEMGK
60 70 80 90
EEDQMAEPQN FECTVHWPRS PLRDLRGALE RLIEEEAGQK KM
Length:92
Mass (Da):10,500
Last modified:April 1, 1988 - v1
Checksum:i494B5C64DA8A3EB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S50870 mRNA. Translation: AAB24572.1.
M12579 mRNA. Translation: AAA41263.1.
M31670 Genomic DNA. Translation: AAA41264.1.
M15527 mRNA. Translation: AAA42141.1. Sequence problems.
M15529 mRNA. Translation: AAA42139.1.
M15528 mRNA. No translation available.
PIRiA40147. RHRTG.
RefSeqiNP_036899.1. NM_012767.2.
UniGeneiRn.159986.
Rn.59459.

Genome annotation databases

EnsembliENSRNOT00000018006; ENSRNOP00000018006; ENSRNOG00000013441.
GeneIDi25194.
KEGGirno:25194.
UCSCiRGD:2720. rat.

Similar proteinsi

Entry informationi

Entry nameiGON1_RAT
AccessioniPrimary (citable) accession number: P07490
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 22, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families