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Protein

Transthyretin

Gene

TTR

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15Thyroid hormoneBy similarity1
Binding sitei54Thyroid hormoneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone, Thyroid hormone
Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Transthyretin
Alternative name(s):
Prealbumin
Gene namesi
Name:TTR
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000506021 – 127TransthyretinAdd BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei424-carboxyglutamateBy similarity1
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Gamma-carboxyglutamic acid, Glycoprotein

Proteomic databases

PRIDEiP07489.

Expressioni

Tissue specificityi

Detected in serum (at protein level).1 Publication

Interactioni

Subunit structurei

Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000014907.

Structurei

3D structure databases

ProteinModelPortaliP07489.
SMRiP07489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni115 – 119Thyroid hormone bindingBy similarity5

Sequence similaritiesi

Belongs to the transthyretin family.Curated

Phylogenomic databases

eggNOGiKOG3006. Eukaryota.
COG2351. LUCA.
HOGENOMiHOG000251776.
HOVERGENiHBG000285.
InParanoidiP07489.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiView protein in InterPro
IPR023418. Thyroxine_BS.
IPR030178. Transthyretin.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
PANTHERiPTHR10395. PTHR10395. 1 hit.
PTHR10395:SF19. PTHR10395:SF19. 1 hit.
PfamiView protein in Pfam
PF00576. Transthyretin. 1 hit.
PRINTSiPR00189. TRNSTHYRETIN.
SMARTiView protein in SMART
SM00095. TR_THY. 1 hit.
SUPFAMiSSF49472. SSF49472. 1 hit.
PROSITEiView protein in PROSITE
PS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P07489-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GPVGTGDSKC PLMVKVLDAV RGSPAVDVSV HVFKKAADET WEPFASGKTS
60 70 80 90 100
KTGELHGLTT SEKFVEGVYK VELDTKSYWK ALGISPFHEY AEVVFTANDS
110 120
GHRSYTIAAL LSPFSYSTTA VVSNPQE
Length:127
Mass (Da):13,657
Last modified:April 1, 1988 - v1
Checksum:iC7FD6A385A9FE62B
GO

Sequence databases

PIRiB22621. VBRB.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTTHY_RABIT
AccessioniPrimary (citable) accession number: P07489
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: May 10, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families