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Protein

Transthyretin

Gene

TTR

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151Thyroid hormoneBy similarity
Binding sitei54 – 541Thyroid hormoneBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone, Thyroid hormone

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transthyretin
Alternative name(s):
Prealbumin
Gene namesi
Name:TTR
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127TransthyretinPRO_0000050602Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 4214-carboxyglutamateBy similarity
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Gamma-carboxyglutamic acid, Glycoprotein

Proteomic databases

PRIDEiP07489.

Expressioni

Tissue specificityi

Detected in serum (at protein level).1 Publication

Interactioni

Subunit structurei

Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000014907.

Structurei

3D structure databases

ProteinModelPortaliP07489.
SMRiP07489. Positions 1-127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni115 – 1195Thyroid hormone bindingBy similarity

Sequence similaritiesi

Belongs to the transthyretin family.Curated

Phylogenomic databases

eggNOGiKOG3006. Eukaryota.
COG2351. LUCA.
HOGENOMiHOG000251776.
HOVERGENiHBG000285.
InParanoidiP07489.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiIPR023418. Thyroxine_BS.
IPR030178. Transthyretin.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view]
PANTHERiPTHR10395:SF12. PTHR10395:SF12. 1 hit.
PfamiPF00576. Transthyretin. 1 hit.
[Graphical view]
PRINTSiPR00189. TRNSTHYRETIN.
SMARTiSM00095. TR_THY. 1 hit.
[Graphical view]
SUPFAMiSSF49472. SSF49472. 1 hit.
PROSITEiPS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07489-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GPVGTGDSKC PLMVKVLDAV RGSPAVDVSV HVFKKAADET WEPFASGKTS
60 70 80 90 100
KTGELHGLTT SEKFVEGVYK VELDTKSYWK ALGISPFHEY AEVVFTANDS
110 120
GHRSYTIAAL LSPFSYSTTA VVSNPQE
Length:127
Mass (Da):13,657
Last modified:April 1, 1988 - v1
Checksum:iC7FD6A385A9FE62B
GO

Sequence databases

PIRiB22621. VBRB.

Cross-referencesi

Sequence databases

PIRiB22621. VBRB.

3D structure databases

ProteinModelPortaliP07489.
SMRiP07489. Positions 1-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000014907.

Proteomic databases

PRIDEiP07489.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3006. Eukaryota.
COG2351. LUCA.
HOGENOMiHOG000251776.
HOVERGENiHBG000285.
InParanoidiP07489.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiIPR023418. Thyroxine_BS.
IPR030178. Transthyretin.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view]
PANTHERiPTHR10395:SF12. PTHR10395:SF12. 1 hit.
PfamiPF00576. Transthyretin. 1 hit.
[Graphical view]
PRINTSiPR00189. TRNSTHYRETIN.
SMARTiSM00095. TR_THY. 1 hit.
[Graphical view]
SUPFAMiSSF49472. SSF49472. 1 hit.
PROSITEiPS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The primary structure of rabbit and rat prealbumin and a comparison with the tertiary structure of human prealbumin."
    Sundelin J., Melhus H., Das S., Eriksson U., Lind P., Traegaardh L., Peterson P.A., Rask L.
    J. Biol. Chem. 260:6481-6487(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiTTHY_RABIT
AccessioniPrimary (citable) accession number: P07489
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 11, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.