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Protein

Fatty acid-binding protein, heart

Gene

Fabp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127Fatty acidBy similarity1
Binding sitei129Fatty acidBy similarity1

GO - Molecular functioni

  • cytoskeletal protein binding Source: Ensembl
  • fatty acid binding Source: RGD
  • icosatetraenoic acid binding Source: RGD
  • long-chain fatty acid transporter activity Source: RGD
  • oleic acid binding Source: Ensembl

GO - Biological processi

  • cholesterol homeostasis Source: Ensembl
  • fatty acid beta-oxidation Source: RGD
  • fatty acid metabolic process Source: RGD
  • long-chain fatty acid import Source: Ensembl
  • long-chain fatty acid transport Source: RGD
  • phospholipid homeostasis Source: Ensembl
  • regulation of fatty acid oxidation Source: Ensembl
  • regulation of phosphatidylcholine biosynthetic process Source: Ensembl
  • response to drug Source: RGD
  • response to fatty acid Source: RGD
  • response to insulin Source: RGD

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-RNO-163560. Triglyceride catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, heart
Alternative name(s):
Fatty acid-binding protein 3
Heart-type fatty acid-binding protein
Short name:
H-FABP
Gene namesi
Name:Fabp3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi69048. Fabp3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000673252 – 133Fatty acid-binding protein, heartAdd BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei8PhosphothreonineCombined sources1
Modified residuei20Phosphotyrosine; by Tyr-kinases1 Publication1
Modified residuei23PhosphoserineCombined sources1
Modified residuei30PhosphothreonineCombined sources1
Modified residuei83PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP07483.
PRIDEiP07483.

PTM databases

iPTMnetiP07483.
PhosphoSitePlusiP07483.

Expressioni

Tissue specificityi

Heart, but also skeletal muscle, kidney, brain and mammary gland.

Gene expression databases

BgeeiENSRNOG00000012879.
GenevisibleiP07483. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017325.

Structurei

3D structure databases

ProteinModelPortaliP07483.
SMRiP07483.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP07483.
KOiK08752.
OMAiTWNLKES.
OrthoDBiEOG091G0QSV.
PhylomeDBiP07483.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiView protein in InterPro
IPR012674. Calycin.
IPR000463. Fatty_acid-bd.
IPR031259. ILBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiView protein in Pfam
PF00061. Lipocalin. 1 hit.
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiView protein in PROSITE
PS00214. FABP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07483-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAFVGTWK LVDSKNFDDY MKSLGVGFAT RQVASMTKPT TIIEKNGDTI
60 70 80 90 100
TIKTHSTFKN TEISFQLGVE FDEVTADDRK VKSVVTLDGG KLVHVQKWDG
110 120 130
QETTLTRELS DGKLILTLTH GNVVSTRTYE KEA
Length:133
Mass (Da):14,775
Last modified:January 23, 2007 - v2
Checksum:i31B49953B232234E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64S → SN AA sequence (PubMed:3162235).Curated1
Sequence conflicti70E → Q AA sequence (PubMed:2775193).Curated1
Sequence conflicti71F → D AA sequence (PubMed:3162235).Curated1
Sequence conflicti116L → LL in AAF19003 (PubMed:10561574).Curated1

Mass spectrometryi

Molecular mass is 14683.9±3 Da from positions 2 - 133. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18034 mRNA. Translation: AAA41137.1.
J02773 mRNA. Translation: AAA41136.1.
AF144090 Genomic DNA. Translation: AAF19003.1.
PIRiA28458. A27452.
RefSeqiNP_077076.1. NM_024162.1.
UniGeneiRn.32566.

Genome annotation databases

EnsembliENSRNOT00000017325; ENSRNOP00000017325; ENSRNOG00000012879.
GeneIDi79131.
KEGGirno:79131.
UCSCiRGD:69048. rat.

Similar proteinsi

Entry informationi

Entry nameiFABPH_RAT
AccessioniPrimary (citable) accession number: P07483
Secondary accession number(s): Q9QY04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families