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Protein

Galanin peptides

Gene

GAL

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.2 Publications

GO - Molecular functioni

GO - Biological processi

  • negative regulation of somatostatin secretion Source: AgBase
  • neuropeptide signaling pathway Source: GO_Central
  • positive regulation of somatostatin secretion Source: AgBase
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB

Keywordsi

Molecular functionHormone, Neuropeptide

Enzyme and pathway databases

ReactomeiR-SSC-375276 Peptide ligand-binding receptors
R-SSC-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin peptides
Cleaved into the following 2 chains:
Gene namesi
Name:GAL
Synonyms:GALN
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000001045420 – 30Add BLAST11
PeptideiPRO_000001045533 – 61GalaninAdd BLAST29
PeptideiPRO_000001045665 – 123Galanin message-associated peptideAdd BLAST59

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61Alanine amide1 Publication1
Modified residuei116PhosphoserineBy similarity1
Modified residuei117PhosphoserineBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP07480
PRIDEiP07480

Expressioni

Gene expression databases

BgeeiENSSSCG00000012883
GenevisibleiP07480 SS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013698

Structurei

3D structure databases

SMRiP07480
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the galanin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZPR Eukaryota
ENOG410YNUP LUCA
HOGENOMiHOG000112690
HOVERGENiHBG005799
InParanoidiP07480
KOiK05244
OMAiWSPAKEK
OrthoDBiEOG091G109K
TreeFamiTF335850

Family and domain databases

InterProiView protein in InterPro
IPR008174 Galanin
IPR008175 Galanin_pre
IPR013068 GMAP
PANTHERiPTHR16839 PTHR16839, 1 hit
PfamiView protein in Pfam
PF01296 Galanin, 1 hit
PF06540 GMAP, 1 hit
PRINTSiPR00273 GALANIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005962 Galanin, 1 hit
PD012185 GMAP, 1 hit
SMARTiView protein in SMART
SM00071 Galanin, 1 hit
PROSITEiView protein in PROSITE
PS00861 GALANIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07480-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGCALLLA SLLLASALSA TLGLGSPVKE KRGWTLNSAG YLLGPHAIDN
60 70 80 90 100
HRSFHDKYGL AGKRELEPED EARPGGFDRL QSEDKAIRTI MEFLAFLHLK
110 120
EAGALGRLPG LPSAASSEDA GQS
Length:123
Mass (Da):13,081
Last modified:April 1, 1988 - v1
Checksum:i486EF70C04F9F24C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13826 mRNA Translation: AAA31097.1
PIRiA23540 RHPGN
RefSeqiNP_999399.1, NM_214234.1
UniGeneiSsc.713

Genome annotation databases

GeneIDi397465
KEGGissc:397465

Similar proteinsi

Entry informationi

Entry nameiGALA_PIG
AccessioniPrimary (citable) accession number: P07480
Secondary accession number(s): Q9TRN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health