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Protein

Galanin peptides

Gene

GAL

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone, Neuropeptide

Enzyme and pathway databases

ReactomeiR-SSC-375276. Peptide ligand-binding receptors.
R-SSC-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin peptides
Cleaved into the following 2 chains:
Gene namesi
Name:GAL
Synonyms:GALN
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000001045420 – 30Add BLAST11
PeptideiPRO_000001045533 – 61GalaninAdd BLAST29
PeptideiPRO_000001045665 – 123Galanin message-associated peptideAdd BLAST59

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61Alanine amide1 Publication1
Modified residuei116PhosphoserineBy similarity1
Modified residuei117PhosphoserineBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP07480.
PRIDEiP07480.

Expressioni

Gene expression databases

GenevisibleiP07480. SS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013698.

Family & Domainsi

Sequence similaritiesi

Belongs to the galanin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZPR. Eukaryota.
ENOG410YNUP. LUCA.
GeneTreeiENSGT00390000009663.
HOGENOMiHOG000112690.
HOVERGENiHBG005799.
InParanoidiP07480.
KOiK05244.
OMAiWSPAKEK.
OrthoDBiEOG091G109K.
TreeFamiTF335850.

Family and domain databases

InterProiIPR008174. Galanin.
IPR008175. Galanin_pre.
IPR013068. GMAP.
[Graphical view]
PfamiPF01296. Galanin. 1 hit.
PF06540. GMAP. 1 hit.
[Graphical view]
PRINTSiPR00273. GALANIN.
ProDomiPD005962. Galanin. 1 hit.
PD012185. GMAP. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00071. Galanin. 1 hit.
[Graphical view]
PROSITEiPS00861. GALANIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07480-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGCALLLA SLLLASALSA TLGLGSPVKE KRGWTLNSAG YLLGPHAIDN
60 70 80 90 100
HRSFHDKYGL AGKRELEPED EARPGGFDRL QSEDKAIRTI MEFLAFLHLK
110 120
EAGALGRLPG LPSAASSEDA GQS
Length:123
Mass (Da):13,081
Last modified:April 1, 1988 - v1
Checksum:i486EF70C04F9F24C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13826 mRNA. Translation: AAA31097.1.
PIRiA23540. RHPGN.
RefSeqiNP_999399.1. NM_214234.1.
UniGeneiSsc.713.

Genome annotation databases

EnsembliENSSSCT00000014084; ENSSSCP00000013698; ENSSSCG00000012883.
GeneIDi397465.
KEGGissc:397465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13826 mRNA. Translation: AAA31097.1.
PIRiA23540. RHPGN.
RefSeqiNP_999399.1. NM_214234.1.
UniGeneiSsc.713.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013698.

Proteomic databases

PaxDbiP07480.
PRIDEiP07480.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000014084; ENSSSCP00000013698; ENSSSCG00000012883.
GeneIDi397465.
KEGGissc:397465.

Organism-specific databases

CTDi51083.

Phylogenomic databases

eggNOGiENOG410IZPR. Eukaryota.
ENOG410YNUP. LUCA.
GeneTreeiENSGT00390000009663.
HOGENOMiHOG000112690.
HOVERGENiHBG005799.
InParanoidiP07480.
KOiK05244.
OMAiWSPAKEK.
OrthoDBiEOG091G109K.
TreeFamiTF335850.

Enzyme and pathway databases

ReactomeiR-SSC-375276. Peptide ligand-binding receptors.
R-SSC-418594. G alpha (i) signalling events.

Gene expression databases

GenevisibleiP07480. SS.

Family and domain databases

InterProiIPR008174. Galanin.
IPR008175. Galanin_pre.
IPR013068. GMAP.
[Graphical view]
PfamiPF01296. Galanin. 1 hit.
PF06540. GMAP. 1 hit.
[Graphical view]
PRINTSiPR00273. GALANIN.
ProDomiPD005962. Galanin. 1 hit.
PD012185. GMAP. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00071. Galanin. 1 hit.
[Graphical view]
PROSITEiPS00861. GALANIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGALA_PIG
AccessioniPrimary (citable) accession number: P07480
Secondary accession number(s): Q9TRN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: October 5, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.