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Protein

Galanin peptides

Gene

GAL

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone, Neuropeptide

Enzyme and pathway databases

ReactomeiR-SSC-375276. Peptide ligand-binding receptors.
R-SSC-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin peptides
Cleaved into the following 2 chains:
Gene namesi
Name:GAL
Synonyms:GALN
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Propeptidei20 – 3011PRO_0000010454Add
BLAST
Peptidei33 – 6129GalaninPRO_0000010455Add
BLAST
Peptidei65 – 12359Galanin message-associated peptidePRO_0000010456Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611Alanine amide1 Publication
Modified residuei117 – 1171PhosphoserineBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP07480.

Expressioni

Gene expression databases

GenevisibleiP07480. SS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013698.

Family & Domainsi

Sequence similaritiesi

Belongs to the galanin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZPR. Eukaryota.
ENOG410YNUP. LUCA.
GeneTreeiENSGT00390000009663.
HOGENOMiHOG000112690.
HOVERGENiHBG005799.
InParanoidiP07480.
KOiK05244.
OMAiWSPAKEK.
OrthoDBiEOG79SF01.
TreeFamiTF335850.

Family and domain databases

InterProiIPR008174. Galanin.
IPR008175. Galanin_pre.
IPR013068. GMAP.
[Graphical view]
PfamiPF01296. Galanin. 1 hit.
PF06540. GMAP. 1 hit.
[Graphical view]
PRINTSiPR00273. GALANIN.
ProDomiPD005962. Galanin. 1 hit.
PD012185. GMAP. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00071. Galanin. 1 hit.
[Graphical view]
PROSITEiPS00861. GALANIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07480-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGCALLLA SLLLASALSA TLGLGSPVKE KRGWTLNSAG YLLGPHAIDN
60 70 80 90 100
HRSFHDKYGL AGKRELEPED EARPGGFDRL QSEDKAIRTI MEFLAFLHLK
110 120
EAGALGRLPG LPSAASSEDA GQS
Length:123
Mass (Da):13,081
Last modified:April 1, 1988 - v1
Checksum:i486EF70C04F9F24C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13826 mRNA. Translation: AAA31097.1.
PIRiA23540. RHPGN.
RefSeqiNP_999399.1. NM_214234.1.
UniGeneiSsc.713.

Genome annotation databases

EnsembliENSSSCT00000014084; ENSSSCP00000013698; ENSSSCG00000012883.
GeneIDi397465.
KEGGissc:397465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13826 mRNA. Translation: AAA31097.1.
PIRiA23540. RHPGN.
RefSeqiNP_999399.1. NM_214234.1.
UniGeneiSsc.713.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013698.

Proteomic databases

PaxDbiP07480.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000014084; ENSSSCP00000013698; ENSSSCG00000012883.
GeneIDi397465.
KEGGissc:397465.

Organism-specific databases

CTDi51083.

Phylogenomic databases

eggNOGiENOG410IZPR. Eukaryota.
ENOG410YNUP. LUCA.
GeneTreeiENSGT00390000009663.
HOGENOMiHOG000112690.
HOVERGENiHBG005799.
InParanoidiP07480.
KOiK05244.
OMAiWSPAKEK.
OrthoDBiEOG79SF01.
TreeFamiTF335850.

Enzyme and pathway databases

ReactomeiR-SSC-375276. Peptide ligand-binding receptors.
R-SSC-418594. G alpha (i) signalling events.

Gene expression databases

GenevisibleiP07480. SS.

Family and domain databases

InterProiIPR008174. Galanin.
IPR008175. Galanin_pre.
IPR013068. GMAP.
[Graphical view]
PfamiPF01296. Galanin. 1 hit.
PF06540. GMAP. 1 hit.
[Graphical view]
PRINTSiPR00273. GALANIN.
ProDomiPD005962. Galanin. 1 hit.
PD012185. GMAP. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00071. Galanin. 1 hit.
[Graphical view]
PROSITEiPS00861. GALANIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Construction of a porcine adrenal medullary cDNA library and nucleotide sequence analysis of two clones encoding a galanin precursor."
    Rokaeus A., Brownstein M.J.
    Proc. Natl. Acad. Sci. U.S.A. 83:6287-6291(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Galanin and galanin extended at the N-terminus with seven and nine amino acids are produced in and secreted from the porcine adrenal medulla in almost equal amounts."
    Bersani M., Thim L., Rasmussen T.N., Holst J.J.
    Endocrinology 129:2693-2698(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Adrenal medulla.
  3. "Galanin - a novel biologically active peptide from porcine intestine."
    Tatemoto K., Rokaeus A., Joernvall H., McDonald T.J., Mutt V.
    FEBS Lett. 164:124-128(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 33-61, FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Intestine.
  4. Cited for: PROTEIN SEQUENCE OF 33-61, FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Gastric corpus.

Entry informationi

Entry nameiGALA_PIG
AccessioniPrimary (citable) accession number: P07480
Secondary accession number(s): Q9TRN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: February 17, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.