Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Involucrin

Gene

IVL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.

GO - Molecular functioni

  • protein binding, bridging Source: UniProtKB
  • structural molecule activity Source: UniProtKB

GO - Biological processi

  • isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine Source: UniProtKB
  • keratinization Source: UniProtKB-KW
  • keratinocyte differentiation Source: UniProtKB
  • peptide cross-linking Source: UniProtKB
  • response to UV-B Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Keratinization

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163207-MONOMER.
ReactomeiR-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Involucrin
Gene namesi
Name:IVL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:6187. IVL.

Subcellular locationi

  • Cytoplasm

  • Note: Constituent of the scaffolding of the cornified envelope.

GO - Cellular componenti

  • cornified envelope Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi3713.
OpenTargetsiENSG00000163207.
PharmGKBiPA29985.

Polymorphism and mutation databases

BioMutaiIVL.
DMDMi254763301.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001597361 – 585InvolucrinAdd BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi79Omega-hydroxyceramide glutamate ester1 Publication1
Lipidationi90Omega-hydroxyceramide glutamate ester1 Publication1
Lipidationi118Omega-hydroxyceramide glutamate ester1 Publication1
Lipidationi133Omega-hydroxyceramide glutamate ester1 Publication1
Cross-linki496Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in other proteins)

Post-translational modificationi

Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.

Keywords - PTMi

Isopeptide bond, Lipoprotein

Proteomic databases

EPDiP07476.
MaxQBiP07476.
PaxDbiP07476.
PeptideAtlasiP07476.
PRIDEiP07476.

PTM databases

iPTMnetiP07476.
PhosphoSitePlusiP07476.

Expressioni

Tissue specificityi

Keratinocytes of epidermis and other stratified squamous epithelia.

Gene expression databases

BgeeiENSG00000163207.
CleanExiHS_IVL.
GenevisibleiP07476. HS.

Organism-specific databases

HPAiCAB002243.
HPA055211.

Interactioni

Subunit structurei

Directly or indirectly cross-linked to cornifelin (CNFN).

Binary interactionsi

WithEntry#Exp.IntActNotes
ACDQ96AP02EBI-11307220,EBI-717666

GO - Molecular functioni

  • protein binding, bridging Source: UniProtKB

Protein-protein interaction databases

BioGridi109917. 34 interactors.
IntActiP07476. 3 interactors.
STRINGi9606.ENSP00000357753.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EU0model-A312-361[»]
DisProtiDP00221.
ProteinModelPortaliP07476.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati153 – 162110
Repeati163 – 172210
Repeati173 – 182310
Repeati183 – 192410
Repeati193 – 202510
Repeati203 – 212610
Repeati213 – 222710
Repeati223 – 232810
Repeati233 – 242910
Repeati243 – 2521010
Repeati253 – 2621110
Repeati263 – 2721210
Repeati273 – 2821310
Repeati283 – 2921410
Repeati293 – 3021510
Repeati303 – 3121610
Repeati313 – 3221710
Repeati323 – 3321810
Repeati333 – 3421910
Repeati343 – 3522010
Repeati353 – 3622110
Repeati363 – 3722210
Repeati373 – 3822310
Repeati383 – 39224; approximate10
Repeati393 – 4022510
Repeati403 – 4122610
Repeati413 – 4222710
Repeati423 – 4322810
Repeati433 – 4422910
Repeati443 – 4523010
Repeati453 – 4623110
Repeati463 – 4723210
Repeati473 – 4823310
Repeati483 – 4923410
Repeati493 – 5023510
Repeati503 – 51236; approximate10
Repeati513 – 5223710
Repeati523 – 5323810
Repeati533 – 54239; approximate10

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni153 – 54239 X 10 AA approximate tandem repeats of [LP]-[EKG]-[LHVYQEK]-[PLSQE]-[EQDV]-[QHEKRGA]-Q-[EMVQLP]-[GKLE]-[QHVNLD]Add BLAST390

Sequence similaritiesi

Belongs to the involucrin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JDU1. Eukaryota.
ENOG410Z08K. LUCA.
GeneTreeiENSGT00730000111623.
HOVERGENiHBG006166.
InParanoidiP07476.
OMAiHLEQQKG.
OrthoDBiEOG091G01GZ.
PhylomeDBiP07476.
TreeFamiTF340025.

Family and domain databases

InterProiIPR019743. Involucrin_CS.
IPR019571. Involucrin_N.
IPR000354. Involucrin_rpt.
[Graphical view]
PfamiPF00904. Involucrin. 40 hits.
PF10583. Involucrin_N. 1 hit.
[Graphical view]
PROSITEiPS00795. INVOLUCRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07476-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQQHTLPVT LSPALSQELL KTVPPPVNTH QEQMKQPTPL PPPCQKVPVE
60 70 80 90 100
LPVEVPSKQE EKHMTAVKGL PEQECEQQQK EPQEQELQQQ HWEQHEEYQK
110 120 130 140 150
AENPEQQLKQ EKTQRDQQLN KQLEEEKKLL DQQLDQELVK RDEQLGMKKE
160 170 180 190 200
QLLELPEQQE GHLKHLEQQE GQLKHPEQQE GQLELPEQQE GQLELPEQQE
210 220 230 240 250
GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPQQQE GQLELSEQQE
260 270 280 290 300
GQLELSEQQE GQLKHLEHQE GQLEVPEEQM GQLKYLEQQE GQLKHLDQQE
310 320 330 340 350
KQPELPEQQM GQLKHLEQQE GQPKHLEQQE GQLEQLEEQE GQLKHLEQQE
360 370 380 390 400
GQLEHLEHQE GQLGLPEQQV LQLKQLEKQQ GQPKHLEEEE GQLKHLVQQE
410 420 430 440 450
GQLKHLVQQE GQLEQQERQV EHLEQQVGQL KHLEEQEGQL KHLEQQQGQL
460 470 480 490 500
EVPEQQVGQP KNLEQEEKQL ELPEQQEGQV KHLEKQEAQL ELPEQQVGQP
510 520 530 540 550
KHLEQQEKHL EHPEQQDGQL KHLEQQEGQL KDLEQQKGQL EQPVFAPAPG
560 570 580
QVQDIQPALP TKGEVLLPVE HQQQKQEVQW PPKHK
Length:585
Mass (Da):68,479
Last modified:July 28, 2009 - v2
Checksum:i775D2AFB90F647E8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029019113T → A.Corresponds to variant rs2229496dbSNPEnsembl.1
Natural variantiVAR_029020166L → P.Corresponds to variant rs11205133dbSNPEnsembl.1
Natural variantiVAR_029021174K → E.Corresponds to variant rs12035307dbSNPEnsembl.1
Natural variantiVAR_058411227E → Q.2 PublicationsCorresponds to variant rs11807064dbSNPEnsembl.1
Natural variantiVAR_058412236P → S.2 PublicationsCorresponds to variant rs17855670dbSNPEnsembl.1
Natural variantiVAR_029022237Q → E.2 PublicationsCorresponds to variant rs7520711dbSNPEnsembl.1
Natural variantiVAR_029023312Q → K.Corresponds to variant rs11205137dbSNPEnsembl.1
Natural variantiVAR_029024480V → L.Corresponds to variant rs7545520dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13903 Genomic DNA. Translation: AAA59186.1.
AL162596 Genomic DNA. Translation: CAI19553.1.
BC046391 mRNA. Translation: AAH46391.1.
CCDSiCCDS1030.1.
PIRiA24168.
RefSeqiNP_005538.2. NM_005547.2.
UniGeneiHs.516439.

Genome annotation databases

EnsembliENST00000368764; ENSP00000357753; ENSG00000163207.
GeneIDi3713.
KEGGihsa:3713.
UCSCiuc001fau.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13903 Genomic DNA. Translation: AAA59186.1.
AL162596 Genomic DNA. Translation: CAI19553.1.
BC046391 mRNA. Translation: AAH46391.1.
CCDSiCCDS1030.1.
PIRiA24168.
RefSeqiNP_005538.2. NM_005547.2.
UniGeneiHs.516439.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EU0model-A312-361[»]
DisProtiDP00221.
ProteinModelPortaliP07476.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109917. 34 interactors.
IntActiP07476. 3 interactors.
STRINGi9606.ENSP00000357753.

PTM databases

iPTMnetiP07476.
PhosphoSitePlusiP07476.

Polymorphism and mutation databases

BioMutaiIVL.
DMDMi254763301.

Proteomic databases

EPDiP07476.
MaxQBiP07476.
PaxDbiP07476.
PeptideAtlasiP07476.
PRIDEiP07476.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368764; ENSP00000357753; ENSG00000163207.
GeneIDi3713.
KEGGihsa:3713.
UCSCiuc001fau.4. human.

Organism-specific databases

CTDi3713.
DisGeNETi3713.
GeneCardsiIVL.
H-InvDBHIX0023860.
HGNCiHGNC:6187. IVL.
HPAiCAB002243.
HPA055211.
MIMi147360. gene.
neXtProtiNX_P07476.
OpenTargetsiENSG00000163207.
PharmGKBiPA29985.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JDU1. Eukaryota.
ENOG410Z08K. LUCA.
GeneTreeiENSGT00730000111623.
HOVERGENiHBG006166.
InParanoidiP07476.
OMAiHLEQQKG.
OrthoDBiEOG091G01GZ.
PhylomeDBiP07476.
TreeFamiTF340025.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163207-MONOMER.
ReactomeiR-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

ChiTaRSiIVL. human.
GeneWikiiInvolucrin.
GenomeRNAii3713.
PROiP07476.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163207.
CleanExiHS_IVL.
GenevisibleiP07476. HS.

Family and domain databases

InterProiIPR019743. Involucrin_CS.
IPR019571. Involucrin_N.
IPR000354. Involucrin_rpt.
[Graphical view]
PfamiPF00904. Involucrin. 40 hits.
PF10583. Involucrin_N. 1 hit.
[Graphical view]
PROSITEiPS00795. INVOLUCRIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINVO_HUMAN
AccessioniPrimary (citable) accession number: P07476
Secondary accession number(s): Q5T7P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: July 28, 2009
Last modified: November 30, 2016
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.