Cytochrome c oxidase subunit 6A2, mitochondrial precursor

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P07471 (CX6A2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 111. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 6A2, mitochondrial

Alternative name(s):
Cytochrome c oxidase polypeptide VIa-heart
Short name=COXVIAH
Cytochrome c oxidase polypeptide VIb

Gene names

Name:	COX6A2
Synonyms:	COX6A

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	97 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular location	Mitochondrion inner membrane.
Tissue specificity	Heart/muscle specific isoform.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 6A family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide Transmembrane Transmembrane helix
PTM	Isopeptide bond Ubl conjugation
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial respiratory chain complex IV Inferred from electronic annotation. Source: InterPro
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 12

Mitochondrion Ref.4

Chain

13 – 97

Cytochrome c oxidase subunit 6A2, mitochondrial

PRO_0000006115

Regions

Topological domain

13 – 24

Mitochondrial matrix

Transmembrane

25 – 49

Helical

Topological domain

50 – 97

Mitochondrial intermembrane

Amino acid modifications

Cross-link

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Secondary structure

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P07471 [UniParc].

Last modified May 1, 1992. Version 2.
Checksum: 59B408A1B9B6AF4F
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FASTA

10,800

        10         20         30         40         50         60 
MALPLKSLSR GLASAAKGDH GGTGARTWRF LTFGLALPSV ALCTLNSWLH SGHRERPAFI 

        70         80         90 
PYHHLRIRTK PFSWGDGNHT FFHNPRVNPL PTGYEKP

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The cDNA for the heart/muscle isoform of bovine cytochrome c oxidase subunit VIa encodes a presequence." Smith E.O., Bement D.M., Grossman L.I., Lomax M.I. Biochim. Biophys. Acta 1089:266-268(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[2]	"Structural organization of the bovine gene for the heart/muscle isoform of cytochrome c oxidase subunit VIa." Smith E.O., Lomax M.I. Biochim. Biophys. Acta 1174:63-71(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Heart ventricle.
[4]	"Studies on cytochrome c oxidase, XII. Isolation and primary structure of polypeptide VIb from bovine heart." Meinecke L., Buse G. Biol. Chem. Hoppe-Seyler 366:687-694(1985) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 13-96. Tissue: Heart.
[5]	"The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A." Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S. Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[6]	"Structure analysis of bovine heart cytochrome c oxidase at 2.8 A resolution." Tomizaki T., Yamashita E., Yamaguchi H., Aoyama H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S. Acta Crystallogr. D 55:31-45(1999) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS). Tissue: Heart.
[7]	"X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution." Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S. Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS). Tissue: Heart.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X56857 mRNA. Translation: CAA40183.1.
S64127 Genomic DNA. Translation: AAB27605.1.
BC103117 mRNA. Translation: AAI03118.1.

IPI

IPI00689990.

PIR

OGBO6. S35702.

RefSeq

NP_776947.1. NM_174522.2.

UniGene

Bt.49093.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1OCC	X-ray	2.80	G/T	13-96	[»]
1OCO	X-ray	2.80	G/T	13-96	[»]
1OCR	X-ray	2.35	G/T	13-96	[»]
1OCZ	X-ray	2.90	G/T	13-96	[»]
1V54	X-ray	1.80	G/T	13-97	[»]
1V55	X-ray	1.90	G/T	13-97	[»]
2DYR	X-ray	1.80	G/T	13-97	[»]
2DYS	X-ray	2.20	G/T	13-97	[»]
2EIJ	X-ray	1.90	G/T	13-97	[»]
2EIK	X-ray	2.10	G/T	13-97	[»]
2EIL	X-ray	2.10	G/T	13-97	[»]
2EIM	X-ray	2.60	G/T	13-97	[»]
2EIN	X-ray	2.70	G/T	13-97	[»]
2OCC	X-ray	2.30	G/T	13-96	[»]
2Y69	X-ray	1.95	G/T	1-97	[»]
2YBB	electron microscopy	19.00	R	13-96	[»]
2ZXW	X-ray	2.50	G/T	13-97	[»]
3ABK	X-ray	2.00	G/T	13-97	[»]
3ABL	X-ray	2.10	G/T	13-97	[»]
3ABM	X-ray	1.95	G/T	13-97	[»]
3AG1	X-ray	2.20	G/T	13-97	[»]
3AG2	X-ray	1.80	G/T	13-97	[»]
3AG3	X-ray	1.80	G/T	13-97	[»]
3AG4	X-ray	2.05	G/T	13-97	[»]
3ASN	X-ray	3.00	G/T	13-97	[»]
3ASO	X-ray	2.30	G/T	13-97	[»]

ProteinModelPortal

P07471.

SMR

P07471. Positions 13-96.

ModBase

Search...

Protein-protein interaction databases

IntAct

P07471. 1 interaction.

STRING

9913.ENSBTAP00000026002.

Proteomic databases

PRIDE

P07471.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSBTAT00000026002; ENSBTAP00000026002; ENSBTAG00000019521.

GeneID

282200.

KEGG

bta:282200.

Organism-specific databases

CTD

1339.

Phylogenomic databases

eggNOG

NOG280964.

GeneTree

ENSGT00390000002756.

HOGENOM

HOG000193965.

HOVERGEN

HBG060482.

InParanoid

P07471.

K02266.

OMA

CTLNSWL.

OrthoDB

EOG4N04GG.

Family and domain databases

Gene3D

4.10.95.10. 1 hit.

InterPro

IPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view]

PANTHER

PTHR11504. PTHR11504. 1 hit.

Pfam

PF02046. COX6A. 1 hit.
[Graphical view]

PIRSF

PIRSF000277. COX6A1. 1 hit.

ProDom

PD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SUPFAM

SSF81411. COX6A. 1 hit.

PROSITE

PS01329. COX6A. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P07471.

NextBio

20806025.

Entry information

Entry name

CX6A2_BOVIN

Accession

Primary (citable) accession number: P07471
Secondary accession number(s): Q3SZ61

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	May 1, 1992
Last modified:	April 3, 2013
This is version 111 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents