Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P07471 (CX6A2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 6A2, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIa-heart
Short name=COXVIAH
Cytochrome c oxidase polypeptide VIb
Gene names
Name:COX6A2
Synonyms:COX6A
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length97 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Subcellular location

Mitochondrion inner membrane.

Tissue specificity

Heart/muscle specific isoform.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 6A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1212Mitochondrion Ref.4
Chain13 – 9785Cytochrome c oxidase subunit 6A2, mitochondrial
PRO_0000006115

Regions

Topological domain13 – 2412Mitochondrial matrix
Transmembrane25 – 4925Helical
Topological domain50 – 9748Mitochondrial intermembrane

Amino acid modifications

Cross-link70Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Secondary structure

............. 97
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P07471 [UniParc].

Last modified May 1, 1992. Version 2.
Checksum: 59B408A1B9B6AF4F

FASTA9710,800
        10         20         30         40         50         60 
MALPLKSLSR GLASAAKGDH GGTGARTWRF LTFGLALPSV ALCTLNSWLH SGHRERPAFI 

        70         80         90 
PYHHLRIRTK PFSWGDGNHT FFHNPRVNPL PTGYEKP 

« Hide

References

« Hide 'large scale' references
[1]"The cDNA for the heart/muscle isoform of bovine cytochrome c oxidase subunit VIa encodes a presequence."
Smith E.O., Bement D.M., Grossman L.I., Lomax M.I.
Biochim. Biophys. Acta 1089:266-268(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[2]"Structural organization of the bovine gene for the heart/muscle isoform of cytochrome c oxidase subunit VIa."
Smith E.O., Lomax M.I.
Biochim. Biophys. Acta 1174:63-71(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Heart ventricle.
[4]"Studies on cytochrome c oxidase, XII. Isolation and primary structure of polypeptide VIb from bovine heart."
Meinecke L., Buse G.
Biol. Chem. Hoppe-Seyler 366:687-694(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 13-96.
Tissue: Heart.
[5]"The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[6]"Structure analysis of bovine heart cytochrome c oxidase at 2.8 A resolution."
Tomizaki T., Yamashita E., Yamaguchi H., Aoyama H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Acta Crystallogr. D 55:31-45(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
Tissue: Heart.
[7]"X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X56857 mRNA. Translation: CAA40183.1.
S64127 Genomic DNA. Translation: AAB27605.1.
BC103117 mRNA. Translation: AAI03118.1.
PIROGBO6. S35702.
RefSeqNP_776947.1. NM_174522.2.
UniGeneBt.49093.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80G/T13-96[»]
1OCOX-ray2.80G/T13-96[»]
1OCRX-ray2.35G/T13-96[»]
1OCZX-ray2.90G/T13-96[»]
1V54X-ray1.80G/T13-97[»]
1V55X-ray1.90G/T13-97[»]
2DYRX-ray1.80G/T13-97[»]
2DYSX-ray2.20G/T13-97[»]
2EIJX-ray1.90G/T13-97[»]
2EIKX-ray2.10G/T13-97[»]
2EILX-ray2.10G/T13-97[»]
2EIMX-ray2.60G/T13-97[»]
2EINX-ray2.70G/T13-97[»]
2OCCX-ray2.30G/T13-96[»]
2Y69X-ray1.95G/T1-97[»]
2YBBelectron microscopy19.00R13-96[»]
2ZXWX-ray2.50G/T13-97[»]
3ABKX-ray2.00G/T13-97[»]
3ABLX-ray2.10G/T13-97[»]
3ABMX-ray1.95G/T13-97[»]
3AG1X-ray2.20G/T13-97[»]
3AG2X-ray1.80G/T13-97[»]
3AG3X-ray1.80G/T13-97[»]
3AG4X-ray2.05G/T13-97[»]
3ASNX-ray3.00G/T13-97[»]
3ASOX-ray2.30G/T13-97[»]
ProteinModelPortalP07471.
SMRP07471. Positions 13-96.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP07471. 1 interaction.
STRING9913.ENSBTAP00000026002.

Proteomic databases

PRIDEP07471.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000026002; ENSBTAP00000026002; ENSBTAG00000019521.
GeneID282200.
KEGGbta:282200.

Organism-specific databases

CTD1339.

Phylogenomic databases

eggNOGNOG280964.
GeneTreeENSGT00390000002756.
HOGENOMHOG000193965.
HOVERGENHBG060482.
InParanoidP07471.
KOK02266.
OMACTLNSWL.
OrthoDBEOG757D0Z.
TreeFamTF105064.

Family and domain databases

Gene3D4.10.95.10. 1 hit.
InterProIPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view]
PANTHERPTHR11504. PTHR11504. 1 hit.
PfamPF02046. COX6A. 1 hit.
[Graphical view]
PIRSFPIRSF000277. COX6A1. 1 hit.
ProDomPD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF81411. SSF81411. 1 hit.
PROSITEPS01329. COX6A. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP07471.
NextBio20806025.

Entry information

Entry nameCX6A2_BOVIN
AccessionPrimary (citable) accession number: P07471
Secondary accession number(s): Q3SZ61
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: May 1, 1992
Last modified: April 16, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references