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P07471

- CX6A2_BOVIN

UniProt

P07471 - CX6A2_BOVIN

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Protein

Cytochrome c oxidase subunit 6A2, mitochondrial

Gene
COX6A2, COX6A
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6A2, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIa-heart
Short name:
COXVIAH
Cytochrome c oxidase polypeptide VIb
Gene namesi
Name:COX6A2
Synonyms:COX6A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 25

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini13 – 2412Mitochondrial matrixAdd
BLAST
Transmembranei25 – 4925HelicalAdd
BLAST
Topological domaini50 – 9748Mitochondrial intermembraneAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain complex IV Source: InterPro
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1212Mitochondrion1 PublicationAdd
BLAST
Chaini13 – 9785Cytochrome c oxidase subunit 6A2, mitochondrialPRO_0000006115Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki70 – 70Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PRIDEiP07471.

Expressioni

Tissue specificityi

Heart/muscle specific isoform.

Interactioni

Protein-protein interaction databases

IntActiP07471. 1 interaction.
STRINGi9913.ENSBTAP00000026002.

Structurei

Secondary structure

1
97
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi21 – 233
Helixi25 – 3410
Helixi36 – 4712
Beta strandi77 – 793
Turni85 – 873
Beta strandi91 – 933

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80G/T13-96[»]
1OCOX-ray2.80G/T13-96[»]
1OCRX-ray2.35G/T13-96[»]
1OCZX-ray2.90G/T13-96[»]
1V54X-ray1.80G/T13-97[»]
1V55X-ray1.90G/T13-97[»]
2DYRX-ray1.80G/T13-97[»]
2DYSX-ray2.20G/T13-97[»]
2EIJX-ray1.90G/T13-97[»]
2EIKX-ray2.10G/T13-97[»]
2EILX-ray2.10G/T13-97[»]
2EIMX-ray2.60G/T13-97[»]
2EINX-ray2.70G/T13-97[»]
2OCCX-ray2.30G/T13-96[»]
2Y69X-ray1.95G/T1-97[»]
2YBBelectron microscopy19.00R13-96[»]
2ZXWX-ray2.50G/T13-97[»]
3ABKX-ray2.00G/T13-97[»]
3ABLX-ray2.10G/T13-97[»]
3ABMX-ray1.95G/T13-97[»]
3AG1X-ray2.20G/T13-97[»]
3AG2X-ray1.80G/T13-97[»]
3AG3X-ray1.80G/T13-97[»]
3AG4X-ray2.05G/T13-97[»]
3ASNX-ray3.00G/T13-97[»]
3ASOX-ray2.30G/T13-97[»]
3WG7X-ray1.90G/T13-97[»]
ProteinModelPortaliP07471.
SMRiP07471. Positions 13-96.

Miscellaneous databases

EvolutionaryTraceiP07471.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280964.
GeneTreeiENSGT00390000002756.
HOGENOMiHOG000193965.
HOVERGENiHBG060482.
InParanoidiP07471.
KOiK02266.
OMAiIRTKPFS.
OrthoDBiEOG757D0Z.
TreeFamiTF105064.

Family and domain databases

Gene3Di4.10.95.10. 1 hit.
InterProiIPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view]
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiPF02046. COX6A. 1 hit.
[Graphical view]
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiPD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiPS01329. COX6A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07471-1 [UniParc]FASTAAdd to Basket

« Hide

MALPLKSLSR GLASAAKGDH GGTGARTWRF LTFGLALPSV ALCTLNSWLH   50
SGHRERPAFI PYHHLRIRTK PFSWGDGNHT FFHNPRVNPL PTGYEKP 97
Length:97
Mass (Da):10,800
Last modified:May 1, 1992 - v2
Checksum:i59B408A1B9B6AF4F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56857 mRNA. Translation: CAA40183.1.
S64127 Genomic DNA. Translation: AAB27605.1.
BC103117 mRNA. Translation: AAI03118.1.
PIRiS35702. OGBO6.
RefSeqiNP_776947.1. NM_174522.2.
UniGeneiBt.49093.

Genome annotation databases

EnsembliENSBTAT00000026002; ENSBTAP00000026002; ENSBTAG00000019521.
GeneIDi282200.
KEGGibta:282200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56857 mRNA. Translation: CAA40183.1 .
S64127 Genomic DNA. Translation: AAB27605.1 .
BC103117 mRNA. Translation: AAI03118.1 .
PIRi S35702. OGBO6.
RefSeqi NP_776947.1. NM_174522.2.
UniGenei Bt.49093.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OCC X-ray 2.80 G/T 13-96 [» ]
1OCO X-ray 2.80 G/T 13-96 [» ]
1OCR X-ray 2.35 G/T 13-96 [» ]
1OCZ X-ray 2.90 G/T 13-96 [» ]
1V54 X-ray 1.80 G/T 13-97 [» ]
1V55 X-ray 1.90 G/T 13-97 [» ]
2DYR X-ray 1.80 G/T 13-97 [» ]
2DYS X-ray 2.20 G/T 13-97 [» ]
2EIJ X-ray 1.90 G/T 13-97 [» ]
2EIK X-ray 2.10 G/T 13-97 [» ]
2EIL X-ray 2.10 G/T 13-97 [» ]
2EIM X-ray 2.60 G/T 13-97 [» ]
2EIN X-ray 2.70 G/T 13-97 [» ]
2OCC X-ray 2.30 G/T 13-96 [» ]
2Y69 X-ray 1.95 G/T 1-97 [» ]
2YBB electron microscopy 19.00 R 13-96 [» ]
2ZXW X-ray 2.50 G/T 13-97 [» ]
3ABK X-ray 2.00 G/T 13-97 [» ]
3ABL X-ray 2.10 G/T 13-97 [» ]
3ABM X-ray 1.95 G/T 13-97 [» ]
3AG1 X-ray 2.20 G/T 13-97 [» ]
3AG2 X-ray 1.80 G/T 13-97 [» ]
3AG3 X-ray 1.80 G/T 13-97 [» ]
3AG4 X-ray 2.05 G/T 13-97 [» ]
3ASN X-ray 3.00 G/T 13-97 [» ]
3ASO X-ray 2.30 G/T 13-97 [» ]
3WG7 X-ray 1.90 G/T 13-97 [» ]
ProteinModelPortali P07471.
SMRi P07471. Positions 13-96.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P07471. 1 interaction.
STRINGi 9913.ENSBTAP00000026002.

Proteomic databases

PRIDEi P07471.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000026002 ; ENSBTAP00000026002 ; ENSBTAG00000019521 .
GeneIDi 282200.
KEGGi bta:282200.

Organism-specific databases

CTDi 1339.

Phylogenomic databases

eggNOGi NOG280964.
GeneTreei ENSGT00390000002756.
HOGENOMi HOG000193965.
HOVERGENi HBG060482.
InParanoidi P07471.
KOi K02266.
OMAi IRTKPFS.
OrthoDBi EOG757D0Z.
TreeFami TF105064.

Miscellaneous databases

EvolutionaryTracei P07471.
NextBioi 20806025.

Family and domain databases

Gene3Di 4.10.95.10. 1 hit.
InterProi IPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view ]
PANTHERi PTHR11504. PTHR11504. 1 hit.
Pfami PF02046. COX6A. 1 hit.
[Graphical view ]
PIRSFi PIRSF000277. COX6A1. 1 hit.
ProDomi PD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF81411. SSF81411. 1 hit.
PROSITEi PS01329. COX6A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The cDNA for the heart/muscle isoform of bovine cytochrome c oxidase subunit VIa encodes a presequence."
    Smith E.O., Bement D.M., Grossman L.I., Lomax M.I.
    Biochim. Biophys. Acta 1089:266-268(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "Structural organization of the bovine gene for the heart/muscle isoform of cytochrome c oxidase subunit VIa."
    Smith E.O., Lomax M.I.
    Biochim. Biophys. Acta 1174:63-71(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.
  4. "Studies on cytochrome c oxidase, XII. Isolation and primary structure of polypeptide VIb from bovine heart."
    Meinecke L., Buse G.
    Biol. Chem. Hoppe-Seyler 366:687-694(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 13-96.
    Tissue: Heart.
  5. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
    Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
    Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
  6. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    Tissue: Heart.
  7. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
    Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
    Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
    Tissue: Heart.

Entry informationi

Entry nameiCX6A2_BOVIN
AccessioniPrimary (citable) accession number: P07471
Secondary accession number(s): Q3SZ61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: May 1, 1992
Last modified: July 9, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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