Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P07471

- CX6A2_BOVIN

UniProt

P07471 - CX6A2_BOVIN

Protein

Cytochrome c oxidase subunit 6A2, mitochondrial

Gene

COX6A2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 6A2, mitochondrial
    Alternative name(s):
    Cytochrome c oxidase polypeptide VIa-heart
    Short name:
    COXVIAH
    Cytochrome c oxidase polypeptide VIb
    Gene namesi
    Name:COX6A2
    Synonyms:COX6A
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 25

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial respiratory chain complex IV Source: InterPro
    3. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1212Mitochondrion1 PublicationAdd
    BLAST
    Chaini13 – 9785Cytochrome c oxidase subunit 6A2, mitochondrialPRO_0000006115Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki70 – 70Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    PRIDEiP07471.

    Expressioni

    Tissue specificityi

    Heart/muscle specific isoform.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-39018N.
    IntActiP07471. 1 interaction.
    STRINGi9913.ENSBTAP00000026002.

    Structurei

    Secondary structure

    1
    97
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi21 – 233
    Helixi25 – 3410
    Helixi36 – 4712
    Beta strandi77 – 793
    Turni85 – 873
    Beta strandi91 – 933

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OCCX-ray2.80G/T13-96[»]
    1OCOX-ray2.80G/T13-96[»]
    1OCRX-ray2.35G/T13-96[»]
    1OCZX-ray2.90G/T13-96[»]
    1V54X-ray1.80G/T13-97[»]
    1V55X-ray1.90G/T13-97[»]
    2DYRX-ray1.80G/T13-97[»]
    2DYSX-ray2.20G/T13-97[»]
    2EIJX-ray1.90G/T13-97[»]
    2EIKX-ray2.10G/T13-97[»]
    2EILX-ray2.10G/T13-97[»]
    2EIMX-ray2.60G/T13-97[»]
    2EINX-ray2.70G/T13-97[»]
    2OCCX-ray2.30G/T13-96[»]
    2Y69X-ray1.95G/T1-97[»]
    2YBBelectron microscopy19.00R13-96[»]
    2ZXWX-ray2.50G/T13-97[»]
    3ABKX-ray2.00G/T13-97[»]
    3ABLX-ray2.10G/T13-97[»]
    3ABMX-ray1.95G/T13-97[»]
    3AG1X-ray2.20G/T13-97[»]
    3AG2X-ray1.80G/T13-97[»]
    3AG3X-ray1.80G/T13-97[»]
    3AG4X-ray2.05G/T13-97[»]
    3ASNX-ray3.00G/T13-97[»]
    3ASOX-ray2.30G/T13-97[»]
    3WG7X-ray1.90G/T13-97[»]
    ProteinModelPortaliP07471.
    SMRiP07471. Positions 13-96.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP07471.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini13 – 2412Mitochondrial matrixAdd
    BLAST
    Topological domaini50 – 9748Mitochondrial intermembraneAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4925HelicalAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG280964.
    GeneTreeiENSGT00390000002756.
    HOGENOMiHOG000193965.
    HOVERGENiHBG060482.
    InParanoidiP07471.
    KOiK02266.
    OMAiIRTKPFS.
    OrthoDBiEOG757D0Z.
    TreeFamiTF105064.

    Family and domain databases

    Gene3Di4.10.95.10. 1 hit.
    InterProiIPR001349. Cyt_c_oxidase_su6a.
    IPR018507. Cyt_c_oxidase_su6a_CS.
    [Graphical view]
    PANTHERiPTHR11504. PTHR11504. 1 hit.
    PfamiPF02046. COX6A. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000277. COX6A1. 1 hit.
    ProDomiPD006036. Cyt_c_oxidase_su6a. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF81411. SSF81411. 1 hit.
    PROSITEiPS01329. COX6A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07471-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALPLKSLSR GLASAAKGDH GGTGARTWRF LTFGLALPSV ALCTLNSWLH   50
    SGHRERPAFI PYHHLRIRTK PFSWGDGNHT FFHNPRVNPL PTGYEKP 97
    Length:97
    Mass (Da):10,800
    Last modified:May 1, 1992 - v2
    Checksum:i59B408A1B9B6AF4F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56857 mRNA. Translation: CAA40183.1.
    S64127 Genomic DNA. Translation: AAB27605.1.
    BC103117 mRNA. Translation: AAI03118.1.
    PIRiS35702. OGBO6.
    RefSeqiNP_776947.1. NM_174522.2.
    UniGeneiBt.49093.

    Genome annotation databases

    EnsembliENSBTAT00000026002; ENSBTAP00000026002; ENSBTAG00000019521.
    GeneIDi282200.
    KEGGibta:282200.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56857 mRNA. Translation: CAA40183.1 .
    S64127 Genomic DNA. Translation: AAB27605.1 .
    BC103117 mRNA. Translation: AAI03118.1 .
    PIRi S35702. OGBO6.
    RefSeqi NP_776947.1. NM_174522.2.
    UniGenei Bt.49093.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OCC X-ray 2.80 G/T 13-96 [» ]
    1OCO X-ray 2.80 G/T 13-96 [» ]
    1OCR X-ray 2.35 G/T 13-96 [» ]
    1OCZ X-ray 2.90 G/T 13-96 [» ]
    1V54 X-ray 1.80 G/T 13-97 [» ]
    1V55 X-ray 1.90 G/T 13-97 [» ]
    2DYR X-ray 1.80 G/T 13-97 [» ]
    2DYS X-ray 2.20 G/T 13-97 [» ]
    2EIJ X-ray 1.90 G/T 13-97 [» ]
    2EIK X-ray 2.10 G/T 13-97 [» ]
    2EIL X-ray 2.10 G/T 13-97 [» ]
    2EIM X-ray 2.60 G/T 13-97 [» ]
    2EIN X-ray 2.70 G/T 13-97 [» ]
    2OCC X-ray 2.30 G/T 13-96 [» ]
    2Y69 X-ray 1.95 G/T 1-97 [» ]
    2YBB electron microscopy 19.00 R 13-96 [» ]
    2ZXW X-ray 2.50 G/T 13-97 [» ]
    3ABK X-ray 2.00 G/T 13-97 [» ]
    3ABL X-ray 2.10 G/T 13-97 [» ]
    3ABM X-ray 1.95 G/T 13-97 [» ]
    3AG1 X-ray 2.20 G/T 13-97 [» ]
    3AG2 X-ray 1.80 G/T 13-97 [» ]
    3AG3 X-ray 1.80 G/T 13-97 [» ]
    3AG4 X-ray 2.05 G/T 13-97 [» ]
    3ASN X-ray 3.00 G/T 13-97 [» ]
    3ASO X-ray 2.30 G/T 13-97 [» ]
    3WG7 X-ray 1.90 G/T 13-97 [» ]
    ProteinModelPortali P07471.
    SMRi P07471. Positions 13-96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-39018N.
    IntActi P07471. 1 interaction.
    STRINGi 9913.ENSBTAP00000026002.

    Proteomic databases

    PRIDEi P07471.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000026002 ; ENSBTAP00000026002 ; ENSBTAG00000019521 .
    GeneIDi 282200.
    KEGGi bta:282200.

    Organism-specific databases

    CTDi 1339.

    Phylogenomic databases

    eggNOGi NOG280964.
    GeneTreei ENSGT00390000002756.
    HOGENOMi HOG000193965.
    HOVERGENi HBG060482.
    InParanoidi P07471.
    KOi K02266.
    OMAi IRTKPFS.
    OrthoDBi EOG757D0Z.
    TreeFami TF105064.

    Miscellaneous databases

    EvolutionaryTracei P07471.
    NextBioi 20806025.

    Family and domain databases

    Gene3Di 4.10.95.10. 1 hit.
    InterProi IPR001349. Cyt_c_oxidase_su6a.
    IPR018507. Cyt_c_oxidase_su6a_CS.
    [Graphical view ]
    PANTHERi PTHR11504. PTHR11504. 1 hit.
    Pfami PF02046. COX6A. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000277. COX6A1. 1 hit.
    ProDomi PD006036. Cyt_c_oxidase_su6a. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF81411. SSF81411. 1 hit.
    PROSITEi PS01329. COX6A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cDNA for the heart/muscle isoform of bovine cytochrome c oxidase subunit VIa encodes a presequence."
      Smith E.O., Bement D.M., Grossman L.I., Lomax M.I.
      Biochim. Biophys. Acta 1089:266-268(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. "Structural organization of the bovine gene for the heart/muscle isoform of cytochrome c oxidase subunit VIa."
      Smith E.O., Lomax M.I.
      Biochim. Biophys. Acta 1174:63-71(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Heart ventricle.
    4. "Studies on cytochrome c oxidase, XII. Isolation and primary structure of polypeptide VIb from bovine heart."
      Meinecke L., Buse G.
      Biol. Chem. Hoppe-Seyler 366:687-694(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 13-96.
      Tissue: Heart.
    5. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
      Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
      Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    6. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
      Tissue: Heart.
    7. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
      Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
      Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
      Tissue: Heart.

    Entry informationi

    Entry nameiCX6A2_BOVIN
    AccessioniPrimary (citable) accession number: P07471
    Secondary accession number(s): Q3SZ61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3