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Protein

Cytochrome c oxidase subunit 6A2, mitochondrial

Gene

COX6A2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6A2, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIa-heart
Short name:
COXVIAH
Cytochrome c oxidase polypeptide VIb
Gene namesi
Name:COX6A2
Synonyms:COX6A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 25

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini13 – 2412Mitochondrial matrixAdd
BLAST
Transmembranei25 – 4925HelicalAdd
BLAST
Topological domaini50 – 9748Mitochondrial intermembraneAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain complex IV Source: InterPro
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1212Mitochondrion1 PublicationAdd
BLAST
Chaini13 – 9785Cytochrome c oxidase subunit 6A2, mitochondrialPRO_0000006115Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki70 – 70Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PRIDEiP07471.

Expressioni

Tissue specificityi

Heart/muscle specific isoform.

Interactioni

Protein-protein interaction databases

DIPiDIP-39018N.
IntActiP07471. 1 interaction.
STRINGi9913.ENSBTAP00000026002.

Structurei

Secondary structure

1
97
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi21 – 233Combined sources
Helixi25 – 3410Combined sources
Helixi36 – 4712Combined sources
Beta strandi77 – 793Combined sources
Turni85 – 873Combined sources
Beta strandi91 – 933Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80G/T13-96[»]
1OCOX-ray2.80G/T13-96[»]
1OCRX-ray2.35G/T13-96[»]
1OCZX-ray2.90G/T13-96[»]
1V54X-ray1.80G/T13-97[»]
1V55X-ray1.90G/T13-97[»]
2DYRX-ray1.80G/T13-97[»]
2DYSX-ray2.20G/T13-97[»]
2EIJX-ray1.90G/T13-97[»]
2EIKX-ray2.10G/T13-97[»]
2EILX-ray2.10G/T13-97[»]
2EIMX-ray2.60G/T13-97[»]
2EINX-ray2.70G/T13-97[»]
2OCCX-ray2.30G/T13-96[»]
2Y69X-ray1.95G/T1-97[»]
2YBBelectron microscopy19.00R13-96[»]
2ZXWX-ray2.50G/T13-97[»]
3ABKX-ray2.00G/T13-97[»]
3ABLX-ray2.10G/T13-97[»]
3ABMX-ray1.95G/T13-97[»]
3AG1X-ray2.20G/T13-97[»]
3AG2X-ray1.80G/T13-97[»]
3AG3X-ray1.80G/T13-97[»]
3AG4X-ray2.05G/T13-97[»]
3ASNX-ray3.00G/T13-97[»]
3ASOX-ray2.30G/T13-97[»]
3WG7X-ray1.90G/T13-97[»]
SMRiP07471. Positions 13-96.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07471.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280964.
GeneTreeiENSGT00390000002756.
HOGENOMiHOG000193965.
HOVERGENiHBG060482.
InParanoidiP07471.
KOiK02266.
OMAiCTLNSWL.
OrthoDBiEOG757D0Z.
TreeFamiTF105064.

Family and domain databases

Gene3Di4.10.95.10. 1 hit.
InterProiIPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view]
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiPF02046. COX6A. 1 hit.
[Graphical view]
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiPD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiPS01329. COX6A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07471-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPLKSLSR GLASAAKGDH GGTGARTWRF LTFGLALPSV ALCTLNSWLH
60 70 80 90
SGHRERPAFI PYHHLRIRTK PFSWGDGNHT FFHNPRVNPL PTGYEKP
Length:97
Mass (Da):10,800
Last modified:May 1, 1992 - v2
Checksum:i59B408A1B9B6AF4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56857 mRNA. Translation: CAA40183.1.
S64127 Genomic DNA. Translation: AAB27605.1.
BC103117 mRNA. Translation: AAI03118.1.
PIRiS35702. OGBO6.
RefSeqiNP_776947.1. NM_174522.3.
UniGeneiBt.49093.

Genome annotation databases

EnsembliENSBTAT00000026002; ENSBTAP00000026002; ENSBTAG00000019521.
GeneIDi282200.
KEGGibta:282200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56857 mRNA. Translation: CAA40183.1.
S64127 Genomic DNA. Translation: AAB27605.1.
BC103117 mRNA. Translation: AAI03118.1.
PIRiS35702. OGBO6.
RefSeqiNP_776947.1. NM_174522.3.
UniGeneiBt.49093.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80G/T13-96[»]
1OCOX-ray2.80G/T13-96[»]
1OCRX-ray2.35G/T13-96[»]
1OCZX-ray2.90G/T13-96[»]
1V54X-ray1.80G/T13-97[»]
1V55X-ray1.90G/T13-97[»]
2DYRX-ray1.80G/T13-97[»]
2DYSX-ray2.20G/T13-97[»]
2EIJX-ray1.90G/T13-97[»]
2EIKX-ray2.10G/T13-97[»]
2EILX-ray2.10G/T13-97[»]
2EIMX-ray2.60G/T13-97[»]
2EINX-ray2.70G/T13-97[»]
2OCCX-ray2.30G/T13-96[»]
2Y69X-ray1.95G/T1-97[»]
2YBBelectron microscopy19.00R13-96[»]
2ZXWX-ray2.50G/T13-97[»]
3ABKX-ray2.00G/T13-97[»]
3ABLX-ray2.10G/T13-97[»]
3ABMX-ray1.95G/T13-97[»]
3AG1X-ray2.20G/T13-97[»]
3AG2X-ray1.80G/T13-97[»]
3AG3X-ray1.80G/T13-97[»]
3AG4X-ray2.05G/T13-97[»]
3ASNX-ray3.00G/T13-97[»]
3ASOX-ray2.30G/T13-97[»]
3WG7X-ray1.90G/T13-97[»]
SMRiP07471. Positions 13-96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-39018N.
IntActiP07471. 1 interaction.
STRINGi9913.ENSBTAP00000026002.

Proteomic databases

PRIDEiP07471.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000026002; ENSBTAP00000026002; ENSBTAG00000019521.
GeneIDi282200.
KEGGibta:282200.

Organism-specific databases

CTDi1339.

Phylogenomic databases

eggNOGiNOG280964.
GeneTreeiENSGT00390000002756.
HOGENOMiHOG000193965.
HOVERGENiHBG060482.
InParanoidiP07471.
KOiK02266.
OMAiCTLNSWL.
OrthoDBiEOG757D0Z.
TreeFamiTF105064.

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Miscellaneous databases

EvolutionaryTraceiP07471.
NextBioi20806025.

Family and domain databases

Gene3Di4.10.95.10. 1 hit.
InterProiIPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view]
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiPF02046. COX6A. 1 hit.
[Graphical view]
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiPD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiPS01329. COX6A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The cDNA for the heart/muscle isoform of bovine cytochrome c oxidase subunit VIa encodes a presequence."
    Smith E.O., Bement D.M., Grossman L.I., Lomax M.I.
    Biochim. Biophys. Acta 1089:266-268(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "Structural organization of the bovine gene for the heart/muscle isoform of cytochrome c oxidase subunit VIa."
    Smith E.O., Lomax M.I.
    Biochim. Biophys. Acta 1174:63-71(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.
  4. "Studies on cytochrome c oxidase, XII. Isolation and primary structure of polypeptide VIb from bovine heart."
    Meinecke L., Buse G.
    Biol. Chem. Hoppe-Seyler 366:687-694(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 13-96.
    Tissue: Heart.
  5. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
    Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
    Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
  6. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    Tissue: Heart.
  7. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
    Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
    Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
    Tissue: Heart.

Entry informationi

Entry nameiCX6A2_BOVIN
AccessioniPrimary (citable) accession number: P07471
Secondary accession number(s): Q3SZ61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: May 1, 1992
Last modified: April 1, 2015
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.