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Protein

Cytochrome c oxidase subunit 6A2, mitochondrial

Gene

COX6A2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6A2, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIa-heart
Short name:
COXVIAH
Cytochrome c oxidase polypeptide VIb
Gene namesi
Name:COX6A2
Synonyms:COX6A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini13 – 24Mitochondrial matrixAdd BLAST12
Transmembranei25 – 49HelicalAdd BLAST25
Topological domaini50 – 97Mitochondrial intermembraneAdd BLAST48

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 12Mitochondrion1 PublicationAdd BLAST12
ChainiPRO_000000611513 – 97Cytochrome c oxidase subunit 6A2, mitochondrialAdd BLAST85

Proteomic databases

PaxDbiP07471.
PRIDEiP07471.

Expressioni

Tissue specificityi

Heart/muscle specific isoform.

Gene expression databases

BgeeiENSBTAG00000019521.

Interactioni

Protein-protein interaction databases

DIPiDIP-39018N.
IntActiP07471. 1 interactor.
STRINGi9913.ENSBTAP00000026002.

Structurei

Secondary structure

197
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 23Combined sources3
Helixi25 – 34Combined sources10
Helixi36 – 47Combined sources12
Beta strandi77 – 79Combined sources3
Turni85 – 87Combined sources3
Beta strandi91 – 93Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80G/T13-96[»]
1OCOX-ray2.80G/T13-96[»]
1OCRX-ray2.35G/T13-96[»]
1OCZX-ray2.90G/T13-96[»]
1V54X-ray1.80G/T13-97[»]
1V55X-ray1.90G/T13-97[»]
2DYRX-ray1.80G/T13-97[»]
2DYSX-ray2.20G/T13-97[»]
2EIJX-ray1.90G/T13-97[»]
2EIKX-ray2.10G/T13-97[»]
2EILX-ray2.10G/T13-97[»]
2EIMX-ray2.60G/T13-97[»]
2EINX-ray2.70G/T13-97[»]
2OCCX-ray2.30G/T13-96[»]
2Y69X-ray1.95G/T1-97[»]
2YBBelectron microscopy19.00R13-96[»]
2ZXWX-ray2.50G/T13-97[»]
3ABKX-ray2.00G/T13-97[»]
3ABLX-ray2.10G/T13-97[»]
3ABMX-ray1.95G/T13-97[»]
3AG1X-ray2.20G/T13-97[»]
3AG2X-ray1.80G/T13-97[»]
3AG3X-ray1.80G/T13-97[»]
3AG4X-ray2.05G/T13-97[»]
3ASNX-ray3.00G/T13-97[»]
3ASOX-ray2.30G/T13-97[»]
3WG7X-ray1.90G/T13-97[»]
3X2QX-ray2.00G/T13-97[»]
5B1AX-ray1.50G/T13-97[»]
5B1BX-ray1.60G/T13-97[»]
5B3SX-ray1.68G/T13-97[»]
5GPNelectron microscopy5.40413-96[»]
5IY5X-ray2.00G/T13-96[»]
5LUFelectron microscopy9.10413-96[»]
ProteinModelPortaliP07471.
SMRiP07471.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07471.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3469. Eukaryota.
ENOG411253X. LUCA.
GeneTreeiENSGT00390000002756.
HOGENOMiHOG000193965.
HOVERGENiHBG060482.
InParanoidiP07471.
KOiK02266.
OMAiREPFAKY.
OrthoDBiEOG091G0C5F.
TreeFamiTF105064.

Family and domain databases

CDDicd00925. Cyt_c_Oxidase_VIa. 1 hit.
Gene3Di4.10.95.10. 1 hit.
InterProiView protein in InterPro
IPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiView protein in Pfam
PF02046. COX6A. 1 hit.
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006036. Cyt_c_oxidase_su6a. 1 hit.
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiView protein in PROSITE
PS01329. COX6A. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07471-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPLKSLSR GLASAAKGDH GGTGARTWRF LTFGLALPSV ALCTLNSWLH
60 70 80 90
SGHRERPAFI PYHHLRIRTK PFSWGDGNHT FFHNPRVNPL PTGYEKP
Length:97
Mass (Da):10,800
Last modified:May 1, 1992 - v2
Checksum:i59B408A1B9B6AF4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56857 mRNA. Translation: CAA40183.1.
S64127 Genomic DNA. Translation: AAB27605.1.
BC103117 mRNA. Translation: AAI03118.1.
PIRiS35702. OGBO6.
RefSeqiNP_776947.1. NM_174522.3.
UniGeneiBt.49093.

Genome annotation databases

EnsembliENSBTAT00000026002; ENSBTAP00000026002; ENSBTAG00000019521.
GeneIDi282200.
KEGGibta:282200.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCX6A2_BOVIN
AccessioniPrimary (citable) accession number: P07471
Secondary accession number(s): Q3SZ61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: May 1, 1992
Last modified: June 7, 2017
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families