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Protein

Cytochrome c oxidase subunit 6A2, mitochondrial

Gene

COX6A2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6A2, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIa-heart
Short name:
COXVIAH
Cytochrome c oxidase polypeptide VIb
Gene namesi
Name:COX6A2
Synonyms:COX6A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini13 – 24Mitochondrial matrixAdd BLAST12
Transmembranei25 – 49HelicalAdd BLAST25
Topological domaini50 – 97Mitochondrial intermembraneAdd BLAST48

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 12Mitochondrion1 PublicationAdd BLAST12
ChainiPRO_000000611513 – 97Cytochrome c oxidase subunit 6A2, mitochondrialAdd BLAST85

Proteomic databases

PaxDbiP07471.
PRIDEiP07471.

Expressioni

Tissue specificityi

Heart/muscle specific isoform.

Gene expression databases

BgeeiENSBTAG00000019521.

Interactioni

Protein-protein interaction databases

DIPiDIP-39018N.
IntActiP07471. 1 interactor.
STRINGi9913.ENSBTAP00000026002.

Structurei

Secondary structure

197
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 23Combined sources3
Helixi25 – 34Combined sources10
Helixi36 – 47Combined sources12
Beta strandi77 – 79Combined sources3
Turni85 – 87Combined sources3
Beta strandi91 – 93Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80G/T13-96[»]
1OCOX-ray2.80G/T13-96[»]
1OCRX-ray2.35G/T13-96[»]
1OCZX-ray2.90G/T13-96[»]
1V54X-ray1.80G/T13-97[»]
1V55X-ray1.90G/T13-97[»]
2DYRX-ray1.80G/T13-97[»]
2DYSX-ray2.20G/T13-97[»]
2EIJX-ray1.90G/T13-97[»]
2EIKX-ray2.10G/T13-97[»]
2EILX-ray2.10G/T13-97[»]
2EIMX-ray2.60G/T13-97[»]
2EINX-ray2.70G/T13-97[»]
2OCCX-ray2.30G/T13-96[»]
2Y69X-ray1.95G/T1-97[»]
2YBBelectron microscopy19.00R13-96[»]
2ZXWX-ray2.50G/T13-97[»]
3ABKX-ray2.00G/T13-97[»]
3ABLX-ray2.10G/T13-97[»]
3ABMX-ray1.95G/T13-97[»]
3AG1X-ray2.20G/T13-97[»]
3AG2X-ray1.80G/T13-97[»]
3AG3X-ray1.80G/T13-97[»]
3AG4X-ray2.05G/T13-97[»]
3ASNX-ray3.00G/T13-97[»]
3ASOX-ray2.30G/T13-97[»]
3WG7X-ray1.90G/T13-97[»]
3X2QX-ray2.00G/T13-97[»]
5B1AX-ray1.50G/T13-97[»]
5B1BX-ray1.60G/T13-97[»]
ProteinModelPortaliP07471.
SMRiP07471.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07471.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3469. Eukaryota.
ENOG411253X. LUCA.
GeneTreeiENSGT00390000002756.
HOGENOMiHOG000193965.
HOVERGENiHBG060482.
InParanoidiP07471.
KOiK02266.
OMAiNSWLHAG.
OrthoDBiEOG091G0C5F.
TreeFamiTF105064.

Family and domain databases

CDDicd00925. Cyt_c_Oxidase_VIa. 1 hit.
Gene3Di4.10.95.10. 1 hit.
InterProiIPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view]
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiPF02046. COX6A. 1 hit.
[Graphical view]
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiPD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiPS01329. COX6A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07471-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPLKSLSR GLASAAKGDH GGTGARTWRF LTFGLALPSV ALCTLNSWLH
60 70 80 90
SGHRERPAFI PYHHLRIRTK PFSWGDGNHT FFHNPRVNPL PTGYEKP
Length:97
Mass (Da):10,800
Last modified:May 1, 1992 - v2
Checksum:i59B408A1B9B6AF4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56857 mRNA. Translation: CAA40183.1.
S64127 Genomic DNA. Translation: AAB27605.1.
BC103117 mRNA. Translation: AAI03118.1.
PIRiS35702. OGBO6.
RefSeqiNP_776947.1. NM_174522.3.
UniGeneiBt.49093.

Genome annotation databases

EnsembliENSBTAT00000026002; ENSBTAP00000026002; ENSBTAG00000019521.
GeneIDi282200.
KEGGibta:282200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56857 mRNA. Translation: CAA40183.1.
S64127 Genomic DNA. Translation: AAB27605.1.
BC103117 mRNA. Translation: AAI03118.1.
PIRiS35702. OGBO6.
RefSeqiNP_776947.1. NM_174522.3.
UniGeneiBt.49093.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80G/T13-96[»]
1OCOX-ray2.80G/T13-96[»]
1OCRX-ray2.35G/T13-96[»]
1OCZX-ray2.90G/T13-96[»]
1V54X-ray1.80G/T13-97[»]
1V55X-ray1.90G/T13-97[»]
2DYRX-ray1.80G/T13-97[»]
2DYSX-ray2.20G/T13-97[»]
2EIJX-ray1.90G/T13-97[»]
2EIKX-ray2.10G/T13-97[»]
2EILX-ray2.10G/T13-97[»]
2EIMX-ray2.60G/T13-97[»]
2EINX-ray2.70G/T13-97[»]
2OCCX-ray2.30G/T13-96[»]
2Y69X-ray1.95G/T1-97[»]
2YBBelectron microscopy19.00R13-96[»]
2ZXWX-ray2.50G/T13-97[»]
3ABKX-ray2.00G/T13-97[»]
3ABLX-ray2.10G/T13-97[»]
3ABMX-ray1.95G/T13-97[»]
3AG1X-ray2.20G/T13-97[»]
3AG2X-ray1.80G/T13-97[»]
3AG3X-ray1.80G/T13-97[»]
3AG4X-ray2.05G/T13-97[»]
3ASNX-ray3.00G/T13-97[»]
3ASOX-ray2.30G/T13-97[»]
3WG7X-ray1.90G/T13-97[»]
3X2QX-ray2.00G/T13-97[»]
5B1AX-ray1.50G/T13-97[»]
5B1BX-ray1.60G/T13-97[»]
ProteinModelPortaliP07471.
SMRiP07471.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-39018N.
IntActiP07471. 1 interactor.
STRINGi9913.ENSBTAP00000026002.

Proteomic databases

PaxDbiP07471.
PRIDEiP07471.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000026002; ENSBTAP00000026002; ENSBTAG00000019521.
GeneIDi282200.
KEGGibta:282200.

Organism-specific databases

CTDi1339.

Phylogenomic databases

eggNOGiKOG3469. Eukaryota.
ENOG411253X. LUCA.
GeneTreeiENSGT00390000002756.
HOGENOMiHOG000193965.
HOVERGENiHBG060482.
InParanoidiP07471.
KOiK02266.
OMAiNSWLHAG.
OrthoDBiEOG091G0C5F.
TreeFamiTF105064.

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Miscellaneous databases

EvolutionaryTraceiP07471.

Gene expression databases

BgeeiENSBTAG00000019521.

Family and domain databases

CDDicd00925. Cyt_c_Oxidase_VIa. 1 hit.
Gene3Di4.10.95.10. 1 hit.
InterProiIPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view]
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiPF02046. COX6A. 1 hit.
[Graphical view]
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiPD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiPS01329. COX6A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCX6A2_BOVIN
AccessioniPrimary (citable) accession number: P07471
Secondary accession number(s): Q3SZ61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: May 1, 1992
Last modified: November 30, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.