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Protein

Cytochrome c oxidase subunit 7A1, mitochondrial

Gene

COX7A1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7A1, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit VIIIc
Short name:
VIIIC
Cytochrome c oxidase subunit VIIa-heart
Short name:
Cytochrome c oxidase subunit VIIa-H
Cytochrome c oxidase subunit VIIa-muscle
Short name:
Cytochrome c oxidase subunit VIIa-M
Gene namesi
Name:COX7A1
Synonyms:COX7A, COX7AH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 46Mitochondrial matrixAdd BLAST25
Transmembranei47 – 75HelicalAdd BLAST29
Topological domaini76 – 80Mitochondrial intermembrane5

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 21Mitochondrion1 PublicationAdd BLAST21
ChainiPRO_000000614822 – 80Cytochrome c oxidase subunit 7A1, mitochondrialAdd BLAST59

Proteomic databases

PaxDbiP07470.
PRIDEiP07470.

Expressioni

Gene expression databases

BgeeiENSBTAG00000014878.

Interactioni

Protein-protein interaction databases

DIPiDIP-38984N.
IntActiP07470. 2 interactors.
STRINGi9913.ENSBTAP00000019808.

Structurei

Secondary structure

180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 33Combined sources8
Helixi41 – 43Combined sources3
Helixi47 – 74Combined sources28

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80J/W22-80[»]
1OCOX-ray2.80J/W22-80[»]
1OCRX-ray2.35J/W22-80[»]
1OCZX-ray2.90J/W22-80[»]
1V54X-ray1.80J/W22-80[»]
1V55X-ray1.90J/W22-80[»]
2DYRX-ray1.80J/W22-80[»]
2DYSX-ray2.20J/W22-80[»]
2EIJX-ray1.90J/W22-80[»]
2EIKX-ray2.10J/W22-80[»]
2EILX-ray2.10J/W22-80[»]
2EIMX-ray2.60J/W22-80[»]
2EINX-ray2.70J/W22-80[»]
2OCCX-ray2.30J/W22-80[»]
2Y69X-ray1.95J/W1-80[»]
2YBBelectron microscopy19.00U22-80[»]
2ZXWX-ray2.50J/W22-80[»]
3ABKX-ray2.00J/W22-80[»]
3ABLX-ray2.10J/W22-80[»]
3ABMX-ray1.95J/W22-80[»]
3AG1X-ray2.20J/W22-80[»]
3AG2X-ray1.80J/W22-80[»]
3AG3X-ray1.80J/W22-80[»]
3AG4X-ray2.05J/W22-80[»]
3ASNX-ray3.00J/W22-80[»]
3ASOX-ray2.30J/W22-80[»]
3WG7X-ray1.90J/W22-80[»]
3X2QX-ray2.00J/W22-80[»]
5B1AX-ray1.50J/W22-80[»]
5B1BX-ray1.60J/W22-80[»]
ProteinModelPortaliP07470.
SMRiP07470.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07470.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIa family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JE1I. Eukaryota.
ENOG410ZCEG. LUCA.
GeneTreeiENSGT00400000022054.
HOGENOMiHOG000264231.
HOVERGENiHBG051095.
InParanoidiP07470.
KOiK02270.
OMAiGWASFPH.
OrthoDBiEOG091G12UD.
TreeFamiTF105067.

Family and domain databases

CDDicd00928. Cyt_c_Oxidase_VIIa. 1 hit.
Gene3Di4.10.91.10. 1 hit.
InterProiIPR003177. Cyt_c_oxidase_su7a.
[Graphical view]
PANTHERiPTHR10510. PTHR10510. 1 hit.
SUPFAMiSSF81419. SSF81419. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07470-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALRVSQAL VRSFSSTARN RFENRVAEKQ KLFQEDNGLP VHLKGGATDN
60 70 80
ILYRVTMTLC LGGTLYSLYC LGWASFPHKK
Length:80
Mass (Da):9,063
Last modified:December 1, 1992 - v2
Checksum:iA33FE89A867472A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73W → H AA sequence (PubMed:3006725).Curated1
Sequence conflicti76 – 78Missing AA sequence (PubMed:3006725).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56739 mRNA. Translation: CAA40063.1.
M83299 Genomic DNA. Translation: AAA30464.1.
BC114907 mRNA. Translation: AAI14908.1.
PIRiA41852. OSBO7A.
RefSeqiNP_788847.1. NM_176674.2.
UniGeneiBt.76.

Genome annotation databases

EnsembliENSBTAT00000019808; ENSBTAP00000019808; ENSBTAG00000014878.
GeneIDi338086.
KEGGibta:338086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56739 mRNA. Translation: CAA40063.1.
M83299 Genomic DNA. Translation: AAA30464.1.
BC114907 mRNA. Translation: AAI14908.1.
PIRiA41852. OSBO7A.
RefSeqiNP_788847.1. NM_176674.2.
UniGeneiBt.76.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80J/W22-80[»]
1OCOX-ray2.80J/W22-80[»]
1OCRX-ray2.35J/W22-80[»]
1OCZX-ray2.90J/W22-80[»]
1V54X-ray1.80J/W22-80[»]
1V55X-ray1.90J/W22-80[»]
2DYRX-ray1.80J/W22-80[»]
2DYSX-ray2.20J/W22-80[»]
2EIJX-ray1.90J/W22-80[»]
2EIKX-ray2.10J/W22-80[»]
2EILX-ray2.10J/W22-80[»]
2EIMX-ray2.60J/W22-80[»]
2EINX-ray2.70J/W22-80[»]
2OCCX-ray2.30J/W22-80[»]
2Y69X-ray1.95J/W1-80[»]
2YBBelectron microscopy19.00U22-80[»]
2ZXWX-ray2.50J/W22-80[»]
3ABKX-ray2.00J/W22-80[»]
3ABLX-ray2.10J/W22-80[»]
3ABMX-ray1.95J/W22-80[»]
3AG1X-ray2.20J/W22-80[»]
3AG2X-ray1.80J/W22-80[»]
3AG3X-ray1.80J/W22-80[»]
3AG4X-ray2.05J/W22-80[»]
3ASNX-ray3.00J/W22-80[»]
3ASOX-ray2.30J/W22-80[»]
3WG7X-ray1.90J/W22-80[»]
3X2QX-ray2.00J/W22-80[»]
5B1AX-ray1.50J/W22-80[»]
5B1BX-ray1.60J/W22-80[»]
ProteinModelPortaliP07470.
SMRiP07470.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-38984N.
IntActiP07470. 2 interactors.
STRINGi9913.ENSBTAP00000019808.

Proteomic databases

PaxDbiP07470.
PRIDEiP07470.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000019808; ENSBTAP00000019808; ENSBTAG00000014878.
GeneIDi338086.
KEGGibta:338086.

Organism-specific databases

CTDi1346.

Phylogenomic databases

eggNOGiENOG410JE1I. Eukaryota.
ENOG410ZCEG. LUCA.
GeneTreeiENSGT00400000022054.
HOGENOMiHOG000264231.
HOVERGENiHBG051095.
InParanoidiP07470.
KOiK02270.
OMAiGWASFPH.
OrthoDBiEOG091G12UD.
TreeFamiTF105067.

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Miscellaneous databases

EvolutionaryTraceiP07470.

Gene expression databases

BgeeiENSBTAG00000014878.

Family and domain databases

CDDicd00928. Cyt_c_Oxidase_VIIa. 1 hit.
Gene3Di4.10.91.10. 1 hit.
InterProiIPR003177. Cyt_c_oxidase_su7a.
[Graphical view]
PANTHERiPTHR10510. PTHR10510. 1 hit.
SUPFAMiSSF81419. SSF81419. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCX7A1_BOVIN
AccessioniPrimary (citable) accession number: P07470
Secondary accession number(s): A4FUH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 1, 1992
Last modified: November 30, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.