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P07470

- CX7A1_BOVIN

UniProt

P07470 - CX7A1_BOVIN

Protein

Cytochrome c oxidase subunit 7A1, mitochondrial

Gene

COX7A1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 7A1, mitochondrial
    Alternative name(s):
    Cytochrome c oxidase subunit VIIIc
    Short name:
    VIIIC
    Cytochrome c oxidase subunit VIIa-heart
    Short name:
    Cytochrome c oxidase subunit VIIa-H
    Cytochrome c oxidase subunit VIIa-muscle
    Short name:
    Cytochrome c oxidase subunit VIIa-M
    Gene namesi
    Name:COX7A1
    Synonyms:COX7A, COX7AH
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 18

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial respiratory chain Source: InterPro
    3. mitochondrion Source: AgBase
    4. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2121Mitochondrion1 PublicationAdd
    BLAST
    Chaini22 – 8059Cytochrome c oxidase subunit 7A1, mitochondrialPRO_0000006148Add
    BLAST

    Proteomic databases

    PRIDEiP07470.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-38984N.
    IntActiP07470. 2 interactions.

    Structurei

    Secondary structure

    1
    80
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi26 – 349
    Turni41 – 455
    Helixi47 – 7428

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OCCX-ray2.80J/W22-80[»]
    1OCOX-ray2.80J/W22-80[»]
    1OCRX-ray2.35J/W22-80[»]
    1OCZX-ray2.90J/W22-80[»]
    1V54X-ray1.80J/W22-80[»]
    1V55X-ray1.90J/W22-80[»]
    2DYRX-ray1.80J/W22-80[»]
    2DYSX-ray2.20J/W22-80[»]
    2EIJX-ray1.90J/W22-80[»]
    2EIKX-ray2.10J/W22-80[»]
    2EILX-ray2.10J/W22-80[»]
    2EIMX-ray2.60J/W22-80[»]
    2EINX-ray2.70J/W22-80[»]
    2OCCX-ray2.30J/W22-80[»]
    2Y69X-ray1.95J/W1-80[»]
    2YBBelectron microscopy19.00U22-80[»]
    2ZXWX-ray2.50J/W22-80[»]
    3ABKX-ray2.00J/W22-80[»]
    3ABLX-ray2.10J/W22-80[»]
    3ABMX-ray1.95J/W22-80[»]
    3AG1X-ray2.20J/W22-80[»]
    3AG2X-ray1.80J/W22-80[»]
    3AG3X-ray1.80J/W22-80[»]
    3AG4X-ray2.05J/W22-80[»]
    3ASNX-ray3.00J/W22-80[»]
    3ASOX-ray2.30J/W22-80[»]
    3WG7X-ray1.90J/W22-80[»]
    ProteinModelPortaliP07470.
    SMRiP07470. Positions 22-79.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP07470.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 4625Mitochondrial matrixAdd
    BLAST
    Topological domaini76 – 805Mitochondrial intermembrane

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei47 – 7529HelicalAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c oxidase VIIa family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG70659.
    GeneTreeiENSGT00400000022054.
    HOGENOMiHOG000264231.
    HOVERGENiHBG051095.
    InParanoidiP07470.
    KOiK02270.
    OMAiAHIGELA.
    OrthoDBiEOG7BGHNV.
    TreeFamiTF105067.

    Family and domain databases

    Gene3Di4.10.91.10. 1 hit.
    InterProiIPR003177. Cyt_c_oxidase_su7a.
    [Graphical view]
    PANTHERiPTHR10510. PTHR10510. 1 hit.
    PfamiPF02238. COX7a. 1 hit.
    [Graphical view]
    SUPFAMiSSF81419. SSF81419. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07470-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRALRVSQAL VRSFSSTARN RFENRVAEKQ KLFQEDNGLP VHLKGGATDN   50
    ILYRVTMTLC LGGTLYSLYC LGWASFPHKK 80
    Length:80
    Mass (Da):9,063
    Last modified:December 1, 1992 - v2
    Checksum:iA33FE89A867472A0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti73 – 731W → H AA sequence (PubMed:3006725)Curated
    Sequence conflicti76 – 783Missing AA sequence (PubMed:3006725)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56739 mRNA. Translation: CAA40063.1.
    M83299 Genomic DNA. Translation: AAA30464.1.
    BC114907 mRNA. Translation: AAI14908.1.
    PIRiA41852. OSBO7A.
    RefSeqiNP_788847.1. NM_176674.2.
    UniGeneiBt.76.

    Genome annotation databases

    EnsembliENSBTAT00000019808; ENSBTAP00000019808; ENSBTAG00000014878.
    GeneIDi338086.
    KEGGibta:338086.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56739 mRNA. Translation: CAA40063.1 .
    M83299 Genomic DNA. Translation: AAA30464.1 .
    BC114907 mRNA. Translation: AAI14908.1 .
    PIRi A41852. OSBO7A.
    RefSeqi NP_788847.1. NM_176674.2.
    UniGenei Bt.76.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OCC X-ray 2.80 J/W 22-80 [» ]
    1OCO X-ray 2.80 J/W 22-80 [» ]
    1OCR X-ray 2.35 J/W 22-80 [» ]
    1OCZ X-ray 2.90 J/W 22-80 [» ]
    1V54 X-ray 1.80 J/W 22-80 [» ]
    1V55 X-ray 1.90 J/W 22-80 [» ]
    2DYR X-ray 1.80 J/W 22-80 [» ]
    2DYS X-ray 2.20 J/W 22-80 [» ]
    2EIJ X-ray 1.90 J/W 22-80 [» ]
    2EIK X-ray 2.10 J/W 22-80 [» ]
    2EIL X-ray 2.10 J/W 22-80 [» ]
    2EIM X-ray 2.60 J/W 22-80 [» ]
    2EIN X-ray 2.70 J/W 22-80 [» ]
    2OCC X-ray 2.30 J/W 22-80 [» ]
    2Y69 X-ray 1.95 J/W 1-80 [» ]
    2YBB electron microscopy 19.00 U 22-80 [» ]
    2ZXW X-ray 2.50 J/W 22-80 [» ]
    3ABK X-ray 2.00 J/W 22-80 [» ]
    3ABL X-ray 2.10 J/W 22-80 [» ]
    3ABM X-ray 1.95 J/W 22-80 [» ]
    3AG1 X-ray 2.20 J/W 22-80 [» ]
    3AG2 X-ray 1.80 J/W 22-80 [» ]
    3AG3 X-ray 1.80 J/W 22-80 [» ]
    3AG4 X-ray 2.05 J/W 22-80 [» ]
    3ASN X-ray 3.00 J/W 22-80 [» ]
    3ASO X-ray 2.30 J/W 22-80 [» ]
    3WG7 X-ray 1.90 J/W 22-80 [» ]
    ProteinModelPortali P07470.
    SMRi P07470. Positions 22-79.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-38984N.
    IntActi P07470. 2 interactions.

    Proteomic databases

    PRIDEi P07470.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000019808 ; ENSBTAP00000019808 ; ENSBTAG00000014878 .
    GeneIDi 338086.
    KEGGi bta:338086.

    Organism-specific databases

    CTDi 1346.

    Phylogenomic databases

    eggNOGi NOG70659.
    GeneTreei ENSGT00400000022054.
    HOGENOMi HOG000264231.
    HOVERGENi HBG051095.
    InParanoidi P07470.
    KOi K02270.
    OMAi AHIGELA.
    OrthoDBi EOG7BGHNV.
    TreeFami TF105067.

    Miscellaneous databases

    EvolutionaryTracei P07470.
    NextBioi 20812533.

    Family and domain databases

    Gene3Di 4.10.91.10. 1 hit.
    InterProi IPR003177. Cyt_c_oxidase_su7a.
    [Graphical view ]
    PANTHERi PTHR10510. PTHR10510. 1 hit.
    Pfami PF02238. COX7a. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81419. SSF81419. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cytochrome c oxidase subunit VIIa isoforms. Characterization and expression of bovine cDNAs."
      Seelan R.S., Grossman L.I.
      J. Biol. Chem. 266:19752-19757(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. "Structure and organization of the heart isoform gene for bovine cytochrome c oxidase subunit VIIa."
      Seelan R.S., Grossman L.I.
      Biochemistry 31:4696-4704(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Heart.
    3. NIH - Mammalian Gene Collection (MGC) project
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal cerebellum.
    4. "Studies on cytochrome-c oxidase, XIII. Amino-acid sequence of the small membrane polypeptide VIIIc from bovine heart respiratory complex IV."
      Meinecke L., Buse G.
      Biol. Chem. Hoppe-Seyler 367:67-73(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-80.
      Tissue: Heart.
    5. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
      Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
      Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    6. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
      Tissue: Heart.
    7. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
      Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
      Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
      Tissue: Heart.

    Entry informationi

    Entry nameiCX7A1_BOVIN
    AccessioniPrimary (citable) accession number: P07470
    Secondary accession number(s): A4FUH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3