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P07470 (CX7A1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 7A1, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit VIIIc
Short name=VIIIC
Cytochrome c oxidase subunit VIIa-heart
Short name=Cytochrome c oxidase subunit VIIa-H
Cytochrome c oxidase subunit VIIa-muscle
Short name=Cytochrome c oxidase subunit VIIa-M
Gene names
Name:COX7A1
Synonyms:COX7A, COX7AH
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length80 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the cytochrome c oxidase VIIa family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2121Mitochondrion Ref.4
Chain22 – 8059Cytochrome c oxidase subunit 7A1, mitochondrial Ref.1
PRO_0000006148

Regions

Topological domain22 – 4625Mitochondrial matrix
Transmembrane47 – 7529Helical
Topological domain76 – 805Mitochondrial intermembrane

Experimental info

Sequence conflict731W → H AA sequence Ref.4
Sequence conflict76 – 783Missing AA sequence Ref.4

Secondary structure

....... 80
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P07470 [UniParc].

Last modified December 1, 1992. Version 2.
Checksum: A33FE89A867472A0

FASTA809,063
        10         20         30         40         50         60 
MRALRVSQAL VRSFSSTARN RFENRVAEKQ KLFQEDNGLP VHLKGGATDN ILYRVTMTLC 

        70         80 
LGGTLYSLYC LGWASFPHKK 

« Hide

References

« Hide 'large scale' references
[1]"Cytochrome c oxidase subunit VIIa isoforms. Characterization and expression of bovine cDNAs."
Seelan R.S., Grossman L.I.
J. Biol. Chem. 266:19752-19757(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[2]"Structure and organization of the heart isoform gene for bovine cytochrome c oxidase subunit VIIa."
Seelan R.S., Grossman L.I.
Biochemistry 31:4696-4704(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Heart.
[3]NIH - Mammalian Gene Collection (MGC) project
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal cerebellum.
[4]"Studies on cytochrome-c oxidase, XIII. Amino-acid sequence of the small membrane polypeptide VIIIc from bovine heart respiratory complex IV."
Meinecke L., Buse G.
Biol. Chem. Hoppe-Seyler 367:67-73(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-80.
Tissue: Heart.
[5]"The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[6]"Structure analysis of bovine heart cytochrome c oxidase at 2.8 A resolution."
Tomizaki T., Yamashita E., Yamaguchi H., Aoyama H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Acta Crystallogr. D 55:31-45(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
Tissue: Heart.
[7]"X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X56739 mRNA. Translation: CAA40063.1.
M83299 Genomic DNA. Translation: AAA30464.1.
BC114907 mRNA. Translation: AAI14908.1.
PIROSBO7A. A41852.
RefSeqNP_788847.1. NM_176674.2.
UniGeneBt.76.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80J/W22-80[»]
1OCOX-ray2.80J/W22-80[»]
1OCRX-ray2.35J/W22-80[»]
1OCZX-ray2.90J/W22-80[»]
1V54X-ray1.80J/W22-80[»]
1V55X-ray1.90J/W22-80[»]
2DYRX-ray1.80J/W22-80[»]
2DYSX-ray2.20J/W22-80[»]
2EIJX-ray1.90J/W22-80[»]
2EIKX-ray2.10J/W22-80[»]
2EILX-ray2.10J/W22-80[»]
2EIMX-ray2.60J/W22-80[»]
2EINX-ray2.70J/W22-80[»]
2OCCX-ray2.30J/W22-80[»]
2Y69X-ray1.95J/W1-80[»]
2YBBelectron microscopy19.00U22-80[»]
2ZXWX-ray2.50J/W22-80[»]
3ABKX-ray2.00J/W22-80[»]
3ABLX-ray2.10J/W22-80[»]
3ABMX-ray1.95J/W22-80[»]
3AG1X-ray2.20J/W22-80[»]
3AG2X-ray1.80J/W22-80[»]
3AG3X-ray1.80J/W22-80[»]
3AG4X-ray2.05J/W22-80[»]
3ASNX-ray3.00J/W22-80[»]
3ASOX-ray2.30J/W22-80[»]
ProteinModelPortalP07470.
SMRP07470. Positions 22-79.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP07470. 2 interactions.

Proteomic databases

PRIDEP07470.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000019808; ENSBTAP00000019808; ENSBTAG00000014878.
GeneID338086.
KEGGbta:338086.

Organism-specific databases

CTD1346.

Phylogenomic databases

eggNOGNOG70659.
GeneTreeENSGT00400000022054.
HOGENOMHOG000264231.
HOVERGENHBG051095.
InParanoidP07470.
KOK02270.
OMASLYCLGW.
OrthoDBEOG7BGHNV.
TreeFamTF105067.

Family and domain databases

Gene3D4.10.91.10. 1 hit.
InterProIPR003177. Cyt_c_oxidase_su7a.
[Graphical view]
PANTHERPTHR10510. PTHR10510. 1 hit.
PfamPF02238. COX7a. 1 hit.
[Graphical view]
SUPFAMSSF81419. SSF81419. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP07470.
NextBio20812533.

Entry information

Entry nameCX7A1_BOVIN
AccessionPrimary (citable) accession number: P07470
Secondary accession number(s): A4FUH9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references