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P07470

- CX7A1_BOVIN

UniProt

P07470 - CX7A1_BOVIN

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Protein

Cytochrome c oxidase subunit 7A1, mitochondrial

Gene

COX7A1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7A1, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit VIIIc
Short name:
VIIIC
Cytochrome c oxidase subunit VIIa-heart
Short name:
Cytochrome c oxidase subunit VIIa-H
Cytochrome c oxidase subunit VIIa-muscle
Short name:
Cytochrome c oxidase subunit VIIa-M
Gene namesi
Name:COX7A1
Synonyms:COX7A, COX7AH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 18

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 4625Mitochondrial matrixAdd
BLAST
Transmembranei47 – 7529HelicalAdd
BLAST
Topological domaini76 – 805Mitochondrial intermembrane

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain Source: InterPro
  3. mitochondrion Source: AgBase
  4. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2121Mitochondrion1 PublicationAdd
BLAST
Chaini22 – 8059Cytochrome c oxidase subunit 7A1, mitochondrialPRO_0000006148Add
BLAST

Proteomic databases

PRIDEiP07470.

Interactioni

Protein-protein interaction databases

DIPiDIP-38984N.
IntActiP07470. 2 interactions.

Structurei

Secondary structure

1
80
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi26 – 349Combined sources
Turni41 – 455Combined sources
Helixi47 – 7428Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80J/W22-80[»]
1OCOX-ray2.80J/W22-80[»]
1OCRX-ray2.35J/W22-80[»]
1OCZX-ray2.90J/W22-80[»]
1V54X-ray1.80J/W22-80[»]
1V55X-ray1.90J/W22-80[»]
2DYRX-ray1.80J/W22-80[»]
2DYSX-ray2.20J/W22-80[»]
2EIJX-ray1.90J/W22-80[»]
2EIKX-ray2.10J/W22-80[»]
2EILX-ray2.10J/W22-80[»]
2EIMX-ray2.60J/W22-80[»]
2EINX-ray2.70J/W22-80[»]
2OCCX-ray2.30J/W22-80[»]
2Y69X-ray1.95J/W1-80[»]
2YBBelectron microscopy19.00U22-80[»]
2ZXWX-ray2.50J/W22-80[»]
3ABKX-ray2.00J/W22-80[»]
3ABLX-ray2.10J/W22-80[»]
3ABMX-ray1.95J/W22-80[»]
3AG1X-ray2.20J/W22-80[»]
3AG2X-ray1.80J/W22-80[»]
3AG3X-ray1.80J/W22-80[»]
3AG4X-ray2.05J/W22-80[»]
3ASNX-ray3.00J/W22-80[»]
3ASOX-ray2.30J/W22-80[»]
3WG7X-ray1.90J/W22-80[»]
ProteinModelPortaliP07470.
SMRiP07470. Positions 22-79.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07470.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIa family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG70659.
GeneTreeiENSGT00400000022054.
HOGENOMiHOG000264231.
HOVERGENiHBG051095.
InParanoidiP07470.
KOiK02270.
OMAiAHIGELA.
OrthoDBiEOG7BGHNV.
TreeFamiTF105067.

Family and domain databases

Gene3Di4.10.91.10. 1 hit.
InterProiIPR003177. Cyt_c_oxidase_su7a.
[Graphical view]
PANTHERiPTHR10510. PTHR10510. 1 hit.
PfamiPF02238. COX7a. 1 hit.
[Graphical view]
SUPFAMiSSF81419. SSF81419. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07470-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRALRVSQAL VRSFSSTARN RFENRVAEKQ KLFQEDNGLP VHLKGGATDN
60 70 80
ILYRVTMTLC LGGTLYSLYC LGWASFPHKK
Length:80
Mass (Da):9,063
Last modified:December 1, 1992 - v2
Checksum:iA33FE89A867472A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731W → H AA sequence (PubMed:3006725)Curated
Sequence conflicti76 – 783Missing AA sequence (PubMed:3006725)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56739 mRNA. Translation: CAA40063.1.
M83299 Genomic DNA. Translation: AAA30464.1.
BC114907 mRNA. Translation: AAI14908.1.
PIRiA41852. OSBO7A.
RefSeqiNP_788847.1. NM_176674.2.
UniGeneiBt.76.

Genome annotation databases

EnsembliENSBTAT00000019808; ENSBTAP00000019808; ENSBTAG00000014878.
GeneIDi338086.
KEGGibta:338086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56739 mRNA. Translation: CAA40063.1 .
M83299 Genomic DNA. Translation: AAA30464.1 .
BC114907 mRNA. Translation: AAI14908.1 .
PIRi A41852. OSBO7A.
RefSeqi NP_788847.1. NM_176674.2.
UniGenei Bt.76.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OCC X-ray 2.80 J/W 22-80 [» ]
1OCO X-ray 2.80 J/W 22-80 [» ]
1OCR X-ray 2.35 J/W 22-80 [» ]
1OCZ X-ray 2.90 J/W 22-80 [» ]
1V54 X-ray 1.80 J/W 22-80 [» ]
1V55 X-ray 1.90 J/W 22-80 [» ]
2DYR X-ray 1.80 J/W 22-80 [» ]
2DYS X-ray 2.20 J/W 22-80 [» ]
2EIJ X-ray 1.90 J/W 22-80 [» ]
2EIK X-ray 2.10 J/W 22-80 [» ]
2EIL X-ray 2.10 J/W 22-80 [» ]
2EIM X-ray 2.60 J/W 22-80 [» ]
2EIN X-ray 2.70 J/W 22-80 [» ]
2OCC X-ray 2.30 J/W 22-80 [» ]
2Y69 X-ray 1.95 J/W 1-80 [» ]
2YBB electron microscopy 19.00 U 22-80 [» ]
2ZXW X-ray 2.50 J/W 22-80 [» ]
3ABK X-ray 2.00 J/W 22-80 [» ]
3ABL X-ray 2.10 J/W 22-80 [» ]
3ABM X-ray 1.95 J/W 22-80 [» ]
3AG1 X-ray 2.20 J/W 22-80 [» ]
3AG2 X-ray 1.80 J/W 22-80 [» ]
3AG3 X-ray 1.80 J/W 22-80 [» ]
3AG4 X-ray 2.05 J/W 22-80 [» ]
3ASN X-ray 3.00 J/W 22-80 [» ]
3ASO X-ray 2.30 J/W 22-80 [» ]
3WG7 X-ray 1.90 J/W 22-80 [» ]
ProteinModelPortali P07470.
SMRi P07470. Positions 22-79.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-38984N.
IntActi P07470. 2 interactions.

Proteomic databases

PRIDEi P07470.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000019808 ; ENSBTAP00000019808 ; ENSBTAG00000014878 .
GeneIDi 338086.
KEGGi bta:338086.

Organism-specific databases

CTDi 1346.

Phylogenomic databases

eggNOGi NOG70659.
GeneTreei ENSGT00400000022054.
HOGENOMi HOG000264231.
HOVERGENi HBG051095.
InParanoidi P07470.
KOi K02270.
OMAi AHIGELA.
OrthoDBi EOG7BGHNV.
TreeFami TF105067.

Miscellaneous databases

EvolutionaryTracei P07470.
NextBioi 20812533.

Family and domain databases

Gene3Di 4.10.91.10. 1 hit.
InterProi IPR003177. Cyt_c_oxidase_su7a.
[Graphical view ]
PANTHERi PTHR10510. PTHR10510. 1 hit.
Pfami PF02238. COX7a. 1 hit.
[Graphical view ]
SUPFAMi SSF81419. SSF81419. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cytochrome c oxidase subunit VIIa isoforms. Characterization and expression of bovine cDNAs."
    Seelan R.S., Grossman L.I.
    J. Biol. Chem. 266:19752-19757(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "Structure and organization of the heart isoform gene for bovine cytochrome c oxidase subunit VIIa."
    Seelan R.S., Grossman L.I.
    Biochemistry 31:4696-4704(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Heart.
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal cerebellum.
  4. "Studies on cytochrome-c oxidase, XIII. Amino-acid sequence of the small membrane polypeptide VIIIc from bovine heart respiratory complex IV."
    Meinecke L., Buse G.
    Biol. Chem. Hoppe-Seyler 367:67-73(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-80.
    Tissue: Heart.
  5. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
    Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
    Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
  6. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    Tissue: Heart.
  7. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
    Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
    Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
    Tissue: Heart.

Entry informationi

Entry nameiCX7A1_BOVIN
AccessioniPrimary (citable) accession number: P07470
Secondary accession number(s): A4FUH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 1, 1992
Last modified: November 26, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3