Cytochrome c oxidase subunit 7A1, mitochondrial precursor

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P07470 (CX7A1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 105. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 7A1, mitochondrial

Alternative name(s):
Cytochrome c oxidase subunit VIIIc
Short name=VIIIC
Cytochrome c oxidase subunit VIIa-heart
Short name=Cytochrome c oxidase subunit VIIa-H
Cytochrome c oxidase subunit VIIa-muscle
Short name=Cytochrome c oxidase subunit VIIa-M

Gene names

Name:	COX7A1
Synonyms:	COX7A, COX7AH

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	80 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the cytochrome c oxidase VIIa family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide Transmembrane Transmembrane helix
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial respiratory chain Inferred from electronic annotation. Source: InterPro
Molecular function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 21

Mitochondrion Ref.4

Chain

22 – 80

Cytochrome c oxidase subunit 7A1, mitochondrial Ref.1

PRO_0000006148

Regions

Topological domain

22 – 46

Mitochondrial matrix

Transmembrane

47 – 75

Helical

Topological domain

76 – 80

Mitochondrial intermembrane

Experimental info

Sequence conflict

W → H AA sequence Ref.4

Sequence conflict

76 – 78

Missing AA sequence Ref.4

Secondary structure

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P07470 [UniParc].

Last modified December 1, 1992. Version 2.
Checksum: A33FE89A867472A0
Show »

FASTA

9,063

        10         20         30         40         50         60 
MRALRVSQAL VRSFSSTARN RFENRVAEKQ KLFQEDNGLP VHLKGGATDN ILYRVTMTLC 

        70         80 
LGGTLYSLYC LGWASFPHKK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cytochrome c oxidase subunit VIIa isoforms. Characterization and expression of bovine cDNAs." Seelan R.S., Grossman L.I. J. Biol. Chem. 266:19752-19757(1991) [PubMed: 1717471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[2]	"Structure and organization of the heart isoform gene for bovine cytochrome c oxidase subunit VIIa." Seelan R.S., Grossman L.I. Biochemistry 31:4696-4704(1992) [PubMed: 1316159] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Heart.
[3]	NIH - Mammalian Gene Collection (MGC) project Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal cerebellum.
[4]	"Studies on cytochrome-c oxidase, XIII. Amino-acid sequence of the small membrane polypeptide VIIIc from bovine heart respiratory complex IV." Meinecke L., Buse G. Biol. Chem. Hoppe-Seyler 367:67-73(1986) [PubMed: 3006725] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-80. Tissue: Heart.
[5]	"The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A." Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S. Science 272:1136-1144(1996) [PubMed: 8638158] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[6]	"Structure analysis of bovine heart cytochrome c oxidase at 2.8 A resolution." Tomizaki T., Yamashita E., Yamaguchi H., Aoyama H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S. Acta Crystallogr. D 55:31-45(1999) [PubMed: 10089392] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS). Tissue: Heart.
[7]	"X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution." Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S. Acta Crystallogr. D 56:529-535(2000) [PubMed: 10771420] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS). Tissue: Heart.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X56739 mRNA. Translation: CAA40063.1.
M83299 Genomic DNA. Translation: AAA30464.1.
BC114907 mRNA. Translation: AAI14908.1.

IPI

IPI00717407.

PIR

OSBO7A. A41852.

RefSeq

NP_788847.1. NM_176674.2.

UniGene

Bt.76.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1OCC	X-ray	2.80	J/W	22-80	[»]
1OCO	X-ray	2.80	J/W	22-80	[»]
1OCR	X-ray	2.35	J/W	22-80	[»]
1OCZ	X-ray	2.90	J/W	22-80	[»]
1V54	X-ray	1.80	J/W	22-80	[»]
1V55	X-ray	1.90	J/W	22-80	[»]
2DYR	X-ray	1.80	J/W	22-80	[»]
2DYS	X-ray	2.20	J/W	22-80	[»]
2EIJ	X-ray	1.90	J/W	22-80	[»]
2EIK	X-ray	2.10	J/W	22-80	[»]
2EIL	X-ray	2.10	J/W	22-80	[»]
2EIM	X-ray	2.60	J/W	22-80	[»]
2EIN	X-ray	2.70	J/W	22-80	[»]
2OCC	X-ray	2.30	J/W	22-80	[»]
2Y69	X-ray	1.95	J/W	1-80	[»]
2YBB	electron microscopy	19.00	U	22-80	[»]
2ZXW	X-ray	2.50	J/W	22-80	[»]
3ABK	X-ray	2.00	J/W	22-80	[»]
3ABL	X-ray	2.10	J/W	22-80	[»]
3ABM	X-ray	1.95	J/W	22-80	[»]
3AG1	X-ray	2.20	J/W	22-80	[»]
3AG2	X-ray	1.80	J/W	22-80	[»]
3AG3	X-ray	1.80	J/W	22-80	[»]
3AG4	X-ray	2.05	J/W	22-80	[»]
3ASN	X-ray	3.00	J/W	22-80	[»]
3ASO	X-ray	2.30	J/W	22-80	[»]

ProteinModelPortal

P07470.

SMR

P07470. Positions 22-79.

ModBase

Search...

Protein-protein interaction databases

IntAct

P07470. 2 interactions.

STRING

P07470.

Proteomic databases

PRIDE

P07470.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSBTAT00000019808; ENSBTAP00000019808; ENSBTAG00000014878.

GeneID

338086.

KEGG

bta:338086.

Organism-specific databases

CTD

1346.

Phylogenomic databases

eggNOG

maNOG21222.

GeneTree

ENSGT00400000022054.

HOVERGEN

HBG051095.

InParanoid

P07470.

OMA

GWASFPH.

OrthoDB

EOG4WQ147.

PhylomeDB

P07470.

Family and domain databases

InterPro

IPR003177. Cyt_c_oxidase_su7a.
[Graphical view]

Gene3D

G3DSA:4.10.91.10. Cyt_c_oxidase_7a_su. 1 hit.

K02270.

PANTHER

PTHR10510. COX7a. 1 hit.

Pfam

PF02238. COX7a. 1 hit.
[Graphical view]

SUPFAM

SSF81419. Cyt_c_oxidase_7a_su. 1 hit.

ProtoNet

Search...

Entry information

Entry name

CX7A1_BOVIN

Accession

Primary (citable) accession number: P07470
Secondary accession number(s): A4FUH9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	December 1, 1992
Last modified:	December 14, 2011
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents