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Protein

Cytochrome c oxidase subunit 7A1, mitochondrial

Gene

COX7A1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7A1, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit VIIIc
Short name:
VIIIC
Cytochrome c oxidase subunit VIIa-heart
Short name:
Cytochrome c oxidase subunit VIIa-H
Cytochrome c oxidase subunit VIIa-muscle
Short name:
Cytochrome c oxidase subunit VIIa-M
Gene namesi
Name:COX7A1
Synonyms:COX7A, COX7AH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 46Mitochondrial matrixAdd BLAST25
Transmembranei47 – 75HelicalAdd BLAST29
Topological domaini76 – 80Mitochondrial intermembrane5

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 21Mitochondrion1 PublicationAdd BLAST21
ChainiPRO_000000614822 – 80Cytochrome c oxidase subunit 7A1, mitochondrialAdd BLAST59

Proteomic databases

PaxDbiP07470.
PRIDEiP07470.

Expressioni

Gene expression databases

BgeeiENSBTAG00000014878.

Interactioni

Protein-protein interaction databases

DIPiDIP-38984N.
IntActiP07470. 2 interactors.
STRINGi9913.ENSBTAP00000019808.

Structurei

Secondary structure

180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 33Combined sources8
Helixi41 – 43Combined sources3
Helixi47 – 74Combined sources28

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80J/W22-80[»]
1OCOX-ray2.80J/W22-80[»]
1OCRX-ray2.35J/W22-80[»]
1OCZX-ray2.90J/W22-80[»]
1V54X-ray1.80J/W22-80[»]
1V55X-ray1.90J/W22-80[»]
2DYRX-ray1.80J/W22-80[»]
2DYSX-ray2.20J/W22-80[»]
2EIJX-ray1.90J/W22-80[»]
2EIKX-ray2.10J/W22-80[»]
2EILX-ray2.10J/W22-80[»]
2EIMX-ray2.60J/W22-80[»]
2EINX-ray2.70J/W22-80[»]
2OCCX-ray2.30J/W22-80[»]
2Y69X-ray1.95J/W1-80[»]
2YBBelectron microscopy19.00U22-80[»]
2ZXWX-ray2.50J/W22-80[»]
3ABKX-ray2.00J/W22-80[»]
3ABLX-ray2.10J/W22-80[»]
3ABMX-ray1.95J/W22-80[»]
3AG1X-ray2.20J/W22-80[»]
3AG2X-ray1.80J/W22-80[»]
3AG3X-ray1.80J/W22-80[»]
3AG4X-ray2.05J/W22-80[»]
3ASNX-ray3.00J/W22-80[»]
3ASOX-ray2.30J/W22-80[»]
3WG7X-ray1.90J/W22-80[»]
3X2QX-ray2.00J/W22-80[»]
5B1AX-ray1.50J/W22-80[»]
5B1BX-ray1.60J/W22-80[»]
5B3SX-ray1.68J/W22-80[»]
5GPNelectron microscopy5.40722-80[»]
5IY5X-ray2.00J/W22-79[»]
5LUFelectron microscopy9.10722-80[»]
ProteinModelPortaliP07470.
SMRiP07470.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07470.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIa family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JE1I. Eukaryota.
ENOG410ZCEG. LUCA.
GeneTreeiENSGT00400000022054.
HOGENOMiHOG000264231.
HOVERGENiHBG051095.
InParanoidiP07470.
KOiK02270.
OMAiGWASFPH.
OrthoDBiEOG091G12UD.
TreeFamiTF105067.

Family and domain databases

CDDicd00928. Cyt_c_Oxidase_VIIa. 1 hit.
InterProiView protein in InterPro
IPR003177. Cyt_c_oxidase_su7a.
PANTHERiPTHR10510. PTHR10510. 1 hit.
SUPFAMiSSF81419. SSF81419. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07470-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALRVSQAL VRSFSSTARN RFENRVAEKQ KLFQEDNGLP VHLKGGATDN
60 70 80
ILYRVTMTLC LGGTLYSLYC LGWASFPHKK
Length:80
Mass (Da):9,063
Last modified:December 1, 1992 - v2
Checksum:iA33FE89A867472A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73W → H AA sequence (PubMed:3006725).Curated1
Sequence conflicti76 – 78Missing AA sequence (PubMed:3006725).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56739 mRNA. Translation: CAA40063.1.
M83299 Genomic DNA. Translation: AAA30464.1.
BC114907 mRNA. Translation: AAI14908.1.
PIRiA41852. OSBO7A.
RefSeqiNP_788847.1. NM_176674.2.
UniGeneiBt.76.

Genome annotation databases

EnsembliENSBTAT00000019808; ENSBTAP00000019808; ENSBTAG00000014878.
GeneIDi338086.
KEGGibta:338086.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCX7A1_BOVIN
AccessioniPrimary (citable) accession number: P07470
Secondary accession number(s): A4FUH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 1, 1992
Last modified: June 7, 2017
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families