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Protein

Insulin-like growth factor II

Gene

IGF2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Hormone, Mitogen

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism, Osteogenesis

Enzyme and pathway databases

ReactomeiR-BTA-114608. Platelet degranulation.
R-BTA-2404192. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
R-BTA-2428928. IRS-related events triggered by IGF1R.
R-BTA-2428933. SHC-related events triggered by IGF1R.
R-BTA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor II
Short name:
IGF-II
Alternative name(s):
Erythrotropin
Cleaved into the following 2 chains:
Gene namesi
Name:IGF2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

  • extracellular exosome Source: Ensembl
  • extracellular space Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 242 PublicationsAdd BLAST24
ChainiPRO_000001571125 – 91Insulin-like growth factor IIAdd BLAST67
PropeptideiPRO_000001571292 – 179E peptideAdd BLAST88
PeptideiPRO_000037037393 – 126PreptinAdd BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 71By similarity
Disulfide bondi45 ↔ 84By similarity
Disulfide bondi70 ↔ 75By similarity
Glycosylationi106O-linked (GalNAc...)1 Publication1
Glycosylationi154O-linked (GalNAc...)1 Publication1
Glycosylationi163O-linked (GalNAc...)1 Publication1

Post-translational modificationi

Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP07456.
PRIDEiP07456.

PTM databases

UniCarbKBiP07456.

Expressioni

Gene expression databases

BgeeiENSBTAG00000013066.
ExpressionAtlasiP07456. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017372.

Structurei

3D structure databases

ProteinModelPortaliP07456.
SMRiP07456.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 52BAdd BLAST28
Regioni53 – 64CAdd BLAST12
Regioni65 – 85AAdd BLAST21
Regioni86 – 91D6

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IY3P. Eukaryota.
ENOG4111KP2. LUCA.
GeneTreeiENSGT00530000063856.
HOGENOMiHOG000233362.
HOVERGENiHBG006137.
InParanoidiP07456.
KOiK13769.
OMAiFFQYDTW.
OrthoDBiEOG091G0H56.
TreeFamiTF332820.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF08365. IGF2_C. 1 hit.
PF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomiPD005188. IGF2_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGITAGKSVL VLLAFLAFAS CCYAAYRPSE TLCGGELVDT LQFVCGDRGF
60 70 80 90 100
YFSRPSSRIN RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSASTTV
110 120 130 140 150
LPDDVTAYPV GKFFQYDIWK QSTQRLRRGL PAFLRARRGR TLAKELEALR
160 170
EAKSHRPLIA LPTQDPATHG GASSKASSD
Length:179
Mass (Da):19,682
Last modified:May 30, 2006 - v4
Checksum:iDEA16ED2D792EA53
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46 – 47GD → DG AA sequence (PubMed:2302223).Curated2
Sequence conflicti58R → L in ABD34310 (PubMed:16120826).Curated1
Sequence conflicti59I → S AA sequence (PubMed:3941093).Curated1
Sequence conflicti168T → I in CAA37620 (PubMed:2388846).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY957981 mRNA. Translation: ABD34310.1.
BC116039 mRNA. Translation: AAI16040.1.
X53553 mRNA. Translation: CAA37620.1.
X53867 mRNA. Translation: CAA37861.1.
PIRiS10983. IGBO2.
RefSeqiNP_776512.2. NM_174087.3.
XP_005227330.1. XM_005227273.1.
XP_005227331.1. XM_005227274.3.
XP_005227332.1. XM_005227275.3.
XP_005227333.1. XM_005227276.1.
XP_015316818.1. XM_015461332.1.
UniGeneiBt.106739.

Genome annotation databases

EnsembliENSBTAT00000017372; ENSBTAP00000017372; ENSBTAG00000013066.
ENSBTAT00000044139; ENSBTAP00000041652; ENSBTAG00000013066.
GeneIDi281240.
KEGGibta:281240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY957981 mRNA. Translation: ABD34310.1.
BC116039 mRNA. Translation: AAI16040.1.
X53553 mRNA. Translation: CAA37620.1.
X53867 mRNA. Translation: CAA37861.1.
PIRiS10983. IGBO2.
RefSeqiNP_776512.2. NM_174087.3.
XP_005227330.1. XM_005227273.1.
XP_005227331.1. XM_005227274.3.
XP_005227332.1. XM_005227275.3.
XP_005227333.1. XM_005227276.1.
XP_015316818.1. XM_015461332.1.
UniGeneiBt.106739.

3D structure databases

ProteinModelPortaliP07456.
SMRiP07456.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017372.

PTM databases

UniCarbKBiP07456.

Proteomic databases

PaxDbiP07456.
PRIDEiP07456.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000017372; ENSBTAP00000017372; ENSBTAG00000013066.
ENSBTAT00000044139; ENSBTAP00000041652; ENSBTAG00000013066.
GeneIDi281240.
KEGGibta:281240.

Organism-specific databases

CTDi3481.

Phylogenomic databases

eggNOGiENOG410IY3P. Eukaryota.
ENOG4111KP2. LUCA.
GeneTreeiENSGT00530000063856.
HOGENOMiHOG000233362.
HOVERGENiHBG006137.
InParanoidiP07456.
KOiK13769.
OMAiFFQYDTW.
OrthoDBiEOG091G0H56.
TreeFamiTF332820.

Enzyme and pathway databases

ReactomeiR-BTA-114608. Platelet degranulation.
R-BTA-2404192. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
R-BTA-2428928. IRS-related events triggered by IGF1R.
R-BTA-2428933. SHC-related events triggered by IGF1R.
R-BTA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Gene expression databases

BgeeiENSBTAG00000013066.
ExpressionAtlasiP07456. baseline and differential.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF08365. IGF2_C. 1 hit.
PF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomiPD005188. IGF2_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGF2_BOVIN
AccessioniPrimary (citable) accession number: P07456
Secondary accession number(s): A0A5F2, Q2HJN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: May 30, 2006
Last modified: November 2, 2016
This is version 137 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.