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Protein

Insulin-like growth factor II

Gene

IGF2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling.By similarity
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.By similarity

Miscellaneous

The IGF2 locus is imprinted. Paternal inherited gene is expressed, while the maternal inherited gene is imprinted, hence silenced.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei48Important for interaction with integrinBy similarity1
Sitei58Important for interaction with integrinBy similarity1
Sitei61Important for interaction with integrinBy similarity1
Sitei62Important for interaction with integrinBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Hormone, Mitogen
Biological processCarbohydrate metabolism, Glucose metabolism, Osteogenesis

Enzyme and pathway databases

ReactomeiR-BTA-114608 Platelet degranulation
R-BTA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-BTA-2428928 IRS-related events triggered by IGF1R
R-BTA-2428933 SHC-related events triggered by IGF1R
R-BTA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor II
Short name:
IGF-II
Alternative name(s):
Erythrotropin
Cleaved into the following 2 chains:
Gene namesi
Name:IGF2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Organism-specific databases

VGNCiVGNC:30078 IGF2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 242 PublicationsAdd BLAST24
ChainiPRO_000001571125 – 91Insulin-like growth factor IIAdd BLAST67
PropeptideiPRO_000001571292 – 179E peptideAdd BLAST88
PeptideiPRO_000037037393 – 126PreptinAdd BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 71By similarity
Disulfide bondi45 ↔ 84By similarity
Disulfide bondi70 ↔ 75By similarity
Glycosylationi106O-linked (GalNAc...) threonine1 Publication1
Glycosylationi154O-linked (GalNAc...) serine1 Publication1
Glycosylationi163O-linked (GalNAc...) threonine1 Publication1

Post-translational modificationi

Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP07456
PRIDEiP07456

PTM databases

GlyConnecti778
iPTMnetiP07456
UniCarbKBiP07456

Expressioni

Gene expression databases

BgeeiENSBTAG00000013066
ExpressionAtlasiP07456 baseline and differential

Interactioni

Subunit structurei

Interacts with MYORG; this interaction is required for IGF2 secretion. Interacts with integrins ITGAV:ITGB3 and ITGA6:ITGB4; integrin-binding is required for IGF2 signaling.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017372

Structurei

3D structure databases

ProteinModelPortaliP07456
SMRiP07456
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 52BAdd BLAST28
Regioni53 – 64CAdd BLAST12
Regioni65 – 85AAdd BLAST21
Regioni86 – 91D6

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IY3P Eukaryota
ENOG4111KP2 LUCA
GeneTreeiENSGT00530000063856
HOGENOMiHOG000233362
HOVERGENiHBG006137
InParanoidiP07456
KOiK13769
OMAiFPRYPVG
OrthoDBiEOG091G0H56
TreeFamiTF332820

Family and domain databases

InterProiView protein in InterPro
IPR022334 IGF2
IPR013576 IGF2_C
IPR016179 Insulin-like
IPR022350 Insulin-like_growth_factor
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF08365 IGF2_C, 1 hit
PF00049 Insulin, 1 hit
PRINTSiPR02002 INSLNLIKEGF
PR02006 INSLNLIKEGF2
PR00276 INSULINFAMLY
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005188 IGF2_C, 1 hit
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGITAGKSVL VLLAFLAFAS CCYAAYRPSE TLCGGELVDT LQFVCGDRGF
60 70 80 90 100
YFSRPSSRIN RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSASTTV
110 120 130 140 150
LPDDVTAYPV GKFFQYDIWK QSTQRLRRGL PAFLRARRGR TLAKELEALR
160 170
EAKSHRPLIA LPTQDPATHG GASSKASSD
Length:179
Mass (Da):19,682
Last modified:May 30, 2006 - v4
Checksum:iDEA16ED2D792EA53
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46 – 47GD → DG AA sequence (PubMed:2302223).Curated2
Sequence conflicti58R → L in ABD34310 (PubMed:16120826).Curated1
Sequence conflicti59I → S AA sequence (PubMed:3941093).Curated1
Sequence conflicti168T → I in CAA37620 (PubMed:2388846).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY957981 mRNA Translation: ABD34310.1
BC116039 mRNA Translation: AAI16040.1
X53553 mRNA Translation: CAA37620.1
X53867 mRNA Translation: CAA37861.1
PIRiS10983 IGBO2
RefSeqiNP_776512.2, NM_174087.3
XP_005227330.1, XM_005227273.1
XP_005227331.1, XM_005227274.3
XP_005227332.1, XM_005227275.3
XP_005227333.1, XM_005227276.1
XP_015316818.1, XM_015461332.1
UniGeneiBt.106739

Genome annotation databases

EnsembliENSBTAT00000017372; ENSBTAP00000017372; ENSBTAG00000013066
ENSBTAT00000044139; ENSBTAP00000041652; ENSBTAG00000013066
GeneIDi281240
KEGGibta:281240

Similar proteinsi

Entry informationi

Entry nameiIGF2_BOVIN
AccessioniPrimary (citable) accession number: P07456
Secondary accession number(s): A0A5F2, Q2HJN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: May 30, 2006
Last modified: May 23, 2018
This is version 147 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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