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P07456

- IGF2_BOVIN

UniProt

P07456 - IGF2_BOVIN

Protein

Insulin-like growth factor II

Gene

IGF2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 4 (30 May 2006)
      Previous versions | rss
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    Functioni

    The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
    Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3 By similarity.By similarity

    GO - Molecular functioni

    1. protein serine/threonine kinase activator activity Source: Ensembl
    2. receptor activator activity Source: Ensembl

    GO - Biological processi

    1. exocrine pancreas development Source: Ensembl
    2. glucose metabolic process Source: UniProtKB-KW
    3. insulin receptor signaling pathway via phosphatidylinositol 3-kinase Source: Ensembl
    4. organ morphogenesis Source: Ensembl
    5. osteoblast differentiation Source: Ensembl
    6. positive regulation of activated T cell proliferation Source: Ensembl
    7. positive regulation of cell division Source: UniProtKB-KW
    8. positive regulation of glycogen (starch) synthase activity Source: Ensembl
    9. positive regulation of glycogen biosynthetic process Source: Ensembl
    10. positive regulation of insulin receptor signaling pathway Source: Ensembl
    11. positive regulation of MAPK cascade Source: Ensembl
    12. positive regulation of mitosis Source: Ensembl
    13. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    14. positive regulation of protein kinase B signaling Source: Ensembl
    15. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    16. striated muscle cell differentiation Source: Ensembl

    Keywords - Molecular functioni

    Growth factor, Hormone, Mitogen

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism, Osteogenesis

    Enzyme and pathway databases

    ReactomeiREACT_201972. SHC-related events triggered by IGF1R.
    REACT_205176. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
    REACT_206584. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
    REACT_225366. IRS-related events triggered by IGF1R.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor II
    Short name:
    IGF-II
    Alternative name(s):
    Erythrotropin
    Cleaved into the following 2 chains:
    Gene namesi
    Name:IGF2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 29

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 24242 PublicationsAdd
    BLAST
    Chaini25 – 9167Insulin-like growth factor IIPRO_0000015711Add
    BLAST
    Propeptidei92 – 17988E peptidePRO_0000015712Add
    BLAST
    Peptidei93 – 12634PreptinPRO_0000370373Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 71By similarity
    Disulfide bondi45 ↔ 84By similarity
    Disulfide bondi70 ↔ 75By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiP07456.

    Structurei

    3D structure databases

    ProteinModelPortaliP07456.
    SMRiP07456. Positions 25-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni25 – 5228BAdd
    BLAST
    Regioni53 – 6412CAdd
    BLAST
    Regioni65 – 8521AAdd
    BLAST
    Regioni86 – 916D

    Sequence similaritiesi

    Belongs to the insulin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44017.
    GeneTreeiENSGT00530000063856.
    HOGENOMiHOG000233362.
    HOVERGENiHBG006137.
    InParanoidiP07456.
    KOiK13769.
    OMAiRYRWQAE.
    OrthoDBiEOG7TF7CG.
    TreeFamiTF332820.

    Family and domain databases

    Gene3Di1.10.100.10. 1 hit.
    InterProiIPR022334. IGF2.
    IPR013576. IGF2_C.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view]
    PfamiPF08365. IGF2_C. 1 hit.
    PF00049. Insulin. 2 hits.
    [Graphical view]
    PRINTSiPR02002. INSLNLIKEGF.
    PR02006. INSLNLIKEGF2.
    PR00276. INSULINFAMLY.
    ProDomiPD005188. IGF2_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 1 hit.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07456-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGITAGKSVL VLLAFLAFAS CCYAAYRPSE TLCGGELVDT LQFVCGDRGF    50
    YFSRPSSRIN RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSASTTV 100
    LPDDVTAYPV GKFFQYDIWK QSTQRLRRGL PAFLRARRGR TLAKELEALR 150
    EAKSHRPLIA LPTQDPATHG GASSKASSD 179
    Length:179
    Mass (Da):19,682
    Last modified:May 30, 2006 - v4
    Checksum:iDEA16ED2D792EA53
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti46 – 472GD → DG AA sequence (PubMed:2302223)Curated
    Sequence conflicti58 – 581R → L in ABD34310. (PubMed:16120826)Curated
    Sequence conflicti59 – 591I → S AA sequence (PubMed:3941093)Curated
    Sequence conflicti168 – 1681T → I in CAA37620. (PubMed:2388846)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY957981 mRNA. Translation: ABD34310.1.
    BC116039 mRNA. Translation: AAI16040.1.
    X53553 mRNA. Translation: CAA37620.1.
    X53867 mRNA. Translation: CAA37861.1.
    PIRiS10983. IGBO2.
    RefSeqiNP_776512.2. NM_174087.3.
    XP_005227330.1. XM_005227273.1.
    XP_005227331.1. XM_005227274.1.
    XP_005227332.1. XM_005227275.1.
    XP_005227333.1. XM_005227276.1.
    XP_005227334.1. XM_005227277.1.
    XP_005227335.1. XM_005227278.1.
    UniGeneiBt.106739.

    Genome annotation databases

    EnsembliENSBTAT00000017372; ENSBTAP00000017372; ENSBTAG00000013066.
    ENSBTAT00000044139; ENSBTAP00000041652; ENSBTAG00000013066.
    GeneIDi281240.
    KEGGibta:281240.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY957981 mRNA. Translation: ABD34310.1 .
    BC116039 mRNA. Translation: AAI16040.1 .
    X53553 mRNA. Translation: CAA37620.1 .
    X53867 mRNA. Translation: CAA37861.1 .
    PIRi S10983. IGBO2.
    RefSeqi NP_776512.2. NM_174087.3.
    XP_005227330.1. XM_005227273.1.
    XP_005227331.1. XM_005227274.1.
    XP_005227332.1. XM_005227275.1.
    XP_005227333.1. XM_005227276.1.
    XP_005227334.1. XM_005227277.1.
    XP_005227335.1. XM_005227278.1.
    UniGenei Bt.106739.

    3D structure databases

    ProteinModelPortali P07456.
    SMRi P07456. Positions 25-91.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P07456.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000017372 ; ENSBTAP00000017372 ; ENSBTAG00000013066 .
    ENSBTAT00000044139 ; ENSBTAP00000041652 ; ENSBTAG00000013066 .
    GeneIDi 281240.
    KEGGi bta:281240.

    Organism-specific databases

    CTDi 3481.

    Phylogenomic databases

    eggNOGi NOG44017.
    GeneTreei ENSGT00530000063856.
    HOGENOMi HOG000233362.
    HOVERGENi HBG006137.
    InParanoidi P07456.
    KOi K13769.
    OMAi RYRWQAE.
    OrthoDBi EOG7TF7CG.
    TreeFami TF332820.

    Enzyme and pathway databases

    Reactomei REACT_201972. SHC-related events triggered by IGF1R.
    REACT_205176. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
    REACT_206584. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
    REACT_225366. IRS-related events triggered by IGF1R.

    Miscellaneous databases

    NextBioi 20805285.

    Family and domain databases

    Gene3Di 1.10.100.10. 1 hit.
    InterProi IPR022334. IGF2.
    IPR013576. IGF2_C.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view ]
    Pfami PF08365. IGF2_C. 1 hit.
    PF00049. Insulin. 2 hits.
    [Graphical view ]
    PRINTSi PR02002. INSLNLIKEGF.
    PR02006. INSLNLIKEGF2.
    PR00276. INSULINFAMLY.
    ProDomi PD005188. IGF2_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 1 hit.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Promoter-specific expression of the imprinted IGF2 gene in cattle (Bos taurus)."
      Curchoe C., Zhang S., Bin Y., Zhang X., Yang L., Feng D., O'Neill M., Tian X.C.
      Biol. Reprod. 73:1275-1281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Ascending colon.
    3. "Insulin-like growth factors I and II in fetal and adult bovine serum. Purification, primary structures, and immunological cross-reactivities."
      Honegger A., Humbel R.E.
      J. Biol. Chem. 261:569-575(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-91.
    4. "Insulin-like growth factors 1 and 2 in bovine colostrum. Sequences and biological activities compared with those of a potent truncated form."
      Francis G.L., Upton F.M., Ballard F.J., McNeil K.A., Wallace J.C.
      Biochem. J. 251:95-103(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    5. "A heparin-binding erythroid cell stimulating factor from fetal bovine serum has the N-terminal sequence of insulin-like growth factor II."
      Li Q., Blacher R., Esch F., Congote L.F.
      Biochem. Biophys. Res. Commun. 166:557-561(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-55.
    6. "The nucleotide and deduced amino acid sequences of insulin-like growth factor II cDNAs from adult bovine and fetal sheep liver."
      Brown W.M., Dziegielewska K.M., Foreman R.C., Saunders N.R.
      Nucleic Acids Res. 18:4614-4614(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-179.
      Tissue: Liver.
    7. "Nucleotide sequence of the central coding region of bovine erythrotropin/insulin-like growth factor II cDNA from fetal intestine and northern analysis of the major IGF II transcripts at the time of hepatic erythropoiesis."
      Congote L.F., Mazza L., Palfree R.G.E.
      Comp. Biochem. Physiol. 103B:127-131(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-86.

    Entry informationi

    Entry nameiIGF2_BOVIN
    AccessioniPrimary (citable) accession number: P07456
    Secondary accession number(s): A0A5F2, Q2HJN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 116 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3