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Protein

Insulin-like growth factor I

Gene

IGF1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell proliferation Source: AgBase
  • hyperosmotic salinity response Source: AgBase
  • insulin-like growth factor receptor signaling pathway Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of release of cytochrome c from mitochondria Source: UniProtKB
  • negative regulation of sodium:potassium-exchanging ATPase activity Source: AgBase
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of glucose import Source: UniProtKB
  • positive regulation of glycogen biosynthetic process Source: UniProtKB
  • positive regulation of sodium:potassium-exchanging ATPase activity Source: AgBase
  • response to electrical stimulus Source: AgBase
  • response to food Source: AgBase
  • response to growth hormone Source: AgBase
  • response to insulin Source: AgBase
  • response to magnetism Source: AgBase

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-BTA-114608 Platelet degranulation
R-BTA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-BTA-2428928 IRS-related events triggered by IGF1R
R-BTA-2428933 SHC-related events triggered by IGF1R
R-BTA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-BTA-422085 Synthesis, secretion, and deacylation of Ghrelin

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor I
Short name:
IGF-I
Alternative name(s):
Somatomedin
Gene namesi
Name:IGF1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:30076 IGF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000015647? – 49
Signal peptidei1 – ?Sequence analysis
ChainiPRO_000001564850 – 119Insulin-like growth factor IAdd BLAST70
PropeptideiPRO_0000015649120 – 154E peptideAdd BLAST35

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55 ↔ 97By similarity
Disulfide bondi67 ↔ 110By similarity
Disulfide bondi96 ↔ 101By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP07455
PRIDEiP07455

Expressioni

Gene expression databases

BgeeiENSBTAG00000011082
ExpressionAtlasiP07455 baseline

Interactioni

Subunit structurei

Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a ternary complex with IGFR1 and ITGA6:ITGB4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055243

Structurei

3D structure databases

ProteinModelPortaliP07455
SMRiP07455
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 78BAdd BLAST29
Regioni79 – 90CAdd BLAST12
Regioni91 – 111AAdd BLAST21
Regioni112 – 119D8

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJ2T Eukaryota
ENOG4111MIV LUCA
GeneTreeiENSGT00530000063856
HOGENOMiHOG000233362
HOVERGENiHBG006137
InParanoidiP07455
KOiK05459
OMAiCFQSCDL

Family and domain databases

InterProiView protein in InterPro
IPR022341 IGF-I
IPR016179 Insulin-like
IPR022350 Insulin-like_growth_factor
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR02002 INSLNLIKEGF
PR02005 INSLNLIKEGF1
PR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07455-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKISSLPTQ LFKCCFCDFL KQVKMPITSS SHLFYLALCL LAFTSSATAG
60 70 80 90 100
PETLCGAELV DALQFVCGDR GFYFNKPTGY GSSSRRAPQT GIVDECCFRS
110 120 130 140 150
CDLRRLEMYC APLKPAKSAR SVRAQRHTDM PKAQKEVHLK NTSRGSAGNK

NYRM
Length:154
Mass (Da):17,066
Last modified:November 1, 1991 - v2
Checksum:i64201B6AF3140999
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15726 mRNA Translation: CAA33746.1
S76122 mRNA Translation: AAD14209.1
PIRiS12672 IGBO1
RefSeqiNP_001071296.1, NM_001077828.1
UniGeneiBt.12750

Genome annotation databases

EnsembliENSBTAT00000014713; ENSBTAP00000014713; ENSBTAG00000011082
GeneIDi281239
KEGGibta:281239

Similar proteinsi

Entry informationi

Entry nameiIGF1_BOVIN
AccessioniPrimary (citable) accession number: P07455
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 1, 1991
Last modified: March 28, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health