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Protein

Insulin-like growth factor I

Gene

IGF1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell proliferation Source: AgBase
  • hyperosmotic salinity response Source: AgBase
  • insulin-like growth factor receptor signaling pathway Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of release of cytochrome c from mitochondria Source: UniProtKB
  • negative regulation of sodium:potassium-exchanging ATPase activity Source: AgBase
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of glucose import Source: UniProtKB
  • positive regulation of glycogen biosynthetic process Source: UniProtKB
  • positive regulation of sodium:potassium-exchanging ATPase activity Source: AgBase
  • response to electrical stimulus Source: AgBase
  • response to food Source: AgBase
  • response to growth hormone Source: AgBase
  • response to insulin Source: AgBase
  • response to magnetism Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-BTA-114608. Platelet degranulation.
R-BTA-2404192. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
R-BTA-2428928. IRS-related events triggered by IGF1R.
R-BTA-2428933. SHC-related events triggered by IGF1R.
R-BTA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-BTA-422085. Synthesis, secretion, and deacylation of Ghrelin.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor I
Short name:
IGF-I
Alternative name(s):
Somatomedin
Gene namesi
Name:IGF1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

  • alphav-beta3 integrin-IGF-1-IGF1R complex Source: UniProtKB
  • cell Source: AgBase
  • cytosol Source: AgBase
  • exocytic vesicle Source: UniProtKB
  • extracellular space Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000015647? – 49
Signal peptidei1 – ?Sequence analysis
ChainiPRO_000001564850 – 119Insulin-like growth factor IAdd BLAST70
PropeptideiPRO_0000015649120 – 154E peptideAdd BLAST35

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55 ↔ 97By similarity
Disulfide bondi67 ↔ 110By similarity
Disulfide bondi96 ↔ 101By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP07455.
PRIDEiP07455.

Expressioni

Gene expression databases

BgeeiENSBTAG00000011082.
ExpressionAtlasiP07455. differential.

Interactioni

Subunit structurei

Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a ternary complex with IGFR1 and ITGA6:ITGB4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055243.

Structurei

3D structure databases

ProteinModelPortaliP07455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 78BAdd BLAST29
Regioni79 – 90CAdd BLAST12
Regioni91 – 111AAdd BLAST21
Regioni112 – 119D8

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJ2T. Eukaryota.
ENOG4111MIV. LUCA.
GeneTreeiENSGT00530000063856.
HOGENOMiHOG000233362.
HOVERGENiHBG006137.
InParanoidiP07455.
KOiK05459.
OMAiHTVSYIH.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07455-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKISSLPTQ LFKCCFCDFL KQVKMPITSS SHLFYLALCL LAFTSSATAG
60 70 80 90 100
PETLCGAELV DALQFVCGDR GFYFNKPTGY GSSSRRAPQT GIVDECCFRS
110 120 130 140 150
CDLRRLEMYC APLKPAKSAR SVRAQRHTDM PKAQKEVHLK NTSRGSAGNK

NYRM
Length:154
Mass (Da):17,066
Last modified:November 1, 1991 - v2
Checksum:i64201B6AF3140999
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15726 mRNA. Translation: CAA33746.1.
S76122 mRNA. Translation: AAD14209.1.
PIRiS12672. IGBO1.
RefSeqiNP_001071296.1. NM_001077828.1.
UniGeneiBt.12750.

Genome annotation databases

EnsembliENSBTAT00000014713; ENSBTAP00000014713; ENSBTAG00000011082.
GeneIDi281239.
KEGGibta:281239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15726 mRNA. Translation: CAA33746.1.
S76122 mRNA. Translation: AAD14209.1.
PIRiS12672. IGBO1.
RefSeqiNP_001071296.1. NM_001077828.1.
UniGeneiBt.12750.

3D structure databases

ProteinModelPortaliP07455.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055243.

Proteomic databases

PaxDbiP07455.
PRIDEiP07455.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000014713; ENSBTAP00000014713; ENSBTAG00000011082.
GeneIDi281239.
KEGGibta:281239.

Organism-specific databases

CTDi3479.

Phylogenomic databases

eggNOGiENOG410IJ2T. Eukaryota.
ENOG4111MIV. LUCA.
GeneTreeiENSGT00530000063856.
HOGENOMiHOG000233362.
HOVERGENiHBG006137.
InParanoidiP07455.
KOiK05459.
OMAiHTVSYIH.

Enzyme and pathway databases

ReactomeiR-BTA-114608. Platelet degranulation.
R-BTA-2404192. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
R-BTA-2428928. IRS-related events triggered by IGF1R.
R-BTA-2428933. SHC-related events triggered by IGF1R.
R-BTA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-BTA-422085. Synthesis, secretion, and deacylation of Ghrelin.

Gene expression databases

BgeeiENSBTAG00000011082.
ExpressionAtlasiP07455. differential.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGF1_BOVIN
AccessioniPrimary (citable) accession number: P07455
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 1, 1991
Last modified: November 30, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.