ID   CAH1_RABIT              Reviewed;         235 AA.
AC   P07452;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   16-JUN-2009, entry version 63.
DE   RecName: Full=Carbonic anhydrase 1;
DE            EC=4.2.1.1;
DE   AltName: Full=Carbonic anhydrase I;
DE            Short=CA-I;
DE   AltName: Full=Carbonate dehydratase I;
DE   Flags: Fragment;
GN   Name=CA1;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=85140156; PubMed=3919381; DOI=10.1073/pnas.82.3.663;
RA   Konialis C.P., Barlow J.H., Butterworth P.H.W.;
RT   "Cloned cDNA for rabbit erythrocyte carbonic anhydrase I: a novel
RT   erythrocyte-specific probe to study development in erythroid
RT   tissues.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:663-667(1985).
CC   -!- FUNCTION: Reversible hydration of carbon dioxide.
CC   -!- CATALYTIC ACTIVITY: H(2)CO(3) = CO(2) + H(2)O.
CC   -!- COFACTOR: Zinc.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
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DR   EMBL; M10412; AAA31183.1; -; mRNA.
DR   PIR; A22962; A22962.
DR   UniGene; Ocu.1836; -.
DR   HSSP; P00915; 1HCB.
DR   SMR; P07452; 1-235.
DR   HOVERGEN; P07452; -.
DR   BRENDA; 4.2.1.1; 255.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004089; F:carbonate dehydratase activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon compound metabolic process; IEA:InterPro.
DR   InterPro; IPR001148; Carbonic_anhydrase_a-class_cat.
DR   InterPro; IPR018338; Carbonic_anhydrase_a-class_CS.
DR   InterPro; IPR018442; Carbonic_anhydrase_CA1.
DR   Gene3D; G3DSA:3.10.200.10; Euk_COanhd; 1.
DR   PANTHER; PTHR18952:SF30; Carbonic_anhydrase_CA1; 1.
DR   PANTHER; PTHR18952; Euk_COanhd; 1.
DR   Pfam; PF00194; Carb_anhydrase; 1.
DR   ProDom; PD000865; Euk_COanhd; 1.
DR   PROSITE; PS00162; ALPHA_CA_1; 1.
DR   PROSITE; PS51144; ALPHA_CA_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Lyase; Metal-binding; Zinc.
FT   CHAIN        <1    235       Carbonic anhydrase 1.
FT                                /FTId=PRO_0000077415.
FT   METAL        69     69       Zinc; catalytic.
FT   METAL        71     71       Zinc; catalytic.
FT   METAL        94     94       Zinc; catalytic.
FT   NON_TER       1      1
SQ   SEQUENCE   235 AA;  25696 MW;  D731C5B806867FA2 CRC64;
     GNKQSPVDIK SSEVKHDTSL KPFSVSYNPA SAKEIINVGH SFHVNFEDDS QSVLKGGPLS
     DNYRLSQFHF HWGKTDDYGS EHTVDGAKFS AELHLVHWNS GKYPNIADSV SKADGLAIVA
     VFLKVGQANP KLQKVLDALS AVKTKGKKAS FTNFDPSTLL PPSLDYWTYS GSLTHPPLHE
     SVTWLICKDS ISISSEQLAQ FRSLLSNAEG EAAVPILHNN RPPQPLKGRT VKASF
//