Reviewed, UniProtKB/Swiss-Prot P07452 (CAH1_RABIT)

Names and origin

Protein names

Recommended name:
    Carbonic anhydrase 1
    EC=4.2.1.1
Alternative name(s):
    Carbonic anhydrase I
      Short name=CA-I
    Carbonate dehydratase I

Gene names

Name:

CA1

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	235 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Zinc.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Lyase
Gene Ontology (GO)
Biological process	one-carbon compound metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 235	›235	Carbonic anhydrase 1		PRO_0000077415
Sites
	Metal binding	69	1	Zinc; catalytic
	Metal binding	71	1	Zinc; catalytic
	Metal binding	94	1	Zinc; catalytic
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P07452-1 [UniParc]. Last modified April 1, 1988. Version 1. Checksum: D731C5B806867FA2	FASTA	235	25,696
	10 20 30 40 50 60 GNKQSPVDIK SSEVKHDTSL KPFSVSYNPA SAKEIINVGH SFHVNFEDDS QSVLKGGPLS 70 80 90 100 110 120 DNYRLSQFHF HWGKTDDYGS EHTVDGAKFS AELHLVHWNS GKYPNIADSV SKADGLAIVA 130 140 150 160 170 180 VFLKVGQANP KLQKVLDALS AVKTKGKKAS FTNFDPSTLL PPSLDYWTYS GSLTHPPLHE 190 200 210 220 230 SVTWLICKDS ISISSEQLAQ FRSLLSNAEG EAAVPILHNN RPPQPLKGRT VKASF

References

[1]	"Cloned cDNA for rabbit erythrocyte carbonic anhydrase I: a novel erythrocyte-specific probe to study development in erythroid tissues." Konialis C.P., Barlow J.H., Butterworth P.H.W. Proc. Natl. Acad. Sci. U.S.A. 82:663-667(1985) [PubMed: 3919381] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M10412 mRNA. Translation: AAA31183.1.
PIR	A22962.
UniGene	Ocu.1836
3D structure databases
HSSP	HSSP built from PDB template 1HCB based on UniProtKB P00915.
SMR	P07452. Positions 1-235.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P07452.
Enzyme and pathway databases
BRENDA	4.2.1.1. 255.
Family and domain databases
InterPro	IPR001148. Carbonic_anhydrase_a-class_cat. IPR018338. Carbonic_anhydrase_a-class_CS. IPR018442. Carbonic_anhydrase_CA1. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
PANTHER	PTHR18952:SF30. Carbonic_anhydrase_CA1. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
ProDom	PD000865. Euk_COanhd. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAH1_RABIT

Accession

Primary (citable) accession number: P07452

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	April 1, 1988
Last modified:	June 16, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)