Carbonic anhydrase 3 - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot P07451 (CAH3_HUMAN)

Last modified June 16, 2009. Version 109. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Carbonic anhydrase 3
    EC=4.2.1.1
Alternative name(s):
    Carbonic anhydrase III
      Short name=CA-III
    Carbonate dehydratase III

Gene names

Name:

CA3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H₂CO₃ = CO₂ + H₂O.
Cofactor	Zinc By similarity.
Subcellular location	Cytoplasm.
Tissue specificity	Muscle specific.
Developmental stage	At 6 weeks gestation, transcripts accumulate at low levels in the somites and at high levels throughout the notochord. As gestation continues, CA3 becomes abundant in all developing muscle masses and continues at high to moderate levels in the notochord. Ref.6
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

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Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Ligand	Metal-binding Zinc
Molecular function	Lyase
Technical term	3D-structure
Gene Ontology (GO)
Biological process	one-carbon compound metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carbonate dehydratase activity Ref.1 Traceable author statement. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 260

259

Carbonic anhydrase 3

PRO_0000077426

Sites

Metal binding

Zinc; catalytic

Metal binding

Zinc; catalytic

Metal binding

119

Zinc; catalytic

Natural variations

Natural variant

V → I: dbSNP rs20571. Ref.4

VAR_016180

Secondary structure

260

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

P07451-1 [UniParc].

Last modified March 20, 2007. Version 3.
Checksum: A305334167233FCF
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FASTA

260

29,557

        10         20         30         40         50         60 
MAKEWGYASH NGPDHWHELF PNAKGENQSP VELHTKDIRH DPSLQPWSVS YDGGSAKTIL 

        70         80         90        100        110        120 
NNGKTCRVVF DDTYDRSMLR GGPLPGPYRL RQFHLHWGSS DDHGSEHTVD GVKYAAELHL 

       130        140        150        160        170        180 
VHWNPKYNTF KEALKQRDGI AVIGIFLKIG HENGEFQIFL DALDKIKTKG KEAPFTKFDP 

       190        200        210        220        230        240 
SCLFPACRDY WTYQGSFTTP PCEECIVWLL LKEPMTVSSD QMAKLRSLLS SAENEPPVPL 

       250        260 
VSNWRPPQPI NNRVVRASFK

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence and derived amino acid sequence of a cDNA encoding human muscle carbonic anhydrase." Lloyd J., McMillan S., Hopkinson D., Edwards Y.H. Gene 41:233-239(1986) [PubMed: 3086182] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Nucleotide sequence, tissue-specific expression, and chromosome location of human carbonic anhydrase III: the human CAIII gene is located on the same chromosome as the closely linked CAI and CAII genes." Wade R., Gunning P., Eddy R., Shows T., Kedes L. Proc. Natl. Acad. Sci. U.S.A. 83:9571-9575(1986) [PubMed: 3099285] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pericardium.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-31. Tissue: Muscle.
[5]	"Human muscle carbonic anhydrase: gene structure and DNA methylation patterns in fetal and adult tissues." Lloyd J., Brownson C., Tweedie S., Charlton J., Edwards Y.H. Genes Dev. 1:594-602(1987) [PubMed: 2824285] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	"Sequence comparisons and functional studies of the proximal promoter of the carbonic anhydrase 3 (CA3) gene." Sowden J., Smith H., Morrison K., Edwards Y. Gene 214:157-165(1998) [PubMed: 9651514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

M29458 Genomic DNA. Translation: AAA52293.1.
M29452 Genomic DNA. No translation available.
AK313254 mRNA. Translation: BAG36064.1.
BC004897 mRNA. Translation: AAH04897.1.
AJ006473 Genomic DNA. Translation: CAA07056.1.

IPI

IPI00216983.

PIR

CRHU3. A26658.

RefSeq

NP_005172.1.

UniGene

Hs.82129

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1Z93	X-ray	2.10	A	1-260	[»]
1Z97	X-ray	2.10	A	1-260	[»]
2HFW	X-ray	2.50	A	1-260	[»]
2HFX	X-ray	1.70	A	1-260	[»]
2HFY	X-ray	2.60	A	1-260	[»]

ModBase

Search...

2-D gel databases

HSC-2DPAGE

P07451.

Genome annotation databases

Ensembl

ENSG00000164879. Homo sapiens. [Contig view]

GeneID

761.

KEGG

hsa:761.

Organism-specific databases

GeneCards

GC08P086537.

H-InvDB

HIX0078885.

HGNC

HGNC:1374. CA3.

HPA

CAB004967.

MIM

114750. gene.

PharmGKB

PA24378.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

P07451.

HOVERGEN

P07451.

OMA

P07451. YDGGSAK.

Enzyme and pathway databases

BRENDA

4.2.1.1. 247.

Gene expression databases

ArrayExpress

P07451.

Bgee

P07451.

CleanEx

HS_CA3.

GermOnline

ENSG00000164879. Homo sapiens.

Family and domain databases

InterPro

IPR001148. Carbonic_anhydrase_a-class_cat.
IPR018338. Carbonic_anhydrase_a-class_CS.
IPR018441. Carbonic_anhydrase_CA3.
[Graphical view]

Gene3D

G3DSA:3.10.200.10. Euk_COanhd. 1 hit.

PANTHER

PTHR18952:SF29. Carbonic_anhydrase_CA3. 1 hit.
PTHR18952. Euk_COanhd. 1 hit.

Pfam

PF00194. Carb_anhydrase. 1 hit.
[Graphical view]

ProDom

PD000865. Euk_COanhd. 1 hit.
[Graphical view] [Entries sharing at least one domain]

PROSITE

PS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

3078.

SOURCE

Search...

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Entry information

Entry name

CAH3_HUMAN

Accession

Primary (citable) accession number: P07451
Secondary accession number(s): B2R867, O60842

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	March 20, 2007
Last modified:	June 16, 2009
This is version 109 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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