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P07446

- RNPB_PENBR

UniProt

P07446 - RNPB_PENBR

Protein

Guanyl-specific ribonuclease Pb1

Gene
N/A
Organism
Penicillium brevicompactum
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Catalytic activityi

    Two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in G-P with 2',3'-cyclic phosphate intermediates.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei38 – 381By similarity
    Active sitei56 – 561Proton acceptorBy similarity
    Active sitei90 – 901Proton donorBy similarity

    GO - Molecular functioni

    1. endoribonuclease activity Source: InterPro
    2. ribonuclease T1 activity Source: UniProtKB-EC
    3. RNA binding Source: InterPro

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanyl-specific ribonuclease Pb1 (EC:3.1.27.3)
    Short name:
    RNase Pb1
    OrganismiPenicillium brevicompactum
    Taxonomic identifieri5074 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicillium

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 102102Guanyl-specific ribonuclease Pb1PRO_0000137372Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi2 ↔ 101 Publication
    Disulfide bondi6 ↔ 1011 Publication

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliP07446.
    SMRiP07446. Positions 1-102.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribonuclease N1/T1 family.Curated

    Family and domain databases

    Gene3Di3.10.450.30. 1 hit.
    InterProiIPR000026. Gua-sp_ribonuclease_N1/T1.
    IPR016191. Ribonuclease/ribotoxin.
    [Graphical view]
    PfamiPF00545. Ribonuclease. 1 hit.
    [Graphical view]
    SUPFAMiSSF53933. SSF53933. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P07446-1 [UniParc]FASTAAdd to Basket

    « Hide

    ACAATCGTVC YTSSAISSAQ AAGYNLYSTN DDVSNYPHEY HNYEGFDFPV    50
    SGTYYEFPIL KSGKVYTGSS PGADRVIFND DDELAGVITH TGASGNNFVA 100
    CT 102
    Length:102
    Mass (Da):10,803
    Last modified:April 1, 1988 - v1
    Checksum:i1D8AA5602C93DEEE
    GO

    Sequence databases

    PIRiA23350. NRPLTB.

    Cross-referencesi

    Sequence databases

    PIRi A23350. NRPLTB.

    3D structure databases

    ProteinModelPortali P07446.
    SMRi P07446. Positions 1-102.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.10.450.30. 1 hit.
    InterProi IPR000026. Gua-sp_ribonuclease_N1/T1.
    IPR016191. Ribonuclease/ribotoxin.
    [Graphical view ]
    Pfami PF00545. Ribonuclease. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53933. SSF53933. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the guanyl-specific ribonuclease structures in fungi: determination of the amino acid sequence and prediction of the secondary ribonuclease structure in Penicillium brevicompactum."
      Shlyapnikov S.V., Yakovlev G.I., Kulikov V.A.
      Dokl. Akad. Nauk SSSR 281:226-229(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, DISULFIDE BONDS.

    Entry informationi

    Entry nameiRNPB_PENBR
    AccessioniPrimary (citable) accession number: P07446
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3