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P07446

- RNPB_PENBR

UniProt

P07446 - RNPB_PENBR

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Protein
Guanyl-specific ribonuclease Pb1
Gene
N/A
Organism
Penicillium brevicompactum
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in G-P with 2',3'-cyclic phosphate intermediates.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381 By similarity
Active sitei56 – 561Proton acceptor By similarity
Active sitei90 – 901Proton donor By similarity

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. endoribonuclease activity Source: InterPro
  3. ribonuclease T1 activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Guanyl-specific ribonuclease Pb1 (EC:3.1.27.3)
Short name:
RNase Pb1
OrganismiPenicillium brevicompactum
Taxonomic identifieri5074 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicillium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 102102Guanyl-specific ribonuclease Pb1
PRO_0000137372Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi2 ↔ 101 Publication
Disulfide bondi6 ↔ 1011 Publication

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP07446.
SMRiP07446. Positions 1-102.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.10.450.30. 1 hit.
InterProiIPR000026. Gua-sp_ribonuclease_N1/T1.
IPR016191. Ribonuclease/ribotoxin.
[Graphical view]
PfamiPF00545. Ribonuclease. 1 hit.
[Graphical view]
SUPFAMiSSF53933. SSF53933. 1 hit.

Sequencei

Sequence statusi: Complete.

P07446-1 [UniParc]FASTAAdd to Basket

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ACAATCGTVC YTSSAISSAQ AAGYNLYSTN DDVSNYPHEY HNYEGFDFPV    50
SGTYYEFPIL KSGKVYTGSS PGADRVIFND DDELAGVITH TGASGNNFVA 100
CT 102
Length:102
Mass (Da):10,803
Last modified:April 1, 1988 - v1
Checksum:i1D8AA5602C93DEEE
GO

Sequence databases

PIRiA23350. NRPLTB.

Cross-referencesi

Sequence databases

PIRi A23350. NRPLTB.

3D structure databases

ProteinModelPortali P07446.
SMRi P07446. Positions 1-102.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.10.450.30. 1 hit.
InterProi IPR000026. Gua-sp_ribonuclease_N1/T1.
IPR016191. Ribonuclease/ribotoxin.
[Graphical view ]
Pfami PF00545. Ribonuclease. 1 hit.
[Graphical view ]
SUPFAMi SSF53933. SSF53933. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Analysis of the guanyl-specific ribonuclease structures in fungi: determination of the amino acid sequence and prediction of the secondary ribonuclease structure in Penicillium brevicompactum."
    Shlyapnikov S.V., Yakovlev G.I., Kulikov V.A.
    Dokl. Akad. Nauk SSSR 281:226-229(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, DISULFIDE BONDS.

Entry informationi

Entry nameiRNPB_PENBR
AccessioniPrimary (citable) accession number: P07446
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3