P07438 (MT1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 108.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Metallothionein-1B Short name=MT-1B Alternative name(s): Metallothionein-IB Short name=MT-IB | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 61 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. |
| Subunit structure | Monomer. |
| Domain | Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Cadmium Copper Metal-binding Metal-thiolate cluster Zinc |
| PTM | Acetylation |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | cellular response to zinc ion Inferred from expression pattern. Source: UniProtKB negative regulation of growthInferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | nucleus Inferred from sequence or structural similarity. Source: UniProtKB perinuclear region of cytoplasmInferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | cadmium ion binding Non-traceable author statement. Source: UniProtKB copper ion bindingNon-traceable author statement. Source: UniProtKB zinc ion bindingInferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 61 | 61 | Metallothionein-1B | PRO_0000197235 | |||||
Regions | |||||||||
| Region | 1 – 29 | 29 | Beta | ||||||
| Region | 30 – 61 | 32 | Alpha | ||||||
Sites | |||||||||
| Metal binding | 5 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 7 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 13 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 15 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 19 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 21 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 24 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 26 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 29 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 33 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 34 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 36 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 37 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 41 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 44 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 48 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 50 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 57 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 59 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 60 | 1 | Divalent metal cation; cluster A | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1 | 1 | N-acetylmethionine By similarity | ||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Structure and tissue-specific expression of the human metallothionein IB gene." Heguy A., West A., Richards R.I., Karin M. Mol. Cell. Biol. 6:2149-2157(1986) [PubMed: 3785191] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Metallothioneins and DNA crosslink damage." Xie J., Jiang F., Head D., Briggs R. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M13485, M13484 Genomic DNA. Translation: AAA36331.1. AY168638 mRNA. Translation: AAN86984.1. BC069421 mRNA. Translation: AAH69421.1. |
| IPI | IPI00011655. |
| PIR | SMHU1B. A25244. |
| RefSeq | NP_005938.1. NM_005947.2. |
| UniGene | Hs.656629. |
3D structure databases | |
| ProteinModelPortal | P07438. |
| SMR | P07438. Positions 1-61. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P07438. |
PTM databases | |
| PhosphoSite | P07438. |
Polymorphism databases | |
| DMDM | 127367. |
Proteomic databases | |
| PRIDE | P07438. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000334346; ENSP00000334998; ENSG00000169688. |
| GeneID | 4490. |
| KEGG | hsa:4490. |
| UCSC | uc002ejs.1. human. |
Organism-specific databases | |
| CTD | 4490. |
| GeneCards | GC16P056685. |
| H-InvDB | HIX0059563. |
| HGNC | HGNC:7394. MT1B. |
| MIM | 156349. gene. |
| neXtProt | NX_P07438. |
| PharmGKB | PA31199. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | maNOG21730. |
| HOVERGEN | HBG094459. |
| InParanoid | P07438. |
| OMA | CACKEAS. |
Gene expression databases | |
| ArrayExpress | P07438. |
| Bgee | P07438. |
| CleanEx | HS_MT1B. |
| Genevestigator | P07438. |
Family and domain databases | |
| InterPro | IPR017854. Metalthion_dom. IPR023587. Metalthion_dom_vert. IPR003019. Metalthion_sfam_euk. IPR000006. Metalthion_vert. IPR018064. Metalthion_vert_metal_BS. [Graphical view] |
| Gene3D | G3DSA:4.10.10.10. Metallothionein_vert. 1 hit. |
| KO | K14739. |
| PANTHER | PTHR23299. Metallothionein_vert. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| PRINTS | PR00860. MTVERTEBRATE. |
| SUPFAM | SSF57868. Metallothionein_sfam. 1 hit. |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 17371. |
| SOURCE | Search... |
Entry information
| Entry name | MT1B_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P07438 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Metallothioneins Classification of metallothioneins and list of entries |
| Human chromosome 16 Human chromosome 16: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |