Reviewed, UniProtKB/Swiss-Prot P07438 (MT1B_HUMAN)

Names and origin

Protein names

Recommended name:
    Metallothionein-1B
      Short name=MT-1B
Alternative name(s):
    Metallothionein-IB
      Short name=MT-IB

Gene names

Name:	MT1B
Synonyms:	MT1Q

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	61 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Subunit structure	Monomer.
Domain	Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Ligand	Cadmium Copper Metal-binding Metal-thiolate cluster Zinc
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Non-traceable author statement. Source: UniProtKB
Molecular function	cadmium ion binding Non-traceable author statement. Source: UniProtKB copper ion binding Non-traceable author statement. Source: UniProtKB zinc ion binding Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 61	61	Metallothionein-1B		PRO_0000197235
Regions
	Region	1 – 29	29	Beta
	Region	30 – 61	32	Alpha
Sites
	Metal binding	5	1	Cluster B
	Metal binding	7	1	Cluster B
	Metal binding	13	1	Cluster B
	Metal binding	15	1	Cluster B
	Metal binding	19	1	Cluster B
	Metal binding	21	1	Cluster B
	Metal binding	24	1	Cluster B
	Metal binding	26	1	Cluster B
	Metal binding	29	1	Cluster B
	Metal binding	33	1	Cluster A
	Metal binding	34	1	Cluster A
	Metal binding	36	1	Cluster A
	Metal binding	37	1	Cluster A
	Metal binding	41	1	Cluster A
	Metal binding	44	1	Cluster A
	Metal binding	48	1	Cluster A
	Metal binding	50	1	Cluster A
	Metal binding	57	1	Cluster A
	Metal binding	59	1	Cluster A
	Metal binding	60	1	Cluster A
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P07438-1 [UniParc]. Last modified April 1, 1988. Version 1. Checksum: 8DC566E5462810D3	FASTA	61	6,115
	10 20 30 40 50 60 MDPNCSCTTG GSCACAGSCK CKECKCTSCK KCCCSCCPVG CAKCAQGCVC KGSSEKCRCC A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and tissue-specific expression of the human metallothionein IB gene." Heguy A., West A., Richards R.I., Karin M. Mol. Cell. Biol. 6:2149-2157(1986) [PubMed: 3785191] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Metallothioneins and DNA crosslink damage." Xie J., Jiang F., Head D., Briggs R. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M13485, M13484 Genomic DNA. Translation: AAA36331.1. AY168638 mRNA. Translation: AAN86984.1. BC069421 mRNA. Translation: AAH69421.1.
IPI	IPI00011655.
PIR	SMHU1B. A25244.
RefSeq	NP_005938.1.
UniGene	Hs.656629
3D structure databases
SMR	P07438. Positions 1-61.
ModBase	Search...
Protein-protein interaction databases
STRING	P07438.
PTM databases
PhosphoSite	P07438.
Proteomic databases
PRIDE	P07438.
Genome annotation databases
Ensembl	ENST00000334346; ENSP00000334998; ENSG00000169688; Homo sapiens. [Genome view]
GeneID	4490.
KEGG	hsa:4490.
UCSC	uc002ejs.1. human.
Organism-specific databases
CTD	4490.
GeneCards	GC16P055243.
H-InvDB	HIX0059564.
HGNC	HGNC:7394. MT1B.
MIM	156349. gene.
PharmGKB	PA26533.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P07438.
HOVERGEN	P07438.
OMA	IDCAKCA
Gene expression databases
ArrayExpress	P07438.
Bgee	P07438.
CleanEx	HS_MT1B.
Genevestigator	P07438.
Family and domain databases
InterPro	IPR017854. Metallothionein_sfam. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. IPR018064. Metallothionein_vert_metal_BS. [Graphical view]
Gene3D	G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHER	PTHR23299. Metallothionein_vert. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00860. MTVERTEBRATE.
PROSITE	PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	17371.
SOURCE	Search...

Entry information

Entry name

MT1B_HUMAN

Accession

Primary (citable) accession number: P07438

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	April 1, 1988
Last modified:	November 24, 2009
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.