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Protein

Metallothionein-1B

Gene

MT1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster B1
Metal bindingi7Divalent metal cation; cluster B1
Metal bindingi13Divalent metal cation; cluster B1
Metal bindingi15Divalent metal cation; cluster B1
Metal bindingi19Divalent metal cation; cluster B1
Metal bindingi21Divalent metal cation; cluster B1
Metal bindingi24Divalent metal cation; cluster B1
Metal bindingi26Divalent metal cation; cluster B1
Metal bindingi29Divalent metal cation; cluster B1
Metal bindingi33Divalent metal cation; cluster A1
Metal bindingi34Divalent metal cation; cluster A1
Metal bindingi36Divalent metal cation; cluster A1
Metal bindingi37Divalent metal cation; cluster A1
Metal bindingi41Divalent metal cation; cluster A1
Metal bindingi44Divalent metal cation; cluster A1
Metal bindingi48Divalent metal cation; cluster A1
Metal bindingi50Divalent metal cation; cluster A1
Metal bindingi57Divalent metal cation; cluster A1
Metal bindingi59Divalent metal cation; cluster A1
Metal bindingi60Divalent metal cation; cluster A1

GO - Molecular functioni

GO - Biological processi

  • cellular response to zinc ion Source: UniProtKB
  • negative regulation of growth Source: UniProtKB

Keywordsi

LigandCadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5661231 Metallothioneins bind metals

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1B
Short name:
MT-1B
Alternative name(s):
Metallothionein-IB
Short name:
MT-IB
Gene namesi
Name:MT1B
Synonyms:MT1Q
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000169688.10
HGNCiHGNC:7394 MT1B
MIMi156349 gene
neXtProtiNX_P07438

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi4490
OpenTargetsiENSG00000169688
PharmGKBiPA31199

Polymorphism and mutation databases

BioMutaiMT1B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972351 – 61Metallothionein-1BAdd BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP07438
PeptideAtlasiP07438
PRIDEiP07438

PTM databases

iPTMnetiP07438
PhosphoSitePlusiP07438

Expressioni

Gene expression databases

BgeeiENSG00000169688
CleanExiHS_MT1B
ExpressionAtlasiP07438 baseline and differential

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

IntActiP07438, 5 interactors
STRINGi9606.ENSP00000334998

Structurei

3D structure databases

ProteinModelPortaliP07438
SMRiP07438
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 61AlphaAdd BLAST32

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410KCEU Eukaryota
ENOG4110P1J LUCA
GeneTreeiENSGT00730000110883
HOGENOMiHOG000236262
HOVERGENiHBG094459
InParanoidiP07438
KOiK14739
TreeFamiTF336054

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit

Sequencei

Sequence statusi: Complete.

P07438-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPNCSCTTG GSCACAGSCK CKECKCTSCK KCCCSCCPVG CAKCAQGCVC
60
KGSSEKCRCC A
Length:61
Mass (Da):6,115
Last modified:April 1, 1988 - v1
Checksum:i8DC566E5462810D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13485, M13484 Genomic DNA Translation: AAA36331.1
AF349000 mRNA Translation: AAO32960.2
AF350250 Genomic DNA Translation: AAO49186.1
AY168638 mRNA Translation: AAN86984.1
BC069421 mRNA Translation: AAH69421.1
BC137478 mRNA Translation: AAI37479.1
BC137479 mRNA Translation: AAI37480.1
CCDSiCCDS10765.1
PIRiA25244 SMHU1B
RefSeqiNP_005938.1, NM_005947.2
UniGeneiHs.656629

Genome annotation databases

EnsembliENST00000334346; ENSP00000334998; ENSG00000169688
GeneIDi4490
KEGGihsa:4490
UCSCiuc002ejs.3 human

Similar proteinsi

Entry informationi

Entry nameiMT1B_HUMAN
AccessioniPrimary (citable) accession number: P07438
Secondary accession number(s): Q86YX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: February 28, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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