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P07438

- MT1B_HUMAN

UniProt

P07438 - MT1B_HUMAN

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Protein

Metallothionein-1B

Gene

MT1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi5 – 51Divalent metal cation; cluster B
Metal bindingi7 – 71Divalent metal cation; cluster B
Metal bindingi13 – 131Divalent metal cation; cluster B
Metal bindingi15 – 151Divalent metal cation; cluster B
Metal bindingi19 – 191Divalent metal cation; cluster B
Metal bindingi21 – 211Divalent metal cation; cluster B
Metal bindingi24 – 241Divalent metal cation; cluster B
Metal bindingi26 – 261Divalent metal cation; cluster B
Metal bindingi29 – 291Divalent metal cation; cluster B
Metal bindingi33 – 331Divalent metal cation; cluster A
Metal bindingi34 – 341Divalent metal cation; cluster A
Metal bindingi36 – 361Divalent metal cation; cluster A
Metal bindingi37 – 371Divalent metal cation; cluster A
Metal bindingi41 – 411Divalent metal cation; cluster A
Metal bindingi44 – 441Divalent metal cation; cluster A
Metal bindingi48 – 481Divalent metal cation; cluster A
Metal bindingi50 – 501Divalent metal cation; cluster A
Metal bindingi57 – 571Divalent metal cation; cluster A
Metal bindingi59 – 591Divalent metal cation; cluster A
Metal bindingi60 – 601Divalent metal cation; cluster A

GO - Molecular functioni

  1. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. cellular response to zinc ion Source: UniProtKB
  2. negative regulation of growth Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Cadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1B
Short name:
MT-1B
Alternative name(s):
Metallothionein-IB
Short name:
MT-IB
Gene namesi
Name:MT1B
Synonyms:MT1Q
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:7394. MT1B.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31199.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6161Metallothionein-1BPRO_0000197235Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP07438.
PRIDEiP07438.

PTM databases

PhosphoSiteiP07438.

Expressioni

Gene expression databases

BgeeiP07438.
CleanExiHS_MT1B.
ExpressionAtlasiP07438. baseline.
GenevestigatoriP07438.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi9606.ENSP00000334998.

Structurei

3D structure databases

ProteinModelPortaliP07438.
SMRiP07438. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2929BetaAdd
BLAST
Regioni30 – 6132AlphaAdd
BLAST

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG138665.
GeneTreeiENSGT00730000110883.
HOGENOMiHOG000236262.
HOVERGENiHBG094459.
InParanoidiP07438.
KOiK14739.
TreeFamiTF336054.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07438-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPNCSCTTG GSCACAGSCK CKECKCTSCK KCCCSCCPVG CAKCAQGCVC
60
KGSSEKCRCC A
Length:61
Mass (Da):6,115
Last modified:April 1, 1988 - v1
Checksum:i8DC566E5462810D3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13485, M13484 Genomic DNA. Translation: AAA36331.1.
AF349000 mRNA. Translation: AAO32960.2.
AF350250 Genomic DNA. Translation: AAO49186.1.
AY168638 mRNA. Translation: AAN86984.1.
BC069421 mRNA. Translation: AAH69421.1.
BC137478 mRNA. Translation: AAI37479.1.
BC137479 mRNA. Translation: AAI37480.1.
CCDSiCCDS10765.1.
PIRiA25244. SMHU1B.
RefSeqiNP_005938.1. NM_005947.2.
UniGeneiHs.656629.

Genome annotation databases

EnsembliENST00000334346; ENSP00000334998; ENSG00000169688.
GeneIDi4490.
KEGGihsa:4490.
UCSCiuc002ejs.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13485 , M13484 Genomic DNA. Translation: AAA36331.1 .
AF349000 mRNA. Translation: AAO32960.2 .
AF350250 Genomic DNA. Translation: AAO49186.1 .
AY168638 mRNA. Translation: AAN86984.1 .
BC069421 mRNA. Translation: AAH69421.1 .
BC137478 mRNA. Translation: AAI37479.1 .
BC137479 mRNA. Translation: AAI37480.1 .
CCDSi CCDS10765.1.
PIRi A25244. SMHU1B.
RefSeqi NP_005938.1. NM_005947.2.
UniGenei Hs.656629.

3D structure databases

ProteinModelPortali P07438.
SMRi P07438. Positions 1-61.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000334998.

PTM databases

PhosphoSitei P07438.

Proteomic databases

PaxDbi P07438.
PRIDEi P07438.

Protocols and materials databases

DNASUi 4490.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334346 ; ENSP00000334998 ; ENSG00000169688 .
GeneIDi 4490.
KEGGi hsa:4490.
UCSCi uc002ejs.3. human.

Organism-specific databases

CTDi 4490.
GeneCardsi GC16P056685.
HGNCi HGNC:7394. MT1B.
MIMi 156349. gene.
neXtProti NX_P07438.
PharmGKBi PA31199.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG138665.
GeneTreei ENSGT00730000110883.
HOGENOMi HOG000236262.
HOVERGENi HBG094459.
InParanoidi P07438.
KOi K14739.
TreeFami TF336054.

Miscellaneous databases

GeneWikii MT1B.
GenomeRNAii 4490.
NextBioi 17371.
PROi P07438.
SOURCEi Search...

Gene expression databases

Bgeei P07438.
CleanExi HS_MT1B.
ExpressionAtlasi P07438. baseline.
Genevestigatori P07438.

Family and domain databases

Gene3Di 4.10.10.10. 1 hit.
InterProi IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view ]
PANTHERi PTHR23299. PTHR23299. 1 hit.
Pfami PF00131. Metallothio. 1 hit.
[Graphical view ]
PRINTSi PR00860. MTVERTEBRATE.
SUPFAMi SSF57868. SSF57868. 1 hit.
PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and tissue-specific expression of the human metallothionein IB gene."
    Heguy A., West A., Richards R.I., Karin M.
    Mol. Cell. Biol. 6:2149-2157(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning of a novel member of the human metallothionein gene family-MT1Q."
    Wang J., Zheng L., Yu L.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "Metallothioneins and DNA crosslink damage."
    Xie J., Jiang F., Head D., Briggs R.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiMT1B_HUMAN
AccessioniPrimary (citable) accession number: P07438
Secondary accession number(s): Q86YX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: October 29, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3