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P07438

- MT1B_HUMAN

UniProt

P07438 - MT1B_HUMAN

Protein

Metallothionein-1B

Gene

MT1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi5 – 51Divalent metal cation; cluster B
    Metal bindingi7 – 71Divalent metal cation; cluster B
    Metal bindingi13 – 131Divalent metal cation; cluster B
    Metal bindingi15 – 151Divalent metal cation; cluster B
    Metal bindingi19 – 191Divalent metal cation; cluster B
    Metal bindingi21 – 211Divalent metal cation; cluster B
    Metal bindingi24 – 241Divalent metal cation; cluster B
    Metal bindingi26 – 261Divalent metal cation; cluster B
    Metal bindingi29 – 291Divalent metal cation; cluster B
    Metal bindingi33 – 331Divalent metal cation; cluster A
    Metal bindingi34 – 341Divalent metal cation; cluster A
    Metal bindingi36 – 361Divalent metal cation; cluster A
    Metal bindingi37 – 371Divalent metal cation; cluster A
    Metal bindingi41 – 411Divalent metal cation; cluster A
    Metal bindingi44 – 441Divalent metal cation; cluster A
    Metal bindingi48 – 481Divalent metal cation; cluster A
    Metal bindingi50 – 501Divalent metal cation; cluster A
    Metal bindingi57 – 571Divalent metal cation; cluster A
    Metal bindingi59 – 591Divalent metal cation; cluster A
    Metal bindingi60 – 601Divalent metal cation; cluster A

    GO - Molecular functioni

    1. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to zinc ion Source: UniProtKB
    2. negative regulation of growth Source: UniProtKB

    Keywords - Ligandi

    Cadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein-1B
    Short name:
    MT-1B
    Alternative name(s):
    Metallothionein-IB
    Short name:
    MT-IB
    Gene namesi
    Name:MT1B
    Synonyms:MT1Q
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:7394. MT1B.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. perinuclear region of cytoplasm Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31199.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6161Metallothionein-1BPRO_0000197235Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP07438.
    PRIDEiP07438.

    PTM databases

    PhosphoSiteiP07438.

    Expressioni

    Gene expression databases

    BgeeiP07438.
    CleanExiHS_MT1B.
    GenevestigatoriP07438.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000334998.

    Structurei

    3D structure databases

    ProteinModelPortaliP07438.
    SMRiP07438. Positions 1-61.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2929BetaAdd
    BLAST
    Regioni30 – 6132AlphaAdd
    BLAST

    Domaini

    Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG138665.
    HOGENOMiHOG000236262.
    HOVERGENiHBG094459.
    InParanoidiP07438.
    KOiK14739.
    TreeFamiTF336054.

    Family and domain databases

    Gene3Di4.10.10.10. 1 hit.
    InterProiIPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view]
    PANTHERiPTHR23299. PTHR23299. 1 hit.
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    PRINTSiPR00860. MTVERTEBRATE.
    SUPFAMiSSF57868. SSF57868. 1 hit.
    PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P07438-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPNCSCTTG GSCACAGSCK CKECKCTSCK KCCCSCCPVG CAKCAQGCVC   50
    KGSSEKCRCC A 61
    Length:61
    Mass (Da):6,115
    Last modified:April 1, 1988 - v1
    Checksum:i8DC566E5462810D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13485, M13484 Genomic DNA. Translation: AAA36331.1.
    AF349000 mRNA. Translation: AAO32960.2.
    AF350250 Genomic DNA. Translation: AAO49186.1.
    AY168638 mRNA. Translation: AAN86984.1.
    BC069421 mRNA. Translation: AAH69421.1.
    BC137478 mRNA. Translation: AAI37479.1.
    BC137479 mRNA. Translation: AAI37480.1.
    CCDSiCCDS10765.1.
    PIRiA25244. SMHU1B.
    RefSeqiNP_005938.1. NM_005947.2.
    UniGeneiHs.656629.

    Genome annotation databases

    EnsembliENST00000334346; ENSP00000334998; ENSG00000169688.
    GeneIDi4490.
    KEGGihsa:4490.
    UCSCiuc002ejs.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13485 , M13484 Genomic DNA. Translation: AAA36331.1 .
    AF349000 mRNA. Translation: AAO32960.2 .
    AF350250 Genomic DNA. Translation: AAO49186.1 .
    AY168638 mRNA. Translation: AAN86984.1 .
    BC069421 mRNA. Translation: AAH69421.1 .
    BC137478 mRNA. Translation: AAI37479.1 .
    BC137479 mRNA. Translation: AAI37480.1 .
    CCDSi CCDS10765.1.
    PIRi A25244. SMHU1B.
    RefSeqi NP_005938.1. NM_005947.2.
    UniGenei Hs.656629.

    3D structure databases

    ProteinModelPortali P07438.
    SMRi P07438. Positions 1-61.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000334998.

    PTM databases

    PhosphoSitei P07438.

    Proteomic databases

    PaxDbi P07438.
    PRIDEi P07438.

    Protocols and materials databases

    DNASUi 4490.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334346 ; ENSP00000334998 ; ENSG00000169688 .
    GeneIDi 4490.
    KEGGi hsa:4490.
    UCSCi uc002ejs.3. human.

    Organism-specific databases

    CTDi 4490.
    GeneCardsi GC16P056685.
    HGNCi HGNC:7394. MT1B.
    MIMi 156349. gene.
    neXtProti NX_P07438.
    PharmGKBi PA31199.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG138665.
    HOGENOMi HOG000236262.
    HOVERGENi HBG094459.
    InParanoidi P07438.
    KOi K14739.
    TreeFami TF336054.

    Miscellaneous databases

    GeneWikii MT1B.
    GenomeRNAii 4490.
    NextBioi 17371.
    PROi P07438.
    SOURCEi Search...

    Gene expression databases

    Bgeei P07438.
    CleanExi HS_MT1B.
    Genevestigatori P07438.

    Family and domain databases

    Gene3Di 4.10.10.10. 1 hit.
    InterProi IPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view ]
    PANTHERi PTHR23299. PTHR23299. 1 hit.
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    PRINTSi PR00860. MTVERTEBRATE.
    SUPFAMi SSF57868. SSF57868. 1 hit.
    PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and tissue-specific expression of the human metallothionein IB gene."
      Heguy A., West A., Richards R.I., Karin M.
      Mol. Cell. Biol. 6:2149-2157(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Cloning of a novel member of the human metallothionein gene family-MT1Q."
      Wang J., Zheng L., Yu L.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    3. "Metallothioneins and DNA crosslink damage."
      Xie J., Jiang F., Head D., Briggs R.
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiMT1B_HUMAN
    AccessioniPrimary (citable) accession number: P07438
    Secondary accession number(s): Q86YX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Metallothioneins
      Classification of metallothioneins and list of entries
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3