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P07438 (MT1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metallothionein-1B

Short name=MT-1B
Alternative name(s):
Metallothionein-IB
Short name=MT-IB
Gene names
Name:MT1B
Synonyms:MT1Q
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length61 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Subunit structure

Monomer.

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Belongs to the metallothionein superfamily. Type 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6161Metallothionein-1B
PRO_0000197235

Regions

Region1 – 2929Beta
Region30 – 6132Alpha

Sites

Metal binding51Divalent metal cation; cluster B
Metal binding71Divalent metal cation; cluster B
Metal binding131Divalent metal cation; cluster B
Metal binding151Divalent metal cation; cluster B
Metal binding191Divalent metal cation; cluster B
Metal binding211Divalent metal cation; cluster B
Metal binding241Divalent metal cation; cluster B
Metal binding261Divalent metal cation; cluster B
Metal binding291Divalent metal cation; cluster B
Metal binding331Divalent metal cation; cluster A
Metal binding341Divalent metal cation; cluster A
Metal binding361Divalent metal cation; cluster A
Metal binding371Divalent metal cation; cluster A
Metal binding411Divalent metal cation; cluster A
Metal binding441Divalent metal cation; cluster A
Metal binding481Divalent metal cation; cluster A
Metal binding501Divalent metal cation; cluster A
Metal binding571Divalent metal cation; cluster A
Metal binding591Divalent metal cation; cluster A
Metal binding601Divalent metal cation; cluster A

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Sequences

Sequence LengthMass (Da)Tools
P07438 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: 8DC566E5462810D3

FASTA616,115
        10         20         30         40         50         60 
MDPNCSCTTG GSCACAGSCK CKECKCTSCK KCCCSCCPVG CAKCAQGCVC KGSSEKCRCC 


A 

« Hide

References

« Hide 'large scale' references
[1]"Structure and tissue-specific expression of the human metallothionein IB gene."
Heguy A., West A., Richards R.I., Karin M.
Mol. Cell. Biol. 6:2149-2157(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Cloning of a novel member of the human metallothionein gene family-MT1Q."
Wang J., Zheng L., Yu L.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]"Metallothioneins and DNA crosslink damage."
Xie J., Jiang F., Head D., Briggs R.
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M13485, M13484 Genomic DNA. Translation: AAA36331.1.
AF349000 mRNA. Translation: AAO32960.2.
AF350250 Genomic DNA. Translation: AAO49186.1.
AY168638 mRNA. Translation: AAN86984.1.
BC069421 mRNA. Translation: AAH69421.1.
BC137478 mRNA. Translation: AAI37479.1.
BC137479 mRNA. Translation: AAI37480.1.
CCDSCCDS10765.1.
PIRSMHU1B. A25244.
RefSeqNP_005938.1. NM_005947.2.
UniGeneHs.656629.

3D structure databases

ProteinModelPortalP07438.
SMRP07438. Positions 1-61.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000334998.

PTM databases

PhosphoSiteP07438.

Proteomic databases

PaxDbP07438.
PRIDEP07438.

Protocols and materials databases

DNASU4490.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334346; ENSP00000334998; ENSG00000169688.
GeneID4490.
KEGGhsa:4490.
UCSCuc002ejs.3. human.

Organism-specific databases

CTD4490.
GeneCardsGC16P056685.
HGNCHGNC:7394. MT1B.
MIM156349. gene.
neXtProtNX_P07438.
PharmGKBPA31199.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG138665.
HOGENOMHOG000236262.
HOVERGENHBG094459.
InParanoidP07438.
KOK14739.
TreeFamTF336054.

Gene expression databases

BgeeP07438.
CleanExHS_MT1B.
GenevestigatorP07438.

Family and domain databases

Gene3D4.10.10.10. 1 hit.
InterProIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERPTHR23299. PTHR23299. 1 hit.
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00860. MTVERTEBRATE.
SUPFAMSSF57868. SSF57868. 1 hit.
PROSITEPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMT1B.
GenomeRNAi4490.
NextBio17371.
PROP07438.
SOURCESearch...

Entry information

Entry nameMT1B_HUMAN
AccessionPrimary (citable) accession number: P07438
Secondary accession number(s): Q86YX0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: July 9, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Metallothioneins

Classification of metallothioneins and list of entries

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM