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Protein

Hemoglobin subunit alpha

Gene

hba-A

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme distal ligand)1
Metal bindingi88Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin
Hemoglobin alpha chain
Gene namesi
Name:hba-A
Synonyms:hba
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000528122 – 142Hemoglobin subunit alphaAdd BLAST141

Proteomic databases

PaxDbiP07428.

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

STRINGi8364.ENSXETP00000002494.

Structurei

3D structure databases

ProteinModelPortaliP07428.
SMRiP07428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP07428.
KOiK13822.
OrthoDBiEOG091G0S0X.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
InterProiView protein in InterPro
IPR000971. Globin.
IPR009050. Globin-like.
IPR002338. Haemoglobin_a-typ.
PfamiView protein in Pfam
PF00042. Globin. 1 hit.
PRINTSiPR00612. ALPHAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiView protein in PROSITE
PS01033. GLOBIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07428-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLTADDKKH IKAIWPSVAA HGDKYGGEAL HRMFMCAPKT KTYFPDFDFS
60 70 80 90 100
EHSKHILAHG KKVSDALNEA CNHLDNIAGC LSKLSDLHAY DLRVDPGNFP
110 120 130 140
LLAHQILVVV AIHFPKQFDP ATHKALDKFL VSVSNVLTSK YR
Length:142
Mass (Da):15,887
Last modified:January 23, 2007 - v2
Checksum:i28A69C015BC99200
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32454 mRNA. Translation: AAA49644.1.
X14260 Genomic DNA. Translation: CAA32473.1.
DQ224419 Genomic DNA. Translation: ABB04106.1.
BC088005 mRNA. Translation: AAH88005.1.
PIRiS02732. HAXLWA.
RefSeqiNP_988860.1. NM_203529.1.
UniGeneiStr.68573.

Genome annotation databases

GeneIDi394454.
KEGGixtr:394454.

Similar proteinsi

Entry informationi

Entry nameiHBA_XENTR
AccessioniPrimary (citable) accession number: P07428
Secondary accession number(s): Q5I0T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families