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Protein

Hemoglobin subunit alpha

Gene

hba-A

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Iron (heme distal ligand)
Metal bindingi88 – 881Iron (heme proximal ligand)

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-XTR-1237044. Erythrocytes take up carbon dioxide and release oxygen.
R-XTR-1247673. Erythrocytes take up oxygen and release carbon dioxide.
R-XTR-2168880. Scavenging of heme from plasma.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin
Hemoglobin alpha chain
Gene namesi
Name:hba-A
Synonyms:hba
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-478141. hba1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 142141Hemoglobin subunit alphaPRO_0000052812Add
BLAST

Proteomic databases

PaxDbiP07428.

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

STRINGi8364.ENSXETP00000002494.

Structurei

3D structure databases

ProteinModelPortaliP07428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP07428.
KOiK13822.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07428-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLTADDKKH IKAIWPSVAA HGDKYGGEAL HRMFMCAPKT KTYFPDFDFS
60 70 80 90 100
EHSKHILAHG KKVSDALNEA CNHLDNIAGC LSKLSDLHAY DLRVDPGNFP
110 120 130 140
LLAHQILVVV AIHFPKQFDP ATHKALDKFL VSVSNVLTSK YR
Length:142
Mass (Da):15,887
Last modified:January 23, 2007 - v2
Checksum:i28A69C015BC99200
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32454 mRNA. Translation: AAA49644.1.
X14260 Genomic DNA. Translation: CAA32473.1.
DQ224419 Genomic DNA. Translation: ABB04106.1.
BC088005 mRNA. Translation: AAH88005.1.
PIRiS02732. HAXLWA.
RefSeqiNP_988860.1. NM_203529.1.
UniGeneiStr.68573.

Genome annotation databases

GeneIDi394454.
KEGGixtr:394454.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32454 mRNA. Translation: AAA49644.1.
X14260 Genomic DNA. Translation: CAA32473.1.
DQ224419 Genomic DNA. Translation: ABB04106.1.
BC088005 mRNA. Translation: AAH88005.1.
PIRiS02732. HAXLWA.
RefSeqiNP_988860.1. NM_203529.1.
UniGeneiStr.68573.

3D structure databases

ProteinModelPortaliP07428.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000002494.

Proteomic databases

PaxDbiP07428.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi394454.
KEGGixtr:394454.

Organism-specific databases

CTDi3039.
XenbaseiXB-GENE-478141. hba1.

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP07428.
KOiK13822.

Enzyme and pathway databases

ReactomeiR-XTR-1237044. Erythrocytes take up carbon dioxide and release oxygen.
R-XTR-1247673. Erythrocytes take up oxygen and release carbon dioxide.
R-XTR-2168880. Scavenging of heme from plasma.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Globin evolution in the genus Xenopus: comparative analysis of cDNAs coding for adult globin polypeptides of Xenopus borealis and Xenopus tropicalis."
    Knoechel W., Korge E., Basner A., Meyerhof W.
    J. Mol. Evol. 23:211-223(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Primary structure and evolutionary relationship between the adult alpha-globin genes and their 5'-flanking regions of Xenopus laevis and Xenopus tropicalis."
    Stalder J., Wirthmueller U., Beck J., Gruber A., Meyerhof W., Knoechel W., Weber R.
    J. Mol. Evol. 28:64-71(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Characterization of alpha globin genes in Xenopus tropicalis."
    Roche D.D., Cheng J.F., Harland R.M.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiHBA_XENTR
AccessioniPrimary (citable) accession number: P07428
Secondary accession number(s): Q5I0T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: February 17, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.