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Protein

Chemotaxis protein methyltransferase

Gene

cheR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.

Catalytic activityi

S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92S-adenosyl-L-methionineBy similarity1
Binding sitei94S-adenosyl-L-methionineBy similarity1
Binding sitei98S-adenosyl-L-methionineBy similarity1
Binding sitei129S-adenosyl-L-methionineBy similarity1
Binding sitei154S-adenosyl-L-methionineBy similarity1

GO - Molecular functioni

  • protein C-terminus binding Source: CAFA
  • protein-glutamate O-methyltransferase activity Source: CAFA

GO - Biological processi

  • chemotaxis Source: UniProtKB-KW
  • protein methylation Source: CAFA

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processChemotaxis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciEcoCyc:CHER-MONOMER
MetaCyc:CHER-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis protein methyltransferase (EC:2.1.1.80)
Gene namesi
Name:cheR
Synonyms:cheX
Ordered Locus Names:b1884, JW1873
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10148 cheR

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
  • methyl accepting chemotaxis protein complex Source: CAFA
  • plasma membrane Source: CAFA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001760331 – 286Chemotaxis protein methyltransferaseAdd BLAST286

Proteomic databases

PaxDbiP07364
PRIDEiP07364

Interactioni

GO - Molecular functioni

  • protein C-terminus binding Source: CAFA

Protein-protein interaction databases

BioGridi4260375, 237 interactors
DIPiDIP-9273N
IntActiP07364, 16 interactors
STRINGi316385.ECDH10B_2025

Structurei

3D structure databases

ProteinModelPortaliP07364
SMRiP07364
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 286CheR-type methyltransferasePROSITE-ProRule annotationAdd BLAST272

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni212 – 213S-adenosyl-L-methionine bindingBy similarity2
Regioni230 – 231S-adenosyl-L-methionine bindingBy similarity2

Phylogenomic databases

eggNOGiENOG4105BZU Bacteria
ENOG410XNMH LUCA
HOGENOMiHOG000254353
InParanoidiP07364
KOiK00575
OMAiFREEHHF
PhylomeDBiP07364

Family and domain databases

Gene3Di1.10.155.10, 1 hit
InterProiView protein in InterPro
IPR026024 Chemotaxis_MeTrfase_CheR
IPR022642 CheR_C
IPR000780 CheR_MeTrfase
IPR022641 CheR_N
IPR036804 CheR_N_sf
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF01739 CheR, 1 hit
PF03705 CheR_N, 1 hit
PIRSFiPIRSF000410 CheR, 1 hit
PRINTSiPR00996 CHERMTFRASE
SMARTiView protein in SMART
SM00138 MeTrc, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS50123 CHER, 1 hit

Sequencei

Sequence statusi: Complete.

P07364-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSLPCGQT SLLLQMTERL ALSDAHFRRI SQLIYQRAGI VLADHKRDMV
60 70 80 90 100
YNRLVRRLRS LGLTDFGHYL NLLESNQHSG EWQAFINSLT TNLTAFFREA
110 120 130 140 150
HHFPLLADHA RRRSGEYRVW SAAASTGEEP YSIAMTLADT LGTAPGRWKV
160 170 180 190 200
FASDIDTEVL EKARSGIYRH EELKNLTPQQ LQRYFMRGTG PHEGLVRVRQ
210 220 230 240 250
ELANYVDFAP LNLLAKQYTV PGPFDAIFCR NVMIYFDQTT QQEILRRFVP
260 270 280
LLKPDGLLFA GHSENFSHLE RRFTLRGQTV YALSKD
Length:286
Mass (Da):32,849
Last modified:November 1, 1997 - v2
Checksum:i2AFA307DD406B135
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113R → G in AAA23568 (PubMed:3510184).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13463 Genomic DNA Translation: AAA23568.1
U00096 Genomic DNA Translation: AAC74954.1
AP009048 Genomic DNA Translation: BAA15700.1
PIRiD64951 XYECCR
RefSeqiNP_416398.1, NC_000913.3
WP_000204337.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74954; AAC74954; b1884
BAA15700; BAA15700; BAA15700
GeneIDi946396
KEGGiecj:JW1873
eco:b1884
PATRICifig|1411691.4.peg.363

Similar proteinsi

Entry informationi

Entry nameiCHER_ECOLI
AccessioniPrimary (citable) accession number: P07364
Secondary accession number(s): P78071
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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