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Protein

Chemotaxis protein methyltransferase

Gene

cheR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.

Catalytic activityi

S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92S-adenosyl-L-methionineBy similarity1
Binding sitei94S-adenosyl-L-methionineBy similarity1
Binding sitei98S-adenosyl-L-methionineBy similarity1
Binding sitei129S-adenosyl-L-methionineBy similarity1
Binding sitei154S-adenosyl-L-methionineBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processChemotaxis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciEcoCyc:CHER-MONOMER.
MetaCyc:CHER-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis protein methyltransferase (EC:2.1.1.80)
Gene namesi
Name:cheR
Synonyms:cheX
Ordered Locus Names:b1884, JW1873
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10148. cheR.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
  • plasma membrane Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001760331 – 286Chemotaxis protein methyltransferaseAdd BLAST286

Proteomic databases

PaxDbiP07364.
PRIDEiP07364.

Interactioni

Protein-protein interaction databases

BioGridi4260375. 237 interactors.
DIPiDIP-9273N.
IntActiP07364. 16 interactors.
STRINGi511145.b1884.

Structurei

3D structure databases

ProteinModelPortaliP07364.
SMRiP07364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 286CheR-type methyltransferasePROSITE-ProRule annotationAdd BLAST272

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni212 – 213S-adenosyl-L-methionine bindingBy similarity2
Regioni230 – 231S-adenosyl-L-methionine bindingBy similarity2

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000254353.
InParanoidiP07364.
KOiK00575.
OMAiFVGHAEN.
PhylomeDBiP07364.

Family and domain databases

Gene3Di1.10.155.10. 1 hit.
3.40.50.150. 1 hit.
InterProiView protein in InterPro
IPR026024. Chemotaxis_MeTrfase_CheR.
IPR022642. CheR_C.
IPR000780. CheR_MeTrfase.
IPR022641. CheR_N.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF01739. CheR. 1 hit.
PF03705. CheR_N. 1 hit.
PIRSFiPIRSF000410. CheR. 1 hit.
PRINTSiPR00996. CHERMTFRASE.
SMARTiView protein in SMART
SM00138. MeTrc. 1 hit.
SUPFAMiSSF47757. SSF47757. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiView protein in PROSITE
PS50123. CHER. 1 hit.

Sequencei

Sequence statusi: Complete.

P07364-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSLPCGQT SLLLQMTERL ALSDAHFRRI SQLIYQRAGI VLADHKRDMV
60 70 80 90 100
YNRLVRRLRS LGLTDFGHYL NLLESNQHSG EWQAFINSLT TNLTAFFREA
110 120 130 140 150
HHFPLLADHA RRRSGEYRVW SAAASTGEEP YSIAMTLADT LGTAPGRWKV
160 170 180 190 200
FASDIDTEVL EKARSGIYRH EELKNLTPQQ LQRYFMRGTG PHEGLVRVRQ
210 220 230 240 250
ELANYVDFAP LNLLAKQYTV PGPFDAIFCR NVMIYFDQTT QQEILRRFVP
260 270 280
LLKPDGLLFA GHSENFSHLE RRFTLRGQTV YALSKD
Length:286
Mass (Da):32,849
Last modified:November 1, 1997 - v2
Checksum:i2AFA307DD406B135
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113R → G in AAA23568 (PubMed:3510184).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13463 Genomic DNA. Translation: AAA23568.1.
U00096 Genomic DNA. Translation: AAC74954.1.
AP009048 Genomic DNA. Translation: BAA15700.1.
PIRiD64951. XYECCR.
RefSeqiNP_416398.1. NC_000913.3.
WP_000204337.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74954; AAC74954; b1884.
BAA15700; BAA15700; BAA15700.
GeneIDi946396.
KEGGiecj:JW1873.
eco:b1884.
PATRICi32119095. VBIEscCol129921_1965.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13463 Genomic DNA. Translation: AAA23568.1.
U00096 Genomic DNA. Translation: AAC74954.1.
AP009048 Genomic DNA. Translation: BAA15700.1.
PIRiD64951. XYECCR.
RefSeqiNP_416398.1. NC_000913.3.
WP_000204337.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP07364.
SMRiP07364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260375. 237 interactors.
DIPiDIP-9273N.
IntActiP07364. 16 interactors.
STRINGi511145.b1884.

Proteomic databases

PaxDbiP07364.
PRIDEiP07364.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74954; AAC74954; b1884.
BAA15700; BAA15700; BAA15700.
GeneIDi946396.
KEGGiecj:JW1873.
eco:b1884.
PATRICi32119095. VBIEscCol129921_1965.

Organism-specific databases

EchoBASEiEB0146.
EcoGeneiEG10148. cheR.

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000254353.
InParanoidiP07364.
KOiK00575.
OMAiFVGHAEN.
PhylomeDBiP07364.

Enzyme and pathway databases

BioCyciEcoCyc:CHER-MONOMER.
MetaCyc:CHER-MONOMER.

Miscellaneous databases

PROiP07364.

Family and domain databases

Gene3Di1.10.155.10. 1 hit.
3.40.50.150. 1 hit.
InterProiView protein in InterPro
IPR026024. Chemotaxis_MeTrfase_CheR.
IPR022642. CheR_C.
IPR000780. CheR_MeTrfase.
IPR022641. CheR_N.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF01739. CheR. 1 hit.
PF03705. CheR_N. 1 hit.
PIRSFiPIRSF000410. CheR. 1 hit.
PRINTSiPR00996. CHERMTFRASE.
SMARTiView protein in SMART
SM00138. MeTrc. 1 hit.
SUPFAMiSSF47757. SSF47757. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiView protein in PROSITE
PS50123. CHER. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCHER_ECOLI
AccessioniPrimary (citable) accession number: P07364
Secondary accession number(s): P78071
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 1, 1997
Last modified: March 15, 2017
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.