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Protein

Chemotaxis protein methyltransferase

Gene

cheR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.

Catalytic activityi

S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921S-adenosyl-L-methionineBy similarity
Binding sitei94 – 941S-adenosyl-L-methionineBy similarity
Binding sitei98 – 981S-adenosyl-L-methionineBy similarity
Binding sitei129 – 1291S-adenosyl-L-methionineBy similarity
Binding sitei154 – 1541S-adenosyl-L-methionineBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Chemotaxis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciEcoCyc:CHER-MONOMER.
ECOL316407:JW1873-MONOMER.
MetaCyc:CHER-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis protein methyltransferase (EC:2.1.1.80)
Gene namesi
Name:cheR
Synonyms:cheX
Ordered Locus Names:b1884, JW1873
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10148. cheR.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Chemotaxis protein methyltransferasePRO_0000176033Add
BLAST

Proteomic databases

PaxDbiP07364.

Interactioni

Protein-protein interaction databases

BioGridi4260375. 237 interactions.
DIPiDIP-9273N.
IntActiP07364. 16 interactions.
STRINGi511145.b1884.

Structurei

3D structure databases

ProteinModelPortaliP07364.
SMRiP07364. Positions 11-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 286272CheR-type methyltransferasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni212 – 2132S-adenosyl-L-methionine bindingBy similarity
Regioni230 – 2312S-adenosyl-L-methionine bindingBy similarity

Sequence similaritiesi

Contains 1 cheR-type methyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000254353.
InParanoidiP07364.
KOiK00575.
OMAiFVGHAEN.
PhylomeDBiP07364.

Family and domain databases

Gene3Di1.10.155.10. 1 hit.
3.40.50.150. 1 hit.
InterProiIPR026024. Chemotaxis_MeTrfase_CheR.
IPR022642. CheR_C.
IPR000780. CheR_MeTrfase.
IPR022641. CheR_N.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01739. CheR. 1 hit.
PF03705. CheR_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000410. CheR. 1 hit.
PRINTSiPR00996. CHERMTFRASE.
SMARTiSM00138. MeTrc. 1 hit.
[Graphical view]
SUPFAMiSSF47757. SSF47757. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiPS50123. CHER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07364-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSLPCGQT SLLLQMTERL ALSDAHFRRI SQLIYQRAGI VLADHKRDMV
60 70 80 90 100
YNRLVRRLRS LGLTDFGHYL NLLESNQHSG EWQAFINSLT TNLTAFFREA
110 120 130 140 150
HHFPLLADHA RRRSGEYRVW SAAASTGEEP YSIAMTLADT LGTAPGRWKV
160 170 180 190 200
FASDIDTEVL EKARSGIYRH EELKNLTPQQ LQRYFMRGTG PHEGLVRVRQ
210 220 230 240 250
ELANYVDFAP LNLLAKQYTV PGPFDAIFCR NVMIYFDQTT QQEILRRFVP
260 270 280
LLKPDGLLFA GHSENFSHLE RRFTLRGQTV YALSKD
Length:286
Mass (Da):32,849
Last modified:November 1, 1997 - v2
Checksum:i2AFA307DD406B135
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131R → G in AAA23568 (PubMed:3510184).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13463 Genomic DNA. Translation: AAA23568.1.
U00096 Genomic DNA. Translation: AAC74954.1.
AP009048 Genomic DNA. Translation: BAA15700.1.
PIRiD64951. XYECCR.
RefSeqiNP_416398.1. NC_000913.3.
WP_000204337.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74954; AAC74954; b1884.
BAA15700; BAA15700; BAA15700.
GeneIDi946396.
KEGGiecj:JW1873.
eco:b1884.
PATRICi32119095. VBIEscCol129921_1965.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13463 Genomic DNA. Translation: AAA23568.1.
U00096 Genomic DNA. Translation: AAC74954.1.
AP009048 Genomic DNA. Translation: BAA15700.1.
PIRiD64951. XYECCR.
RefSeqiNP_416398.1. NC_000913.3.
WP_000204337.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP07364.
SMRiP07364. Positions 11-284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260375. 237 interactions.
DIPiDIP-9273N.
IntActiP07364. 16 interactions.
STRINGi511145.b1884.

Proteomic databases

PaxDbiP07364.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74954; AAC74954; b1884.
BAA15700; BAA15700; BAA15700.
GeneIDi946396.
KEGGiecj:JW1873.
eco:b1884.
PATRICi32119095. VBIEscCol129921_1965.

Organism-specific databases

EchoBASEiEB0146.
EcoGeneiEG10148. cheR.

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000254353.
InParanoidiP07364.
KOiK00575.
OMAiFVGHAEN.
PhylomeDBiP07364.

Enzyme and pathway databases

BioCyciEcoCyc:CHER-MONOMER.
ECOL316407:JW1873-MONOMER.
MetaCyc:CHER-MONOMER.

Miscellaneous databases

PROiP07364.

Family and domain databases

Gene3Di1.10.155.10. 1 hit.
3.40.50.150. 1 hit.
InterProiIPR026024. Chemotaxis_MeTrfase_CheR.
IPR022642. CheR_C.
IPR000780. CheR_MeTrfase.
IPR022641. CheR_N.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01739. CheR. 1 hit.
PF03705. CheR_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000410. CheR. 1 hit.
PRINTSiPR00996. CHERMTFRASE.
SMARTiSM00138. MeTrc. 1 hit.
[Graphical view]
SUPFAMiSSF47757. SSF47757. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiPS50123. CHER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHER_ECOLI
AccessioniPrimary (citable) accession number: P07364
Secondary accession number(s): P78071
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.