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Protein

Alpha-1-acid glycoprotein 2

Gene

Orm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Acute phase, Transport

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-acid glycoprotein 2
Short name:
AGP 2
Alternative name(s):
Orosomucoid-2
Short name:
OMD 2
Gene namesi
Name:Orm2
Synonyms:Agp-2, Orm-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:97444. Orm2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Add
BLAST
Chaini19 – 207189Alpha-1-acid glycoprotein 2PRO_0000017863Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191Pyrrolidone carboxylic acidBy similarity
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence analysis
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence analysis
Glycosylationi76 – 761N-linked (GlcNAc...)1 Publication
Disulfide bondi91 ↔ 184By similarity
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP07361.
MaxQBiP07361.
PaxDbiP07361.
PRIDEiP07361.

PTM databases

PhosphoSiteiP07361.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Inductioni

Synthesis is controlled by glucocorticoids, interleukin-1 and interleukin-6, It increases 5- to 50-fold upon inflammation.

Gene expression databases

BgeeiP07361.
CleanExiMM_ORM2.
GenevisibleiP07361. MM.

Interactioni

Protein-protein interaction databases

IntActiP07361. 1 interaction.
MINTiMINT-4086337.
STRINGi10090.ENSMUSP00000074810.

Structurei

3D structure databases

ProteinModelPortaliP07361.
SMRiP07361. Positions 31-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Contains a beta-barrel that binds various ligands in its interior.By similarity

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZI. Eukaryota.
ENOG4111C49. LUCA.
GeneTreeiENSGT00390000012130.
HOGENOMiHOG000125170.
HOVERGENiHBG000035.
InParanoidiP07361.
OMAiENGREHY.
OrthoDBiEOG7B5WXT.
PhylomeDBiP07361.
TreeFamiTF343791.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR001500. A1A_glycop.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11967. PTHR11967. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFiPIRSF036899. AGP. 1 hit.
PRINTSiPR00708. A1AGLPROTEIN.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07361-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALHMILVMV SLLPLLEAQN PEHVNITIGD PITNETLSWL SDKWFFIGAA
60 70 80 90 100
VLNPDYRQEI QKTQMVFFNL TPNLINDTME LREYHTIDDH CVYNSTHLGI
110 120 130 140 150
QRENGTLSKY VGGVKIFADL IVLKMHGAFM LAFDLKDEKK RGLSLNAKRP
160 170 180 190 200
DITPELREVF QKAVTHVGMD ESEIIFVDWK KDRCSQQEKQ QLELEKETKK

DPEEGQA
Length:207
Mass (Da):23,843
Last modified:April 1, 1988 - v1
Checksum:i0FBCBEA99C558A6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17376 Genomic DNA. Translation: AAA37193.1.
M27009 mRNA. Translation: AAA37196.1.
BC057985 mRNA. Translation: AAH57985.1.
M12566 mRNA. Translation: AAA91744.1.
CCDSiCCDS18253.1.
PIRiA29294. OMMS1.
RefSeqiNP_035146.1. NM_011016.2.
UniGeneiMm.14173.

Genome annotation databases

EnsembliENSMUST00000075341; ENSMUSP00000074810; ENSMUSG00000061540.
GeneIDi18406.
KEGGimmu:18406.
UCSCiuc008tga.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17376 Genomic DNA. Translation: AAA37193.1.
M27009 mRNA. Translation: AAA37196.1.
BC057985 mRNA. Translation: AAH57985.1.
M12566 mRNA. Translation: AAA91744.1.
CCDSiCCDS18253.1.
PIRiA29294. OMMS1.
RefSeqiNP_035146.1. NM_011016.2.
UniGeneiMm.14173.

3D structure databases

ProteinModelPortaliP07361.
SMRiP07361. Positions 31-197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP07361. 1 interaction.
MINTiMINT-4086337.
STRINGi10090.ENSMUSP00000074810.

PTM databases

PhosphoSiteiP07361.

Proteomic databases

EPDiP07361.
MaxQBiP07361.
PaxDbiP07361.
PRIDEiP07361.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075341; ENSMUSP00000074810; ENSMUSG00000061540.
GeneIDi18406.
KEGGimmu:18406.
UCSCiuc008tga.1. mouse.

Organism-specific databases

CTDi5005.
MGIiMGI:97444. Orm2.

Phylogenomic databases

eggNOGiENOG410IWZI. Eukaryota.
ENOG4111C49. LUCA.
GeneTreeiENSGT00390000012130.
HOGENOMiHOG000125170.
HOVERGENiHBG000035.
InParanoidiP07361.
OMAiENGREHY.
OrthoDBiEOG7B5WXT.
PhylomeDBiP07361.
TreeFamiTF343791.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Miscellaneous databases

PROiP07361.
SOURCEiSearch...

Gene expression databases

BgeeiP07361.
CleanExiMM_ORM2.
GenevisibleiP07361. MM.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR001500. A1A_glycop.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11967. PTHR11967. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFiPIRSF036899. AGP. 1 hit.
PRINTSiPR00708. A1AGLPROTEIN.
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the mouse alpha 1-acid glycoprotein gene 1."
    Cooper R., Eckley D.M., Papaconstantinou J.
    Biochemistry 26:5244-5250(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/cJ.
  2. "Molecular cloning of cDNAs corresponding to two genes of alpha 1-acid glycoprotein and characterization of two alleles of AGP-1 in the mouse."
    Lee S.C., Chang C.J., Lee Y.M., Lei H.Y., Lai M.Y., Chen D.S.
    DNA 8:245-251(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  4. "Evidence for the existence of multiple alpha 1-acid glycoprotein genes in the mouse."
    Cooper R., Papaconstantinou J.
    J. Biol. Chem. 261:1849-1853(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 70-207.
  5. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
    Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
    J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-76.
    Strain: C57BL/6J.
    Tissue: Plasma.

Entry informationi

Entry nameiA1AG2_MOUSE
AccessioniPrimary (citable) accession number: P07361
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: June 8, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.