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Protein

Complement component C8 gamma chain

Gene

C8G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement alternate pathway, Complement pathway, Cytolysis, Immunity, Innate immunity

Keywords - Ligandi

Retinol-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176919-MONOMER.
ReactomeiR-HSA-166665. Terminal pathway of complement.
R-HSA-977606. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component C8 gamma chain
Gene namesi
Name:C8G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:1354. C8G.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • membrane attack complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane attack complex, Secreted

Pathology & Biotechi

Organism-specific databases

MalaCardsiC8G.
OpenTargetsiENSG00000176919.
Orphaneti169150. Immunodeficiency due to a late component of complements deficiency.
PharmGKBiPA25953.

Polymorphism and mutation databases

BioMutaiC8G.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001788121 – 202Complement component C8 gamma chainAdd BLAST182

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi60Interchain (with C-194 in C8-alpha chain)
Disulfide bondi96 ↔ 188

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP07360.
PeptideAtlasiP07360.
PRIDEiP07360.

PTM databases

iPTMnetiP07360.
PhosphoSitePlusiP07360.

Expressioni

Gene expression databases

BgeeiENSG00000176919.
CleanExiHS_C8G.
ExpressionAtlasiP07360. baseline and differential.
GenevisibleiP07360. HS.

Organism-specific databases

HPAiHPA046269.

Interactioni

Subunit structurei

C8 is composed of three chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded.

Protein-protein interaction databases

BioGridi107194. 6 interactors.
IntActiP07360. 1 interactor.
STRINGi9606.ENSP00000224181.

Structurei

Secondary structure

1202
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi32 – 35Combined sources4
Helixi44 – 47Combined sources4
Beta strandi49 – 57Combined sources9
Helixi61 – 66Combined sources6
Helixi67 – 69Combined sources3
Beta strandi73 – 80Combined sources8
Beta strandi83 – 92Combined sources10
Beta strandi95 – 105Combined sources11
Beta strandi111 – 114Combined sources4
Beta strandi117 – 121Combined sources5
Beta strandi123 – 130Combined sources8
Beta strandi132 – 142Combined sources11
Beta strandi145 – 156Combined sources12
Helixi159 – 171Combined sources13
Helixi176 – 178Combined sources3
Beta strandi179 – 181Combined sources3
Helixi193 – 195Combined sources3
Beta strandi196 – 198Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IW2X-ray1.90A21-202[»]
1LF7X-ray1.20A21-202[»]
2OVAX-ray1.50A21-202[»]
2OVDX-ray1.80A21-202[»]
2OVEX-ray2.00A21-202[»]
2QOSX-ray1.81C30-202[»]
2RD7X-ray2.15C21-202[»]
3OJYX-ray2.51C21-202[»]
ProteinModelPortaliP07360.
SMRiP07360.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07360.

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX6K. Eukaryota.
ENOG4111Y9C. LUCA.
GeneTreeiENSGT00440000034309.
HOGENOMiHOG000111143.
HOVERGENiHBG005369.
InParanoidiP07360.
KOiK03999.
OMAiDAQQFAG.
OrthoDBiEOG091G0QPN.
PhylomeDBiP07360.
TreeFamiTF336103.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR002968. A1-microglobln.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01215. A1MCGLOBULIN.
PR00179. LIPOCALIN.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07360-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPPGTATLL TLLLAAGSLG QKPQRPRRPA SPISTIQPKA NFDAQQFAGT
60 70 80 90 100
WLLVAVGSAC RFLQEQGHRA EATTLHVAPQ GTAMAVSTFR KLDGICWQVR
110 120 130 140 150
QLYGDTGVLG RFLLQARDAR GAVHVVVAET DYQSFAVLYL ERAGQLSVKL
160 170 180 190 200
YARSLPVSDS VLSGFEQRVQ EAHLTEDQIF YFPKYGFCEA ADQFHVLDEV

RR
Length:202
Mass (Da):22,277
Last modified:October 3, 2006 - v3
Checksum:i4E4F73140E607FFE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01466869R → Q.Corresponds to variant rs17614dbSNPEnsembl.1
Natural variantiVAR_044319118D → G.5 PublicationsCorresponds to variant rs7850844dbSNPEnsembl.1
Natural variantiVAR_014669124H → N.1 PublicationCorresponds to variant rs17613dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17263 mRNA. Translation: AAA51888.1.
M17999 mRNA. Translation: AAA51863.1.
X06465 mRNA. Translation: CAA29773.1.
U08198 Genomic DNA. Translation: AAA18482.1.
AL807752 Genomic DNA. Translation: CAI12749.1.
CH471090 Genomic DNA. Translation: EAW88316.1.
BC113624 mRNA. Translation: AAI13625.1.
BC113626 mRNA. Translation: AAI13627.1.
CCDSiCCDS7017.1.
PIRiA27487. C8HUG.
RefSeqiNP_000597.2. NM_000606.2.
UniGeneiHs.1285.

Genome annotation databases

EnsembliENST00000224181; ENSP00000224181; ENSG00000176919.
GeneIDi733.
KEGGihsa:733.
UCSCiuc004cka.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17263 mRNA. Translation: AAA51888.1.
M17999 mRNA. Translation: AAA51863.1.
X06465 mRNA. Translation: CAA29773.1.
U08198 Genomic DNA. Translation: AAA18482.1.
AL807752 Genomic DNA. Translation: CAI12749.1.
CH471090 Genomic DNA. Translation: EAW88316.1.
BC113624 mRNA. Translation: AAI13625.1.
BC113626 mRNA. Translation: AAI13627.1.
CCDSiCCDS7017.1.
PIRiA27487. C8HUG.
RefSeqiNP_000597.2. NM_000606.2.
UniGeneiHs.1285.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IW2X-ray1.90A21-202[»]
1LF7X-ray1.20A21-202[»]
2OVAX-ray1.50A21-202[»]
2OVDX-ray1.80A21-202[»]
2OVEX-ray2.00A21-202[»]
2QOSX-ray1.81C30-202[»]
2RD7X-ray2.15C21-202[»]
3OJYX-ray2.51C21-202[»]
ProteinModelPortaliP07360.
SMRiP07360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107194. 6 interactors.
IntActiP07360. 1 interactor.
STRINGi9606.ENSP00000224181.

PTM databases

iPTMnetiP07360.
PhosphoSitePlusiP07360.

Polymorphism and mutation databases

BioMutaiC8G.

Proteomic databases

PaxDbiP07360.
PeptideAtlasiP07360.
PRIDEiP07360.

Protocols and materials databases

DNASUi733.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000224181; ENSP00000224181; ENSG00000176919.
GeneIDi733.
KEGGihsa:733.
UCSCiuc004cka.3. human.

Organism-specific databases

CTDi733.
GeneCardsiC8G.
H-InvDBHIX0201411.
HGNCiHGNC:1354. C8G.
HPAiHPA046269.
MalaCardsiC8G.
MIMi120930. gene.
neXtProtiNX_P07360.
OpenTargetsiENSG00000176919.
Orphaneti169150. Immunodeficiency due to a late component of complements deficiency.
PharmGKBiPA25953.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX6K. Eukaryota.
ENOG4111Y9C. LUCA.
GeneTreeiENSGT00440000034309.
HOGENOMiHOG000111143.
HOVERGENiHBG005369.
InParanoidiP07360.
KOiK03999.
OMAiDAQQFAG.
OrthoDBiEOG091G0QPN.
PhylomeDBiP07360.
TreeFamiTF336103.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176919-MONOMER.
ReactomeiR-HSA-166665. Terminal pathway of complement.
R-HSA-977606. Regulation of Complement cascade.

Miscellaneous databases

EvolutionaryTraceiP07360.
GenomeRNAii733.
PROiP07360.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176919.
CleanExiHS_C8G.
ExpressionAtlasiP07360. baseline and differential.
GenevisibleiP07360. HS.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR002968. A1-microglobln.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01215. A1MCGLOBULIN.
PR00179. LIPOCALIN.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCO8G_HUMAN
AccessioniPrimary (citable) accession number: P07360
Secondary accession number(s): Q14CT8, Q14CU0, Q5SQ07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: October 3, 2006
Last modified: November 30, 2016
This is version 175 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.