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P07356

- ANXA2_MOUSE

UniProt

P07356 - ANXA2_MOUSE

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Protein

Annexin A2

Gene

Anxa2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.

GO - Molecular functioni

  1. calcium-dependent phospholipid binding Source: UniProtKB-KW
  2. calcium ion binding Source: InterPro
  3. phosphatidylinositol-4,5-bisphosphate binding Source: Ensembl
  4. phospholipase A2 inhibitor activity Source: Ensembl
  5. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. angiogenesis Source: MGI
  2. body fluid secretion Source: Ensembl
  3. collagen fibril organization Source: MGI
  4. fibrinolysis Source: MGI
  5. membrane budding Source: Ensembl
  6. membrane raft assembly Source: Ensembl
  7. osteoclast development Source: Ensembl
  8. positive regulation of binding Source: MGI
  9. positive regulation of fibroblast proliferation Source: Ensembl
  10. positive regulation of protein phosphorylation Source: Ensembl
  11. positive regulation of vesicle fusion Source: Ensembl
  12. protein heterotetramerization Source: Ensembl
  13. protein targeting to plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Enzyme and pathway databases

ReactomeiREACT_235291. Dissolution of Fibrin Clot.
REACT_268398. Orphan transporters.

Protein family/group databases

TCDBi9.A.48.1.1. the unconventional protein secretion (ups) system.

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A2
Alternative name(s):
Annexin II
Annexin-2
Calpactin I heavy chain
Calpactin-1 heavy chain
Chromobindin-8
Lipocortin II
Placental anticoagulant protein IV
Short name:
PAP-IV
Protein I
p36
Gene namesi
Name:Anxa2
Synonyms:Anx2, Cal1h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:88246. Anxa2.

Subcellular locationi

Secretedextracellular spaceextracellular matrixbasement membrane. Melanosome By similarity
Note: In the lamina beneath the plasma membrane.

GO - Cellular componenti

  1. basement membrane Source: UniProtKB-KW
  2. cell cortex Source: Ensembl
  3. cell surface Source: Ensembl
  4. cytoplasm Source: MGI
  5. early endosome Source: MGI
  6. extracellular space Source: Ensembl
  7. extracellular vesicular exosome Source: Ensembl
  8. extrinsic component of plasma membrane Source: MGI
  9. late endosome membrane Source: Ensembl
  10. lipid particle Source: Ensembl
  11. lysosomal membrane Source: Ensembl
  12. macropinosome Source: Ensembl
  13. membrane raft Source: Ensembl
  14. midbody Source: Ensembl
  15. myelin sheath adaxonal region Source: BHF-UCL
  16. nucleus Source: Ensembl
  17. perinuclear region of cytoplasm Source: Ensembl
  18. protein complex Source: Ensembl
  19. ruffle Source: Ensembl
  20. sarcolemma Source: MGI
  21. Schmidt-Lanterman incisure Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 339338Annexin A2PRO_0000067471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei24 – 241Phosphotyrosine; by SRCBy similarity
Modified residuei26 – 261Phosphoserine; by PKCBy similarity
Modified residuei49 – 491N6-acetyllysine1 Publication
Modified residuei152 – 1521N6-acetyllysine1 Publication
Modified residuei199 – 1991Phosphotyrosine1 Publication
Modified residuei227 – 2271N6-acetyllysine1 Publication

Post-translational modificationi

ISGylated.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP07356.
PaxDbiP07356.
PRIDEiP07356.

2D gel databases

REPRODUCTION-2DPAGEIPI00468203.
P07356.
SWISS-2DPAGEP07356.

PTM databases

PhosphoSiteiP07356.

Expressioni

Gene expression databases

BgeeiP07356.
CleanExiMM_ANXA2.
ExpressionAtlasiP07356. baseline and differential.
GenevestigatoriP07356.

Interactioni

Subunit structurei

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with DYSF. Interacts with ATP1B1 (By similarity). Interacts with COCH (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
S100a10P082072EBI-738510,EBI-643986

Protein-protein interaction databases

BioGridi198448. 7 interactions.
IntActiP07356. 9 interactions.
MINTiMINT-274998.

Structurei

Secondary structure

1
339
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 85Combined sources
Helixi35 – 4612Combined sources
Helixi53 – 619Combined sources
Helixi65 – 7915Combined sources
Helixi83 – 908Combined sources
Helixi93 – 10311Combined sources
Helixi106 – 11813Combined sources
Helixi125 – 13410Combined sources
Helixi137 – 15115Combined sources
Helixi155 – 1628Combined sources
Helixi165 – 17511Combined sources
Helixi188 – 20114Combined sources
Beta strandi204 – 2074Combined sources
Helixi210 – 21910Combined sources
Helixi222 – 23514Combined sources
Helixi240 – 2478Combined sources
Helixi251 – 26414Combined sources
Helixi266 – 27813Combined sources
Beta strandi279 – 2824Combined sources
Helixi285 – 29410Combined sources
Turni296 – 2994Combined sources
Helixi300 – 31112Combined sources
Helixi315 – 3228Combined sources
Helixi325 – 33511Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HREX-ray2.79A/B/C/D1-339[»]
ProteinModelPortaliP07356.
SMRiP07356. Positions 2-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati42 – 10261Annexin 1Add
BLAST
Repeati114 – 17461Annexin 2Add
BLAST
Repeati199 – 25961Annexin 3Add
BLAST
Repeati274 – 33461Annexin 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 2423S100A10-binding siteSequence AnalysisAdd
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiNOG259189.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP07356.
KOiK17092.
OMAiFIQQDTK.
OrthoDBiEOG74XS72.
PhylomeDBiP07356.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view]
PANTHERiPTHR10502:SF18. PTHR10502:SF18. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07356-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTVHEILCK LSLEGDHSTP PSAYGSVKPY TNFDAERDAL NIETAVKTKG
60 70 80 90 100
VDEVTIVNIL TNRSNVQRQD IAFAYQRRTK KELPSALKSA LSGHLETVIL
110 120 130 140 150
GLLKTPAQYD ASELKASMKG LGTDEDSLIE IICSRTNQEL QEINRVYKEM
160 170 180 190 200
YKTDLEKDII SDTSGDFRKL MVALAKGRRA EDGSVIDYEL IDQDARELYD
210 220 230 240 250
AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM LESIKKEVKG
260 270 280 290 300
DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM
310 320 330
LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD
Length:339
Mass (Da):38,676
Last modified:January 23, 2007 - v2
Checksum:i4407E572097FB2C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14044 mRNA. Translation: AAA37360.1.
BC003327 mRNA. Translation: AAH03327.1.
BC005763 mRNA. Translation: AAH05763.1.
M33321 Genomic DNA. Translation: AAA37361.1.
M33322 Genomic DNA. Translation: AAA37362.1.
D10024 mRNA. Translation: BAA00914.1.
S82177 Genomic DNA. No translation available.
CCDSiCCDS23316.1.
PIRiA23943. LUMS36.
RefSeqiNP_031611.1. NM_007585.3.
XP_006510859.1. XM_006510796.1.
UniGeneiMm.238343.

Genome annotation databases

EnsembliENSMUST00000034756; ENSMUSP00000034756; ENSMUSG00000032231.
GeneIDi12306.
KEGGimmu:12306.
UCSCiuc009qng.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

Red velvet - Issue 86 of September 2007

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14044 mRNA. Translation: AAA37360.1 .
BC003327 mRNA. Translation: AAH03327.1 .
BC005763 mRNA. Translation: AAH05763.1 .
M33321 Genomic DNA. Translation: AAA37361.1 .
M33322 Genomic DNA. Translation: AAA37362.1 .
D10024 mRNA. Translation: BAA00914.1 .
S82177 Genomic DNA. No translation available.
CCDSi CCDS23316.1.
PIRi A23943. LUMS36.
RefSeqi NP_031611.1. NM_007585.3.
XP_006510859.1. XM_006510796.1.
UniGenei Mm.238343.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HRE X-ray 2.79 A/B/C/D 1-339 [» ]
ProteinModelPortali P07356.
SMRi P07356. Positions 2-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198448. 7 interactions.
IntActi P07356. 9 interactions.
MINTi MINT-274998.

Protein family/group databases

TCDBi 9.A.48.1.1. the unconventional protein secretion (ups) system.

PTM databases

PhosphoSitei P07356.

2D gel databases

REPRODUCTION-2DPAGE IPI00468203.
P07356.
SWISS-2DPAGE P07356.

Proteomic databases

MaxQBi P07356.
PaxDbi P07356.
PRIDEi P07356.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034756 ; ENSMUSP00000034756 ; ENSMUSG00000032231 .
GeneIDi 12306.
KEGGi mmu:12306.
UCSCi uc009qng.1. mouse.

Organism-specific databases

CTDi 302.
MGIi MGI:88246. Anxa2.

Phylogenomic databases

eggNOGi NOG259189.
HOGENOMi HOG000158803.
HOVERGENi HBG061815.
InParanoidi P07356.
KOi K17092.
OMAi FIQQDTK.
OrthoDBi EOG74XS72.
PhylomeDBi P07356.
TreeFami TF105452.

Enzyme and pathway databases

Reactomei REACT_235291. Dissolution of Fibrin Clot.
REACT_268398. Orphan transporters.

Miscellaneous databases

ChiTaRSi Anxa2. mouse.
NextBioi 280840.
PROi P07356.
SOURCEi Search...

Gene expression databases

Bgeei P07356.
CleanExi MM_ANXA2.
ExpressionAtlasi P07356. baseline and differential.
Genevestigatori P07356.

Family and domain databases

Gene3Di 1.10.220.10. 4 hits.
InterProi IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view ]
PANTHERi PTHR10502:SF18. PTHR10502:SF18. 1 hit.
Pfami PF00191. Annexin. 4 hits.
[Graphical view ]
PRINTSi PR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTi SM00335. ANX. 4 hits.
[Graphical view ]
PROSITEi PS00223. ANNEXIN. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats."
    Saris C.J.M., Tack B.F., Kristensen T., Glenney J.R. Jr., Hunter T.
    Cell 46:201-212(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Structure and chromosome assignment of the murine p36 (calpactin I heavy chain) gene."
    Amiguet P., D'Eustachio P., Kristensen T., Wetsel R.A., Saris C.J.M., Hunter T., Chaplin D.D., Tack B.F.
    Biochemistry 29:1226-1232(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16 AND 322-339.
  4. "Complete structure of the murine p36 (annexin II) gene. Identification of mRNAs for both the murine and the human gene with alternatively spliced 5' noncoding exons."
    Fey M.F., Moffat G.J., Vik D.P., Meisenhelder J., Saris C.J., Hunter T., Tack B.F.
    Biochim. Biophys. Acta 1306:160-170(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16.
  5. "Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing."
    Lennon N.J., Kho A., Bacskai B.J., Perlmutter S.L., Hyman B.T., Brown R.H. Jr.
    J. Biol. Chem. 278:50466-50473(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DYSF.
  6. Cited for: ISGYLATION.
  7. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-199, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-49; LYS-152 AND LYS-227, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiANXA2_MOUSE
AccessioniPrimary (citable) accession number: P07356
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3