Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P07356 (ANXA2_MOUSE)

Last modified December 15, 2009. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Annexin A2
Alternative name(s):
    Annexin-2
    Annexin II
    Lipocortin II
    Calpactin I heavy chain
    Chromobindin-8
    p36
    Protein I
    Placental anticoagulant protein IV
      Short name=PAP-IV
Gene names
Name: Anxa2
Synonyms: Anx2, Cal1h
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.

Subunit structure

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with DYSF. Interacts with ATP1B1 By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrixbasement membrane. Melanosome By similarity. Note: In the lamina beneath the plasma membrane.

Domain

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Miscellaneous

It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

Sequence similarities

Belongs to the annexin family.

Contains 4 annexin repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 339338Annexin A2
PRO_0000067471

Regions

Repeat42 – 10261Annexin 1
Repeat114 – 17461Annexin 2
Repeat199 – 25961Annexin 3
Repeat274 – 33461Annexin 4
Region2 – 2423S100A10-binding site Potential

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue181Phosphoserine By similarity
Modified residue191Phosphothreonine By similarity
Modified residue241Phosphotyrosine; by SRC Ref.6
Modified residue261Phosphoserine; by PKC By similarity
Modified residue301Phosphotyrosine By similarity
Modified residue1041N6-acetyllysine By similarity
Modified residue1151N6-acetyllysine By similarity
Modified residue1481N6-acetyllysine By similarity
Modified residue1521N6-acetyllysine By similarity
Modified residue1571N6-acetyllysine By similarity
Modified residue1881Phosphotyrosine Ref.6
Modified residue1991Phosphotyrosine By similarity
Modified residue2271N6-acetyllysine By similarity
Modified residue2381Phosphotyrosine By similarity
Modified residue2751Phosphotyrosine By similarity
Modified residue2791N6-acetyllysine By similarity
Modified residue3021N6-acetyllysine By similarity
Modified residue3131N6-acetyllysine By similarity
Modified residue3161Phosphotyrosine By similarity
Modified residue3171Phosphotyrosine By similarity
Modified residue3181Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
P07356-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 4407E572097FB2C0

FASTA33938,676
        10         20         30         40         50         60 
MSTVHEILCK LSLEGDHSTP PSAYGSVKPY TNFDAERDAL NIETAVKTKG VDEVTIVNIL 

        70         80         90        100        110        120 
TNRSNVQRQD IAFAYQRRTK KELPSALKSA LSGHLETVIL GLLKTPAQYD ASELKASMKG 

       130        140        150        160        170        180 
LGTDEDSLIE IICSRTNQEL QEINRVYKEM YKTDLEKDII SDTSGDFRKL MVALAKGRRA 

       190        200        210        220        230        240 
EDGSVIDYEL IDQDARELYD AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM 

       250        260        270        280        290        300 
LESIKKEVKG DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM 

       310        320        330 
LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD 

« Hide

References

« Hide 'large scale' references
[1]"The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats."
Saris C.J.M., Tack B.F., Kristensen T., Glenney J.R. Jr., Hunter T.
Cell 46:201-212(1986) [PubMed: 3013423] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Structure and chromosome assignment of the murine p36 (calpactin I heavy chain) gene."
Amiguet P., D'Eustachio P., Kristensen T., Wetsel R.A., Saris C.J.M., Hunter T., Chaplin D.D., Tack B.F.
Biochemistry 29:1226-1232(1990) [PubMed: 2138915] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16 AND 322-339.
[4]"Complete structure of the murine p36 (annexin II) gene. Identification of mRNAs for both the murine and the human gene with alternatively spliced 5' noncoding exons."
Fey M.F., Moffat G.J., Vik D.P., Meisenhelder J., Saris C.J., Hunter T., Tack B.F.
Biochim. Biophys. Acta 1306:160-170(1996) [PubMed: 8634333] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16.
[5]"Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing."
Lennon N.J., Kho A., Bacskai B.J., Perlmutter S.L., Hyman B.T., Brown R.H. Jr.
J. Biol. Chem. 278:50466-50473(2003) [PubMed: 14506282] [Abstract]
Cited for: INTERACTION WITH DYSF.
[6]"Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks."
Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.
Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007) [PubMed: 17389395] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-24 AND TYR-188, MASS SPECTROMETRY.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Red velvet - Issue 86 of September 2007

Cross-references

Sequence databases

M14044 mRNA. Translation: AAA37360.1.
BC003327 mRNA. Translation: AAH03327.1.
BC005763 mRNA. Translation: AAH05763.1.
M33321 Genomic DNA. Translation: AAA37361.1.
M33322 Genomic DNA. Translation: AAA37362.1.
D10024 mRNA. Translation: BAA00914.1.
S82177 Genomic DNA. No translation available.
IPIIPI00468203.
PIRLUMS36. A23943.
RefSeqNP_031611.1.
UniGeneMm.238343

3D structure databases

SMRP07356. Positions 21-339.
ModBaseSearch...

Protein-protein interaction databases

IntActP07356. 2 interactions.
STRINGP07356.

Protein family/group databases

TCDB9.A.48.1.1. unconventional protein secretion (UPS) system.

PTM databases

PhosphoSiteP07356.

2-D gel databases

SWISS-2DPAGEP07356.
REPRODUCTION-2DPAGEP07356.

Proteomic databases

PRIDEP07356.

Genome annotation databases

EnsemblENSMUST00000034756; ENSMUSP00000034756; ENSMUSG00000032231; Mus musculus. [Genome view]
GeneID12306.
KEGGmmu:12306.
UCSCuc009qng.1. mouse.

Organism-specific databases

CTD12306.
MGIMGI:88246. Anxa2.

Phylogenomic databases

HOGENOMHBG745057.
HOVERGENP07356.
InParanoidP07356.
OMACHLQKVF.
OrthoDBEOG9B2WHD.

Gene expression databases

ArrayExpressP07356.
BgeeP07356.
CleanExMM_ANXA2.
GenevestigatorP07356.
GermOnlineENSMUSG00000032231. Mus musculus.

Family and domain databases

InterProIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view]
Gene3DG3DSA:1.10.220.10. Annexin. 4 hits.
PANTHERPTHR10502. Annexin. 1 hit.
PTHR10502:SF18. AnnexinII. 1 hit.
PfamPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSPR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTSM00335. ANX. 4 hits.
[Graphical view]
PROSITEPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio280840.
SOURCESearch...

Entry information

Entry nameANXA2_MOUSE
AccessionPrimary (citable) accession number: P07356
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: December 15, 2009
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents