Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P07356

- ANXA2_MOUSE

UniProt

P07356 - ANXA2_MOUSE

Protein

Annexin A2

Gene

Anxa2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 151 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.

    GO - Molecular functioni

    1. calcium-dependent phospholipid binding Source: UniProtKB-KW
    2. calcium ion binding Source: InterPro
    3. phosphatidylinositol-4,5-bisphosphate binding Source: Ensembl
    4. phospholipase inhibitor activity Source: InterPro
    5. protein binding Source: IntAct

    GO - Biological processi

    1. angiogenesis Source: MGI
    2. body fluid secretion Source: Ensembl
    3. cellular response to acid chemical Source: MGI
    4. collagen fibril organization Source: MGI
    5. fibrinolysis Source: MGI
    6. positive regulation of binding Source: MGI
    7. positive regulation of fibroblast proliferation Source: Ensembl
    8. positive regulation of protein phosphorylation Source: Ensembl
    9. positive regulation of vesicle fusion Source: Ensembl
    10. protein targeting to plasma membrane Source: Ensembl

    Keywords - Ligandi

    Calcium, Calcium/phospholipid-binding

    Protein family/group databases

    TCDBi9.A.48.1.1. the unconventional protein secretion (ups) system.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Annexin A2
    Alternative name(s):
    Annexin II
    Annexin-2
    Calpactin I heavy chain
    Calpactin-1 heavy chain
    Chromobindin-8
    Lipocortin II
    Placental anticoagulant protein IV
    Short name:
    PAP-IV
    Protein I
    p36
    Gene namesi
    Name:Anxa2
    Synonyms:Anx2, Cal1h
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:88246. Anxa2.

    Subcellular locationi

    Secretedextracellular spaceextracellular matrixbasement membrane. Melanosome By similarity
    Note: In the lamina beneath the plasma membrane.

    GO - Cellular componenti

    1. basement membrane Source: UniProtKB-SubCell
    2. cell cortex Source: Ensembl
    3. cytoplasm Source: MGI
    4. early endosome Source: MGI
    5. extracellular vesicular exosome Source: Ensembl
    6. extrinsic component of plasma membrane Source: MGI
    7. lipid particle Source: Ensembl
    8. macropinosome Source: Ensembl
    9. melanosome Source: UniProtKB-SubCell
    10. midbody Source: Ensembl
    11. myelin sheath adaxonal region Source: BHF-UCL
    12. perinuclear region of cytoplasm Source: Ensembl
    13. protein complex Source: Ensembl
    14. ruffle Source: Ensembl
    15. sarcolemma Source: MGI
    16. Schmidt-Lanterman incisure Source: BHF-UCL

    Keywords - Cellular componenti

    Basement membrane, Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 339338Annexin A2PRO_0000067471Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei24 – 241Phosphotyrosine; by SRCBy similarity
    Modified residuei26 – 261Phosphoserine; by PKCBy similarity
    Modified residuei49 – 491N6-acetyllysine1 Publication
    Modified residuei152 – 1521N6-acetyllysine1 Publication
    Modified residuei199 – 1991Phosphotyrosine1 Publication
    Modified residuei227 – 2271N6-acetyllysine1 Publication

    Post-translational modificationi

    ISGylated.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP07356.
    PaxDbiP07356.
    PRIDEiP07356.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00468203.
    P07356.
    SWISS-2DPAGEP07356.

    PTM databases

    PhosphoSiteiP07356.

    Expressioni

    Gene expression databases

    ArrayExpressiP07356.
    BgeeiP07356.
    CleanExiMM_ANXA2.
    GenevestigatoriP07356.

    Interactioni

    Subunit structurei

    Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with DYSF. Interacts with ATP1B1 By similarity. Interacts with COCH By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    S100a10P082072EBI-738510,EBI-643986

    Protein-protein interaction databases

    BioGridi198448. 7 interactions.
    IntActiP07356. 9 interactions.
    MINTiMINT-274998.

    Structurei

    Secondary structure

    1
    339
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 85
    Helixi35 – 4612
    Helixi53 – 619
    Helixi65 – 7915
    Helixi83 – 908
    Helixi93 – 10311
    Helixi106 – 11813
    Helixi125 – 13410
    Helixi137 – 15115
    Helixi155 – 1628
    Helixi165 – 17511
    Helixi188 – 20114
    Beta strandi204 – 2074
    Helixi210 – 21910
    Helixi222 – 23514
    Helixi240 – 2478
    Helixi251 – 26414
    Helixi266 – 27813
    Beta strandi279 – 2824
    Helixi285 – 29410
    Turni296 – 2994
    Helixi300 – 31112
    Helixi315 – 3228
    Helixi325 – 33511

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HREX-ray2.79A/B/C/D1-339[»]
    ProteinModelPortaliP07356.
    SMRiP07356. Positions 2-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati42 – 10261Annexin 1Add
    BLAST
    Repeati114 – 17461Annexin 2Add
    BLAST
    Repeati199 – 25961Annexin 3Add
    BLAST
    Repeati274 – 33461Annexin 4Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 2423S100A10-binding siteSequence AnalysisAdd
    BLAST

    Domaini

    A pair of annexin repeats may form one binding site for calcium and phospholipid.

    Sequence similaritiesi

    Belongs to the annexin family.Curated
    Contains 4 annexin repeats.Curated

    Keywords - Domaini

    Annexin, Repeat

    Phylogenomic databases

    eggNOGiNOG259189.
    HOGENOMiHOG000158803.
    HOVERGENiHBG061815.
    InParanoidiP07356.
    KOiK17092.
    OMAiFIQQDTK.
    OrthoDBiEOG74XS72.
    PhylomeDBiP07356.
    TreeFamiTF105452.

    Family and domain databases

    Gene3Di1.10.220.10. 4 hits.
    InterProiIPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002389. AnnexinII.
    [Graphical view]
    PANTHERiPTHR10502:SF18. PTHR10502:SF18. 1 hit.
    PfamiPF00191. Annexin. 4 hits.
    [Graphical view]
    PRINTSiPR00196. ANNEXIN.
    PR00198. ANNEXINII.
    SMARTiSM00335. ANX. 4 hits.
    [Graphical view]
    PROSITEiPS00223. ANNEXIN. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07356-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTVHEILCK LSLEGDHSTP PSAYGSVKPY TNFDAERDAL NIETAVKTKG    50
    VDEVTIVNIL TNRSNVQRQD IAFAYQRRTK KELPSALKSA LSGHLETVIL 100
    GLLKTPAQYD ASELKASMKG LGTDEDSLIE IICSRTNQEL QEINRVYKEM 150
    YKTDLEKDII SDTSGDFRKL MVALAKGRRA EDGSVIDYEL IDQDARELYD 200
    AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM LESIKKEVKG 250
    DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM 300
    LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD 339
    Length:339
    Mass (Da):38,676
    Last modified:January 23, 2007 - v2
    Checksum:i4407E572097FB2C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M14044 mRNA. Translation: AAA37360.1.
    BC003327 mRNA. Translation: AAH03327.1.
    BC005763 mRNA. Translation: AAH05763.1.
    M33321 Genomic DNA. Translation: AAA37361.1.
    M33322 Genomic DNA. Translation: AAA37362.1.
    D10024 mRNA. Translation: BAA00914.1.
    S82177 Genomic DNA. No translation available.
    CCDSiCCDS23316.1.
    PIRiA23943. LUMS36.
    RefSeqiNP_031611.1. NM_007585.3.
    XP_006510859.1. XM_006510796.1.
    UniGeneiMm.238343.

    Genome annotation databases

    EnsembliENSMUST00000034756; ENSMUSP00000034756; ENSMUSG00000032231.
    GeneIDi12306.
    KEGGimmu:12306.
    UCSCiuc009qng.1. mouse.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Red velvet - Issue 86 of September 2007

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M14044 mRNA. Translation: AAA37360.1 .
    BC003327 mRNA. Translation: AAH03327.1 .
    BC005763 mRNA. Translation: AAH05763.1 .
    M33321 Genomic DNA. Translation: AAA37361.1 .
    M33322 Genomic DNA. Translation: AAA37362.1 .
    D10024 mRNA. Translation: BAA00914.1 .
    S82177 Genomic DNA. No translation available.
    CCDSi CCDS23316.1.
    PIRi A23943. LUMS36.
    RefSeqi NP_031611.1. NM_007585.3.
    XP_006510859.1. XM_006510796.1.
    UniGenei Mm.238343.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HRE X-ray 2.79 A/B/C/D 1-339 [» ]
    ProteinModelPortali P07356.
    SMRi P07356. Positions 2-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198448. 7 interactions.
    IntActi P07356. 9 interactions.
    MINTi MINT-274998.

    Protein family/group databases

    TCDBi 9.A.48.1.1. the unconventional protein secretion (ups) system.

    PTM databases

    PhosphoSitei P07356.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00468203.
    P07356.
    SWISS-2DPAGE P07356.

    Proteomic databases

    MaxQBi P07356.
    PaxDbi P07356.
    PRIDEi P07356.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034756 ; ENSMUSP00000034756 ; ENSMUSG00000032231 .
    GeneIDi 12306.
    KEGGi mmu:12306.
    UCSCi uc009qng.1. mouse.

    Organism-specific databases

    CTDi 302.
    MGIi MGI:88246. Anxa2.

    Phylogenomic databases

    eggNOGi NOG259189.
    HOGENOMi HOG000158803.
    HOVERGENi HBG061815.
    InParanoidi P07356.
    KOi K17092.
    OMAi FIQQDTK.
    OrthoDBi EOG74XS72.
    PhylomeDBi P07356.
    TreeFami TF105452.

    Miscellaneous databases

    NextBioi 280840.
    PROi P07356.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P07356.
    Bgeei P07356.
    CleanExi MM_ANXA2.
    Genevestigatori P07356.

    Family and domain databases

    Gene3Di 1.10.220.10. 4 hits.
    InterProi IPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002389. AnnexinII.
    [Graphical view ]
    PANTHERi PTHR10502:SF18. PTHR10502:SF18. 1 hit.
    Pfami PF00191. Annexin. 4 hits.
    [Graphical view ]
    PRINTSi PR00196. ANNEXIN.
    PR00198. ANNEXINII.
    SMARTi SM00335. ANX. 4 hits.
    [Graphical view ]
    PROSITEi PS00223. ANNEXIN. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats."
      Saris C.J.M., Tack B.F., Kristensen T., Glenney J.R. Jr., Hunter T.
      Cell 46:201-212(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Structure and chromosome assignment of the murine p36 (calpactin I heavy chain) gene."
      Amiguet P., D'Eustachio P., Kristensen T., Wetsel R.A., Saris C.J.M., Hunter T., Chaplin D.D., Tack B.F.
      Biochemistry 29:1226-1232(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16 AND 322-339.
    4. "Complete structure of the murine p36 (annexin II) gene. Identification of mRNAs for both the murine and the human gene with alternatively spliced 5' noncoding exons."
      Fey M.F., Moffat G.J., Vik D.P., Meisenhelder J., Saris C.J., Hunter T., Tack B.F.
      Biochim. Biophys. Acta 1306:160-170(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16.
    5. "Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing."
      Lennon N.J., Kho A., Bacskai B.J., Perlmutter S.L., Hyman B.T., Brown R.H. Jr.
      J. Biol. Chem. 278:50466-50473(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DYSF.
    6. Cited for: ISGYLATION.
    7. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-199, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-49; LYS-152 AND LYS-227, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiANXA2_MOUSE
    AccessioniPrimary (citable) accession number: P07356
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 151 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3