##gff-version 3 P07355 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.7 P07355 UniProtKB Chain 2 339 . . . ID=PRO_0000067470;Note=Annexin A2 P07355 UniProtKB Repeat 33 104 . . . Note=Annexin 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01245 P07355 UniProtKB Repeat 105 176 . . . Note=Annexin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01245 P07355 UniProtKB Repeat 189 261 . . . Note=Annexin 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01245 P07355 UniProtKB Repeat 265 336 . . . Note=Annexin 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01245 P07355 UniProtKB Region 2 24 . . . Note=S100A10-binding site;Ontology_term=ECO:0000255;evidence=ECO:0000255 P07355 UniProtKB Modified residue 2 2 . . . Note=N-acetylserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.7 P07355 UniProtKB Modified residue 24 24 . . . Note=Phosphotyrosine%3B by SRC;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15302870,ECO:0000269|PubMed:28669632;Dbxref=PMID:15302870,PMID:28669632 P07355 UniProtKB Modified residue 26 26 . . . Note=Phosphoserine%3B by PKC;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:28669632,ECO:0000269|PubMed:2946940;Dbxref=PMID:28669632,PMID:2946940 P07355 UniProtKB Modified residue 49 49 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07356 P07355 UniProtKB Modified residue 152 152 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07356 P07355 UniProtKB Modified residue 184 184 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P07355 UniProtKB Modified residue 199 199 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07356 P07355 UniProtKB Modified residue 227 227 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07356 P07355 UniProtKB Cross-link 49 49 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:25114211;Dbxref=PMID:25114211 P07355 UniProtKB Cross-link 49 49 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P07355 UniProtKB Alternative sequence 1 1 . . . ID=VSP_038091;Note=In isoform 2. M->MGRQLAGCGDAGKKASFKM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 P07355 UniProtKB Natural variant 98 98 . . . ID=VAR_012982;Note=Does not affect interaction with PCSK9. V->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:22848640;Dbxref=dbSNP:rs17845226,PMID:15489334,PMID:22848640 P07355 UniProtKB Mutagenesis 24 24 . . . Note=Abolishes heat stress-induced cell surface localization. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15302870;Dbxref=PMID:15302870 P07355 UniProtKB Mutagenesis 26 26 . . . Note=Stronger interaction with S100A4. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28669632;Dbxref=PMID:28669632 P07355 UniProtKB Mutagenesis 28 36 . . . Note=No effect on interaction with PCSK9. KAYTNFDAE->SAYTNFNAS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22848640;Dbxref=PMID:22848640 P07355 UniProtKB Mutagenesis 37 47 . . . Note=Slightly decreases interaction with PCSK9. RDALNIETAIK->SDALNIHTAIM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22848640;Dbxref=PMID:22848640 P07355 UniProtKB Mutagenesis 77 81 . . . Note=Strongly decreases interaction with PCSK9. RRTKK->AATAA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18799458,ECO:0000269|PubMed:22848640;Dbxref=PMID:18799458,PMID:22848640 P07355 UniProtKB Mutagenesis 77 80 . . . Note=Decreases interaction with PCSK9. Strongly decreases interaction with PCSK9%3B when associated with K-88. RRTK->AATA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18799458;Dbxref=PMID:18799458 P07355 UniProtKB Mutagenesis 80 84 . . . Note=No effect on interaction with PCSK9. KKELA->GKPLD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18799458;Dbxref=PMID:18799458 P07355 UniProtKB Mutagenesis 88 88 . . . Note=Strongly decreases interaction with PCSK9%3B when associated with 77-A--A-80. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18799458;Dbxref=PMID:18799458 P07355 UniProtKB Sequence conflict 29 29 . . . Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 P07355 UniProtKB Sequence conflict 166 166 . . . Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 P07355 UniProtKB Sequence conflict 293 293 . . . Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 P07355 UniProtKB Helix 4 12 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5LPU P07355 UniProtKB Turn 24 27 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7QQM P07355 UniProtKB Helix 35 47 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Beta strand 48 50 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5N7D P07355 UniProtKB Helix 53 60 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Helix 65 79 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Helix 83 90 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Helix 93 103 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Helix 106 117 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Beta strand 120 122 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W7B P07355 UniProtKB Helix 125 134 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Helix 137 151 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Helix 155 161 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Helix 165 175 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Helix 188 200 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Turn 201 204 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Beta strand 205 207 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Helix 210 219 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Helix 222 232 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Turn 233 235 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Beta strand 236 238 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DTO P07355 UniProtKB Helix 240 247 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Helix 250 264 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Helix 266 278 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Beta strand 279 282 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Helix 285 295 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Turn 296 298 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Helix 300 311 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Helix 315 322 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV P07355 UniProtKB Helix 325 335 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HYV