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P07353

- IFNG_BOVIN

UniProt

P07353 - IFNG_BOVIN

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Protein

Interferon gamma

Gene

IFNG

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functioni

  1. cytokine activity Source: RefGenome

GO - Biological processi

  1. adaptive immune response Source: RefGenome
  2. antigen processing and presentation Source: Ensembl
  3. CD8-positive, alpha-beta T cell differentiation involved in immune response Source: Ensembl
  4. cell cycle arrest Source: Ensembl
  5. cellular response to interleukin-18 Source: Ensembl
  6. cellular response to lipopolysaccharide Source: Ensembl
  7. defense response to bacterium Source: Ensembl
  8. defense response to protozoan Source: Ensembl
  9. defense response to virus Source: UniProtKB-KW
  10. endoplasmic reticulum unfolded protein response Source: Ensembl
  11. extrinsic apoptotic signaling pathway Source: Ensembl
  12. humoral immune response Source: RefGenome
  13. negative regulation of growth of symbiont in host Source: Ensembl
  14. negative regulation of interleukin-17 production Source: Ensembl
  15. negative regulation of myelination Source: Ensembl
  16. negative regulation of smooth muscle cell proliferation Source: Ensembl
  17. neutrophil apoptotic process Source: Ensembl
  18. neutrophil chemotaxis Source: Ensembl
  19. positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
  20. positive regulation of chemokine biosynthetic process Source: Ensembl
  21. positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Source: Ensembl
  22. positive regulation of fructose 1,6-bisphosphate metabolic process Source: Ensembl
  23. positive regulation of interleukin-12 biosynthetic process Source: Ensembl
  24. positive regulation of interleukin-12 production Source: Ensembl
  25. positive regulation of interleukin-1 beta secretion Source: Ensembl
  26. positive regulation of interleukin-23 production Source: Ensembl
  27. positive regulation of interleukin-6 biosynthetic process Source: Ensembl
  28. positive regulation of isotype switching to IgG isotypes Source: Ensembl
  29. positive regulation of killing of cells of other organism Source: Ensembl
  30. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
  31. positive regulation of MHC class II biosynthetic process Source: Ensembl
  32. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  33. positive regulation of osteoclast differentiation Source: Ensembl
  34. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: Ensembl
  35. positive regulation of smooth muscle cell apoptotic process Source: Ensembl
  36. positive regulation of T cell proliferation Source: Ensembl
  37. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  38. positive regulation of tumor necrosis factor (ligand) superfamily member 11 production Source: Ensembl
  39. positive regulation of tumor necrosis factor production Source: Ensembl
  40. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
  41. positive regulation of vitamin D biosynthetic process Source: Ensembl
  42. protein import into nucleus, translocation Source: Ensembl
  43. regulation of insulin secretion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense, Growth regulation

Enzyme and pathway databases

ReactomeiREACT_212455. Interferon gamma signaling.
REACT_224754. Regulation of IFNG signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
BoIFNG
Short name:
IFN-gamma
Gene namesi
Name:IFNG
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular space Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 166143Interferon gammaPRO_0000016433Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
Glycosylationi39 – 391N-linked (GlcNAc...)By similarity
Glycosylationi106 – 1061N-linked (GlcNAc...)By similarity

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiP07353.

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

1
166
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi25 – 3814
Turni39 – 413
Helixi43 – 464
Helixi53 – 586
Turni59 – 613
Turni63 – 653
Helixi66 – 8116
Turni82 – 854
Turni87 – 893
Helixi90 – 10415
Helixi109 – 11911
Helixi126 – 1349
Helixi136 – 1438

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D9CX-ray2.00A/B24-144[»]
1D9GX-ray2.90A/B24-144[»]
1RFBX-ray3.00A/B24-142[»]
ProteinModelPortaliP07353.
SMRiP07353. Positions 24-144.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07353.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45353.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP07353.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG7VHSZM.
TreeFamiTF336308.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07353-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKYTSYFLAL LLCGLLGFSG SYGQGQFFRE IENLKEYFNA SSPDVAKGGP
60 70 80 90 100
LFSEILKNWK DESDKKIIQS QIVSFYFKLF ENLKDNQVIQ RSMDIIKQDM
110 120 130 140 150
FQKFLNGSSE KLEDFKKLIQ IPVDDLQIQR KAINELIKVM NDLSPKSNLR
160
KRKRSQNLFR GRRASM
Length:166
Mass (Da):19,393
Last modified:April 1, 1988 - v1
Checksum:i27B268B950BB3B1F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti14 – 141G → V.1 Publication
Natural varianti166 – 1661M → T May represent an allelic difference or a cloning artifact. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29867 mRNA. Translation: AAB64477.1.
Z54144 Genomic DNA. Translation: CAA90859.1.
EF675629 mRNA. Translation: ABS11696.1.
EU276066 mRNA. Translation: ABX72064.1.
PIRiA24390. IVBOG.
RefSeqiNP_776511.1. NM_174086.1.
UniGeneiBt.188.

Genome annotation databases

EnsembliENSBTAT00000016634; ENSBTAP00000016634; ENSBTAG00000012529.
GeneIDi281237.
KEGGibta:281237.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29867 mRNA. Translation: AAB64477.1 .
Z54144 Genomic DNA. Translation: CAA90859.1 .
EF675629 mRNA. Translation: ABS11696.1 .
EU276066 mRNA. Translation: ABX72064.1 .
PIRi A24390. IVBOG.
RefSeqi NP_776511.1. NM_174086.1.
UniGenei Bt.188.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1D9C X-ray 2.00 A/B 24-144 [» ]
1D9G X-ray 2.90 A/B 24-144 [» ]
1RFB X-ray 3.00 A/B 24-142 [» ]
ProteinModelPortali P07353.
SMRi P07353. Positions 24-144.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P07353.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000016634 ; ENSBTAP00000016634 ; ENSBTAG00000012529 .
GeneIDi 281237.
KEGGi bta:281237.

Organism-specific databases

CTDi 3458.

Phylogenomic databases

eggNOGi NOG45353.
GeneTreei ENSGT00390000007831.
HOGENOMi HOG000254784.
HOVERGENi HBG056912.
InParanoidi P07353.
KOi K04687.
OMAi KEYFNAS.
OrthoDBi EOG7VHSZM.
TreeFami TF336308.

Enzyme and pathway databases

Reactomei REACT_212455. Interferon gamma signaling.
REACT_224754. Regulation of IFNG signaling.

Miscellaneous databases

EvolutionaryTracei P07353.
NextBioi 20805283.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view ]
PANTHERi PTHR11419. PTHR11419. 1 hit.
Pfami PF00714. IFN-gamma. 1 hit.
[Graphical view ]
PIRSFi PIRSF001936. IFN-gamma. 1 hit.
ProDomi PD002435. Interferon_gamma. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, sequence, and expression of bovine interferon-gamma."
    Cerretti D.P., McKereghan K., Larsen A., Cosman D., Gillis S., Baker P.E.
    J. Immunol. 136:4561-4564(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A comprehensive survey for polymorphisms in the bovine IFN-gamma gene reveals a highly polymorphic intronic DNA sequence allowing improved genotyping of Bovinae."
    Schmidt P., Kuehn C., Maillard J.-C., Pitra C., Tiemann U., Weikard R., Schwerin M.
    J. Interferon Cytokine Res. 22:923-934(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-14.
    Strain: Deutsche Schwarzbunte.
  3. "Cloning and sequence analysis of cattle interferon gamma."
    Li G., Hu Y., Ren X., Ma D., Gai R.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-166.
  4. "U.S. veterinary immune reagent network: expressed bovine gene sequences."
    U.S. Veterinary Immune Reagent Network
    Hudgens T., Tompkins D., Baldwin C.L.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Belted Galloway.
    Tissue: Peripheral blood.
  5. "Structure of recombinant bovine interferon-gamma at 3.0-A resolution."
    Samudzi C.T., Rubin J.R.
    Acta Crystallogr. D 49:513-521(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
  6. "The 2.0-A structure of bovine interferon-gamma; assessment of the structural differences between species."
    Randal M., Kossiakoff A.A.
    Acta Crystallogr. D 56:14-24(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

Entry informationi

Entry nameiIFNG_BOVIN
AccessioniPrimary (citable) accession number: P07353
Secondary accession number(s): A7L687, A9QWQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: October 1, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3