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Protein

Interferon gamma

Gene

IFNG

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense, Growth regulation

Enzyme and pathway databases

ReactomeiREACT_272797. Regulation of IFNG signaling.
REACT_353696. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
BoIFNG
Short name:
IFN-gamma
Gene namesi
Name:IFNG
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  • external side of plasma membrane Source: Ensembl
  • extracellular space Source: AgBase
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 166143Interferon gammaPRO_0000016433Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
Glycosylationi39 – 391N-linked (GlcNAc...)By similarity
Glycosylationi106 – 1061N-linked (GlcNAc...)By similarity

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiP07353.

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016634.

Structurei

Secondary structure

1
166
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi25 – 3814Combined sources
Turni39 – 413Combined sources
Helixi43 – 464Combined sources
Helixi53 – 586Combined sources
Turni59 – 613Combined sources
Turni63 – 653Combined sources
Helixi66 – 8116Combined sources
Turni82 – 854Combined sources
Turni87 – 893Combined sources
Helixi90 – 10415Combined sources
Helixi109 – 11911Combined sources
Helixi126 – 1349Combined sources
Helixi136 – 1438Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D9CX-ray2.00A/B24-144[»]
1D9GX-ray2.90A/B24-144[»]
1RFBX-ray3.00A/B24-142[»]
ProteinModelPortaliP07353.
SMRiP07353. Positions 24-144.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07353.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45353.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP07353.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG7VHSZM.
TreeFamiTF336308.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYTSYFLAL LLCGLLGFSG SYGQGQFFRE IENLKEYFNA SSPDVAKGGP
60 70 80 90 100
LFSEILKNWK DESDKKIIQS QIVSFYFKLF ENLKDNQVIQ RSMDIIKQDM
110 120 130 140 150
FQKFLNGSSE KLEDFKKLIQ IPVDDLQIQR KAINELIKVM NDLSPKSNLR
160
KRKRSQNLFR GRRASM
Length:166
Mass (Da):19,393
Last modified:April 1, 1988 - v1
Checksum:i27B268B950BB3B1F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti14 – 141G → V.1 Publication
Natural varianti166 – 1661M → T May represent an allelic difference or a cloning artifact. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29867 mRNA. Translation: AAB64477.1.
Z54144 Genomic DNA. Translation: CAA90859.1.
EF675629 mRNA. Translation: ABS11696.1.
EU276066 mRNA. Translation: ABX72064.1.
PIRiA24390. IVBOG.
RefSeqiNP_776511.1. NM_174086.1.
UniGeneiBt.188.

Genome annotation databases

EnsembliENSBTAT00000016634; ENSBTAP00000016634; ENSBTAG00000012529.
GeneIDi281237.
KEGGibta:281237.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29867 mRNA. Translation: AAB64477.1.
Z54144 Genomic DNA. Translation: CAA90859.1.
EF675629 mRNA. Translation: ABS11696.1.
EU276066 mRNA. Translation: ABX72064.1.
PIRiA24390. IVBOG.
RefSeqiNP_776511.1. NM_174086.1.
UniGeneiBt.188.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D9CX-ray2.00A/B24-144[»]
1D9GX-ray2.90A/B24-144[»]
1RFBX-ray3.00A/B24-142[»]
ProteinModelPortaliP07353.
SMRiP07353. Positions 24-144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016634.

Proteomic databases

PRIDEiP07353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000016634; ENSBTAP00000016634; ENSBTAG00000012529.
GeneIDi281237.
KEGGibta:281237.

Organism-specific databases

CTDi3458.

Phylogenomic databases

eggNOGiNOG45353.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP07353.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG7VHSZM.
TreeFamiTF336308.

Enzyme and pathway databases

ReactomeiREACT_272797. Regulation of IFNG signaling.
REACT_353696. Interferon gamma signaling.

Miscellaneous databases

EvolutionaryTraceiP07353.
NextBioi20805283.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, sequence, and expression of bovine interferon-gamma."
    Cerretti D.P., McKereghan K., Larsen A., Cosman D., Gillis S., Baker P.E.
    J. Immunol. 136:4561-4564(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A comprehensive survey for polymorphisms in the bovine IFN-gamma gene reveals a highly polymorphic intronic DNA sequence allowing improved genotyping of Bovinae."
    Schmidt P., Kuehn C., Maillard J.-C., Pitra C., Tiemann U., Weikard R., Schwerin M.
    J. Interferon Cytokine Res. 22:923-934(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-14.
    Strain: Deutsche Schwarzbunte.
  3. "Cloning and sequence analysis of cattle interferon gamma."
    Li G., Hu Y., Ren X., Ma D., Gai R.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-166.
  4. "U.S. veterinary immune reagent network: expressed bovine gene sequences."
    U.S. Veterinary Immune Reagent Network
    Hudgens T., Tompkins D., Baldwin C.L.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Belted Galloway.
    Tissue: Peripheral blood.
  5. "Structure of recombinant bovine interferon-gamma at 3.0-A resolution."
    Samudzi C.T., Rubin J.R.
    Acta Crystallogr. D 49:513-521(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
  6. "The 2.0-A structure of bovine interferon-gamma; assessment of the structural differences between species."
    Randal M., Kossiakoff A.A.
    Acta Crystallogr. D 56:14-24(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

Entry informationi

Entry nameiIFNG_BOVIN
AccessioniPrimary (citable) accession number: P07353
Secondary accession number(s): A7L687, A9QWQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: July 22, 2015
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.