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P07353 (IFNG_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon gamma

Short name=BoIFNG
Short name=IFN-gamma
Gene names
Name:IFNG
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length166 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

Subunit structure

Homodimer.

Subcellular location

Secreted.

Tissue specificity

Released primarily from activated T lymphocytes.

Sequence similarities

Belongs to the type II (or gamma) interferon family.

Ontologies

Keywords
   Biological processAntiviral defense
Growth regulation
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionCytokine
   PTMGlycoprotein
Pyrrolidone carboxylic acid
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processCD8-positive, alpha-beta T cell differentiation involved in immune response

Inferred from electronic annotation. Source: Ensembl

adaptive immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

antigen processing and presentation

Inferred from electronic annotation. Source: Ensembl

cell cycle arrest

Inferred from electronic annotation. Source: Ensembl

cellular response to interleukin-18

Inferred from electronic annotation. Source: Ensembl

cellular response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

defense response to bacterium

Inferred from electronic annotation. Source: Ensembl

defense response to protozoan

Inferred from electronic annotation. Source: Ensembl

defense response to virus

Inferred from electronic annotation. Source: UniProtKB-KW

endoplasmic reticulum unfolded protein response

Inferred from electronic annotation. Source: Ensembl

extrinsic apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

humoral immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of growth of symbiont in host

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-17 production

Inferred from electronic annotation. Source: Ensembl

negative regulation of myelination

Inferred from electronic annotation. Source: Ensembl

negative regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

neutrophil apoptotic process

Inferred from electronic annotation. Source: Ensembl

neutrophil chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of MHC class II biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of calcidiol 1-monooxygenase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of chemokine biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of fructose 1,6-bisphosphate metabolic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-1 beta secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-12 biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-12 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-23 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-6 biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of isotype switching to IgG isotypes

Inferred from electronic annotation. Source: Ensembl

positive regulation of killing of cells of other organism

Inferred from electronic annotation. Source: Ensembl

positive regulation of membrane protein ectodomain proteolysis

Inferred from electronic annotation. Source: Ensembl

positive regulation of nitric oxide biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of osteoclast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-serine phosphorylation of STAT protein

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of tumor necrosis factor (ligand) superfamily member 11 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of tumor necrosis factor production

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of Stat1 protein

Inferred from electronic annotation. Source: Ensembl

positive regulation of vitamin D biosynthetic process

Inferred from electronic annotation. Source: Ensembl

protein import into nucleus, translocation

Inferred from electronic annotation. Source: Ensembl

regulation of insulin secretion

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentexternal side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functioncytokine activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 166143Interferon gamma
PRO_0000016433

Amino acid modifications

Modified residue241Pyrrolidone carboxylic acid By similarity
Glycosylation391N-linked (GlcNAc...) By similarity
Glycosylation1061N-linked (GlcNAc...) By similarity

Natural variations

Natural variant141G → V. Ref.2
Natural variant1661M → T May represent an allelic difference or a cloning artifact. Ref.3

Secondary structure

...................... 166
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P07353 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: 27B268B950BB3B1F

FASTA16619,393
        10         20         30         40         50         60 
MKYTSYFLAL LLCGLLGFSG SYGQGQFFRE IENLKEYFNA SSPDVAKGGP LFSEILKNWK 

        70         80         90        100        110        120 
DESDKKIIQS QIVSFYFKLF ENLKDNQVIQ RSMDIIKQDM FQKFLNGSSE KLEDFKKLIQ 

       130        140        150        160 
IPVDDLQIQR KAINELIKVM NDLSPKSNLR KRKRSQNLFR GRRASM 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, sequence, and expression of bovine interferon-gamma."
Cerretti D.P., McKereghan K., Larsen A., Cosman D., Gillis S., Baker P.E.
J. Immunol. 136:4561-4564(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A comprehensive survey for polymorphisms in the bovine IFN-gamma gene reveals a highly polymorphic intronic DNA sequence allowing improved genotyping of Bovinae."
Schmidt P., Kuehn C., Maillard J.-C., Pitra C., Tiemann U., Weikard R., Schwerin M.
J. Interferon Cytokine Res. 22:923-934(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-14.
Strain: Deutsche Schwarzbunte.
[3]"Cloning and sequence analysis of cattle interferon gamma."
Li G., Hu Y., Ren X., Ma D., Gai R.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-166.
[4]"U.S. veterinary immune reagent network: expressed bovine gene sequences."
U.S. Veterinary Immune Reagent Network
Hudgens T., Tompkins D., Baldwin C.L.
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Belted Galloway.
Tissue: Peripheral blood.
[5]"Structure of recombinant bovine interferon-gamma at 3.0-A resolution."
Samudzi C.T., Rubin J.R.
Acta Crystallogr. D 49:513-521(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
[6]"The 2.0-A structure of bovine interferon-gamma; assessment of the structural differences between species."
Randal M., Kossiakoff A.A.
Acta Crystallogr. D 56:14-24(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M29867 mRNA. Translation: AAB64477.1.
Z54144 Genomic DNA. Translation: CAA90859.1.
EF675629 mRNA. Translation: ABS11696.1.
EU276066 mRNA. Translation: ABX72064.1.
PIRIVBOG. A24390.
RefSeqNP_776511.1. NM_174086.1.
UniGeneBt.188.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1D9CX-ray2.00A/B24-144[»]
1D9GX-ray2.90A/B24-144[»]
1RFBX-ray3.00A/B24-142[»]
ProteinModelPortalP07353.
SMRP07353. Positions 24-144.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP07353.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000016634; ENSBTAP00000016634; ENSBTAG00000012529.
GeneID281237.
KEGGbta:281237.

Organism-specific databases

CTD3458.

Phylogenomic databases

eggNOGNOG45353.
GeneTreeENSGT00390000007831.
HOGENOMHOG000254784.
HOVERGENHBG056912.
InParanoidP07353.
KOK04687.
OMAKEYFNAS.
OrthoDBEOG7VHSZM.
TreeFamTF336308.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERPTHR11419. PTHR11419. 1 hit.
PfamPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFPIRSF001936. IFN-gamma. 1 hit.
ProDomPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF47266. SSF47266. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP07353.
NextBio20805283.

Entry information

Entry nameIFNG_BOVIN
AccessionPrimary (citable) accession number: P07353
Secondary accession number(s): A7L687, A9QWQ4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: April 16, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references