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P07353

- IFNG_BOVIN

UniProt

P07353 - IFNG_BOVIN

Protein

Interferon gamma

Gene

IFNG

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

    GO - Molecular functioni

    1. cytokine activity Source: RefGenome

    GO - Biological processi

    1. adaptive immune response Source: RefGenome
    2. antigen processing and presentation Source: Ensembl
    3. CD8-positive, alpha-beta T cell differentiation involved in immune response Source: Ensembl
    4. cell cycle arrest Source: Ensembl
    5. cellular response to interleukin-18 Source: Ensembl
    6. cellular response to lipopolysaccharide Source: Ensembl
    7. defense response to bacterium Source: Ensembl
    8. defense response to protozoan Source: Ensembl
    9. defense response to virus Source: UniProtKB-KW
    10. endoplasmic reticulum unfolded protein response Source: Ensembl
    11. extrinsic apoptotic signaling pathway Source: Ensembl
    12. humoral immune response Source: RefGenome
    13. negative regulation of growth of symbiont in host Source: Ensembl
    14. negative regulation of interleukin-17 production Source: Ensembl
    15. negative regulation of myelination Source: Ensembl
    16. negative regulation of smooth muscle cell proliferation Source: Ensembl
    17. neutrophil apoptotic process Source: Ensembl
    18. neutrophil chemotaxis Source: Ensembl
    19. positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
    20. positive regulation of chemokine biosynthetic process Source: Ensembl
    21. positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Source: Ensembl
    22. positive regulation of fructose 1,6-bisphosphate metabolic process Source: Ensembl
    23. positive regulation of interleukin-12 biosynthetic process Source: Ensembl
    24. positive regulation of interleukin-12 production Source: Ensembl
    25. positive regulation of interleukin-1 beta secretion Source: Ensembl
    26. positive regulation of interleukin-23 production Source: Ensembl
    27. positive regulation of interleukin-6 biosynthetic process Source: Ensembl
    28. positive regulation of isotype switching to IgG isotypes Source: Ensembl
    29. positive regulation of killing of cells of other organism Source: Ensembl
    30. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
    31. positive regulation of MHC class II biosynthetic process Source: Ensembl
    32. positive regulation of nitric oxide biosynthetic process Source: Ensembl
    33. positive regulation of osteoclast differentiation Source: Ensembl
    34. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: Ensembl
    35. positive regulation of smooth muscle cell apoptotic process Source: Ensembl
    36. positive regulation of T cell proliferation Source: Ensembl
    37. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    38. positive regulation of tumor necrosis factor (ligand) superfamily member 11 production Source: Ensembl
    39. positive regulation of tumor necrosis factor production Source: Ensembl
    40. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
    41. positive regulation of vitamin D biosynthetic process Source: Ensembl
    42. protein import into nucleus, translocation Source: Ensembl
    43. regulation of insulin secretion Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense, Growth regulation

    Enzyme and pathway databases

    ReactomeiREACT_212455. Interferon gamma signaling.
    REACT_224754. Regulation of IFNG signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon gamma
    Short name:
    BoIFNG
    Short name:
    IFN-gamma
    Gene namesi
    Name:IFNG
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 5

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular space Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 166143Interferon gammaPRO_0000016433Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
    Glycosylationi39 – 391N-linked (GlcNAc...)By similarity
    Glycosylationi106 – 1061N-linked (GlcNAc...)By similarity

    Keywords - PTMi

    Glycoprotein, Pyrrolidone carboxylic acid

    Proteomic databases

    PRIDEiP07353.

    Expressioni

    Tissue specificityi

    Released primarily from activated T lymphocytes.

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    Secondary structure

    1
    166
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi25 – 3814
    Turni39 – 413
    Helixi43 – 464
    Helixi53 – 586
    Turni59 – 613
    Turni63 – 653
    Helixi66 – 8116
    Turni82 – 854
    Turni87 – 893
    Helixi90 – 10415
    Helixi109 – 11911
    Helixi126 – 1349
    Helixi136 – 1438

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1D9CX-ray2.00A/B24-144[»]
    1D9GX-ray2.90A/B24-144[»]
    1RFBX-ray3.00A/B24-142[»]
    ProteinModelPortaliP07353.
    SMRiP07353. Positions 24-144.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP07353.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45353.
    GeneTreeiENSGT00390000007831.
    HOGENOMiHOG000254784.
    HOVERGENiHBG056912.
    InParanoidiP07353.
    KOiK04687.
    OMAiKEYFNAS.
    OrthoDBiEOG7VHSZM.
    TreeFamiTF336308.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR002069. Interferon_gamma.
    [Graphical view]
    PANTHERiPTHR11419. PTHR11419. 1 hit.
    PfamiPF00714. IFN-gamma. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001936. IFN-gamma. 1 hit.
    ProDomiPD002435. Interferon_gamma. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07353-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYTSYFLAL LLCGLLGFSG SYGQGQFFRE IENLKEYFNA SSPDVAKGGP    50
    LFSEILKNWK DESDKKIIQS QIVSFYFKLF ENLKDNQVIQ RSMDIIKQDM 100
    FQKFLNGSSE KLEDFKKLIQ IPVDDLQIQR KAINELIKVM NDLSPKSNLR 150
    KRKRSQNLFR GRRASM 166
    Length:166
    Mass (Da):19,393
    Last modified:April 1, 1988 - v1
    Checksum:i27B268B950BB3B1F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti14 – 141G → V.1 Publication
    Natural varianti166 – 1661M → T May represent an allelic difference or a cloning artifact. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29867 mRNA. Translation: AAB64477.1.
    Z54144 Genomic DNA. Translation: CAA90859.1.
    EF675629 mRNA. Translation: ABS11696.1.
    EU276066 mRNA. Translation: ABX72064.1.
    PIRiA24390. IVBOG.
    RefSeqiNP_776511.1. NM_174086.1.
    UniGeneiBt.188.

    Genome annotation databases

    EnsembliENSBTAT00000016634; ENSBTAP00000016634; ENSBTAG00000012529.
    GeneIDi281237.
    KEGGibta:281237.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29867 mRNA. Translation: AAB64477.1 .
    Z54144 Genomic DNA. Translation: CAA90859.1 .
    EF675629 mRNA. Translation: ABS11696.1 .
    EU276066 mRNA. Translation: ABX72064.1 .
    PIRi A24390. IVBOG.
    RefSeqi NP_776511.1. NM_174086.1.
    UniGenei Bt.188.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1D9C X-ray 2.00 A/B 24-144 [» ]
    1D9G X-ray 2.90 A/B 24-144 [» ]
    1RFB X-ray 3.00 A/B 24-142 [» ]
    ProteinModelPortali P07353.
    SMRi P07353. Positions 24-144.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P07353.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000016634 ; ENSBTAP00000016634 ; ENSBTAG00000012529 .
    GeneIDi 281237.
    KEGGi bta:281237.

    Organism-specific databases

    CTDi 3458.

    Phylogenomic databases

    eggNOGi NOG45353.
    GeneTreei ENSGT00390000007831.
    HOGENOMi HOG000254784.
    HOVERGENi HBG056912.
    InParanoidi P07353.
    KOi K04687.
    OMAi KEYFNAS.
    OrthoDBi EOG7VHSZM.
    TreeFami TF336308.

    Enzyme and pathway databases

    Reactomei REACT_212455. Interferon gamma signaling.
    REACT_224754. Regulation of IFNG signaling.

    Miscellaneous databases

    EvolutionaryTracei P07353.
    NextBioi 20805283.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR002069. Interferon_gamma.
    [Graphical view ]
    PANTHERi PTHR11419. PTHR11419. 1 hit.
    Pfami PF00714. IFN-gamma. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001936. IFN-gamma. 1 hit.
    ProDomi PD002435. Interferon_gamma. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequence, and expression of bovine interferon-gamma."
      Cerretti D.P., McKereghan K., Larsen A., Cosman D., Gillis S., Baker P.E.
      J. Immunol. 136:4561-4564(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "A comprehensive survey for polymorphisms in the bovine IFN-gamma gene reveals a highly polymorphic intronic DNA sequence allowing improved genotyping of Bovinae."
      Schmidt P., Kuehn C., Maillard J.-C., Pitra C., Tiemann U., Weikard R., Schwerin M.
      J. Interferon Cytokine Res. 22:923-934(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-14.
      Strain: Deutsche Schwarzbunte.
    3. "Cloning and sequence analysis of cattle interferon gamma."
      Li G., Hu Y., Ren X., Ma D., Gai R.
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-166.
    4. "U.S. veterinary immune reagent network: expressed bovine gene sequences."
      U.S. Veterinary Immune Reagent Network
      Hudgens T., Tompkins D., Baldwin C.L.
      Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Belted Galloway.
      Tissue: Peripheral blood.
    5. "Structure of recombinant bovine interferon-gamma at 3.0-A resolution."
      Samudzi C.T., Rubin J.R.
      Acta Crystallogr. D 49:513-521(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
    6. "The 2.0-A structure of bovine interferon-gamma; assessment of the structural differences between species."
      Randal M., Kossiakoff A.A.
      Acta Crystallogr. D 56:14-24(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

    Entry informationi

    Entry nameiIFNG_BOVIN
    AccessioniPrimary (citable) accession number: P07353
    Secondary accession number(s): A7L687, A9QWQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3