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Protein

Interferon gamma

Gene

IFNG

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense, Growth regulation

Enzyme and pathway databases

ReactomeiR-BTA-877300. Interferon gamma signaling.
R-BTA-877312. Regulation of IFNG signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
BoIFNG
Short name:
IFN-gamma
Gene namesi
Name:IFNG
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  • external side of plasma membrane Source: Ensembl
  • extracellular space Source: AgBase
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000001643324 – 166Interferon gammaAdd BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acidBy similarity1
Glycosylationi39N-linked (GlcNAc...)By similarity1
Glycosylationi106N-linked (GlcNAc...)By similarity1

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP07353.
PRIDEiP07353.

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016634.

Structurei

Secondary structure

1166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 38Combined sources14
Turni39 – 41Combined sources3
Helixi43 – 46Combined sources4
Helixi53 – 58Combined sources6
Turni59 – 61Combined sources3
Turni63 – 65Combined sources3
Helixi66 – 81Combined sources16
Turni82 – 85Combined sources4
Turni87 – 89Combined sources3
Helixi90 – 104Combined sources15
Helixi109 – 119Combined sources11
Helixi126 – 134Combined sources9
Helixi136 – 143Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D9CX-ray2.00A/B24-144[»]
1D9GX-ray2.90A/B24-144[»]
1RFBX-ray3.00A/B24-142[»]
ProteinModelPortaliP07353.
SMRiP07353.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07353.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWSY. Eukaryota.
ENOG410Z8I5. LUCA.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP07353.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG091G0ZH0.
TreeFamiTF336308.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYTSYFLAL LLCGLLGFSG SYGQGQFFRE IENLKEYFNA SSPDVAKGGP
60 70 80 90 100
LFSEILKNWK DESDKKIIQS QIVSFYFKLF ENLKDNQVIQ RSMDIIKQDM
110 120 130 140 150
FQKFLNGSSE KLEDFKKLIQ IPVDDLQIQR KAINELIKVM NDLSPKSNLR
160
KRKRSQNLFR GRRASM
Length:166
Mass (Da):19,393
Last modified:April 1, 1988 - v1
Checksum:i27B268B950BB3B1F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti14G → V.1 Publication1
Natural varianti166M → T May represent an allelic difference or a cloning artifact. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29867 mRNA. Translation: AAB64477.1.
Z54144 Genomic DNA. Translation: CAA90859.1.
EF675629 mRNA. Translation: ABS11696.1.
EU276066 mRNA. Translation: ABX72064.1.
PIRiA24390. IVBOG.
RefSeqiNP_776511.1. NM_174086.1.
UniGeneiBt.188.

Genome annotation databases

EnsembliENSBTAT00000016634; ENSBTAP00000016634; ENSBTAG00000012529.
GeneIDi281237.
KEGGibta:281237.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29867 mRNA. Translation: AAB64477.1.
Z54144 Genomic DNA. Translation: CAA90859.1.
EF675629 mRNA. Translation: ABS11696.1.
EU276066 mRNA. Translation: ABX72064.1.
PIRiA24390. IVBOG.
RefSeqiNP_776511.1. NM_174086.1.
UniGeneiBt.188.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D9CX-ray2.00A/B24-144[»]
1D9GX-ray2.90A/B24-144[»]
1RFBX-ray3.00A/B24-142[»]
ProteinModelPortaliP07353.
SMRiP07353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016634.

Proteomic databases

PaxDbiP07353.
PRIDEiP07353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000016634; ENSBTAP00000016634; ENSBTAG00000012529.
GeneIDi281237.
KEGGibta:281237.

Organism-specific databases

CTDi3458.

Phylogenomic databases

eggNOGiENOG410IWSY. Eukaryota.
ENOG410Z8I5. LUCA.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP07353.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG091G0ZH0.
TreeFamiTF336308.

Enzyme and pathway databases

ReactomeiR-BTA-877300. Interferon gamma signaling.
R-BTA-877312. Regulation of IFNG signaling.

Miscellaneous databases

EvolutionaryTraceiP07353.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIFNG_BOVIN
AccessioniPrimary (citable) accession number: P07353
Secondary accession number(s): A7L687, A9QWQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 2, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.