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Protein

Interferon alpha-4

Gene

Ifna4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO - Biological processi

  • defense response to virus Source: MGI
  • natural killer cell activation involved in immune response Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-4
Short name:
IFN-alpha-4
Gene namesi
Name:Ifna4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:107664. Ifna4.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 186162Interferon alpha-4PRO_0000016377Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 123By similarity
Disulfide bondi53 ↔ 158By similarity
Glycosylationi102 – 1021N-linked (GlcNAc...)Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP07351.
PRIDEiP07351.

Expressioni

Gene expression databases

CleanExiMM_IFNA4.
ExpressionAtlasiP07351. baseline and differential.
GenevisibleiP07351. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092581.

Structurei

3D structure databases

ProteinModelPortaliP07351.
SMRiP07351. Positions 25-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J735. Eukaryota.
ENOG410ZH91. LUCA.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP07351.
KOiK05414.
OMAiITMYLRE.
OrthoDBiEOG7WMCKW.
PhylomeDBiP07351.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07351-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLCAFLMI LVMMSYYWSA CSLGCDLPHT YNLGNKRALT VLEEMRRLPP
60 70 80 90 100
LSCLKDRKDF GFPLEKVDNQ QIQKAQAILV LRDLTQQILN LFTSKDLSAT
110 120 130 140 150
WNATLLDSFC NDLHQQLNDL KACVMQEPPL TQEDSLLAVR TYFHRITVYL
160 170 180
RKKKHSLCAW EVIRAEVWRA LSSSTNLLAR LSEEKE
Length:186
Mass (Da):21,524
Last modified:April 1, 1988 - v1
Checksum:iFC5D46D473741794
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01973 Genomic DNA. Translation: CAA26005.1.
CCDSiCCDS18346.1.
PIRiB23087. IVMSA4.
RefSeqiNP_034634.1. NM_010504.2.
UniGeneiMm.377088.

Genome annotation databases

EnsembliENSMUST00000094973; ENSMUSP00000092581; ENSMUSG00000070904.
GeneIDi15967.
KEGGimmu:15967.
UCSCiuc008tob.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01973 Genomic DNA. Translation: CAA26005.1.
CCDSiCCDS18346.1.
PIRiB23087. IVMSA4.
RefSeqiNP_034634.1. NM_010504.2.
UniGeneiMm.377088.

3D structure databases

ProteinModelPortaliP07351.
SMRiP07351. Positions 25-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092581.

Proteomic databases

PaxDbiP07351.
PRIDEiP07351.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094973; ENSMUSP00000092581; ENSMUSG00000070904.
GeneIDi15967.
KEGGimmu:15967.
UCSCiuc008tob.2. mouse.

Organism-specific databases

CTDi3441.
MGIiMGI:107664. Ifna4.

Phylogenomic databases

eggNOGiENOG410J735. Eukaryota.
ENOG410ZH91. LUCA.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP07351.
KOiK05414.
OMAiITMYLRE.
OrthoDBiEOG7WMCKW.
PhylomeDBiP07351.
TreeFamiTF336177.

Miscellaneous databases

PROiP07351.
SOURCEiSearch...

Gene expression databases

CleanExiMM_IFNA4.
ExpressionAtlasiP07351. baseline and differential.
GenevisibleiP07351. MM.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of a mouse interferon gene locus I. Isolation of a cluster of four alpha interferon genes."
    Kelly K.A., Pitha P.M.
    Nucleic Acids Res. 13:805-823(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiIFNA4_MOUSE
AccessioniPrimary (citable) accession number: P07351
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: June 8, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.