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Protein

Fructose-bisphosphate aldolase B

Gene

ALDOB

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (RCJMB04_1c14), Glucose-6-phosphate isomerase (GPI)
  3. ATP-dependent 6-phosphofructokinase (pfk), ATP-dependent 6-phosphofructokinase (pfk), ATP-dependent 6-phosphofructokinase (PFKL)
  4. Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase B (ALDOB), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase C (ALDOC)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56SubstrateBy similarity1
Binding sitei147SubstrateBy similarity1
Active sitei188Proton acceptorBy similarity1
Active sitei230Schiff-base intermediate with dihydroxyacetone-PBy similarity1
Sitei364Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

ReactomeiR-GGA-352875. Gluconeogenesis.
R-GGA-352882. Glycolysis.
R-GGA-70171. Glycolysis.
R-GGA-70263. Gluconeogenesis.
R-GGA-70350. Fructose catabolism.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase B (EC:4.1.2.13)
Alternative name(s):
Liver-type aldolase
Gene namesi
Name:ALDOB
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome Z

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002169452 – 364Fructose-bisphosphate aldolase BAdd BLAST363

Proteomic databases

PaxDbiP07341.
PRIDEiP07341.

Expressioni

Gene expression databases

BgeeiENSGALG00000015544.

Interactioni

Subunit structurei

Homotetramer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi686645. 1 interactor.
IntActiP07341. 1 interactor.
STRINGi9031.ENSGALP00000025010.

Structurei

3D structure databases

ProteinModelPortaliP07341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1557. Eukaryota.
COG3588. LUCA.
GeneTreeiENSGT00390000010235.
HOGENOMiHOG000220876.
HOVERGENiHBG002386.
InParanoidiP07341.
KOiK01623.
OMAiANCQAAQ.
OrthoDBiEOG091G0A9T.
PhylomeDBiP07341.
TreeFamiTF314203.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07341-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHQFPALSP EQKKALSDIA QRIVASGKGI LAADESVGTM GNRLQRINVE
60 70 80 90 100
NTEENRRAFR EILFSSDASI SKSIGGVILF HETLYQKDSS GKPFPAIIKE
110 120 130 140 150
KGMVVGIKLD AGTAPLAGTN GETTIQGLDK LAERCAQYKK DGADFGKWRA
160 170 180 190 200
VLKISSTTPS QLAIQENANT LARYASICQQ NGLVPIVEPE VLPDGDHDLQ
210 220 230 240 250
RCQYVTEKVL AAVYKALNDH HVYLEGTLLK PNMVTAGHSC PKKYTPQDVA
260 270 280 290 300
VATVTTLLRT VPAAVPGICF LSGGQSEEEA SLNLNAMNQS PLPKPWKLTF
310 320 330 340 350
SYGRALQASA LAAWLGKSEN KKAAQEAFCK RAQINSLACR GQYVTSGKTD
360
TAATQSLFTA SYTY
Length:364
Mass (Da):39,296
Last modified:January 23, 2007 - v3
Checksum:i40E0C300FB574CEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10946 Genomic DNA. Translation: AAA48587.1.
PIRiA22568. ADCHB.
RefSeqiNP_001007978.1. NM_001007977.2.
UniGeneiGga.4760.

Genome annotation databases

EnsembliENSGALT00000037630; ENSGALP00000036836; ENSGALG00000015544.
GeneIDi427308.
KEGGigga:427308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10946 Genomic DNA. Translation: AAA48587.1.
PIRiA22568. ADCHB.
RefSeqiNP_001007978.1. NM_001007977.2.
UniGeneiGga.4760.

3D structure databases

ProteinModelPortaliP07341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi686645. 1 interactor.
IntActiP07341. 1 interactor.
STRINGi9031.ENSGALP00000025010.

Proteomic databases

PaxDbiP07341.
PRIDEiP07341.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000037630; ENSGALP00000036836; ENSGALG00000015544.
GeneIDi427308.
KEGGigga:427308.

Organism-specific databases

CTDi229.

Phylogenomic databases

eggNOGiKOG1557. Eukaryota.
COG3588. LUCA.
GeneTreeiENSGT00390000010235.
HOGENOMiHOG000220876.
HOVERGENiHBG002386.
InParanoidiP07341.
KOiK01623.
OMAiANCQAAQ.
OrthoDBiEOG091G0A9T.
PhylomeDBiP07341.
TreeFamiTF314203.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.
ReactomeiR-GGA-352875. Gluconeogenesis.
R-GGA-352882. Glycolysis.
R-GGA-70171. Glycolysis.
R-GGA-70263. Gluconeogenesis.
R-GGA-70350. Fructose catabolism.

Miscellaneous databases

PROiP07341.

Gene expression databases

BgeeiENSGALG00000015544.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALDOB_CHICK
AccessioniPrimary (citable) accession number: P07341
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.