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P07341

- ALDOB_CHICK

UniProt

P07341 - ALDOB_CHICK

Protein

Fructose-bisphosphate aldolase B

Gene

ALDOB

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei56 – 561SubstrateBy similarity
    Binding sitei147 – 1471SubstrateBy similarity
    Active sitei188 – 1881Proton acceptorBy similarity
    Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-PBy similarity
    Sitei364 – 3641Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity

    GO - Molecular functioni

    1. fructose binding Source: Ensembl
    2. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. fructose 1,6-bisphosphate metabolic process Source: Ensembl
    3. fructose metabolic process Source: Ensembl
    4. gluconeogenesis Source: Reactome
    5. glycolytic process Source: Reactome
    6. liver development Source: AgBase
    7. NADH oxidation Source: Ensembl
    8. positive regulation of ATPase activity Source: Ensembl
    9. small molecule metabolic process Source: Reactome
    10. vacuolar proton-transporting V-type ATPase complex assembly Source: Ensembl

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    ReactomeiREACT_115534. Gluconeogenesis.
    REACT_115767. Glycolysis.
    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase B (EC:4.1.2.13)
    Alternative name(s):
    Liver-type aldolase
    Gene namesi
    Name:ALDOB
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome Z

    Subcellular locationi

    GO - Cellular componenti

    1. centriolar satellite Source: Ensembl
    2. cytosol Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 364363Fructose-bisphosphate aldolase BPRO_0000216945Add
    BLAST

    Proteomic databases

    PaxDbiP07341.
    PRIDEiP07341.

    Interactioni

    Subunit structurei

    Homotetramer.

    Protein-protein interaction databases

    BioGridi686645. 1 interaction.
    IntActiP07341. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP07341.
    SMRiP07341. Positions 3-364.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG3588.
    GeneTreeiENSGT00390000010235.
    HOGENOMiHOG000220876.
    HOVERGENiHBG002386.
    InParanoidiP07341.
    KOiK01623.
    OMAiDMEHCQY.
    OrthoDBiEOG744T94.
    PhylomeDBiP07341.
    TreeFamiTF314203.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view]
    PfamiPF00274. Glycolytic. 1 hit.
    [Graphical view]
    PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07341-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTHQFPALSP EQKKALSDIA QRIVASGKGI LAADESVGTM GNRLQRINVE    50
    NTEENRRAFR EILFSSDASI SKSIGGVILF HETLYQKDSS GKPFPAIIKE 100
    KGMVVGIKLD AGTAPLAGTN GETTIQGLDK LAERCAQYKK DGADFGKWRA 150
    VLKISSTTPS QLAIQENANT LARYASICQQ NGLVPIVEPE VLPDGDHDLQ 200
    RCQYVTEKVL AAVYKALNDH HVYLEGTLLK PNMVTAGHSC PKKYTPQDVA 250
    VATVTTLLRT VPAAVPGICF LSGGQSEEEA SLNLNAMNQS PLPKPWKLTF 300
    SYGRALQASA LAAWLGKSEN KKAAQEAFCK RAQINSLACR GQYVTSGKTD 350
    TAATQSLFTA SYTY 364
    Length:364
    Mass (Da):39,296
    Last modified:January 23, 2007 - v3
    Checksum:i40E0C300FB574CEB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M10946 Genomic DNA. Translation: AAA48587.1.
    PIRiA22568. ADCHB.
    RefSeqiNP_001007978.1. NM_001007977.2.
    UniGeneiGga.4760.

    Genome annotation databases

    EnsembliENSGALT00000025056; ENSGALP00000025010; ENSGALG00000015544.
    ENSGALT00000037630; ENSGALP00000036836; ENSGALG00000015544.
    GeneIDi427308.
    KEGGigga:427308.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M10946 Genomic DNA. Translation: AAA48587.1 .
    PIRi A22568. ADCHB.
    RefSeqi NP_001007978.1. NM_001007977.2.
    UniGenei Gga.4760.

    3D structure databases

    ProteinModelPortali P07341.
    SMRi P07341. Positions 3-364.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 686645. 1 interaction.
    IntActi P07341. 1 interaction.

    Proteomic databases

    PaxDbi P07341.
    PRIDEi P07341.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000025056 ; ENSGALP00000025010 ; ENSGALG00000015544 .
    ENSGALT00000037630 ; ENSGALP00000036836 ; ENSGALG00000015544 .
    GeneIDi 427308.
    KEGGi gga:427308.

    Organism-specific databases

    CTDi 229.

    Phylogenomic databases

    eggNOGi COG3588.
    GeneTreei ENSGT00390000010235.
    HOGENOMi HOG000220876.
    HOVERGENi HBG002386.
    InParanoidi P07341.
    KOi K01623.
    OMAi DMEHCQY.
    OrthoDBi EOG744T94.
    PhylomeDBi P07341.
    TreeFami TF314203.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .
    Reactomei REACT_115534. Gluconeogenesis.
    REACT_115767. Glycolysis.

    Miscellaneous databases

    NextBioi 20828589.
    PROi P07341.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view ]
    Pfami PF00274. Glycolytic. 1 hit.
    [Graphical view ]
    PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the chicken aldolase B gene."
      Burgess D.G., Penhoet E.E.
      J. Biol. Chem. 260:4604-4614(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiALDOB_CHICK
    AccessioniPrimary (citable) accession number: P07341
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 111 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3