P07341 (ALDOB_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fructose-bisphosphate aldolase B
EC=4.1.2.13

Alternative name(s):
Liver-type aldolase

Gene names

Name:

ALDOB

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
Subunit structure	Homotetramer.
Miscellaneous	In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.
Sequence similarities	Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	NADH oxidation Inferred from electronic annotation. Source: Compara fructose 1,6-bisphosphate metabolic process Inferred from electronic annotation. Source: Compara fructose metabolic process Inferred from electronic annotation. Source: Compara gluconeogenesis Traceable author statement. Source: Reactome glycolysis Traceable author statement. Source: Reactome liver development Inferred from expression pattern PubMed 2350361. Source: AgBase positive regulation of ATPase activity Inferred from electronic annotation. Source: Compara small molecule metabolic process Traceable author statement. Source: Reactome vacuolar proton-transporting V-type ATPase complex assembly Inferred from electronic annotation. Source: Compara
Cellular_component	centriolar satellite Inferred from electronic annotation. Source: Compara cytosol Traceable author statement. Source: Reactome
Molecular_function	fructose binding Inferred from electronic annotation. Source: Compara fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 364	363	Fructose-bisphosphate aldolase B		PRO_0000216945
Sites
	Active site	188	1	Proton acceptor By similarity
	Active site	230	1	Schiff-base intermediate with dihydroxyacetone-P By similarity
	Binding site	56	1	Substrate By similarity
	Binding site	147	1	Substrate By similarity
	Site	364	1	Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P07341 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 40E0C300FB574CEB	FASTA	364	39,296
	10 20 30 40 50 60 MTHQFPALSP EQKKALSDIA QRIVASGKGI LAADESVGTM GNRLQRINVE NTEENRRAFR 70 80 90 100 110 120 EILFSSDASI SKSIGGVILF HETLYQKDSS GKPFPAIIKE KGMVVGIKLD AGTAPLAGTN 130 140 150 160 170 180 GETTIQGLDK LAERCAQYKK DGADFGKWRA VLKISSTTPS QLAIQENANT LARYASICQQ 190 200 210 220 230 240 NGLVPIVEPE VLPDGDHDLQ RCQYVTEKVL AAVYKALNDH HVYLEGTLLK PNMVTAGHSC 250 260 270 280 290 300 PKKYTPQDVA VATVTTLLRT VPAAVPGICF LSGGQSEEEA SLNLNAMNQS PLPKPWKLTF 310 320 330 340 350 360 SYGRALQASA LAAWLGKSEN KKAAQEAFCK RAQINSLACR GQYVTSGKTD TAATQSLFTA SYTY

References

[1]	"Characterization of the chicken aldolase B gene." Burgess D.G., Penhoet E.E. J. Biol. Chem. 260:4604-4614(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M10946 Genomic DNA. Translation: AAA48587.1.
IPI	IPI00601855.
PIR	ADCHB. A22568.
RefSeq	NP_001007978.1. NM_001007977.2.
UniGene	Gga.4760.
3D structure databases
ProteinModelPortal	P07341.
SMR	P07341. Positions 3-364.
ModBase	Search...
Protein-protein interaction databases
IntAct	P07341. 1 interaction.
Proteomic databases
PaxDb	P07341.
PRIDE	P07341.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000025056; ENSGALP00000025010; ENSGALG00000015544.
GeneID	427308.
KEGG	gga:427308.
Organism-specific databases
CTD	229.
Phylogenomic databases
eggNOG	COG3588.
GeneTree	ENSGT00390000010235.
HOGENOM	HOG000220876.
HOVERGEN	HBG002386.
InParanoid	P07341.
KO	K01623.
OMA	IDNQCPS.
OrthoDB	EOG444KKK.
Enzyme and pathway databases
Reactome	REACT_115655. Metabolism.
UniPathway	UPA00109; UER00183.
Gene expression databases
ArrayExpress	P07341.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR000741. Aldolase_I. IPR013785. Aldolase_TIM. [Graphical view]
PANTHER	PTHR11627. PTHR11627. 1 hit.
Pfam	PF00274. Glycolytic. 1 hit. [Graphical view]
PROSITE	PS00158. ALDOLASE_CLASS_I. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20828589.

Entry information

Entry name

ALDOB_CHICK

Accession

Primary (citable) accession number: P07341

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 101 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program