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Protein

Fructose-bisphosphate aldolase B

Gene

ALDOB

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561SubstrateBy similarity
Binding sitei147 – 1471SubstrateBy similarity
Active sitei188 – 1881Proton acceptorBy similarity
Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-PBy similarity
Sitei364 – 3641Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity

GO - Molecular functioni

  1. fructose-1-phosphate aldolase activity Source: Ensembl
  2. fructose binding Source: Ensembl
  3. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. fructose 1,6-bisphosphate metabolic process Source: Ensembl
  3. fructose metabolic process Source: Ensembl
  4. gluconeogenesis Source: Reactome
  5. glycolytic process Source: Reactome
  6. liver development Source: AgBase
  7. NADH oxidation Source: Ensembl
  8. positive regulation of ATPase activity Source: Ensembl
  9. small molecule metabolic process Source: Reactome
  10. vacuolar proton-transporting V-type ATPase complex assembly Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

ReactomeiREACT_115534. Gluconeogenesis.
REACT_115767. Glycolysis.
REACT_284496. Glycolysis.
REACT_309960. Fructose catabolism.
REACT_352557. Gluconeogenesis.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase B (EC:4.1.2.13)
Alternative name(s):
Liver-type aldolase
Gene namesi
Name:ALDOB
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Chromosome Z

Subcellular locationi

GO - Cellular componenti

  1. centriolar satellite Source: Ensembl
  2. cytosol Source: Reactome
  3. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 364363Fructose-bisphosphate aldolase BPRO_0000216945Add
BLAST

Proteomic databases

PaxDbiP07341.
PRIDEiP07341.

Expressioni

Gene expression databases

ExpressionAtlasiP07341. baseline and differential.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

BioGridi686645. 1 interaction.
IntActiP07341. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP07341.
SMRiP07341. Positions 3-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3588.
GeneTreeiENSGT00390000010235.
HOGENOMiHOG000220876.
HOVERGENiHBG002386.
InParanoidiP07341.
KOiK01623.
OMAiRAMANCQ.
OrthoDBiEOG744T94.
PhylomeDBiP07341.
TreeFamiTF314203.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view]
PANTHERiPTHR11627. PTHR11627. 1 hit.
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07341-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHQFPALSP EQKKALSDIA QRIVASGKGI LAADESVGTM GNRLQRINVE
60 70 80 90 100
NTEENRRAFR EILFSSDASI SKSIGGVILF HETLYQKDSS GKPFPAIIKE
110 120 130 140 150
KGMVVGIKLD AGTAPLAGTN GETTIQGLDK LAERCAQYKK DGADFGKWRA
160 170 180 190 200
VLKISSTTPS QLAIQENANT LARYASICQQ NGLVPIVEPE VLPDGDHDLQ
210 220 230 240 250
RCQYVTEKVL AAVYKALNDH HVYLEGTLLK PNMVTAGHSC PKKYTPQDVA
260 270 280 290 300
VATVTTLLRT VPAAVPGICF LSGGQSEEEA SLNLNAMNQS PLPKPWKLTF
310 320 330 340 350
SYGRALQASA LAAWLGKSEN KKAAQEAFCK RAQINSLACR GQYVTSGKTD
360
TAATQSLFTA SYTY
Length:364
Mass (Da):39,296
Last modified:January 22, 2007 - v3
Checksum:i40E0C300FB574CEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10946 Genomic DNA. Translation: AAA48587.1.
PIRiA22568. ADCHB.
RefSeqiNP_001007978.1. NM_001007977.2.
UniGeneiGga.4760.

Genome annotation databases

EnsembliENSGALT00000025056; ENSGALP00000025010; ENSGALG00000015544.
ENSGALT00000037630; ENSGALP00000036836; ENSGALG00000015544.
GeneIDi427308.
KEGGigga:427308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10946 Genomic DNA. Translation: AAA48587.1.
PIRiA22568. ADCHB.
RefSeqiNP_001007978.1. NM_001007977.2.
UniGeneiGga.4760.

3D structure databases

ProteinModelPortaliP07341.
SMRiP07341. Positions 3-364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi686645. 1 interaction.
IntActiP07341. 1 interaction.

Proteomic databases

PaxDbiP07341.
PRIDEiP07341.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000025056; ENSGALP00000025010; ENSGALG00000015544.
ENSGALT00000037630; ENSGALP00000036836; ENSGALG00000015544.
GeneIDi427308.
KEGGigga:427308.

Organism-specific databases

CTDi229.

Phylogenomic databases

eggNOGiCOG3588.
GeneTreeiENSGT00390000010235.
HOGENOMiHOG000220876.
HOVERGENiHBG002386.
InParanoidiP07341.
KOiK01623.
OMAiRAMANCQ.
OrthoDBiEOG744T94.
PhylomeDBiP07341.
TreeFamiTF314203.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.
ReactomeiREACT_115534. Gluconeogenesis.
REACT_115767. Glycolysis.
REACT_284496. Glycolysis.
REACT_309960. Fructose catabolism.
REACT_352557. Gluconeogenesis.

Miscellaneous databases

NextBioi20828589.
PROiP07341.

Gene expression databases

ExpressionAtlasiP07341. baseline and differential.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view]
PANTHERiPTHR11627. PTHR11627. 1 hit.
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of the chicken aldolase B gene."
    Burgess D.G., Penhoet E.E.
    J. Biol. Chem. 260:4604-4614(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiALDOB_CHICK
AccessioniPrimary (citable) accession number: P07341
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 31, 1988
Last sequence update: January 22, 2007
Last modified: March 31, 2015
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.