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P07341

- ALDOB_CHICK

UniProt

P07341 - ALDOB_CHICK

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Protein

Fructose-bisphosphate aldolase B

Gene

ALDOB

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561SubstrateBy similarity
Binding sitei147 – 1471SubstrateBy similarity
Active sitei188 – 1881Proton acceptorBy similarity
Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-PBy similarity
Sitei364 – 3641Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity

GO - Molecular functioni

  1. fructose binding Source: Ensembl
  2. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. fructose 1,6-bisphosphate metabolic process Source: Ensembl
  3. fructose metabolic process Source: Ensembl
  4. gluconeogenesis Source: Reactome
  5. glycolytic process Source: Reactome
  6. liver development Source: AgBase
  7. NADH oxidation Source: Ensembl
  8. positive regulation of ATPase activity Source: Ensembl
  9. small molecule metabolic process Source: Reactome
  10. vacuolar proton-transporting V-type ATPase complex assembly Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

ReactomeiREACT_115534. Gluconeogenesis.
REACT_115767. Glycolysis.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase B (EC:4.1.2.13)
Alternative name(s):
Liver-type aldolase
Gene namesi
Name:ALDOB
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome Z

Subcellular locationi

GO - Cellular componenti

  1. centriolar satellite Source: Ensembl
  2. cytosol Source: Reactome
  3. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 364363Fructose-bisphosphate aldolase BPRO_0000216945Add
BLAST

Proteomic databases

PaxDbiP07341.
PRIDEiP07341.

Expressioni

Gene expression databases

ExpressionAtlasiP07341. baseline.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

BioGridi686645. 1 interaction.
IntActiP07341. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP07341.
SMRiP07341. Positions 3-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3588.
GeneTreeiENSGT00390000010235.
HOGENOMiHOG000220876.
HOVERGENiHBG002386.
InParanoidiP07341.
KOiK01623.
OMAiDMEHCQY.
OrthoDBiEOG744T94.
PhylomeDBiP07341.
TreeFamiTF314203.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view]
PANTHERiPTHR11627. PTHR11627. 1 hit.
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07341-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTHQFPALSP EQKKALSDIA QRIVASGKGI LAADESVGTM GNRLQRINVE
60 70 80 90 100
NTEENRRAFR EILFSSDASI SKSIGGVILF HETLYQKDSS GKPFPAIIKE
110 120 130 140 150
KGMVVGIKLD AGTAPLAGTN GETTIQGLDK LAERCAQYKK DGADFGKWRA
160 170 180 190 200
VLKISSTTPS QLAIQENANT LARYASICQQ NGLVPIVEPE VLPDGDHDLQ
210 220 230 240 250
RCQYVTEKVL AAVYKALNDH HVYLEGTLLK PNMVTAGHSC PKKYTPQDVA
260 270 280 290 300
VATVTTLLRT VPAAVPGICF LSGGQSEEEA SLNLNAMNQS PLPKPWKLTF
310 320 330 340 350
SYGRALQASA LAAWLGKSEN KKAAQEAFCK RAQINSLACR GQYVTSGKTD
360
TAATQSLFTA SYTY
Length:364
Mass (Da):39,296
Last modified:January 23, 2007 - v3
Checksum:i40E0C300FB574CEB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M10946 Genomic DNA. Translation: AAA48587.1.
PIRiA22568. ADCHB.
RefSeqiNP_001007978.1. NM_001007977.2.
UniGeneiGga.4760.

Genome annotation databases

EnsembliENSGALT00000025056; ENSGALP00000025010; ENSGALG00000015544.
ENSGALT00000037630; ENSGALP00000036836; ENSGALG00000015544.
GeneIDi427308.
KEGGigga:427308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M10946 Genomic DNA. Translation: AAA48587.1 .
PIRi A22568. ADCHB.
RefSeqi NP_001007978.1. NM_001007977.2.
UniGenei Gga.4760.

3D structure databases

ProteinModelPortali P07341.
SMRi P07341. Positions 3-364.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 686645. 1 interaction.
IntActi P07341. 1 interaction.

Proteomic databases

PaxDbi P07341.
PRIDEi P07341.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000025056 ; ENSGALP00000025010 ; ENSGALG00000015544 .
ENSGALT00000037630 ; ENSGALP00000036836 ; ENSGALG00000015544 .
GeneIDi 427308.
KEGGi gga:427308.

Organism-specific databases

CTDi 229.

Phylogenomic databases

eggNOGi COG3588.
GeneTreei ENSGT00390000010235.
HOGENOMi HOG000220876.
HOVERGENi HBG002386.
InParanoidi P07341.
KOi K01623.
OMAi DMEHCQY.
OrthoDBi EOG744T94.
PhylomeDBi P07341.
TreeFami TF314203.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
Reactomei REACT_115534. Gluconeogenesis.
REACT_115767. Glycolysis.

Miscellaneous databases

NextBioi 20828589.
PROi P07341.

Gene expression databases

ExpressionAtlasi P07341. baseline.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view ]
PANTHERi PTHR11627. PTHR11627. 1 hit.
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of the chicken aldolase B gene."
    Burgess D.G., Penhoet E.E.
    J. Biol. Chem. 260:4604-4614(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiALDOB_CHICK
AccessioniPrimary (citable) accession number: P07341
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3