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P07341 (ALDOB_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase B

EC=4.1.2.13
Alternative name(s):
Liver-type aldolase
Gene names
Name:ALDOB
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Subunit structure

Homotetramer.

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriolar satellite By similarity.

Miscellaneous

In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

Sequence similarities

Belongs to the class I fructose-bisphosphate aldolase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 364363Fructose-bisphosphate aldolase B
PRO_0000216945

Sites

Active site1881Proton acceptor By similarity
Active site2301Schiff-base intermediate with dihydroxyacetone-P By similarity
Binding site561Substrate By similarity
Binding site1471Substrate By similarity
Site3641Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
P07341 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 40E0C300FB574CEB

FASTA36439,296
        10         20         30         40         50         60 
MTHQFPALSP EQKKALSDIA QRIVASGKGI LAADESVGTM GNRLQRINVE NTEENRRAFR 

        70         80         90        100        110        120 
EILFSSDASI SKSIGGVILF HETLYQKDSS GKPFPAIIKE KGMVVGIKLD AGTAPLAGTN 

       130        140        150        160        170        180 
GETTIQGLDK LAERCAQYKK DGADFGKWRA VLKISSTTPS QLAIQENANT LARYASICQQ 

       190        200        210        220        230        240 
NGLVPIVEPE VLPDGDHDLQ RCQYVTEKVL AAVYKALNDH HVYLEGTLLK PNMVTAGHSC 

       250        260        270        280        290        300 
PKKYTPQDVA VATVTTLLRT VPAAVPGICF LSGGQSEEEA SLNLNAMNQS PLPKPWKLTF 

       310        320        330        340        350        360 
SYGRALQASA LAAWLGKSEN KKAAQEAFCK RAQINSLACR GQYVTSGKTD TAATQSLFTA 


SYTY 

« Hide

References

[1]"Characterization of the chicken aldolase B gene."
Burgess D.G., Penhoet E.E.
J. Biol. Chem. 260:4604-4614(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M10946 Genomic DNA. Translation: AAA48587.1.
PIRADCHB. A22568.
RefSeqNP_001007978.1. NM_001007977.2.
UniGeneGga.4760.

3D structure databases

ProteinModelPortalP07341.
SMRP07341. Positions 3-364.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid686645. 1 interaction.
IntActP07341. 1 interaction.

Proteomic databases

PaxDbP07341.
PRIDEP07341.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000025056; ENSGALP00000025010; ENSGALG00000015544.
ENSGALT00000037630; ENSGALP00000036836; ENSGALG00000015544.
GeneID427308.
KEGGgga:427308.

Organism-specific databases

CTD229.

Phylogenomic databases

eggNOGCOG3588.
GeneTreeENSGT00390000010235.
HOGENOMHOG000220876.
HOVERGENHBG002386.
InParanoidP07341.
KOK01623.
OMADMEHCQY.
OrthoDBEOG744T94.
PhylomeDBP07341.
TreeFamTF314203.

Enzyme and pathway databases

ReactomeREACT_115655. Metabolism.
UniPathwayUPA00109; UER00183.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR000741. Aldolase_I.
IPR013785. Aldolase_TIM.
[Graphical view]
PANTHERPTHR11627. PTHR11627. 1 hit.
PfamPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20828589.
PROP07341.

Entry information

Entry nameALDOB_CHICK
AccessionPrimary (citable) accession number: P07341
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways